Gene: SKP2

6502
FBL1|FBXL1|FLB1|p45
S-phase kinase associated protein 2
protein-coding
5p13.2
Ensembl:ENSG00000145604 MIM:601436 Vega:OTTHUMG00000131106 UniprotKB:Q13309
NG_029643.1
PubMed
0   ANCO-SNPs
ND
3   
NA (AD)  NA (ND)   (Frontal_Cortex)
3.429e-1 (AD)  3.295e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
UBR20.845
ZBTB340.832
SUPT20H0.826
USP300.815
SLC35D10.81
WDR330.809
ZNF1750.808
HERC40.807
C5orf510.805
SMC60.8

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.511
OR4F29-0.461
KLRC2-0.255
CETP-0.253
KLRB1-0.249
IFNG-0.237
KRT72-0.21
KRTAP10-7-0.202
KRT73-0.2
KRTAP4-3-0.199

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C5691071-(2-chlorobenzyl)-5'-phenyl-3'H-spiro(indoline-3,2'-(1,3,4)thiadiazol)-2-one"1-(2-chlorobenzyl)-5'-phenyl-3'H-spiro(indoline-3,2'-(1,3,4)thiadiazol)-2-one results in decreased expression of SKP2 mRNA"23826121
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"[1,4-bis(2-(3,5-dichloropyridyloxy))benzene co-treated with Pregnenolone Carbonitrile] results in increased expression of SKP2 mRNA"23626729
C5321622-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine"[PIK3CA gene mutant form results in increased susceptibility to 2-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine] which results in decreased expression of SKP2 protein"20453058
C0294972,3-bis(3'-hydroxybenzyl)butyrolactone"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in increased expression of SKP2 mRNA"19167446
C513485(3-(4-(bis(2-chloroethyl)amino)phenyl)-3-propyl)carbamic acid 2-(6-(17-hydroxy-13-methyl-3-oxo-2,3,6,7,8,11,12,13,14,15,16,17-dodecahydro-1H-cyclopenta(a)phenanthren-11-yl)hexylamino)ethyl ester"(3-(4-(bis(2-chloroethyl)amino)phenyl)-3-propyl)carbamic acid 2-(6-(17-hydroxy-13-methyl-3-oxo-2,3,6,7,8,11,12,13,14,15,16,17-dodecahydro-1H-cyclopenta(a)phenanthren-11-yl)hexylamino)ethyl ester analog results in decreased expression of SKP2 protein"16039525
C513485(3-(4-(bis(2-chloroethyl)amino)phenyl)-3-propyl)carbamic acid 2-(6-(17-hydroxy-13-methyl-3-oxo-2,3,6,7,8,11,12,13,14,15,16,17-dodecahydro-1H-cyclopenta(a)phenanthren-11-yl)hexylamino)ethyl ester"(3-(4-(bis(2-chloroethyl)amino)phenyl)-3-propyl)carbamic acid 2-(6-(17-hydroxy-13-methyl-3-oxo-2,3,6,7,8,11,12,13,14,15,16,17-dodecahydro-1H-cyclopenta(a)phenanthren-11-yl)hexylamino)ethyl ester results in decreased expression of SKP2 protein"16039525
C5830744,4'-hexafluorisopropylidene diphenol"4,4'-hexafluorisopropylidene diphenol results in increased expression of SKP2 mRNA"25912373
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SKP2 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SKP2 mRNA"27188386
C517041(4-amino-1,4-dihydro-3-(2-pyridyl)-5-thioxo-1,2,4-triazole)copper(II)"(4-amino-1,4-dihydro-3-(2-pyridyl)-5-thioxo-1,2,4-triazole)copper(II) results in decreased expression of SKP2 mRNA"19561079
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine results in increased expression of SKP2 protein"24568477
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SKP2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SKP2 mRNA"27188386
C1217077,3'-dihydroxy-4'-methoxyisoflavone"7,3'-dihydroxy-4'-methoxyisoflavone results in decreased expression of SKP2 mRNA"24455688
C5538177-(benzylamino)-1,3,4,8-tetrahydropyrrolo(4,3,2-de)quinolin-8(1H)-one"7-(benzylamino)-1,3,4,8-tetrahydropyrrolo(4,3,2-de)quinolin-8(1H)-one results in decreased expression of SKP2 mRNA"19936915
D000082AcetaminophenAcetaminophen results in decreased expression of SKP2 mRNA21420995
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of SKP2 mRNA21632981|2164198
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of SKP2 gene27153756
D016718Arachidonic AcidArachidonic Acid results in decreased expression of SKP2 mRNA16704987
D001151ArsenicArsenic affects the methylation of SKP2 gene25304211
C006632arsenic trioxidearsenic trioxide results in decreased expression of SKP2 protein25174355|2533511
C015001arsenitearsenite affects the expression of SKP2 mRNA22959463
D001280AtrazineAtrazine results in increased expression of SKP2 mRNA25929836
D001379AzathioprineAzathioprine results in decreased expression of SKP2 mRNA22623647
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of SKP2 mRNA20106945|2163298
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of SKP2 mRNA"20382639
C072553benzyloxycarbonylleucyl-leucyl-leucine aldehydebenzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of SKP2 mRNA20061341
D004958EstradiolEstradiol results in increased expression of SKP2 protein23029392
D004958Estradiollactacystin inhibits the reaction [Estradiol results in increased expression of SKP2 protein]23029392
D004958Estradiol[Progesterone co-treated with Estradiol] results in decreased expression of SKP2 protein23029392
D004958EstradiolSKP2 mutant form inhibits the reaction [Estradiol results in increased degradation of CDKN1B protein]23029392
D004958EstradiolSKP2 protein results in increased susceptibility to Estradiol23029392
C044887beta-methylcholinebeta-methylcholine affects the expression of SKP2 mRNA21179406
C543008bis(4-hydroxyphenyl)sulfonebis(4-hydroxyphenyl)sulfone results in increased expression of SKP2 mRNA25912373
C006780bisphenol Abisphenol A affects the expression of SKP2 mRNA21786754
C006780bisphenol Abisphenol A results in increased expression of SKP2 mRNA29027980
C006780bisphenol Abisphenol A results in decreased expression of SKP2 mRNA25270620|2606340
C006780bisphenol Abisphenol A results in decreased expression of SKP2 mRNA25181051
C005961bis(tri-n-butyltin)oxidebis(tri-n-butyltin)oxide results in decreased expression of SKP2 mRNA18958704|2527062
D000069286BortezomibBortezomib results in decreased expression of SKP2 protein18850583|1963629
D000069286BortezomibCisplatin promotes the reaction [Bortezomib results in decreased expression of SKP2 protein]19636294
D000069286BortezomibBortezomib results in decreased expression of SKP2 protein18451165
D002083Butylated HydroxyanisoleButylated Hydroxyanisole results in decreased expression of SKP2 mRNA25086368
D002083Butylated Hydroxyanisole[propylparaben co-treated with Butylated Hydroxyanisole] results in decreased expression of SKP2 mRNA25086368
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in decreased expression of SKP2 mRNA15336504
D002104CadmiumCadmium results in decreased expression of SKP2 mRNA21120746
D019256Cadmium ChlorideCadmium Chloride results in increased expression of SKP2 mRNA26472689
D019256Cadmium ChlorideCadmium Chloride results in increased expression of SKP2 mRNA20061341
D019256Cadmium ChlorideCadmium Chloride results in increased methylation of SKP2 promoter22457795
C035000CAF protocolSKP2 protein results in decreased susceptibility to CAF protocol18644126
D004390ChlorpyrifosChlorpyrifos results in decreased expression of SKP2 mRNA20350560
C018021cobaltous chloridecobaltous chloride results in decreased expression of SKP2 mRNA19320972|1937684
D003300Copper[NSC 689534 binds to Copper] which results in decreased expression of SKP2 mRNA20971185
D003300CopperCopper deficiency results in increased expression of SKP2 mRNA26033743
D019327Copper SulfateCopper Sulfate results in decreased expression of SKP2 mRNA19549813
D003375Coumestrol"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in increased expression of SKP2 mRNA"19167446
D003375Coumestrol[Coumestrol co-treated with resveratrol] results in increased expression of SKP2 mRNA19167446
D003375CoumestrolCoumestrol results in increased expression of SKP2 mRNA19167446
D016572CyclosporineCyclosporine results in decreased expression of SKP2 mRNA20106945|2163298
D003703DemecolcineDemecolcine results in decreased expression of SKP2 mRNA23649840
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of SKP2 mRNA21266533
D002945CisplatinCisplatin promotes the reaction [Bortezomib results in decreased expression of SKP2 protein]19636294
D019422Dietary SucroseDietary Sucrose results in increased expression of SKP2 mRNA26033743
D002117CalcitriolCalcitriol results in decreased expression of SKP2 mRNA21592394
D002117CalcitriolCalcitriol results in decreased expression of SKP2 protein12954644
D002117Calcitriol[Testosterone co-treated with Calcitriol] results in decreased expression of SKP2 mRNA21592394
C472511dimethylarsinous aciddimethylarsinous acid results in increased expression of SKP2 mRNA19945496
D004317DoxorubicinDoxorubicin affects the expression of SKP2 mRNA17893511
D004317DoxorubicinDoxorubicin affects the expression of SKP2 protein17893511
D004317DoxorubicinSKP2 protein affects the susceptibility to Doxorubicin16217747
C045651epigallocatechin gallate[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of SKP2 mRNA22079256
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of SKP2 mRNA17942748
C007738fluoranthene[fluoranthene co-treated with Permethrin] results in decreased expression of SKP2 mRNA22406618
D005492Folic Acid[Folic Acid deficiency co-treated with Methotrexate] results in decreased expression of SKP2 mRNA24657277
D005557FormaldehydeFormaldehyde results in decreased expression of SKP2 mRNA20655997|2364984
C069837fullerene C60fullerene C60 results in decreased expression of SKP2 mRNA19167457
D017965gamma-Linolenic Acidgamma-Linolenic Acid results in decreased expression of SKP2 mRNA20664735
C492448ICG 001ICG 001 results in decreased expression of SKP2 mRNA26191083
D007213IndomethacinIndomethacin results in increased expression of SKP2 mRNA28201806
C051890irinotecanSKP2 protein results in increased susceptibility to irinotecan16734730
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of SKP2 mRNA24796395
C067713lactacystinlactacystin inhibits the reaction [Estradiol results in increased expression of SKP2 protein]23029392
C067713lactacystinlactacystin results in decreased expression of SKP2 protein23029392
C045463leflunomideleflunomide results in decreased expression of SKP2 mRNA28988120
D008727Methotrexate[Folic Acid deficiency co-treated with Methotrexate] results in decreased expression of SKP2 mRNA24657277
D008727MethotrexateMethotrexate results in decreased expression of SKP2 mRNA24657277
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of SKP2 mRNA28001369
C406082monomethylarsonous acidmonomethylarsonous acid results in increased expression of SKP2 mRNA19945496
D009151Mustard GasMustard Gas results in decreased expression of SKP2 mRNA25102026
C044361M-VAC protocolSKP2 protein results in increased susceptibility to M-VAC protocol15814643
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of SKP2 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of SKP2 mRNA"25554681
C017096n-butoxyethanoln-butoxyethanol results in increased expression of SKP2 mRNA19812364
D009532NickelMT1 affects the reaction [Nickel affects the expression of SKP2 mRNA]16166738
D009532NickelMT2 affects the reaction [Nickel affects the expression of SKP2 mRNA]16166738
C022838nickel chloridenickel chloride results in decreased expression of SKP2 mRNA17312168
C558013NSC 689534[NSC 689534 binds to Copper] which results in decreased expression of SKP2 mRNA20971185
C055122orlistat[orlistat results in decreased activity of FASN protein] which results in decreased expression of SKP2 protein15138278
C055122orlistatorlistat results in decreased expression of SKP2 protein15138278
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in decreased expression of SKP2 mRNA25729387
C030110oxaliplatinoxaliplatin results in decreased expression of SKP2 mRNA25729387
D010100OxygenOxygen results in decreased expression of SKP2 mRNA27103661
D017239PaclitaxelSKP2 protein affects the susceptibility to Paclitaxel16217747
D010433PentylenetetrazolePentylenetetrazole affects the expression of SKP2 mRNA21503142
C027579periodate-oxidized adenosineperiodate-oxidized adenosine affects the expression of SKP2 mRNA17097637
D026023Permethrin[fluoranthene co-treated with Permethrin] results in decreased expression of SKP2 mRNA22406618
D026023PermethrinPermethrin results in decreased expression of SKP2 mRNA22406618
C058305phenethyl isothiocyanatephenethyl isothiocyanate results in decreased expression of SKP2 mRNA26678675
D010634PhenobarbitalPhenobarbital affects the expression of SKP2 mRNA23091169
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SKP2 mRNA"27188386
D010894PiroxicamPiroxicam results in decreased expression of SKP2 mRNA21858171
D010936Plant ExtractsPlant Extracts results in decreased expression of SKP2 mRNA24095829
D010936Plant ExtractsPlant Extracts results in decreased expression of SKP2 protein24095829
D010938Plant OilsPlant Oils results in decreased expression of SKP2 mRNA23370395
C060540polyhexamethyleneguanidinepolyhexamethyleneguanidine results in decreased expression of SKP2 mRNA24583197
D011137PolystyrenesPolystyrenes analog results in decreased expression of SKP2 mRNA25102311
D011137PolystyrenesPolystyrenes results in decreased expression of SKP2 mRNA25102311
C027373potassium chromate(VI)[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of SKP2 mRNA22079256
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of SKP2 mRNA22079256
D011192Potassium DichromatePotassium Dichromate results in decreased expression of SKP2 protein23718831
D011192Potassium DichromatePotassium Dichromate results in increased expression of SKP2 protein23718831
D011285Pregnenolone Carbonitrile"[1,4-bis(2-(3,5-dichloropyridyloxy))benzene co-treated with Pregnenolone Carbonitrile] results in increased expression of SKP2 mRNA"23626729
D011374Progesterone[Progesterone co-treated with Estradiol] results in decreased expression of SKP2 protein23029392
C006068propylparaben[propylparaben co-treated with Butylated Hydroxyanisole] results in decreased expression of SKP2 mRNA25086368
D011794QuercetinQuercetin results in decreased expression of SKP2 mRNA21632981|2372791
C059514resveratrol[Coumestrol co-treated with resveratrol] results in increased expression of SKP2 mRNA19167446
C059514resveratrolresveratrol results in decreased expression of SKP2 protein24568477
C089730rosiglitazonerosiglitazone results in decreased expression of SKP2 mRNA17077279
D012835Silver NitrateSilver Nitrate analog results in increased expression of SKP2 mRNA22831968
D020123SirolimusSirolimus results in decreased expression of SKP2 protein21092744
C017947sodium arsenitesodium arsenite results in decreased expression of SKP2 mRNA23876855
C017947sodium arsenitesodium arsenite results in increased expression of SKP2 mRNA28595984
C016104sodium bichromatesodium bichromate affects the expression of SKP2 mRNA22110744
C025399sodium tungstate(VI)sodium tungstate(VI) results in increased expression of SKP2 mRNA26164860
C025462sulindac sulfidesulindac sulfide results in decreased expression of SKP2 mRNA16184548
C061133tamibarotenetamibarotene results in decreased expression of SKP2 mRNA15498508
D013739Testosterone[Testosterone co-treated with Calcitriol] results in decreased expression of SKP2 mRNA21592394
D013739TestosteroneTestosterone results in decreased expression of SKP2 mRNA21592394
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of SKP2 mRNA20106945|2163298
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of SKP2 mRNA21570461
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of SKP2 mRNA17942748
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of SKP2 mRNA19465110
D019772TopotecanSKP2 protein affects the susceptibility to Topotecan16217747
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in decreased expression of SKP2 mRNA25729387
D014118Toxins, Biological"Toxins, Biological affects the expression of SKP2 mRNA"19682533
C496197trans-10,cis-12-conjugated linoleic acid"trans-10,cis-12-conjugated linoleic acid results in decreased expression of SKP2 mRNA"17951470
D014212TretinoinSKP2 protein results in decreased susceptibility to Tretinoin11595732
D014212TretinoinTretinoin results in decreased expression of SKP2 mRNA15498508
D014212TretinoinTretinoin results in decreased expression of SKP2 protein16618747
D014212TretinoinTretinoin results in increased ubiquitination of and results in increased degradation of SKP2 protein11595732
D014212Tretinoin[Tretinoin results in increased ubiquitination of and results in increased degradation of SKP2 protein] which results in increased expression of CDKN1B protein11595732
C034613triacsin Ctriacsin C results in decreased expression of SKP2 mRNA16704987
C015559trimellitic anhydridetrimellitic anhydride results in increased expression of SKP2 mRNA19042947
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of SKP2 mRNA"26179874
C057693troglitazoneSKP2 protein results in decreased susceptibility to troglitazone12717389
C057693troglitazonetroglitazone results in decreased expression of SKP2 mRNA12717389|1914023
C057693troglitazonetroglitazone results in decreased expression of SKP2 protein12717389|1461861
D014520UrethaneUrethane results in decreased expression of SKP2 mRNA28818685
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SKP2 mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of SKP2 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of SKP2 mRNA23179753|2438349
D014635Valproic AcidValproic Acid results in decreased methylation of SKP2 gene29154799
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of SKP2 gene25560391
D014747VinblastineSKP2 protein affects the susceptibility to Vinblastine16217747
D014750VincristineVincristine results in decreased expression of SKP2 mRNA23649840

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004842ubiquitin-protein transferase activity-EXP19028597  
GO:0004842ubiquitin-protein transferase activity-TAS-  
GO:0005515protein binding-IPI11931757  12504026  12609982  12813041  16209941  16286470  
16376880  16880511  17157259  18239684  18805092  18818696  
21856198  22632967  22770219  23911321  25241761  27705803  
GO:0042802identical protein binding-IPI22770219  
GO:0061630ubiquitin protein ligase activityCONTRIBUTES_TOIBA21873635  
GO:0061630ubiquitin protein ligase activity-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0000082G1/S transition of mitotic cell cycle-IEA-  
GO:0000086G2/M transition of mitotic cell cycle-IBA21873635  
GO:0000086G2/M transition of mitotic cell cycle-IEA-  
GO:0000209protein polyubiquitination-TAS-  
GO:0006511ubiquitin-dependent protein catabolic process-IEA-  
GO:0008283cell proliferation-TAS7553852  
GO:0016579protein deubiquitination-TAS-  
GO:0031146SCF-dependent proteasomal ubiquitin-dependent protein catabolic process-IBA21873635  
GO:0033148positive regulation of intracellular estrogen receptor signaling pathway-IEA-  
GO:0042981regulation of apoptotic process-IDA23277542  
GO:0043687post-translational protein modification-TAS-  
GO:0048661positive regulation of smooth muscle cell proliferation-IEA-  
GO:0051726regulation of cell cycle-IBA21873635  
GO:0051726regulation of cell cycle-IEA-  
GO:0071460cellular response to cell-matrix adhesion-IEA-  
GO:1902916positive regulation of protein polyubiquitination-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IBA21873635  
GO:0005634nucleus-IDA-  
GO:0005654nucleoplasm-TAS-  
GO:0005730nucleolus-IDA-  
GO:0005829cytosol-IBA21873635  
GO:0005829cytosol-IDA-  
GO:0005829cytosol-TAS-  
GO:0019005SCF ubiquitin ligase complex-IBA21873635  
GO:0019005SCF ubiquitin ligase complex-IDA16880511  
KEGG ID KEGG Term
hsa04110Cell cycle
hsa04120Ubiquitin mediated proteolysis
hsa05200Pathways in cancer
hsa05222Small cell lung cancer
Reactome ID Reactome Term Evidence
R-HSA-1280218Adaptive Immune SystemTAS
R-HSA-1640170Cell CycleTAS
R-HSA-168256Immune SystemTAS
R-HSA-174143APC/C-mediated degradation of cell cycle proteinsTAS
R-HSA-174178APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1TAS
R-HSA-187577SCF(Skp2)-mediated degradation of p27/p21TAS
R-HSA-212436Generic Transcription PathwayTAS
R-HSA-392499Metabolism of proteinsTAS
R-HSA-453276Regulation of mitotic cell cycleTAS
R-HSA-453279Mitotic G1-G1/S phasesTAS
R-HSA-5688426DeubiquitinationTAS
R-HSA-5689880Ub-specific processing proteasesTAS
R-HSA-597592Post-translational protein modificationTAS
R-HSA-68949Orc1 removal from chromatinTAS
R-HSA-69052Switching of origins to a post-replicative stateTAS
R-HSA-69202Cyclin E associated events during G1/S transition TAS
R-HSA-69206G1/S TransitionTAS
R-HSA-69231Cyclin D associated events in G1TAS
R-HSA-69236G1 PhaseTAS
R-HSA-69239Synthesis of DNATAS
R-HSA-69242S PhaseTAS
R-HSA-69278Cell Cycle, MitoticTAS
R-HSA-69306DNA ReplicationTAS
R-HSA-69656Cyclin A:Cdk2-associated events at S phase entryTAS
R-HSA-73857RNA Polymerase II TranscriptionTAS
R-HSA-74160Gene expression (Transcription)TAS
R-HSA-8878166Transcriptional regulation by RUNX2TAS
R-HSA-8939902Regulation of RUNX2 expression and activityTAS
R-HSA-8951664NeddylationTAS
R-HSA-983168Antigen processing: Ubiquitination & Proteasome degradationTAS
R-HSA-983169Class I MHC mediated antigen processing & presentationTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
17760257[Expression of SKP2 protein in lung carcinoma and its implication for prognosis]. (2007 Apr)Zhao JZhonghua Zhong Liu Za Zhi
19174556WIF1, a Wnt pathway inhibitor, regulates SKP2 and c-myc expression leading to G1 arrest and growth inhibition of human invasive urinary bladder cancer cells. (2009 Feb)Tang YMol Cancer Ther
20735967[The expression of Skp2 in human non-small cell lung cancer and its correlation with expression of p27 protein.]. (2008 Aug 20)Hu XZhongguo Fei Ai Za Zhi