Gene: SIM2

6493
HMC13F06|HMC29C01|SIM|bHLHe15
SIM bHLH transcription factor 2
protein-coding
21q22.13
Ensembl:ENSG00000159263 MIM:600892 Vega:OTTHUMG00000086637 UniprotKB:Q14190
NG_029519.1
SNP Mapped
1   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
7.395e-1 (AD)  1.574e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs9977521chr21:36710512 (GRCh38.p7)C>Talcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
POLR1C0.708
INO80C0.69
PRR30.682
ZC3HC10.681
TOMM340.678
PUS10.669
AP4B10.667
NAALAD20.666
RPP300.664
ZMYND80.663

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.402
OR4F29-0.358
ANXA13-0.3
PDE11A-0.29
GPR174-0.286
XPNPEP2-0.277
CYTIP-0.276
TFPI2-0.273
VRK2-0.272
TMEM102-0.267

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in decreased expression of SIM2 mRNA"27291303
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SIM2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SIM2 mRNA"27188386
D020106AcrylamideAcrylamide affects the expression of SIM2 mRNA28959563
C015001arsenitearsenite results in increased methylation of SIM2 promoter23974009
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of SIM2 mRNA21839799
C006780bisphenol Abisphenol A affects the methylation of SIM2 promoter27334623
C006780bisphenol A[bisphenol A co-treated with Testosterone] results in decreased expression of SIM2 mRNA26496021
C006780bisphenol Abisphenol A results in decreased expression of SIM2 mRNA25181051
D004390ChlorpyrifosChlorpyrifos results in increased expression of SIM2 mRNA20691718
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of SIM2 gene20938992
D003042CocaineCocaine results in decreased expression of SIM2 mRNA27899881
C030973cupric oxidecupric oxide results in decreased expression of SIM2 mRNA22077320
D003474CurcuminCurcumin inhibits the reaction [Glucose results in increased expression of SIM2 mRNA]23333261
D003474CurcuminCurcumin inhibits the reaction [Glucose results in increased expression of SIM2 protein]23333261
C000541cyclopaminecyclopamine results in decreased expression of SIM2 mRNA22265815
C023614dibenzofurandibenzofuran analog results in increased expression of SIM2 mRNA20566336
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in decreased expression of SIM2 mRNA27392435
D002945CisplatinCisplatin results in decreased expression of SIM2 mRNA27392435
D004041Dietary FatsDietary Fats results in increased expression of SIM2 mRNA18042831
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of SIM2 gene20938992
D005947GlucoseCurcumin inhibits the reaction [Glucose results in increased expression of SIM2 mRNA]23333261
D005947GlucoseCurcumin inhibits the reaction [Glucose results in increased expression of SIM2 protein]23333261
D005947GlucoseGlucose results in increased expression of SIM2 mRNA23333261
D005947GlucoseGlucose results in increased expression of SIM2 protein23333261
D005947GlucoseSIM2 protein results in increased susceptibility to Glucose23333261
C544151jinfukang[Cisplatin co-treated with jinfukang] results in decreased expression of SIM2 mRNA27392435
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of SIM2 gene20938992
D009532NickelNickel results in decreased expression of SIM2 mRNA24768652|2558310
D000073878Palm OilPalm Oil results in increased expression of SIM2 mRNA18042831
D052638Particulate MatterParticulate Matter results in increased expression of SIM2 mRNA22178795
C027373potassium chromate(VI)potassium chromate(VI) results in increased expression of SIM2 mRNA22714537
C009166retinol acetateretinol acetate results in increased expression of SIM2 mRNA16772331
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of SIM2 mRNA25895662
C017947sodium arsenitesodium arsenite affects the methylation of SIM2 gene28589171
C017947sodium arsenitesodium arsenite results in decreased expression of SIM2 mRNA22714537
D013311StreptozocinStreptozocin results in increased expression of SIM2 protein23333261
D013739Testosterone[bisphenol A co-treated with Testosterone] results in decreased expression of SIM2 mRNA26496021
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of SIM2 mRNA24058054
C012589trichostatin Atrichostatin A results in decreased expression of SIM2 mRNA24935251
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SIM2 mRNA"27188386
D014635Valproic AcidValproic Acid results in decreased expression of SIM2 mRNA26272509
D014638VanadatesVanadates results in decreased expression of SIM2 mRNA22714537
C029297vinylidene chloridevinylidene chloride results in decreased expression of SIM2 mRNA26682919

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-IBA21873635  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISA-  
GO:0003677DNA binding-IEA-  
GO:0003700DNA-binding transcription factor activity-TAS8661114  9199934  
GO:0046982protein heterodimerization activity-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0000122negative regulation of transcription by RNA polymerase II-IEA-  
GO:0006351transcription, DNA-templated-IEA-  
GO:0006357regulation of transcription by RNA polymerase II-IBA21873635  
GO:0009880embryonic pattern specification-IEA-  
GO:0030154cell differentiation-IEA-  
GO:0030324lung development-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IBA21873635  
GO:0005654nucleoplasm-IDA-  
GO:0016604nuclear body-IDA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal