Gene: ACD

65057
PIP1|PTOP|TINT1|TPP1
ACD, shelterin complex subunit and telomerase recruitment factor
protein-coding
16q22.1
Ensembl:ENSG00000102977 MIM:609377 Vega:OTTHUMG00000137547 UniprotKB:Q96AP0
NG_042874.1
PubMed
0   ANCO-SNPs
ND|AD
8   
NA (AD)  NA (ND)   (Frontal_Cortex)
4.303e-1 (AD)  8.482e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ATG4B0.953
MEN10.941
LRSAM10.937
EDC40.934
GAK0.932
CDK100.931
TRMT10.926
MED150.926
CCDC220.925
DMAP10.925

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.643
OR4F29-0.599
MTRNR2L9-0.347
MTRNR2L6-0.332
KCNJ15-0.328
PROK2-0.321
CXCR2-0.321
MBNL3-0.316
FCGR3B-0.315
MTRNR2L10-0.315

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of ACD mRNA"19114083
D000082AcetaminophenAcetaminophen results in increased expression of ACD mRNA22230336
D001564Benzo(a)pyreneBenzo(a)pyrene promotes the reaction [AHR protein binds to ACD promoter]19654925
C006780bisphenol Abisphenol A affects the expression of ACD mRNA21786754
C006780bisphenol Abisphenol A results in decreased expression of ACD mRNA29275510
C006780bisphenol Abisphenol A results in decreased methylation of ACD promoter27312807
C006780bisphenol Abisphenol A results in increased expression of ACD mRNA25181051
C018021cobaltous chloridecobaltous chloride results in increased expression of ACD mRNA21139344
D019327Copper SulfateCopper Sulfate results in decreased expression of ACD mRNA19549813
D016572CyclosporineCyclosporine results in increased expression of ACD mRNA20106945
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of ACD mRNA21266533
D018120FinasterideFinasteride results in increased expression of ACD mRNA24136188
C039281furanfuran results in increased methylation of ACD gene22079235
D005839GentamicinsGentamicins results in increased expression of ACD mRNA22061828
D006861Hydrogen PeroxideHydrogen Peroxide affects the expression of ACD mRNA20044591
C544151jinfukangjinfukang results in increased expression of ACD mRNA27392435
C410337K 7174K 7174 results in decreased expression of ACD mRNA24086573
D007854LeadLead results in decreased expression of ACD mRNA19921347
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of ACD mRNA23649840
C568376MT19c compoundMT19c compound results in decreased expression of ACD mRNA21781307
D009151Mustard GasMustard Gas results in decreased expression of ACD mRNA25102026
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of ACD mRNA19710929
D010936Plant ExtractsPlant Extracts results in decreased expression of ACD mRNA23557933
D012402RotenoneRotenone results in increased expression of ACD mRNA19013527
D012645SelenomethionineSelenomethionine affects the expression of ACD mRNA17222674
D012999SomanSoman results in increased expression of ACD mRNA19281266
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of ACD mRNA21570461
C057693troglitazonetroglitazone results in decreased expression of ACD mRNA19140230
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of ACD gene25560391
C025643vinclozolinvinclozolin results in increased expression of ACD mRNA23034163

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI15181449  15231715  15380063  15383534  16189514  16880378  
17237768  17632522  19648609  21044950  21829167  22101936  
22763445  25172512  25416956  25910212  26496610  
GO:0042162telomeric DNA binding-IDA23685356  
GO:0044877protein-containing complex binding-IPI25172512  
GO:0070182DNA polymerase binding-IPI17237767  25172512  
GO:0070182DNA polymerase binding-TAS25467444  
GO ID GO Term Qualifier Evidence PubMed
GO:0000723telomere maintenance-IDA15181449  
GO:0006886intracellular protein transport-IMP15181449  
GO:0016233telomere capping-IDA25172512  
GO:0016233telomere capping-IGI17632522  
GO:0016233telomere capping-NAS17237767  
GO:0016233telomere capping-TAS17237768  
GO:0031848protection from non-homologous end joining at telomere-ISS18185984  
GO:0032202telomere assembly-IMP16880378  
GO:0032211negative regulation of telomere maintenance via telomerase-IGI15181449  
GO:0032211negative regulation of telomere maintenance via telomerase-IMP15380063  
GO:0032211negative regulation of telomere maintenance via telomerase-TAS17237768  25467444  
GO:0032212positive regulation of telomere maintenance via telomerase-IDA17237768  
GO:0051973positive regulation of telomerase activity-IDA17237768  
GO:0060381positive regulation of single-stranded telomeric DNA binding-IDA17237767  
GO:0070198protein localization to chromosome, telomeric region-IDA15181449  
GO:0070198protein localization to chromosome, telomeric region-IMP15181449  
GO:0070200establishment of protein localization to telomere-IMP25589350  
GO:0070200establishment of protein localization to telomere-TAS25467444  
GO ID GO Term Qualifier Evidence PubMed
GO:0000783nuclear telomere cap complex-IDA16880378  
GO:0000784nuclear chromosome, telomeric region-HDA19135898  
GO:0000784nuclear chromosome, telomeric region-IDA15380063  23685356  24270157  25172512  
GO:0005654nucleoplasm-TAS-  
GO:0016604nuclear body-IDA-  
GO:0070187shelterin complex-IDA15383534  23685356  
GO:0070187shelterin complex-IMP21852327  
GO:0070187shelterin complex-TAS17237768  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-1221632Meiotic synapsisIEA
R-HSA-1474165ReproductionIEA
R-HSA-1500620MeiosisIEA
R-HSA-157579Telomere MaintenanceTAS
R-HSA-1640170Cell CycleTAS
R-HSA-1640170Cell CycleIEA
R-HSA-171306Packaging Of Telomere EndsTAS
R-HSA-2262752Cellular responses to stressTAS
R-HSA-2559583Cellular SenescenceTAS
R-HSA-2559586DNA Damage/Telomere Stress Induced SenescenceTAS
R-HSA-73886Chromosome MaintenanceTAS
R-HSA-8953897Cellular responses to external stimuliTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
16955155[Influence of smoking on apoptosis in human gingival epithelium]. (2006 Aug)Yu XJShanghai Kou Qiang Yi Xue
25324788Effect of Acetaldehyde Intoxication and Withdrawal on NPY Expression: Focus on Endocannabinoidergic System Involvement. (2014)Plescia FFront Psychiatry
20482506Turning the clock ahead: potential preclinical and clinical neuropharmacological targets for alcohol dependence. (2010)Leggio LCurr Pharm Des
20301779Dyskeratosis Congenita (1993)Savage SA-
12732400Serum uric acid in hypertensive patients with and without peripheral arterial disease. (2003 May)Langlois MAtherosclerosis
21659451Anaemia in rheumatoid arthritis: can we afford to ignore it? (2011 Sep)Bloxham EPostgrad Med J
8773597Positron emission tomographic studies of cerebral benzodiazepine-receptor binding in chronic alcoholics. (1996 Aug)Gilman SAnn Neurol
22355163Levels of inflammatory mediators in chronic obstructive pulmonary disease patients with anemia of chronic disease: a case-control study. (2012 Jul)Boutou AKQJM