Gene: MRPL36

64979
BRIP1|L36mt|MRP-L36|PRPL36|RPMJ
mitochondrial ribosomal protein L36
protein-coding
5p15.33
Ensembl:ENSG00000171421 MIM:611842 Vega:OTTHUMG00000090373 UniprotKB:Q9P0J6
NC_000005.10
PubMed|SNP Mapped
0   ANCO-SNPs
ND|AD
0   
3.629e-2 (AD)  3.346e-1 (ND)   (Frontal_Cortex)
1.603e-1 (AD)  8.010e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
COX140.919
MRPS240.919
LAMTOR20.914
TOMM50.912
MRPS110.911
MRPS120.909
NHP20.909
MRPS70.908
MEA10.908
CHCHD10.907

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.693
OR4F29-0.634
P2RY14-0.38
IL18RAP-0.36
CXCR2-0.324
SLC26A5-0.321
MMP9-0.32
VNN2-0.313
COL4A3-0.313
VNN1-0.312

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in decreased expression of MRPL36 mRNA"21354444
C0512461-methylanthracene[1-methylanthracene co-treated with fluoranthene] results in decreased expression of MRPL36 mRNA28329830
D000082AcetaminophenAcetaminophen affects the expression of MRPL36 mRNA17562736
D000517alpha-Chlorohydrinalpha-Chlorohydrin results in decreased expression of MRPL36 mRNA28522335
D018501Antirheumatic AgentsAntirheumatic Agents results in increased expression of MRPL36 mRNA24449571
D001280AtrazineAtrazine results in decreased expression of MRPL36 mRNA22378314
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of MRPL36 mRNA27195522
C006780bisphenol Abisphenol A results in increased expression of MRPL36 mRNA25047013
C006780bisphenol A[bisphenol A co-treated with Testosterone] results in increased expression of MRPL36 mRNA26496021
C006780bisphenol Abisphenol A results in increased expression of MRPL36 mRNA25181051
C059041calyculin Acalyculin A results in decreased expression of MRPL36 mRNA25270620
C100187chloropicrinchloropicrin results in decreased expression of MRPL36 mRNA26352163
D019327Copper SulfateCopper Sulfate results in decreased expression of MRPL36 mRNA19549813
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of MRPL36 mRNA21266533
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of MRPL36 mRNA21266533
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of MRPL36 mRNA17942748
C007738fluoranthene[1-methylanthracene co-treated with fluoranthene] results in decreased expression of MRPL36 mRNA28329830
D005485FlutamideFlutamide results in decreased expression of MRPL36 mRNA24793618
D005947Glucose[INS protein co-treated with Glucose] results in increased expression of MRPL36 mRNA22634610
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of MRPL36 mRNA26011545
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of MRPL36 mRNA"28673683
C051752nefazodonenefazodone results in increased expression of MRPL36 mRNA24136188
C006253pirinixic acidpirinixic acid results in increased expression of MRPL36 mRNA18301758
C059514resveratrolresveratrol results in increased expression of MRPL36 mRNA22610192
C009277sodium arsenatesodium arsenate results in increased expression of MRPL36 mRNA23922661
D013739Testosterone[bisphenol A co-treated with Testosterone] results in increased expression of MRPL36 mRNA26496021
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of MRPL36 mRNA21570461
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of MRPL36 mRNA17942748
C066340tolcaponetolcapone results in decreased expression of MRPL36 mRNA24136188
D014520UrethaneUrethane results in decreased expression of MRPL36 mRNA28818685
D014635Valproic AcidValproic Acid affects the expression of MRPL36 mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of MRPL36 mRNA23179753|2800136
D014635Valproic AcidValproic Acid results in increased methylation of MRPL36 gene29154799
C025643vinclozolinvinclozolin results in increased expression of MRPL36 mRNA22570695
C111237vorinostatvorinostat results in increased expression of MRPL36 mRNA27188386

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003735structural constituent of ribosome-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006412translation-NAS11279069  
GO:0070125mitochondrial translational elongation-TAS-  
GO:0070126mitochondrial translational termination-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005739mitochondrion-IDA-  
GO:0005743mitochondrial inner membrane-TAS-  
GO:0005762mitochondrial large ribosomal subunit-IDA25278503  
GO:0005762mitochondrial large ribosomal subunit-NAS11279069  
GO:0016604nuclear body-IDA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-392499Metabolism of proteinsTAS
R-HSA-392499Metabolism of proteinsIEA
R-HSA-5368286Mitochondrial translation initiationIEA
R-HSA-5368287Mitochondrial translationTAS
R-HSA-5368287Mitochondrial translationIEA
R-HSA-5389840Mitochondrial translation elongationIEA
R-HSA-5389840Mitochondrial translation elongationTAS
R-HSA-5419276Mitochondrial translation terminationTAS
R-HSA-72766TranslationTAS
R-HSA-72766TranslationIEA

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal