Gene: PINK1

65018
BRPK|PARK6
PTEN induced putative kinase 1
protein-coding
1p36.12
Ensembl:ENSG00000158828 MIM:608309 Vega:OTTHUMG00000002841 UniprotKB:Q9BXM7
NG_008164.1
PubMed
0   ANCO-SNPs
ND
6   
NA (AD)  NA (ND)   (Frontal_Cortex)
7.183e-1 (AD)  1.551e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OAZ20.936
CHMP4B0.923
MFN20.92
CUEDC20.918
CFL10.916
FAM192A0.916
VTI1B0.915
NGRN0.914
PEBP10.913
STUB10.912

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F29-0.847
OR4F5-0.821
MTRNR2L6-0.265
MTRNR2L10-0.253
GPR171-0.238
MTRNR2L9-0.237
IL24-0.232
CLEC12A-0.23
SIX1-0.229
MTRNR2L3-0.218

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of PINK1 mRNA"21346803
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of PINK1 mRNA"21346803
C4574992-chloro-5-nitrobenzanilide2-chloro-5-nitrobenzanilide promotes the reaction [decamethrin affects the localization of PINK1 protein]27553674
C0303702-methoxy-5-(2',3',4'-trimethoxyphenyl)tropone"2-methoxy-5-(2',3',4'-trimethoxyphenyl)tropone results in decreased expression of PINK1 mRNA"20206263
C5490413-(2,4-dichloro-5-methoxyphenyl)-2-sulfanyl-4(3H)-quinazolinone"3-(2,4-dichloro-5-methoxyphenyl)-2-sulfanyl-4(3H)-quinazolinone inhibits the reaction [arsenic trioxide results in increased expression of PINK1 protein]"27318970
D000082AcetaminophenAcetaminophen results in increased expression of PINK1 mRNA22230336|2570463
D000082AcetaminophenAcetaminophen affects the expression of PINK1 mRNA17562736
D000108AcetylcarnitineAcetylcarnitine inhibits the reaction [Cadmium results in increased expression of PINK1]25464205
D000111AcetylcysteineAcetylcysteine inhibits the reaction [Cadmium results in increased expression of PINK1]25464205
D020106AcrylamideAcrylamide results in decreased expression of PINK1 mRNA28959563
D000255Adenosine TriphosphatePINK1 protein results in increased chemical synthesis of Adenosine Triphosphate27003823
D034341Aristolochic AcidsAristolochic Acids results in increased expression of PINK1 mRNA19717638
C006632arsenic trioxide"3-(2,4-dichloro-5-methoxyphenyl)-2-sulfanyl-4(3H)-quinazolinone inhibits the reaction [arsenic trioxide results in increased expression of PINK1 protein]"27318970
C006632arsenic trioxidearsenic trioxide results in increased expression of PINK1 protein27318970
C006632arsenic trioxideCyclosporine inhibits the reaction [arsenic trioxide results in increased expression of PINK1 protein]27318970
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of PINK1 mRNA20127859
C006780bisphenol Abisphenol A results in increased expression of PINK1 mRNA26063408
C006780bisphenol Abisphenol A affects the expression of PINK1 mRNA21786754
C006780bisphenol Abisphenol A results in increased expression of PINK1 mRNA25181051|2613960
C006780bisphenol Abisphenol A results in increased expression of PINK1 protein26139607
D001786Blood Glucose[Blood Glucose deficiency co-treated with Oxygen deficiency] results in increased expression of PINK1 protein28477916
D001786Blood Glucosegenipin inhibits the reaction [[Blood Glucose deficiency co-treated with Oxygen deficiency] results in increased expression of PINK1 protein]28477916
D002065BuspironeBuspirone results in increased expression of PINK1 mRNA24136188
D002104CadmiumAcetylcarnitine inhibits the reaction [Cadmium results in increased expression of PINK1]25464205
D002104CadmiumAcetylcysteine inhibits the reaction [Cadmium results in increased expression of PINK1]25464205
D002104CadmiumCadmium results in increased expression of PINK125464205
D002104CadmiumCyclosporine inhibits the reaction [Cadmium results in increased expression of PINK1]25464205
D019256Cadmium ChlorideCadmium Chloride results in increased expression of PINK1 mRNA20883709
D002251Carbon TetrachlorideCarbon Tetrachloride results in decreased expression of PINK1 protein26882442
D002251Carbon TetrachlorideMelatonin inhibits the reaction [Carbon Tetrachloride results in decreased expression of PINK1 protein]26882442
D002258Carbonyl Cyanide m-Chlorophenyl Hydrazone[Carbonyl Cyanide m-Chlorophenyl Hydrazone co-treated with PRKN protein] results in increased expression of PINK1 protein28673964
D002258Carbonyl Cyanide m-Chlorophenyl HydrazoneCarbonyl Cyanide m-Chlorophenyl Hydrazone results in increased expression of PINK1 protein27318970
D002258Carbonyl Cyanide m-Chlorophenyl HydrazoneCarbonyl Cyanide m-Chlorophenyl Hydrazone results in increased stability of PINK1 protein26070385
D002258Carbonyl Cyanide m-Chlorophenyl HydrazonePINK1 gene mutant form inhibits the reaction [Carbonyl Cyanide m-Chlorophenyl Hydrazone affects the localization of PARK2 protein]22872702
D002258Carbonyl Cyanide m-Chlorophenyl HydrazoneBECN1 protein affects the reaction [Carbonyl Cyanide m-Chlorophenyl Hydrazone affects the localization of PINK1 protein]24879156
D002258Carbonyl Cyanide m-Chlorophenyl HydrazoneCarbonyl Cyanide m-Chlorophenyl Hydrazone affects the localization of PINK1 protein24879156
D002258Carbonyl Cyanide m-Chlorophenyl HydrazonePINK1 protein affects the reaction [Carbonyl Cyanide m-Chlorophenyl Hydrazone affects the localization of PRKN protein]24879156
D002259Carbonyl Cyanide p-TrifluoromethoxyphenylhydrazonePINK1 protein affects the reaction [Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone affects the localization of PARK2 protein]24879156
D004390ChlorpyrifosChlorpyrifos results in increased stability of PINK1 protein26070385
D002995Clofibric AcidClofibric Acid affects the expression of PINK1 mRNA17602206
D005576ColforsinPINK1 protein affects the reaction [Colforsin results in decreased expression of DNM1L protein]24792327
D003300CopperCopper results in decreased expression of PINK1 mRNA22465980
D003375CoumestrolCoumestrol results in decreased expression of PINK1 mRNA19167446
D003474CurcuminCurcumin inhibits the reaction [Cisplatin results in increased expression of PINK1 protein]28698153
D016572CyclosporineCyclosporine inhibits the reaction [arsenic trioxide results in increased expression of PINK1 protein]27318970
D016572CyclosporineCyclosporine results in decreased expression of PINK1 protein27318970
D016572CyclosporineCyclosporine inhibits the reaction [Cadmium results in increased expression of PINK1]25464205
C017180decamethrin2-chloro-5-nitrobenzanilide promotes the reaction [decamethrin affects the localization of PINK1 protein]27553674
C017180decamethrindecamethrin results in decreased expression of and affects the localization of PINK1 protein27553674
C017180decamethrinrosiglitazone inhibits the reaction [decamethrin results in decreased expression of and affects the localization of PINK1 protein]27553674
C014347decitabinedecitabine affects the expression of PINK1 mRNA23300844
D013759DronabinolDronabinol results in decreased expression of PINK1 mRNA12237329
D003976DiazinonDiazinon results in decreased expression of PINK1 mRNA21968025
D002945CisplatinCisplatin affects the expression of PINK1 mRNA23300844
D002945Cisplatin[Piroxicam co-treated with Cisplatin] results in increased expression of PINK1 mRNA21858171
D002945CisplatinCisplatin results in increased expression of PINK1 protein28698153
D002945CisplatinCurcumin inhibits the reaction [Cisplatin results in increased expression of PINK1 protein]28698153
D002117CalcitriolCalcitriol results in increased expression of PINK1 mRNA16002434
D007980Levodopa[OTC protein modified form co-treated with PINK1 gene mutant form] results in decreased susceptibility to Levodopa24161480
D004298DopamineParaquat affects the reaction [PINK1 protein affects the abundance of Dopamine]22043175
D004298Dopamine[PINK1 mutant form results in increased susceptibility to Paraquat] which results in decreased abundance of Dopamine22043175
D004298DopaminePINK1 protein affects the abundance of Dopamine22043175
D004317DoxorubicinDoxorubicin results in increased expression of PINK1 protein26678157
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of PINK1 mRNA17555576
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of PINK1 mRNA17942748
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in decreased expression of PINK1 mRNA17942748
D005038EthylnitrosoureaEthylnitrosourea results in increased mutagenesis of PINK1 gene16495775
C007834genipingenipin inhibits the reaction [[Blood Glucose deficiency co-treated with Oxygen deficiency] results in increased expression of PINK1 protein]28477916
D005897GlafenineGlafenine results in decreased expression of PINK1 mRNA24136188
D005978GlutathioneGlutathione inhibits the reaction [Hydrogen Peroxide results in increased expression of PINK1 mRNA]24324558
D006861Hydrogen PeroxideGlutathione inhibits the reaction [Hydrogen Peroxide results in increased expression of PINK1 mRNA]24324558
D006861Hydrogen PeroxideHydrogen Peroxide results in increased expression of PINK1 mRNA24324558
D006861Hydrogen PeroxideHMOX1 protein affects the reaction [PINK1 protein affects the susceptibility to Hydrogen Peroxide]21366594
D006861Hydrogen PeroxidePINK1 protein affects the reaction [Hydrogen Peroxide results in increased expression of HMOX1 protein]21366594
D006861Hydrogen PeroxidePINK1 protein affects the reaction [Hydrogen Peroxide results in increased expression of TRAP1 protein]21366594
D006861Hydrogen PeroxidePINK1 protein affects the susceptibility to Hydrogen Peroxide21366594
D006861Hydrogen PeroxidePINK1 protein affects the reaction [Hydrogen Peroxide results in increased chemical synthesis of Reactive Oxygen Species]21421046
D006861Hydrogen PeroxideHydrogen Peroxide results in increased expression of PINK1 protein21159781
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of PINK1 mRNA25613284
C544151jinfukangjinfukang results in increased expression of PINK1 mRNA27392435
C561695(+)-JQ1 compound(+)-JQ1 compound results in increased expression of PINK1 mRNA26752646
D007657Ketone BodiesKetone Bodies results in increased expression of PINK1 mRNA16807920
D007854LeadLead affects the expression of PINK1 mRNA28903495
D008070LipopolysaccharidesLipopolysaccharides results in decreased expression of PINK1 mRNA25613284
D058185Magnetite Nanoparticles[Succimer co-treated with Magnetite Nanoparticles] results in decreased expression of PINK1 mRNA26378955
C025340manganese chloridemanganese chloride results in decreased expression of PINK1 mRNA27913844
C025340manganese chloridemanganese chloride results in increased methylation of PINK1 gene27913844
D008550MelatoninMelatonin inhibits the reaction [Carbon Tetrachloride results in decreased expression of PINK1 protein]26882442
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of PINK1 mRNA28001369
D0156551-Methyl-4-phenylpyridiniumPINK1 gene mutant form results in increased susceptibility to 1-Methyl-4-phenylpyridinium20547144
D0156551-Methyl-4-phenylpyridiniumPINK1 protein affects the reaction [1-Methyl-4-phenylpyridinium results in increased expression of HMOX1 mRNA]21366594
D0156551-Methyl-4-phenylpyridiniumPINK1 protein affects the reaction [1-Methyl-4-phenylpyridinium results in increased expression of HMOX1 protein]21366594
D0156551-Methyl-4-phenylpyridiniumPINK1 protein affects the susceptibility to 1-Methyl-4-phenylpyridinium16226715
D0156551-Methyl-4-phenylpyridinium1-Methyl-4-phenylpyridinium results in decreased expression of PINK1 protein24475098
D0156321-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine"PINK1 protein results in decreased susceptibility to 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine"22043175
C555916MitoTEMPOMitoTEMPO inhibits the reaction [trifloxystrobin results in increased expression of PINK1 protein]27853101
C064769N-acetylsphingosinePINK1 protein results in decreased susceptibility to N-acetylsphingosine24792327
C064769N-acetylsphingosinePINK1 protein results in decreased susceptibility to N-acetylsphingosine24792327
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of PINK1 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of PINK1 mRNA"25554681
C051752nefazodonenefazodone results in increased expression of PINK1 mRNA24136188
C025256nonylphenolnonylphenol results in increased expression of PINK1 mRNA22982499
C025589ochratoxin Aochratoxin A results in increased expression of PINK1 mRNA19717638
D010100Oxygen[Blood Glucose deficiency co-treated with Oxygen deficiency] results in increased expression of PINK1 protein28477916
D010100Oxygengenipin inhibits the reaction [[Blood Glucose deficiency co-treated with Oxygen deficiency] results in increased expression of PINK1 protein]28477916
D010100Oxygen[Oxygen deficiency co-treated with Oxygen] results in increased expression of PINK1 protein21159781
D010269ParaquatParaquat affects the reaction [PINK1 protein affects the abundance of Dopamine]22043175
D010269ParaquatParaquat results in decreased expression of PINK1 mRNA22563483
D010269ParaquatPINK1 mutant form results in increased susceptibility to Paraquat22043175
D010269Paraquat[PINK1 mutant form results in increased susceptibility to Paraquat] which results in decreased abundance of Dopamine22043175
D010695PhlorhizinPhlorhizin results in increased expression of PINK1 mRNA22538082
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of PINK1 mRNA19710929
D010894Piroxicam[Piroxicam co-treated with Cisplatin] results in increased expression of PINK1 mRNA21858171
D010936Plant ExtractsPlant Extracts results in increased expression of PINK1 mRNA23557933
D017382Reactive Oxygen SpeciesPINK1 gene mutant form results in increased chemical synthesis of Reactive Oxygen Species20547144
D017382Reactive Oxygen SpeciesPINK1 protein affects the reaction [Hydrogen Peroxide results in increased chemical synthesis of Reactive Oxygen Species]21421046
D017382Reactive Oxygen SpeciesPINK1 protein results in decreased chemical synthesis of Reactive Oxygen Species21421046
C059514resveratrolresveratrol results in increased expression of PINK1 mRNA22610192
C089730rosiglitazonePINK1 protein affects the susceptibility to rosiglitazone27553674
C089730rosiglitazonerosiglitazone inhibits the reaction [decamethrin results in decreased expression of and affects the localization of PINK1 protein]27553674
C089730rosiglitazonerosiglitazone results in increased expression of PINK1 protein27553674
D012402RotenonePINK1 protein affects the susceptibility to Rotenone16226715|2094014
D012402RotenonePINK1 protein results in decreased susceptibility to Rotenone19492085
D012402RotenonePINK1 protein affects the susceptibility to Rotenone21421046
D012402RotenoneRotenone results in increased expression of PINK1 protein20464527
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of PINK1 mRNA25895662
C017947sodium arsenitesodium arsenite affects the methylation of PINK1 gene28589171
C017947sodium arsenitesodium arsenite results in increased expression of PINK1 mRNA20883709
C016104sodium bichromatesodium bichromate results in decreased expression of PINK1 mRNA25993096
C471405sorafenibPINK1 protein affects the reaction [sorafenib affects the localization of PRKN protein]28673964
C471405sorafenib[sorafenib co-treated with PRKN protein] results in increased expression of PINK1 protein28673964
C471405sorafenibsorafenib results in increased expression of PINK1 protein28673964
C471405sorafenibPINK1 protein affects the susceptibility to sorafenib28673964
C471405sorafenibsorafenib results in increased expression of PINK1 protein28673964
D004113Succimer[Succimer co-treated with Magnetite Nanoparticles] results in decreased expression of PINK1 mRNA26378955
C016766sulforafansulforafan results in increased expression of PINK1 mRNA26833863
D013481SuperoxidesPINK1 protein affects the abundance of Superoxides21421046
D016559TacrolimusPINK1 protein affects the reaction [Tacrolimus results in increased phosphorylation of DNM1L protein]19492085
D013629TamoxifenTamoxifen affects the expression of PINK1 mRNA17555576
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of PINK1 mRNA20106945|2163298
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in decreased expression of PINK1 mRNA17942748
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of PINK1 mRNA21215274
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of PINK1 mRNA25613284
D019284ThapsigarginThapsigargin results in increased expression of PINK1 mRNA22378314
C009495titanium dioxidetitanium dioxide results in decreased expression of PINK1 mRNA23557971
C012589trichostatin Atrichostatin A affects the expression of PINK1 mRNA28542535
C467051trifloxystrobinMitoTEMPO inhibits the reaction [trifloxystrobin results in increased expression of PINK1 protein]27853101
C467051trifloxystrobintrifloxystrobin results in increased expression of PINK1 protein27853101
C080163trovafloxacintrovafloxacin results in increased expression of PINK1 mRNA24136188
D014415TunicamycinTunicamycin results in increased expression of PINK1 mRNA22378314
D014415TunicamycinTunicamycin results in decreased expression of PINK1 mRNA17127020
D014520UrethaneUrethane results in increased expression of PINK1 mRNA28818685
D014635Valproic AcidValproic Acid results in increased expression of PINK1 mRNA23179753|2493525
D014635Valproic AcidValproic Acid affects the expression of PINK1 mRNA17292431
D014640VancomycinVancomycin results in increased expression of PINK1 mRNA18930951
C029297vinylidene chloridevinylidene chloride results in decreased expression of PINK1 mRNA26682919
D014810Vitamin EVitamin E results in increased expression of PINK1 mRNA19244175
D019287Zinc SulfateZinc Sulfate results in increased expression of PINK1 mRNA27504894

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000287magnesium ion binding-IDA14607334  
GO:0002020protease binding-IPI21138942  
GO:0002020protease binding-TAS24522549  
GO:0004672protein kinase activity-IBA21873635  
GO:0004672protein kinase activity-IMP25527497  
GO:0004674protein serine/threonine kinase activity-IBA21873635  
GO:0004674protein serine/threonine kinase activity-IDA14607334  17579517  19880420  24784582  25527291  
GO:0004674protein serine/threonine kinase activity-ISS-  
GO:0004674protein serine/threonine kinase activity-TAS24522549  
GO:0005515protein binding-IPI16632486  17579517  19229105  20153330  21177249  22078885  
23933751  24357652  24475098  25814554  
GO:0005524ATP binding-IDA14607334  
GO:0010857calcium-dependent protein kinase activity-IDA19880420  
GO:0016301kinase activity-IDA15824318  
GO:0016301kinase activity-NAS21563316  
GO:0016504peptidase activator activity-TAS24522549  
GO:0031625ubiquitin protein ligase binding-IPI20798600  
GO:0043422protein kinase B binding-IDA21177249  
GO:0055131C3HC4-type RING finger domain binding-IPI19880420  
GO ID GO Term Qualifier Evidence PubMed
GO:0000422autophagy of mitochondrion-IBA21873635  
GO:0000422autophagy of mitochondrion-IMP20798600  23933751  24896179  
GO:0001934positive regulation of protein phosphorylation-IDA25244949  
GO:0002082regulation of oxidative phosphorylation-IDA20871098  
GO:0002931response to ischemia-IEA-  
GO:0006468protein phosphorylation-IBA21873635  
GO:0006468protein phosphorylation-IDA14607334  21177249  25527291  
GO:0006468protein phosphorylation-IMP25527497  
GO:0006468protein phosphorylation-TAS24522549  
GO:0006511ubiquitin-dependent protein catabolic process-TAS24522549  
GO:0006979response to oxidative stress-IGI24475098  
GO:0007005mitochondrion organization-IMP18560593  
GO:0010310regulation of hydrogen peroxide metabolic process-IEA-  
GO:0010629negative regulation of gene expression-ISS24475098  
GO:0010821regulation of mitochondrion organization-IMP21508222  
GO:0010952positive regulation of peptidase activity-TAS24522549  
GO:0016236macroautophagy-TAS-  
GO:0016239positive regulation of macroautophagy-IMP20871098  
GO:0016242negative regulation of macroautophagy-IMP19279012  
GO:0016567protein ubiquitination-IMP23933751  
GO:0018105peptidyl-serine phosphorylation-IDA17579517  19880420  
GO:0018105peptidyl-serine phosphorylation-ISS-  
GO:0018105peptidyl-serine phosphorylation-TAS23626584  
GO:0022904respiratory electron transport chain-IEA-  
GO:0031396regulation of protein ubiquitination-IDA19880420  
GO:0031396regulation of protein ubiquitination-IMP20871098  23212910  
GO:0031398positive regulation of protein ubiquitination-ISS-  
GO:0032148activation of protein kinase B activity-IC21177249  
GO:0032226positive regulation of synaptic transmission, dopaminergic-IEA-  
GO:0033138positive regulation of peptidyl-serine phosphorylation-IDA21177249  
GO:0033138positive regulation of peptidyl-serine phosphorylation-IMP24660806  
GO:0033138positive regulation of peptidyl-serine phosphorylation-TAS18221368  
GO:0033603positive regulation of dopamine secretion-IEA-  
GO:0034599cellular response to oxidative stress-IMP22764206  
GO:0035307positive regulation of protein dephosphorylation-IEA-  
GO:0035556intracellular signal transduction-IDA14607334  
GO:0036289peptidyl-serine autophosphorylation-IMP25527497  
GO:0036289peptidyl-serine autophosphorylation-TAS23626584  
GO:0038203TORC2 signaling-IC21177249  
GO:0042981regulation of apoptotic process-IBA21873635  
GO:0043123positive regulation of I-kappaB kinase/NF-kappaB signaling-IDA19880420  
GO:0043254regulation of protein complex assembly-IDA19880420  
GO:0043524negative regulation of neuron apoptotic process-IMP18560593  
GO:0045727positive regulation of translation-IEA-  
GO:0046329negative regulation of JNK cascade-TAS18221368  
GO:0050821protein stabilization-IMP19229105  
GO:0051091positive regulation of DNA-binding transcription factor activity-IEA-  
GO:0051443positive regulation of ubiquitin-protein transferase activity-TAS24522549  
GO:0051881regulation of mitochondrial membrane potential-IGI24475098  
GO:0051881regulation of mitochondrial membrane potential-IMP18560593  21138942  
GO:0051897positive regulation of protein kinase B signaling-IC21177249  
GO:0061136regulation of proteasomal protein catabolic process-NAS22078885  
GO:0071456cellular response to hypoxia-IMP24553947  
GO:0072655establishment of protein localization to mitochondrion-IMP25527497  
GO:0072656maintenance of protein location in mitochondrion-IMP25527497  
GO:0090141positive regulation of mitochondrial fission-IBA21873635  
GO:0090200positive regulation of release of cytochrome c from mitochondria-IMP19880420  
GO:0090258negative regulation of mitochondrial fission-IMP19279012  
GO:0097237cellular response to toxic substance-TAS18221368  
GO:0098779positive regulation of mitophagy in response to mitochondrial depolarization-IMP20871098  
GO:0099074mitochondrion to lysosome transport-IMP24446486  
GO:1900407regulation of cellular response to oxidative stress-IMP24446486  
GO:1901727positive regulation of histone deacetylase activity-IEA-  
GO:1902803regulation of synaptic vesicle transport-TAS21563316  
GO:1902902negative regulation of autophagosome assembly-IMP19279012  
GO:1902958positive regulation of mitochondrial electron transport, NADH to ubiquinone-TAS21138942  
GO:1903146regulation of autophagy of mitochondrion-TAS21563316  
GO:1903147negative regulation of autophagy of mitochondrion-IMP19279012  
GO:1903202negative regulation of oxidative stress-induced cell death-IDA16632486  
GO:1903204negative regulation of oxidative stress-induced neuron death-TAS24522549  
GO:1903214regulation of protein targeting to mitochondrion-IDA25244949  
GO:1903214regulation of protein targeting to mitochondrion-IGI21508222  
GO:1903214regulation of protein targeting to mitochondrion-IMP23212910  
GO:1903298negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway-IEA-  
GO:1903384negative regulation of hydrogen peroxide-induced neuron intrinsic apoptotic signaling pathway-IDA21177249  
GO:1903384negative regulation of hydrogen peroxide-induced neuron intrinsic apoptotic signaling pathway-IMP23261939  
GO:1903751negative regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide-IDA17579517  
GO:1903852positive regulation of cristae formation-IMP19279012  
GO:1903955positive regulation of protein targeting to mitochondrion-HMP24270810  
GO:1904544positive regulation of free ubiquitin chain polymerization-ISS-  
GO:1904783positive regulation of NMDA glutamate receptor activity-IEA-  
GO:1904881cellular response to hydrogen sulfide-IEA-  
GO:2000377regulation of reactive oxygen species metabolic process-IGI24475098  
GO:2000377regulation of reactive oxygen species metabolic process-IMP21138942  
GO:2000378negative regulation of reactive oxygen species metabolic process-IMP18560593  
GO:2001171positive regulation of ATP biosynthetic process-TAS20871098  
GO:2001243negative regulation of intrinsic apoptotic signaling pathway-IDA15087508  
GO ID GO Term Qualifier Evidence PubMed
GO:0000151ubiquitin ligase complexcolocalizes_withISS-  
GO:0000785chromatin-IDA24798695  
GO:0005634nucleus-IDA24798695  
GO:0005737cytoplasm-IDA16702191  
GO:0005739mitochondrion-IBA21873635  
GO:0005739mitochondrion-IDA15087508  15824318  16702191  19229105  20798600  21138942  23933751  
GO:0005739mitochondrioncolocalizes_withIGI21355049  
GO:0005739mitochondrioncolocalizes_withIMP24184327  
GO:0005741mitochondrial outer membrane-IDA21426348  
GO:0005741mitochondrial outer membranecolocalizes_withIMP25527497  
GO:0005741mitochondrial outer membrane-TAS-  
GO:0005742mitochondrial outer membrane translocase complexcolocalizes_withIMP24270810  
GO:0005743mitochondrial inner membrane-IDA17579517  21426348  
GO:0005758mitochondrial intermembrane space-IDA17579517  21426348  
GO:0005758mitochondrial intermembrane space-TAS-  
GO:0005829cytosol-IDA19229105  19880420  20798600  21138942  21426348  24798695  
GO:0005829cytosol-TAS-  
GO:0005856cytoskeleton-IDA24798695  
GO:0016020membrane-IDA24798695  
GO:0030424axon-IDA16702191  
GO:0030426growth cone-IEA-  
GO:0031307integral component of mitochondrial outer membrane-IDA18687899  
GO:0031932TORC2 complexcolocalizes_withIPI21177249  
GO:0044297cell body-IDA16702191  
GO:0048471perinuclear region of cytoplasm-IDA16702191  
GO:0097413Lewy body-TAS24522549  
GO:0097449astrocyte projection-IDA16702191  
KEGG ID KEGG Term
hsa05012Parkinson's disease
Reactome ID Reactome Term Evidence
R-HSA-5205647MitophagyTAS
R-HSA-5205685Pink/Parkin Mediated MitophagyTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
27590295Impulsive-compulsive behaviors in parkin-associated Parkinson disease. (2016 Oct 4)Morgante FNeurology
17699801Are Parkinson disease patients protected from some but not all cancers? (2007 Oct 9)Inzelberg RNeurology
28289797[Epidemiology and causes of Parkinson's disease]. (2017 Apr)Lill CMNervenarzt
24088173Prolonged cigarette smoke exposure alters mitochondrial structure and function in airway epithelial cells. (2013 Oct 2)Hoffmann RFRespir Res
29070578Is mitochondrial dysfunction a driving mechanism linking COPD to nonsmall cell lung carcinoma? (2017 Dec 31)Ng Kee Kwong FEur Respir Rev
19944740PINK1 polymorphism IVS1-7 A-->G, exposure to environmental risk factors and anticipation of disease onset in Brazilian patients with early-onset Parkinson's Disease. (2010 Jan 18)Godeiro C JrNeurosci Lett