Gene: SKIV2L

6499
170A|DDX13|HLP|SKI2|SKI2W|SKIV2|SKIV2L1|THES2
Ski2 like RNA helicase
protein-coding
6p21.33
Ensembl:ENSG00000204351 MIM:600478 Vega:OTTHUMG00000031146 UniprotKB:Q15477
NG_032652.1
PubMed|SNP Mapped
3   ANCO-SNPs
ND|AD
1   
4.951e-1 (AD)  3.222e-1 (ND)   (Frontal_Cortex)
NA (AD)  NA (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs410851chr6:31968891 (GRCh38.p7)T>Calcohol dependenceSNV(Single Nucleotide Variation)
rs437179chr6:31961237 (GRCh38.p7)A>Calcohol dependenceSNV(Single Nucleotide Variation)
rs419788chr6:31961022 (GRCh38.p7)T>Calcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
TBCD0.943
TSC20.927
MMS190.923
KIAA0895L0.92
VPS160.917
GBF10.916
FAM160B20.913
GTF2H40.909
INTS30.909
MAP3K120.908

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.593
OR4F29-0.538
MTRNR2L6-0.352
MTRNR2L9-0.346
TRDN-0.331
MTRNR2L10-0.321
AGTR1-0.286
KLRC2-0.283
YES1-0.282
TMSB15A-0.279

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of SKIV2L mRNA"21346803
D001151ArsenicArsenic affects the methylation of SKIV2L gene25304211
D001554BenzeneBenzene affects the expression of SKIV2L mRNA16188086
D001564Benzo(a)pyreneBenzo(a)pyrene promotes the reaction [AHR protein binds to SKIV2L promoter]19654925
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of SKIV2L mRNA22228805
C006780bisphenol Abisphenol A affects the expression of SKIV2L mRNA21786754
C006780bisphenol Abisphenol A affects the expression of SKIV2L mRNA21786754
C006780bisphenol Abisphenol A results in increased expression of SKIV2L mRNA25181051
C000611646bisphenol F[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of SKIV2L mRNA28628672
D019256Cadmium ChlorideCadmium Chloride results in decreased methylation of SKIV2L promoter22457795
D016572CyclosporineCyclosporine results in increased expression of SKIV2L mRNA25562108
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of SKIV2L mRNA28628672
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of SKIV2L mRNA17555576
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of SKIV2L mRNA17942748
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of SKIV2L mRNA17942748
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of SKIV2L mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of SKIV2L mRNA28628672
C028007nickel monoxidenickel monoxide results in increased expression of SKIV2L mRNA19167457
C029938nickel sulfatenickel sulfate results in increased expression of SKIV2L mRNA22714537
D013629TamoxifenTamoxifen affects the expression of SKIV2L mRNA17555576
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of SKIV2L mRNA21570461
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of SKIV2L mRNA17942748
C057693troglitazonetroglitazone results in decreased expression of SKIV2L mRNA28973697
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of SKIV2L gene25560391

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003723RNA binding-IEA-  
GO:0004004ATP-dependent RNA helicase activity-IBA21873635  
GO:0004004ATP-dependent RNA helicase activity-TAS7610041  
GO:0005524ATP binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006401RNA catabolic process-IBA21873635  
GO:0043928exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay-TAS-  
GO:0070478nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IEA-  
GO:0005829cytosol-TAS-  
GO:0055087Ski complex-IBA21873635  
GO:0055087Ski complex-IDA16024656  
KEGG ID KEGG Term
hsa03018RNA degradation
Reactome ID Reactome Term Evidence
R-HSA-390466Chaperonin-mediated protein foldingIEA
R-HSA-390471Association of TriC/CCT with target proteins during biosynthesisIEA
R-HSA-391251Protein foldingIEA
R-HSA-392499Metabolism of proteinsIEA
R-HSA-429914Deadenylation-dependent mRNA decayTAS
R-HSA-429958mRNA decay by 3' to 5' exoribonucleaseTAS
R-HSA-8953854Metabolism of RNATAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
18806297Further assessment of the complement component 2 and factor B region associated with age-related macular degeneration. (2009 Feb)McKay GJInvest Ophthalmol Vis Sci