Gene info: ID 6497

Gene: SKI

GENE ID: 6497

Synonyms: SGS|SKV

Description: SKI proto-oncogene

Gene type: protein-coding

Location: 1p36.33-p36.32

dbXrefs: Ensembl:ENSG00000157933 MIM:164780 Vega:OTTHUMG00000001407 UniprotKB:P12755

RefSeq: NG_013084.1

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: ND

# Publications: 7

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 6.810e-1 (AD) 4.653e-1 (ND)

DNA Methylation

Probe	Locus(GRCh37)	Gene	Region	p-val	Trait	PubMed ID
cg18934822	chr1:2191402	SKI	Gene body	5.741e-5	Alcohol use disorders	26763658
cg05603985	chr1:2161049	SKI		1.800e-43	Smoking	27651444
cg09469355	chr1:2161886	SKI		1.300e-24	Smoking	27651444
cg08884752	chr1:2162001	SKI		1.700e-11	Smoking	27651444
cg01979157	chr1:2161013	SKI		2.200e-10	Smoking	27651444
cg08640824	chr1:2162506	SKI		3.100e-10	Smoking	27651444
cg03466562	chr1:2220317	SKI		1.100e-9	Smoking	27651444
cg15935121	chr1:2230601	SKI		4.000e-9	Smoking	27651444
cg01787285	chr1:2162682	SKI		3.200e-8	Smoking	27651444
cg05603985	chr1:2161049	SKI		7.860e-13	Alcohol consumption per day	27843151
cg01979157	chr1:2161013	SKI		5.940e-12	Alcohol consumption der day	27843151
cg05603985	chr1:2161049	SKI		1.940e-8	Alcohol consumption der day	27843151
cg05603985	chr1:2161049	SKI		2.040e-9	Tobacco smoking	28225026
cg26332488	chr1:2230640	SKI		1.250e-9	Smoking	28686328
cg15935121	chr1:2230601	SKI		1.390e-9	Smoking	28686328
cg01979157	chr1:2161013	SKI		2.990e-8	Smoking	28686328

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
RAPGEF1	0.919
PPARD	0.9
TRAF7	0.898
ERGIC1	0.889
PRRC2A	0.888
ZCCHC14	0.882
TNRC18	0.879
SHANK3	0.879
WDTC1	0.877
SAMD4B	0.876

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
OR4F5	-0.715
OR4F29	-0.664
UTS2	-0.315
ODAM	-0.298
SIM1	-0.296
FOXB1	-0.292
HMX2	-0.288
C22orf42	-0.288
LHX5	-0.282
OTP	-0.282

There is no DrugBank record for this gene !

ID	Drug Name	Action	PubMed
C111118	2',3,3',4',5-pentachloro-4-hydroxybiphenyl	"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of SKI mRNA"	19114083
C023514	2,6-dinitrotoluene	"2,6-dinitrotoluene results in decreased expression of SKI mRNA"	20406850
C000595015	6,7-dimethoxy-2-(pyrrolidin-1-yl)-N-(5-(pyrrolidin-1-yl)pentyl)quinazolin-4-amine	"6,7-dimethoxy-2-(pyrrolidin-1-yl)-N-(5-(pyrrolidin-1-yl)pentyl)quinazolin-4-amine results in decreased expression of SKI mRNA"	28073004
D000082	Acetaminophen	Acetaminophen results in increased expression of SKI mRNA	29067470
D000082	Acetaminophen	Acetaminophen affects the expression of SKI mRNA	17562736
D016604	Aflatoxin B1	Aflatoxin B1 results in increased expression of SKI mRNA	19770486
D000535	Aluminum	[APP protein modified form binds to Aluminum] which results in decreased expression of SKI mRNA	21298039
D018501	Antirheumatic Agents	Antirheumatic Agents results in increased expression of SKI mRNA	24449571
D001151	Arsenic	Arsenic affects the methylation of SKI gene	25304211
D001280	Atrazine	Atrazine results in increased expression of SKI mRNA	22378314
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of SKI mRNA	26238291
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of SKI mRNA	19770486
D015123	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of SKI mRNA"	19150397
D015123	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased expression of SKI mRNA"	20018196
C006780	bisphenol A	bisphenol A results in increased expression of SKI mRNA	26063408
C006780	bisphenol A	bisphenol A affects the expression of SKI mRNA	25181051
C000611646	bisphenol F	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of SKI mRNA	28628672
D002251	Carbon Tetrachloride	Carbon Tetrachloride results in increased expression of SKI mRNA	15056808
D002794	Choline	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of and results in increased expression of SKI	20938992
D002794	Choline	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of SKI gene	20938992
D003300	Copper	[Disulfiram binds to Copper] which results in decreased expression of SKI mRNA	24690739
D016572	Cyclosporine	Cyclosporine results in decreased expression of SKI mRNA	25562108
D016572	Cyclosporine	Cyclosporine results in decreased expression of SKI mRNA	19770486
C014347	decitabine	decitabine results in increased expression of SKI mRNA	27915011
D003907	Dexamethasone	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of SKI mRNA	28628672
D003993	Dibutyl Phthalate	Dibutyl Phthalate results in increased expression of SKI mRNA	21266533
D002945	Cisplatin	Cisplatin results in decreased expression of SKI mRNA	27594783
C000944	dicrotophos	dicrotophos results in increased expression of SKI mRNA	28302478
D004054	Diethylstilbestrol	Diethylstilbestrol results in increased expression of SKI mRNA	15766595
D004221	Disulfiram	[Disulfiram binds to Copper] which results in decreased expression of SKI mRNA	24690739
D005485	Flutamide	Flutamide results in decreased expression of SKI mRNA	24136188
D005492	Folic Acid	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of and results in increased expression of SKI	20938992
D005492	Folic Acid	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of SKI gene	20938992
C419708	gefitinib	gefitinib results in increased expression of SKI mRNA	16685379
D017313	Fenretinide	Fenretinide results in decreased expression of SKI mRNA	28973697
D006830	Hydralazine	[Hydralazine co-treated with Valproic Acid] results in decreased expression of SKI mRNA	17183730
D007213	Indomethacin	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of SKI mRNA	28628672
D015056	1-Methyl-3-isobutylxanthine	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of SKI mRNA	28628672
C561695	(+)-JQ1 compound	(+)-JQ1 compound results in increased expression of SKI mRNA	24796395\|2743299
D008715	Methionine	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of and results in increased expression of SKI	20938992
D008715	Methionine	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of SKI gene	20938992
D008727	Methotrexate	Methotrexate affects the expression of SKI mRNA	18502557
C517284	monomethyl phthalate	monomethyl phthalate affects the expression of SKI mRNA	26924002
C012655	nimesulide	nimesulide results in decreased expression of SKI mRNA	24136188
C006253	pirinixic acid	pirinixic acid results in decreased expression of SKI mRNA	23811191
D011078	Polychlorinated Biphenyls	Polychlorinated Biphenyls affects the expression of SKI mRNA	21334430
D012643	Selenium	Selenium results in increased expression of SKI mRNA	19244175
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of SKI mRNA	19770486
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of SKI mRNA	17586704
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution results in decreased expression of SKI mRNA	28111298
D014212	Tretinoin	Tretinoin results in increased expression of SKI mRNA	16604517
D014241	Trichloroethylene	PPARA protein inhibits the reaction [Trichloroethylene results in decreased expression of SKI mRNA]	15363585
D014520	Urethane	Urethane results in increased expression of SKI mRNA	28818685
D014635	Valproic Acid	[Hydralazine co-treated with Valproic Acid] results in decreased expression of SKI mRNA	17183730
D014635	Valproic Acid	Valproic Acid affects the expression of SKI mRNA	25979313
D014635	Valproic Acid	Valproic Acid results in increased methylation of SKI gene	29154799
D014635	Valproic Acid	Valproic Acid affects the expression of SKI mRNA	17963808
D001335	Vehicle Emissions	Vehicle Emissions results in increased methylation of SKI gene	25560391
D014810	Vitamin E	Vitamin E results in increased expression of SKI mRNA	19244175

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0000981	RNA polymerase II transcription factor activity, sequence-specific DNA binding	-	ISM	19274049
GO:0000981	RNA polymerase II transcription factor activity, sequence-specific DNA binding	-	NAS	19274049
GO:0003714	transcription corepressor activity	-	IDA	17469184
GO:0003714	transcription corepressor activity	-	IMP	12435627
GO:0005515	protein binding	-	IPI	8514802 9569025 10049357 12419246 12435627 12646588 12857746 14525983 15231748 18729074 19008232 19032343 19049980 22334647 22442258 23610558 25609649 26977879
GO:0008270	zinc ion binding	-	IDA	12419246
GO:0019901	protein kinase binding	-	IPI	12874272
GO:0019904	protein domain specific binding	-	IPI	11441023
GO:0031625	ubiquitin protein ligase binding	-	IPI	17510063
GO:0046332	SMAD binding	-	IBA	21873635
GO:0046332	SMAD binding	-	IPI	15107821 17469184
GO:0046811	histone deacetylase inhibitor activity	-	ISS	-
GO:0070491	repressing transcription factor binding	-	IPI	12435627

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0000122	negative regulation of transcription by RNA polymerase II	-	IDA	17469184
GO:0000122	negative regulation of transcription by RNA polymerase II	-	IMP	12435627
GO:0000122	negative regulation of transcription by RNA polymerase II	-	TAS	-
GO:0001843	neural tube closure	-	ISS	-
GO:0002089	lens morphogenesis in camera-type eye	-	ISS	-
GO:0006351	transcription, DNA-templated	-	IEA	-
GO:0007179	transforming growth factor beta receptor signaling pathway	-	NAS	14583455
GO:0008283	cell proliferation	-	NAS	14583455
GO:0008285	negative regulation of cell proliferation	-	IDA	11430826
GO:0009948	anterior/posterior axis specification	-	ISS	-
GO:0010626	negative regulation of Schwann cell proliferation	-	IGI	15312649
GO:0014902	myotube differentiation	-	IDA	19008232
GO:0021772	olfactory bulb development	-	ISS	-
GO:0022011	myelination in peripheral nervous system	-	ISS	-
GO:0030177	positive regulation of Wnt signaling pathway	-	NAS	14583455
GO:0030326	embryonic limb morphogenesis	-	ISS	-
GO:0030509	BMP signaling pathway	-	TAS	-
GO:0030512	negative regulation of transforming growth factor beta receptor signaling pathway	-	IBA	21873635
GO:0030512	negative regulation of transforming growth factor beta receptor signaling pathway	-	IDA	17469184
GO:0030512	negative regulation of transforming growth factor beta receptor signaling pathway	-	IGI	15312649
GO:0030512	negative regulation of transforming growth factor beta receptor signaling pathway	-	IMP	17054724 19049980
GO:0030514	negative regulation of BMP signaling pathway	-	IBA	21873635
GO:0030514	negative regulation of BMP signaling pathway	-	IDA	14699069
GO:0030514	negative regulation of BMP signaling pathway	-	IMP	17054724
GO:0031064	negative regulation of histone deacetylation	-	IEA	-
GO:0032926	negative regulation of activin receptor signaling pathway	-	IDA	14699069
GO:0035019	somatic stem cell population maintenance	-	ISS	-
GO:0043010	camera-type eye development	-	ISS	-
GO:0043388	positive regulation of DNA binding	-	IDA	15107821
GO:0043585	nose morphogenesis	-	ISS	-
GO:0045596	negative regulation of cell differentiation	-	IBA	21873635
GO:0045668	negative regulation of osteoblast differentiation	-	IDA	14699069
GO:0045944	positive regulation of transcription by RNA polymerase II	-	ISS	-
GO:0048147	negative regulation of fibroblast proliferation	-	ISS	-
GO:0048593	camera-type eye morphogenesis	-	ISS	-
GO:0048666	neuron development	-	IBA	21873635
GO:0048741	skeletal muscle fiber development	-	ISS	-
GO:0048870	cell motility	-	NAS	14583455
GO:0060021	roof of mouth development	-	ISS	-
GO:0060041	retina development in camera-type eye	-	ISS	-
GO:0060325	face morphogenesis	-	ISS	-
GO:0060349	bone morphogenesis	-	ISS	-
GO:0060395	SMAD protein signal transduction	-	IDA	12874272
GO:0070207	protein homotrimerization	-	IDA	8514802

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005634	nucleus	-	IDA	17054724 17510063
GO:0005654	nucleoplasm	-	IDA	-
GO:0005654	nucleoplasm	-	TAS	-
GO:0005667	transcription factor complex	-	ISS	-
GO:0005737	cytoplasm	-	ISS	-
GO:0005813	centrosome	-	IDA	21600873
GO:0016604	nuclear body	-	IDA	12874272
GO:0016605	PML body	-	IDA	11430826
GO:0017053	transcriptional repressor complex	-	ISS	-
GO:0032991	protein-containing complex	-	IDA	23610558

KEGG ID	KEGG Term

Reactome ID	Reactome Term	Evidence
R-HSA-162582	Signal Transduction	TAS
R-HSA-162582	Signal Transduction	IEA
R-HSA-170834	Signaling by TGF-beta Receptor Complex	TAS
R-HSA-170834	Signaling by TGF-beta Receptor Complex	IEA
R-HSA-201451	Signaling by BMP	TAS
R-HSA-212436	Generic Transcription Pathway	TAS
R-HSA-212436	Generic Transcription Pathway	IEA
R-HSA-2173793	Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer	TAS
R-HSA-2173793	Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer	IEA
R-HSA-2173795	Downregulation of SMAD2/3:SMAD4 transcriptional activity	TAS
R-HSA-2173795	Downregulation of SMAD2/3:SMAD4 transcriptional activity	IEA
R-HSA-73857	RNA Polymerase II Transcription	TAS
R-HSA-73857	RNA Polymerase II Transcription	IEA
R-HSA-74160	Gene expression (Transcription)	TAS
R-HSA-74160	Gene expression (Transcription)	IEA
R-HSA-9006936	Signaling by TGF-beta family members	TAS
R-HSA-9006936	Signaling by TGF-beta family members	IEA

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
28738884	Health status and health behaviors among citizen endurance Nordic skiers in the United States. (2017 Jul 24)	Anderson PJ	BMC Res Notes
25670239	Cancer incidence in participants in a long-distance ski race (Vasaloppet, Sweden) compared to the background population. (2015 Mar)	Hallmarker U	Eur J Cancer
17404079	3q26 Amplification and polysomy of chromosome 3 in squamous cell lesions of the lung: a fluorescence in situ hybridization study. (2007 Apr 1)	Pelosi G	Clin Cancer Res
25827685	Risk of recurrent ischaemic events after myocardial infarction in long-distance ski race participants. (2016 Feb)	Hallmarker U	Eur J Prev Cardiol
26404760	Risk of Recurrent Stroke and Death After First Stroke in Long-Distance Ski Race Participants. (2015 Sep 24)	Hallmarker U	J Am Heart Assoc
29191063	Changes in DNA methylation induced by multi-walled carbon nanotube exposure in the workplace. (2017 Nov - Dec)	Ghosh M	Nanotoxicology
2260059	[Pulmonary damage caused by ski waxing]. (1990 Nov 20)	Strom E	Tidsskr Nor Laegeforen