Gene: NDRG4

65009
BDM1|SMAP-8|SMAP8
NDRG family member 4
protein-coding
16q21
Ensembl:ENSG00000103034 MIM:614463 Vega:OTTHUMG00000133485 UniprotKB:Q9ULP0
NG_041803.1
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
3.360e-1 (AD)  1.178e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SCAMP50.974
DNAJC50.97
CALM30.968
RAB3A0.968
MAPRE30.967
SPRYD30.966
ENO20.966
SV2A0.966
BSCL20.965
SYNGR10.964

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.677
OR4F29-0.634
TFPI2-0.493
RAI14-0.447
WWTR1-0.44
REST-0.438
CLEC2B-0.438
CST7-0.438
KCNJ15-0.437
IL18RAP-0.434

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of NDRG4 mRNA"23196670
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of NDRG4 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of NDRG4 mRNA"27188386
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of NDRG4 mRNA27153756
D000499AllylamineAllylamine affects the expression of NDRG4 mRNA15910882
D000643Ammonium ChlorideAmmonium Chloride affects the expression of NDRG4 mRNA16483693
C059765amphotericin B, deoxycholate drug combination"amphotericin B, deoxycholate drug combination results in decreased expression of NDRG4 mRNA"22863853
D018501Antirheumatic AgentsAntirheumatic Agents results in increased expression of NDRG4 mRNA24449571
C006632arsenic trioxidearsenic trioxide results in increased expression of NDRG4 mRNA22521957
C015001arsenitearsenite results in decreased expression of NDRG4 mRNA23744399
C015001arseniteTaurine inhibits the reaction [arsenite results in decreased expression of NDRG4 mRNA]23744399
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of NDRG4 mRNA20106945|2163298
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased expression of NDRG4 mRNA"26238291
D004958EstradiolEstradiol results in increased expression of NDRG4 mRNA19484750
D001622BetaineBetaine results in decreased expression of NDRG4 mRNA26391144
C044887beta-methylcholinebeta-methylcholine affects the expression of NDRG4 mRNA21179406
C002791bismuth tripotassium dicitratebismuth tripotassium dicitrate results in decreased expression of NDRG4 mRNA15912405
C006780bisphenol Abisphenol A results in decreased expression of NDRG4 mRNA28159858
C006780bisphenol A[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of NDRG4 mRNA28628672
C006780bisphenol Abisphenol A results in increased expression of NDRG4 mRNA26063408
C006780bisphenol Abisphenol A affects the expression of NDRG4 mRNA25181051
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in decreased expression of NDRG4 mRNA15336504
D002251Carbon TetrachlorideCarbon Tetrachloride affects the expression of NDRG4 mRNA17484886
D020111Chlorodiphenyl (54% Chlorine)Chlorodiphenyl (54% Chlorine) results in increased expression of NDRG4 mRNA23650126
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of NDRG4 mRNA20938992
C018021cobaltous chloridecobaltous chloride results in decreased expression of NDRG4 mRNA17553155
D003300CopperCopper results in decreased expression of NDRG4 mRNA26293553
D019327Copper SulfateCopper Sulfate results in decreased expression of NDRG4 mRNA18579281
D016572CyclosporineCyclosporine results in decreased expression of NDRG4 mRNA27989131
D016572CyclosporineCyclosporine results in decreased methylation of NDRG4 promoter27989131
D016572CyclosporineCyclosporine results in increased expression of NDRG4 mRNA25562108
C014347decitabinedecitabine affects the expression of NDRG4 mRNA23300844
D013759DronabinolDronabinol results in decreased expression of NDRG4 mRNA12237329
D003907DexamethasoneDexamethasone inhibits the reaction [RX3 gene mutant form affects the expression of NDRG4 mRNA]27941970
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of NDRG4 mRNA28628672
D003907DexamethasoneDexamethasone results in increased expression of NDRG4 mRNA14618091
D002945CisplatinCisplatin affects the expression of NDRG4 mRNA23300844
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in increased expression of NDRG4 mRNA27392435
D002945CisplatinCisplatin results in increased expression of NDRG4 mRNA27392435
D002945Cisplatin[Cisplatin co-treated with RELB mutant form] results in increased expression of NDRG4 mRNA23625948
D004041Dietary FatsDietary Fats results in increased expression of NDRG4 mRNA18042831
C012301domoic aciddomoic acid results in decreased expression of NDRG4 mRNA18936300
D004317DoxorubicinDoxorubicin results in decreased expression of NDRG4 mRNA25896364
D000431EthanolEthanol results in decreased expression of NDRG4 mRNA29018328
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of NDRG4 mRNA20938992
D005947Glucose[INS protein co-treated with Glucose] results in increased expression of NDRG4 mRNA22634610
D017313FenretinideFenretinide results in decreased expression of NDRG4 mRNA28973697
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of NDRG4 mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of NDRG4 mRNA28628672
C544151jinfukang[Cisplatin co-treated with jinfukang] results in increased expression of NDRG4 mRNA27392435
C544151jinfukangjinfukang results in increased expression of NDRG4 mRNA27392435
D007854LeadLead affects the expression of NDRG4 mRNA28903495
C045463leflunomideleflunomide results in decreased expression of NDRG4 mRNA19751817
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of NDRG4 mRNA20938992
D008748MethylcholanthreneMethylcholanthrene results in increased expression of NDRG4 mRNA20713471
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of NDRG4 protein25809596
C523799MRK 003NDRG4 results in increased susceptibility to MRK 00319903844
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of NDRG4 mRNA"25554681
D009532NickelNickel results in decreased expression of NDRG4 mRNA24768652|2558310
D000073878Palm OilPalm Oil results in increased expression of NDRG4 mRNA18042831
D011374ProgesteroneProgesterone results in increased expression of NDRG4 mRNA20726854
C005556propionaldehydepropionaldehyde results in increased expression of NDRG4 mRNA26079696
D020849Raloxifene Hydrochloride[Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of NDRG4 mRNA19059307
D012822Silicon DioxideSilicon Dioxide results in increased expression of NDRG4 mRNA25351596
C016104sodium bichromatesodium bichromate results in decreased expression of NDRG4 mRNA22155349
D018038Sodium SeleniteSodium Selenite results in decreased expression of NDRG4 mRNA18175754
D0150852,4,5-Trichlorophenoxyacetic Acid"2,4,5-Trichlorophenoxyacetic Acid results in decreased expression of NDRG4 mRNA"18579281
D013629Tamoxifen[Tamoxifen co-treated with ESR2 protein] results in decreased expression of NDRG4 mRNA19059307
D013654TaurineTaurine inhibits the reaction [arsenite results in decreased expression of NDRG4 mRNA]23744399
C020806tetrabromobisphenol Atetrabromobisphenol A results in decreased expression of NDRG4 mRNA25172293
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of NDRG4 mRNA20106945|2163298
D013749TetrachlorodibenzodioxinAHR protein promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of NDRG4 mRNA]19759094
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of NDRG4 mRNA19759094
C009495titanium dioxidetitanium dioxide results in decreased expression of NDRG4 mRNA23557971
D014212TretinoinTretinoin results in increased expression of NDRG4 mRNA23830798
C012589trichostatin Atrichostatin A results in decreased expression of NDRG4 mRNA15901671
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of NDRG4 mRNA"26743178
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of NDRG4 mRNA"26179874
C057693troglitazonetroglitazone results in increased expression of NDRG4 mRNA17569031
D014501UraniumUranium results in increased expression of NDRG4 mRNA15672453
C005460uranyl acetateuranyl acetate results in increased expression of NDRG4 mRNA15672453
D014635Valproic AcidValproic Acid results in decreased expression of NDRG4 mRNA15901671
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of NDRG4 mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of NDRG4 mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of NDRG4 mRNA23179753|2438349
D014635Valproic AcidValproic Acid results in increased methylation of NDRG4 gene29154799
D014635Valproic AcidValproic Acid affects the expression of NDRG4 mRNA17963808
C025643vinclozolinvinclozolin results in increased expression of NDRG4 mRNA23869203
C070417Win 55212-2Win 55212-2 results in decreased expression of NDRG4 mRNA12237329
D015034Zinc OxideZinc Oxide analog results in decreased expression of NDRG4 mRNA27215404
C088658zoledronic acidzoledronic acid results in increased expression of NDRG4 mRNA24714768

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003674molecular_function-ND-  
GO:0005515protein binding-IPI25416956  
GO ID GO Term Qualifier Evidence PubMed
GO:0001947heart looping-ISS-  
GO:0007165signal transduction-IBA21873635  
GO:0007420brain development-IBA21873635  
GO:0008542visual learning-IEA-  
GO:0010642negative regulation of platelet-derived growth factor receptor signaling pathway-IDA12755708  
GO:0010976positive regulation of neuron projection development-ISS-  
GO:0014912negative regulation of smooth muscle cell migration-IDA12755708  
GO:0030154cell differentiation-NAS11352569  11978393  
GO:0035050embryonic heart tube development-ISS-  
GO:0048278vesicle docking-IEA-  
GO:0048662negative regulation of smooth muscle cell proliferation-IDA12755708  
GO:0060038cardiac muscle cell proliferation-ISS-  
GO:0060973cell migration involved in heart development-IEA-  
GO:0070374positive regulation of ERK1 and ERK2 cascade-IBA21873635  
GO:0070374positive regulation of ERK1 and ERK2 cascade-IDA12755708  
GO:0070374positive regulation of ERK1 and ERK2 cascade-ISS-  
GO:2001135regulation of endocytic recycling-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005737cytoplasm-IBA21873635  
GO:0005737cytoplasm-IDA12755708  
GO:0005737cytoplasm-NAS11352569  
GO:0005739mitochondrion-ISS-  
GO:0005789endoplasmic reticulum membrane-ISS-  
GO:0005829cytosol-IEA-  
GO:0016323basolateral plasma membrane-IDA19535783  
GO:0031253cell projection membrane-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
22083596Stool DNA testing for the detection of pancreatic cancer: assessment of methylation marker candidates. (2012 May 15)Kisiel JBCancer