Gene info: ID 6506

Gene: SLC1A2

GENE ID: 6506

Synonyms: EAAT2|EIEE41|GLT-1|HBGT

Description: solute carrier family 1 member 2

Gene type: protein-coding

Location: 11p13

dbXrefs: Ensembl:ENSG00000110436 MIM:600300 Vega:OTTHUMG00000044391 UniprotKB:P43004

RefSeq: NG_008727.1

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: ND|AD

# Publications: 5

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 1.933e-1 (AD) 1.076e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
NTRK2	0.945
FGFR3	0.932
SLC4A4	0.929
MLC1	0.926
SLC15A2	0.915
ACSBG1	0.908
SLC1A3	0.907
SPON1	0.907
GABRG1	0.899
GPR37L1	0.899

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
OR4F5	-0.479
OR4F29	-0.445
GADL1	-0.38
TDRD1	-0.361
KLK8	-0.352
FER1L6	-0.351
CD163L1	-0.348
BMP5	-0.332
OR5M9	-0.323
TBC1D8B	-0.322

ID	Drug Name	Drug Type	CAS Num	Status	Role
DB00142	Glutamic Acid	Small Molecule	56-86-0	Approved\|Nutraceutical	Target

ID	Drug Name	Action	PubMed
C517943	1-(4-(6-bromobenzo(1,3)dioxol-5-yl)-3a,4,5,9b-tetrahydro-3H-cyclopenta(c)quinolin-8-yl)ethanone	"[1-(4-(6-bromobenzo(1,3)dioxol-5-yl)-3a,4,5,9b-tetrahydro-3H-cyclopenta(c)quinolin-8-yl)ethanone binds to and results in increased activity of GPER1 protein] which results in increased activity of SLC1A2 mRNA"	22645130
C517943	1-(4-(6-bromobenzo(1,3)dioxol-5-yl)-3a,4,5,9b-tetrahydro-3H-cyclopenta(c)quinolin-8-yl)ethanone	"[1-(4-(6-bromobenzo(1,3)dioxol-5-yl)-3a,4,5,9b-tetrahydro-3H-cyclopenta(c)quinolin-8-yl)ethanone binds to and results in increased activity of GPER1 protein] which results in increased expression of SLC1A2 mRNA"	22645130
C517943	1-(4-(6-bromobenzo(1,3)dioxol-5-yl)-3a,4,5,9b-tetrahydro-3H-cyclopenta(c)quinolin-8-yl)ethanone	"[1-(4-(6-bromobenzo(1,3)dioxol-5-yl)-3a,4,5,9b-tetrahydro-3H-cyclopenta(c)quinolin-8-yl)ethanone binds to and results in increased activity of GPER1 protein] which results in increased expression of SLC1A2 protein"	22645130
C517943	1-(4-(6-bromobenzo(1,3)dioxol-5-yl)-3a,4,5,9b-tetrahydro-3H-cyclopenta(c)quinolin-8-yl)ethanone	"1-(4-(6-bromobenzo(1,3)dioxol-5-yl)-3a,4,5,9b-tetrahydro-3H-cyclopenta(c)quinolin-8-yl)ethanone inhibits the reaction [Manganese results in decreased expression of SLC1A2 mRNA]"	22645130
C517943	1-(4-(6-bromobenzo(1,3)dioxol-5-yl)-3a,4,5,9b-tetrahydro-3H-cyclopenta(c)quinolin-8-yl)ethanone	"1-(4-(6-bromobenzo(1,3)dioxol-5-yl)-3a,4,5,9b-tetrahydro-3H-cyclopenta(c)quinolin-8-yl)ethanone inhibits the reaction [Manganese results in decreased expression of SLC1A2 protein]"	22645130
C517943	1-(4-(6-bromobenzo(1,3)dioxol-5-yl)-3a,4,5,9b-tetrahydro-3H-cyclopenta(c)quinolin-8-yl)ethanone	"1-(4-(6-bromobenzo(1,3)dioxol-5-yl)-3a,4,5,9b-tetrahydro-3H-cyclopenta(c)quinolin-8-yl)ethanone promotes the reaction [NFKB1 protein binds to SLC1A2 promoter]"	22645130
C517943	1-(4-(6-bromobenzo(1,3)dioxol-5-yl)-3a,4,5,9b-tetrahydro-3H-cyclopenta(c)quinolin-8-yl)ethanone	"1-(4-(6-bromobenzo(1,3)dioxol-5-yl)-3a,4,5,9b-tetrahydro-3H-cyclopenta(c)quinolin-8-yl)ethanone promotes the reaction [RELA protein binds to SLC1A2 promoter]"	22645130
C517943	1-(4-(6-bromobenzo(1,3)dioxol-5-yl)-3a,4,5,9b-tetrahydro-3H-cyclopenta(c)quinolin-8-yl)ethanone	"2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [[1-(4-(6-bromobenzo(1,3)dioxol-5-yl)-3a,4,5,9b-tetrahydro-3H-cyclopenta(c)quinolin-8-yl)ethanone binds to and results in increased activity of GPER1 protein] which results in increased expression of SLC1A2 protein]"	22645130
C517943	1-(4-(6-bromobenzo(1,3)dioxol-5-yl)-3a,4,5,9b-tetrahydro-3H-cyclopenta(c)quinolin-8-yl)ethanone	"2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[1-(4-(6-bromobenzo(1,3)dioxol-5-yl)-3a,4,5,9b-tetrahydro-3H-cyclopenta(c)quinolin-8-yl)ethanone binds to and results in increased activity of GPER1 protein] which results in increased expression of SLC1A2 protein]"	22645130
C517943	1-(4-(6-bromobenzo(1,3)dioxol-5-yl)-3a,4,5,9b-tetrahydro-3H-cyclopenta(c)quinolin-8-yl)ethanone	"4-(6-bromo-1,3-benzodioxol-5-yl)-3a,4,5,9b-3H-cyclopenta(c)quinoline inhibits the reaction [[1-(4-(6-bromobenzo(1,3)dioxol-5-yl)-3a,4,5,9b-tetrahydro-3H-cyclopenta(c)quinolin-8-yl)ethanone binds to and results in increased activity of GPER1 protein] which results in increased expression of SLC1A2 protein]"	22645130
C517943	1-(4-(6-bromobenzo(1,3)dioxol-5-yl)-3a,4,5,9b-tetrahydro-3H-cyclopenta(c)quinolin-8-yl)ethanone	"AG 1879 inhibits the reaction [[1-(4-(6-bromobenzo(1,3)dioxol-5-yl)-3a,4,5,9b-tetrahydro-3H-cyclopenta(c)quinolin-8-yl)ethanone binds to and results in increased activity of GPER1 protein] which results in increased expression of SLC1A2 protein]"	22645130
C517943	1-(4-(6-bromobenzo(1,3)dioxol-5-yl)-3a,4,5,9b-tetrahydro-3H-cyclopenta(c)quinolin-8-yl)ethanone	"GPER1 protein affects the reaction [1-(4-(6-bromobenzo(1,3)dioxol-5-yl)-3a,4,5,9b-tetrahydro-3H-cyclopenta(c)quinolin-8-yl)ethanone results in increased expression of SLC1A2]"	22645130
C517943	1-(4-(6-bromobenzo(1,3)dioxol-5-yl)-3a,4,5,9b-tetrahydro-3H-cyclopenta(c)quinolin-8-yl)ethanone	"KT 5720 inhibits the reaction [[1-(4-(6-bromobenzo(1,3)dioxol-5-yl)-3a,4,5,9b-tetrahydro-3H-cyclopenta(c)quinolin-8-yl)ethanone binds to and results in increased activity of GPER1 protein] which results in increased expression of SLC1A2 protein]"	22645130
C517943	1-(4-(6-bromobenzo(1,3)dioxol-5-yl)-3a,4,5,9b-tetrahydro-3H-cyclopenta(c)quinolin-8-yl)ethanone	"N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [[1-(4-(6-bromobenzo(1,3)dioxol-5-yl)-3a,4,5,9b-tetrahydro-3H-cyclopenta(c)quinolin-8-yl)ethanone binds to and results in increased activity of GPER1 protein] which results in increased expression of SLC1A2 mRNA]"	22645130
C517943	1-(4-(6-bromobenzo(1,3)dioxol-5-yl)-3a,4,5,9b-tetrahydro-3H-cyclopenta(c)quinolin-8-yl)ethanone	"N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [[1-(4-(6-bromobenzo(1,3)dioxol-5-yl)-3a,4,5,9b-tetrahydro-3H-cyclopenta(c)quinolin-8-yl)ethanone binds to and results in increased activity of GPER1 protein] which results in increased expression of SLC1A2 protein]"	22645130
C517943	1-(4-(6-bromobenzo(1,3)dioxol-5-yl)-3a,4,5,9b-tetrahydro-3H-cyclopenta(c)quinolin-8-yl)ethanone	"Pertussis Toxin inhibits the reaction [[1-(4-(6-bromobenzo(1,3)dioxol-5-yl)-3a,4,5,9b-tetrahydro-3H-cyclopenta(c)quinolin-8-yl)ethanone binds to and results in increased activity of GPER1 protein] which results in increased activity of SLC1A2 protein]"	22645130
C517943	1-(4-(6-bromobenzo(1,3)dioxol-5-yl)-3a,4,5,9b-tetrahydro-3H-cyclopenta(c)quinolin-8-yl)ethanone	"Pertussis Toxin inhibits the reaction [[1-(4-(6-bromobenzo(1,3)dioxol-5-yl)-3a,4,5,9b-tetrahydro-3H-cyclopenta(c)quinolin-8-yl)ethanone binds to and results in increased activity of GPER1 protein] which results in increased expression of SLC1A2 protein]"	22645130
C517943	1-(4-(6-bromobenzo(1,3)dioxol-5-yl)-3a,4,5,9b-tetrahydro-3H-cyclopenta(c)quinolin-8-yl)ethanone	"pyrrolidine dithiocarbamic acid inhibits the reaction [[1-(4-(6-bromobenzo(1,3)dioxol-5-yl)-3a,4,5,9b-tetrahydro-3H-cyclopenta(c)quinolin-8-yl)ethanone binds to and results in increased activity of GPER1 protein] which results in increased expression of SLC1A2 protein]"	22645130
C517943	1-(4-(6-bromobenzo(1,3)dioxol-5-yl)-3a,4,5,9b-tetrahydro-3H-cyclopenta(c)quinolin-8-yl)ethanone	"Quinazolines inhibits the reaction [[1-(4-(6-bromobenzo(1,3)dioxol-5-yl)-3a,4,5,9b-tetrahydro-3H-cyclopenta(c)quinolin-8-yl)ethanone binds to and results in increased activity of GPER1 protein] which results in increased expression of SLC1A2 protein]"	22645130
C517943	1-(4-(6-bromobenzo(1,3)dioxol-5-yl)-3a,4,5,9b-tetrahydro-3H-cyclopenta(c)quinolin-8-yl)ethanone	"tyrphostin AG 1478 inhibits the reaction [[1-(4-(6-bromobenzo(1,3)dioxol-5-yl)-3a,4,5,9b-tetrahydro-3H-cyclopenta(c)quinolin-8-yl)ethanone binds to and results in increased activity of GPER1 protein] which results in increased expression of SLC1A2 protein]"	22645130
C028474	1,4-bis(2-(3,5-dichloropyridyloxy))benzene	"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in decreased expression of SLC1A2 mRNA"	28903501
C465664	2-(1-(3-dimethylaminopropyl)-5-methoxyindol-3-yl)-3-(1H-indol-3-yl)maleimide	2-(1-(3-dimethylaminopropyl)-5-methoxyindol-3-yl)-3-(1H-indol-3-yl)maleimide inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of SLC1A2 protein]	26988466
C548651	2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester	2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in increased expression of SLC1A2 mRNA	19933214
C093973	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	"2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [[1-(4-(6-bromobenzo(1,3)dioxol-5-yl)-3a,4,5,9b-tetrahydro-3H-cyclopenta(c)quinolin-8-yl)ethanone binds to and results in increased activity of GPER1 protein] which results in increased expression of SLC1A2 protein]"	22645130
C093973	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	"2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [4,4',4''-(4-propyl-((1)H)-pyrazole-1,3,5-triyl) tris-phenol results in increased expression of SLC1A2 protein]"	24782323
C093973	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [diarylpropionitrile results in increased expression of SLC1A2 protein]	24782323
C093973	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Raloxifene Hydrochloride results in increased expression of SLC1A2 mRNA]	24782323
C093973	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Raloxifene Hydrochloride results in increased expression of SLC1A2 protein]	24782323
C063002	2,3-dimethoxy-1,4-naphthoquinone	"2,3-dimethoxy-1,4-naphthoquinone results in decreased expression of SLC1A2 mRNA"	17547211
C085911	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	"2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[1-(4-(6-bromobenzo(1,3)dioxol-5-yl)-3a,4,5,9b-tetrahydro-3H-cyclopenta(c)quinolin-8-yl)ethanone binds to and results in increased activity of GPER1 protein] which results in increased expression of SLC1A2 protein]"	22645130
C085911	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	"2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [4,4',4''-(4-propyl-((1)H)-pyrazole-1,3,5-triyl) tris-phenol results in increased expression of SLC1A2 protein]"	24782323
C085911	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [diarylpropionitrile results in increased expression of SLC1A2 protein]	24782323
C028451	3,4,3',4'-tetrachlorobiphenyl	"3,4,3',4'-tetrachlorobiphenyl inhibits the reaction [Dietary Fats results in increased expression of SLC1A2 mRNA]"	19467301
C026137	3-hydroxyacetanilide	3-hydroxyacetanilide results in decreased expression of SLC1A2 mRNA	18544908
C486184	4,4',4''-(4-propyl-((1)H)-pyrazole-1,3,5-triyl) tris-phenol	"2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [4,4',4''-(4-propyl-((1)H)-pyrazole-1,3,5-triyl) tris-phenol results in increased expression of SLC1A2 protein]"	24782323
C486184	4,4',4''-(4-propyl-((1)H)-pyrazole-1,3,5-triyl) tris-phenol	"2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [4,4',4''-(4-propyl-((1)H)-pyrazole-1,3,5-triyl) tris-phenol results in increased expression of SLC1A2 protein]"	24782323
C486184	4,4',4''-(4-propyl-((1)H)-pyrazole-1,3,5-triyl) tris-phenol	"[4,4',4''-(4-propyl-((1)H)-pyrazole-1,3,5-triyl) tris-phenol binds to and results in increased activity of ESR1 protein] which results in increased expression of SLC1A2 protein"	24782323
C486184	4,4',4''-(4-propyl-((1)H)-pyrazole-1,3,5-triyl) tris-phenol	"fulvestrant inhibits the reaction [4,4',4''-(4-propyl-((1)H)-pyrazole-1,3,5-triyl) tris-phenol results in increased expression of SLC1A2 protein]"	24782323
C486184	4,4',4''-(4-propyl-((1)H)-pyrazole-1,3,5-triyl) tris-phenol	"tyrphostin AG 1478 inhibits the reaction [4,4',4''-(4-propyl-((1)H)-pyrazole-1,3,5-triyl) tris-phenol results in increased expression of SLC1A2 protein]"	24782323
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SLC1A2 mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SLC1A2 mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SLC1A2 mRNA"	27188386
C568862	4-(6-bromo-1,3-benzodioxol-5-yl)-3a,4,5,9b-3H-cyclopenta(c)quinoline	"[4-(6-bromo-1,3-benzodioxol-5-yl)-3a,4,5,9b-3H-cyclopenta(c)quinoline binds to and results in decreased activity of GPER1 protein] inhibits the reaction [[Raloxifene Hydrochloride results in increased activity of GPER1 protein] which results in increased expression of SLC1A2 protein]"	24782323
C568862	4-(6-bromo-1,3-benzodioxol-5-yl)-3a,4,5,9b-3H-cyclopenta(c)quinoline	"[4-(6-bromo-1,3-benzodioxol-5-yl)-3a,4,5,9b-3H-cyclopenta(c)quinoline binds to and results in decreased activity of GPER1 protein] which results in decreased expression of SLC1A2 protein"	24782323
C568862	4-(6-bromo-1,3-benzodioxol-5-yl)-3a,4,5,9b-3H-cyclopenta(c)quinoline	"4-(6-bromo-1,3-benzodioxol-5-yl)-3a,4,5,9b-3H-cyclopenta(c)quinoline inhibits the reaction [[1-(4-(6-bromobenzo(1,3)dioxol-5-yl)-3a,4,5,9b-tetrahydro-3H-cyclopenta(c)quinolin-8-yl)ethanone binds to and results in increased activity of GPER1 protein] which results in increased expression of SLC1A2 protein]"	22645130
C029370	4-toluidine	4-toluidine results in decreased expression of SLC1A2 mRNA	27638505
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SLC1A2 mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SLC1A2 mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SLC1A2 mRNA"	27188386
D000082	Acetaminophen	Acetaminophen affects the expression of SLC1A2 mRNA	17562736
D000082	Acetaminophen	Acetaminophen results in decreased expression of SLC1A2 mRNA	18544908
D000111	Acetylcysteine	Acetylcysteine inhibits the reaction [cobaltous chloride results in decreased expression of SLC1A2 protein]	22895544
D000111	Acetylcysteine	Acetylcysteine inhibits the reaction [Cocaine results in decreased expression of SLC1A2 protein]	19717140
D016604	Aflatoxin B1	Aflatoxin B1 results in decreased methylation of SLC1A2 gene	27153756
D016604	Aflatoxin B1	Aflatoxin B1 results in increased expression of SLC1A2 mRNA	21641981
C412373	AG 1879	"AG 1879 inhibits the reaction [[1-(4-(6-bromobenzo(1,3)dioxol-5-yl)-3a,4,5,9b-tetrahydro-3H-cyclopenta(c)quinolin-8-yl)ethanone binds to and results in increased activity of GPER1 protein] which results in increased expression of SLC1A2 protein]"	22645130
D000447	Aldehydes	Aldehydes results in increased expression of SLC1A2 mRNA	25014914
D000535	Aluminum	[APP protein modified form binds to Aluminum] which results in decreased expression of SLC1A2 mRNA	21298039
D000643	Ammonium Chloride	Ammonium Chloride affects the expression of SLC1A2 mRNA	16483693
D000667	Ampicillin	Ampicillin results in increased expression of SLC1A2 protein	17138558
D018501	Antirheumatic Agents	Antirheumatic Agents results in decreased expression of SLC1A2 mRNA	24449571
C058317	arsenic disulfide	arsenic disulfide results in decreased expression of SLC1A2 mRNA	24865513
C058317	arsenic disulfide	arsenic disulfide results in decreased expression of SLC1A2 protein	24865513
C006632	arsenic trioxide	arsenic trioxide results in decreased expression of SLC1A2 mRNA	17547211
D000069059	Atorvastatin Calcium	Atorvastatin Calcium inhibits the reaction [APP protein results in decreased expression of SLC1A2 protein]	20816828
C022921	benzo(k)fluoranthene	benzo(k)fluoranthene results in increased expression of SLC1A2 mRNA	26377693
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of SLC1A2 mRNA	22316170\|2623829
D004958	Estradiol	Estradiol results in decreased expression of SLC1A2 mRNA	20106945\|2163298
D004958	Estradiol	[Estradiol co-treated with Progesterone] results in increased expression of SLC1A2 mRNA	22154832
D004958	Estradiol	Estradiol results in increased expression of SLC1A2 mRNA	22154832
D004958	Estradiol	Estradiol results in increased expression of SLC1A2 protein	22645130
D004958	Estradiol	Pertussis Toxin inhibits the reaction [Estradiol results in increased expression of SLC1A2 protein]	22645130
C006780	bisphenol A	bisphenol A results in decreased expression of SLC1A2 mRNA	26063408
C006780	bisphenol A	bisphenol A affects the expression of SLC1A2 mRNA	27571134
C006780	bisphenol A	[bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben] results in increased expression of SLC1A2 mRNA	25607892
C006780	bisphenol A	bisphenol A results in decreased expression of SLC1A2 mRNA	25181051
C006780	bisphenol A	bisphenol A results in increased expression of SLC1A2 mRNA	29097150
C006780	bisphenol A	bisphenol A results in increased methylation of SLC1A2 gene	28505145
D001761	Bleomycin	Bleomycin results in increased expression of SLC1A2 mRNA	15808516
D001786	Blood Glucose	[Oxygen deficiency co-treated with Blood Glucose deficiency] results in decreased expression of SLC1A2 protein	25727173
D001786	Blood Glucose	resveratrol inhibits the reaction [[Oxygen deficiency co-treated with Blood Glucose deficiency] results in decreased expression of SLC1A2 protein]	25727173
C038091	butylparaben	[bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben] results in increased expression of SLC1A2 mRNA	25607892
C018475	butyraldehyde	butyraldehyde results in increased expression of SLC1A2 mRNA	26079696
D020148	Butyric Acid	Butyric Acid inhibits the reaction [Manganese results in decreased expression of SLC1A2 mRNA]	28610743
D020148	Butyric Acid	Butyric Acid inhibits the reaction [Manganese results in decreased expression of SLC1A2 protein]	28610743
D020148	Butyric Acid	Butyric Acid inhibits the reaction [Manganese results in decreased expression of SLC1A2 mRNA]	24469401
D019256	Cadmium Chloride	Cadmium Chloride results in decreased activity of SLC1A2 protein mutant form	11724778
D002251	Carbon Tetrachloride	Carbon Tetrachloride results in decreased expression of SLC1A2 mRNA	27339419
D002251	Carbon Tetrachloride	Carbon Tetrachloride results in decreased expression of SLC1A2 protein	12629582
D002443	Ceftriaxone	Ceftriaxone inhibits the reaction [Cocaine results in decreased expression of SLC1A2 protein]	19717140
D002443	Ceftriaxone	Ceftriaxone promotes the reaction [Kainic Acid results in increased expression of SLC1A2 protein]	28257918
D002443	Ceftriaxone	Ceftriaxone results in increased expression of SLC1A2 protein	19625514\|2825791
D005023	Ethylene Chlorohydrin	Ethylene Chlorohydrin results in decreased expression of SLC1A2 protein	27596522
D020111	Chlorodiphenyl (54% Chlorine)	Chlorodiphenyl (54% Chlorine) results in decreased expression of SLC1A2 mRNA	22627295
D020111	Chlorodiphenyl (54% Chlorine)	Chlorodiphenyl (54% Chlorine) results in decreased expression of SLC1A2 protein	22627295
D020245	p-Chloromercuribenzoic Acid	"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SLC1A2 mRNA"	27188386
D020245	p-Chloromercuribenzoic Acid	p-Chloromercuribenzoic Acid results in decreased expression of SLC1A2 mRNA	26272509
D004390	Chlorpyrifos	[Chlorpyrifos co-treated with NGF protein] results in increased expression of SLC1A2 mRNA	20600679
D004390	Chlorpyrifos	Chlorpyrifos results in decreased expression of SLC1A2 mRNA	17452286
C012843	cinnamic aldehyde	cinnamic aldehyde results in increased expression of SLC1A2 mRNA	19524605
D002994	Clofibrate	Clofibrate results in decreased expression of SLC1A2 mRNA	23811191
D003024	Clozapine	Clozapine results in decreased activity of SLC1A2 protein	11443521
D003024	Clozapine	Clozapine results in decreased expression of SLC1A2 mRNA	12873733
D003024	Clozapine	Clozapine results in decreased expression of SLC1A2 protein	11443521
D003035	Cobalt	[tungsten carbide co-treated with Cobalt] results in decreased expression of SLC1A2 mRNA	18078969
C018021	cobaltous chloride	Acetylcysteine inhibits the reaction [cobaltous chloride results in decreased expression of SLC1A2 protein]	22895544
C018021	cobaltous chloride	cobaltous chloride results in decreased expression of SLC1A2 mRNA	24386269
C018021	cobaltous chloride	cobaltous chloride results in decreased expression of SLC1A2 protein	22895544
C018021	cobaltous chloride	sodium bisulfide inhibits the reaction [cobaltous chloride results in decreased expression of SLC1A2 protein]	22895544
C018021	cobaltous chloride	U 0126 inhibits the reaction [cobaltous chloride results in decreased expression of SLC1A2 protein]	22895544
D003042	Cocaine	Acetylcysteine inhibits the reaction [Cocaine results in decreased expression of SLC1A2 protein]	19717140
D003042	Cocaine	Ceftriaxone inhibits the reaction [Cocaine results in decreased expression of SLC1A2 protein]	19717140
D003042	Cocaine	Cocaine results in decreased expression of SLC1A2 protein	19717140
C118336	copper(II)(1,10-phenanthroline)3	"copper(II)(1,10-phenanthroline)3 results in decreased activity of SLC1A2 protein mutant form"	11724778
C118336	copper(II)(1,10-phenanthroline)3	"dihydrokainic acid inhibits the reaction [copper(II)(1,10-phenanthroline)3 results in decreased activity of SLC1A2 protein mutant form]"	11724778
C118336	copper(II)(1,10-phenanthroline)3	"Dithiothreitol inhibits the reaction [copper(II)(1,10-phenanthroline)3 results in decreased activity of SLC1A2 protein mutant form]"	11724778
D019327	Copper Sulfate	Copper Sulfate results in decreased expression of SLC1A2 mRNA	19549813
D003345	Corticosterone	Corticosterone inhibits the reaction [Hydrogen Peroxide results in decreased expression of SLC1A2 protein]	17138558
D003345	Corticosterone	Corticosterone results in increased expression of SLC1A2 protein	17138558
D003345	Corticosterone	Vitamin A promotes the reaction [Corticosterone results in increased expression of SLC1A2 protein]	17138558
D003345	Corticosterone	Corticosterone results in increased expression of SLC1A2 protein	17138558
C030123	coumarin	coumarin results in increased expression of SLC1A2 mRNA	18480146
D003471	Cuprizone	Cuprizone results in decreased expression of SLC1A2 mRNA	26577399
D016572	Cyclosporine	Cyclosporine results in decreased expression of SLC1A2 mRNA	25562108
C014347	decitabine	decitabine results in increased expression of SLC1A2 mRNA	15251184
C014347	decitabine	[Tetrachlorodibenzodioxin co-treated with decitabine] results in increased expression of SLC1A2 mRNA	15251184
C492519	diarylpropionitrile	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [diarylpropionitrile results in increased expression of SLC1A2 protein]	24782323
C492519	diarylpropionitrile	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [diarylpropionitrile results in increased expression of SLC1A2 protein]	24782323
C492519	diarylpropionitrile	[diarylpropionitrile binds to and results in increased activity of ESR2 protein] which results in increased expression of SLC1A2 protein	24782323
C492519	diarylpropionitrile	fulvestrant inhibits the reaction [diarylpropionitrile results in increased expression of SLC1A2 protein]	24782323
C492519	diarylpropionitrile	tyrphostin AG 1478 inhibits the reaction [diarylpropionitrile results in increased expression of SLC1A2 protein]	24782323
D003976	Diazinon	Diazinon results in decreased expression of SLC1A2 mRNA	17452286
D003993	Dibutyl Phthalate	[Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in decreased expression of SLC1A2 mRNA	25607892
D002945	Cisplatin	SLC1A2 gene mutant form results in decreased susceptibility to Cisplatin	21471434
D003633	Dichlorodiphenyl Dichloroethylene	[Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in decreased expression of SLC1A2 mRNA	25607892
D004041	Dietary Fats	"3,4,3',4'-tetrachlorobiphenyl inhibits the reaction [Dietary Fats results in increased expression of SLC1A2 mRNA]"	19467301
D004041	Dietary Fats	Dietary Fats results in decreased expression of SLC1A2 mRNA	25016146
D004041	Dietary Fats	Dietary Fats results in increased expression of SLC1A2 mRNA	19467301
D004051	Diethylhexyl Phthalate	[Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in decreased expression of SLC1A2 mRNA	25607892
C020889	dihydrokainic acid	"dihydrokainic acid inhibits the reaction [copper(II)(1,10-phenanthroline)3 results in decreased activity of SLC1A2 protein mutant form]"	11724778
D004229	Dithiothreitol	"Dithiothreitol inhibits the reaction [copper(II)(1,10-phenanthroline)3 results in decreased activity of SLC1A2 protein mutant form]"	11724778
D007980	Levodopa	[Levodopa co-treated with Oxidopamine] results in increased expression of SLC1A2 mRNA	17329435
C038939	enzacamene	[bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben] results in increased expression of SLC1A2 mRNA	25607892
C109476	epoxiconazole	[Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in decreased expression of SLC1A2 mRNA	25607892
D000431	Ethanol	Ethanol results in decreased expression of SLC1A2 mRNA	20655511
D000431	Ethanol	"N-methyl-N-(6-methoxy-1-phenyl-1,2,3,4-tetrahydronaphthalen-2-ylmethyl)aminomethylcarboxylic acid inhibits the reaction [Ethanol results in decreased expression of SLC1A2 mRNA]"	20655511
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in increased expression of SLC1A2 mRNA	17942748
D004997	Ethinyl Estradiol	[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of SLC1A2 mRNA	17942748
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in increased expression of SLC1A2 mRNA	29097150
C024565	ethylene dichloride	ethylene dichloride results in decreased expression of SLC1A2 mRNA	28189721
D018683	Excitatory Amino Acid Agents	Mercuric Chloride inhibits the reaction [SLC1A2 protein results in increased uptake of Excitatory Amino Acid Agents]	16632895
D018683	Excitatory Amino Acid Agents	SLC1A2 protein results in increased uptake of Excitatory Amino Acid Agents	16632895
C070081	fulvestrant	"fulvestrant inhibits the reaction [4,4',4''-(4-propyl-((1)H)-pyrazole-1,3,5-triyl) tris-phenol results in increased expression of SLC1A2 protein]"	24782323
C070081	fulvestrant	fulvestrant inhibits the reaction [diarylpropionitrile results in increased expression of SLC1A2 protein]	24782323
C070081	fulvestrant	fulvestrant results in increased expression of SLC1A2 protein	24782323
C039281	furan	furan results in decreased expression of SLC1A2 mRNA	25539665\|2619464
D019833	Genistein	[Genistein co-treated with Methoxychlor] results in decreased expression of SLC1A2 mRNA	21782745
D006220	Haloperidol	Haloperidol results in decreased expression of SLC1A2 mRNA	12873733
D006861	Hydrogen Peroxide	Corticosterone inhibits the reaction [Hydrogen Peroxide results in decreased expression of SLC1A2 protein]	17138558
D006861	Hydrogen Peroxide	Hydrogen Peroxide results in decreased expression of SLC1A2 protein	17138558
C016517	indole-3-carbinol	indole-3-carbinol affects the expression of SLC1A2 mRNA	21396975
D015759	Ionomycin	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of SLC1A2 mRNA	25613284
C561695	(+)-JQ1 compound	(+)-JQ1 compound results in decreased expression of SLC1A2 mRNA	26752646
D007608	Kainic Acid	[Kainic Acid co-treated with zinc chloride] results in decreased expression of SLC1A2 protein	19061913
D007608	Kainic Acid	Ceftriaxone promotes the reaction [Kainic Acid results in increased expression of SLC1A2 protein]	28257918
D007608	Kainic Acid	Kainic Acid results in increased expression of SLC1A2 protein	28257918
D007649	Ketamine	Ketamine results in increased expression of SLC1A2 mRNA	20080153
D048628	Ketolides	Ketolides analog results in increased expression of SLC1A2 mRNA	24967691
C057416	KT 5720	"KT 5720 inhibits the reaction [[1-(4-(6-bromobenzo(1,3)dioxol-5-yl)-3a,4,5,9b-tetrahydro-3H-cyclopenta(c)quinolin-8-yl)ethanone binds to and results in increased activity of GPER1 protein] which results in increased expression of SLC1A2 protein]"	22645130
C029310	lard	lard results in decreased expression of SLC1A2 mRNA	26115784
D007854	Lead	Lead results in decreased expression of SLC1A2 mRNA	15955607
D007854	Lead	Lead results in decreased expression of SLC1A2 protein	15955607
C008261	lead acetate	lead acetate results in decreased expression of SLC1A2 mRNA	15985313
D008044	Linuron	[Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in decreased expression of SLC1A2 mRNA	25607892
D008345	Manganese	Butyric Acid inhibits the reaction [Manganese results in decreased expression of SLC1A2 mRNA]	28610743
D008345	Manganese	Butyric Acid inhibits the reaction [Manganese results in decreased expression of SLC1A2 protein]	28610743
D008345	Manganese	Manganese results in decreased expression of SLC1A2 mRNA	28610743
D008345	Manganese	Manganese results in decreased expression of SLC1A2 protein	28610743
D008345	Manganese	Valproic Acid inhibits the reaction [Manganese results in decreased expression of SLC1A2 mRNA]	28610743
D008345	Manganese	Valproic Acid inhibits the reaction [Manganese results in decreased expression of SLC1A2 protein]	28610743
D008345	Manganese	"1-(4-(6-bromobenzo(1,3)dioxol-5-yl)-3a,4,5,9b-tetrahydro-3H-cyclopenta(c)quinolin-8-yl)ethanone inhibits the reaction [Manganese results in decreased expression of SLC1A2 mRNA]"	22645130
D008345	Manganese	"1-(4-(6-bromobenzo(1,3)dioxol-5-yl)-3a,4,5,9b-tetrahydro-3H-cyclopenta(c)quinolin-8-yl)ethanone inhibits the reaction [Manganese results in decreased expression of SLC1A2 protein]"	22645130
D008345	Manganese	Butyric Acid inhibits the reaction [Manganese results in decreased expression of SLC1A2 mRNA]	24469401
D008345	Manganese	Manganese promotes the reaction [YY1 protein binds to SLC1A2 promoter]	24469401
D008345	Manganese	Manganese results in decreased expression of SLC1A2 mRNA	22645130\|2446940
D008345	Manganese	Manganese results in decreased expression of SLC1A2 protein	22645130
D008345	Manganese	romidepsin inhibits the reaction [Manganese results in decreased expression of SLC1A2 mRNA]	24469401
D008345	Manganese	trichostatin A inhibits the reaction [Manganese results in decreased expression of SLC1A2 mRNA]	24469401
D008345	Manganese	Valproic Acid inhibits the reaction [Manganese results in decreased expression of SLC1A2 mRNA]	24469401
D008345	Manganese	vorinostat inhibits the reaction [Manganese results in decreased expression of SLC1A2 mRNA]	24469401
D008345	Manganese	YY1 protein affects the reaction [Manganese results in decreased expression of SLC1A2 mRNA]	24469401
D008345	Manganese	Manganese results in decreased expression of SLC1A2 protein	24469401
C025340	manganese chloride	manganese chloride results in decreased expression of SLC1A2 mRNA	19615351\|2478232
C025340	manganese chloride	manganese chloride results in decreased expression of SLC1A2 protein	19615351\|2478232
C025340	manganese chloride	Raloxifene Hydrochloride inhibits the reaction [manganese chloride results in decreased expression of SLC1A2 mRNA]	24782323
C025340	manganese chloride	Raloxifene Hydrochloride inhibits the reaction [manganese chloride results in decreased expression of SLC1A2 protein]	24782323
C025340	manganese chloride	Riluzole inhibits the reaction [manganese chloride results in decreased expression of SLC1A2 mRNA]	19615351
C025340	manganese chloride	Riluzole inhibits the reaction [manganese chloride results in decreased expression of SLC1A2 protein]	19615351
C039798	manganese sulfate	manganese sulfate results in decreased expression of SLC1A2 mRNA	17347134
C039798	manganese sulfate	manganese sulfate results in decreased expression of SLC1A2 protein	17347134
C039798	manganese sulfate	manganese sulfate results in increased expression of SLC1A2 mRNA	17347134
C042720	mercuric bromide	mercuric bromide results in decreased expression of SLC1A2 mRNA	26272509
C042720	mercuric bromide	"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SLC1A2 mRNA"	27188386
D008627	Mercuric Chloride	Mercuric Chloride inhibits the reaction [SLC1A2 protein results in increased uptake of Excitatory Amino Acid Agents]	16632895
D008627	Mercuric Chloride	Mercuric Chloride results in decreased expression of SLC1A2 mRNA	16632895
D008694	Methamphetamine	Methamphetamine results in increased expression of SLC1A2 mRNA	17105907
D008694	Methamphetamine	Methamphetamine results in increased expression of SLC1A2 mRNA	18419818
D008731	Methoxychlor	[Genistein co-treated with Methoxychlor] results in decreased expression of SLC1A2 mRNA	21782745
D008456	2-Methyl-4-chlorophenoxyacetic Acid	2-Methyl-4-chlorophenoxyacetic Acid affects the expression of SLC1A2 protein	16019039
C004925	methylmercuric chloride	methylmercuric chloride results in increased expression of SLC1A2 mRNA	23179753
C004925	methylmercuric chloride	methylmercuric chloride results in decreased expression of and results in decreased activity of SLC1A2 protein	22966415
C004925	methylmercuric chloride	methylmercuric chloride results in decreased expression of SLC1A2 mRNA	22966415
C004925	methylmercuric chloride	Riluzole inhibits the reaction [methylmercuric chloride results in decreased expression of and results in decreased activity of SLC1A2 protein]	22966415
C004925	methylmercuric chloride	Riluzole inhibits the reaction [methylmercuric chloride results in decreased expression of SLC1A2 mRNA]	22966415
D008767	Methylmercury Compounds	Methylmercury Compounds results in increased activity of SLC1A2 protein	16286679
D009151	Mustard Gas	Mustard Gas results in increased expression of SLC1A2 mRNA	15674843
C063509	N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide	"N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [[1-(4-(6-bromobenzo(1,3)dioxol-5-yl)-3a,4,5,9b-tetrahydro-3H-cyclopenta(c)quinolin-8-yl)ethanone binds to and results in increased activity of GPER1 protein] which results in increased expression of SLC1A2 mRNA]"	22645130
C063509	N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide	"N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [[1-(4-(6-bromobenzo(1,3)dioxol-5-yl)-3a,4,5,9b-tetrahydro-3H-cyclopenta(c)quinolin-8-yl)ethanone binds to and results in increased activity of GPER1 protein] which results in increased expression of SLC1A2 protein]"	22645130
C063509	N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide	N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Raloxifene Hydrochloride results in increased expression of SLC1A2 mRNA]	24782323
C063509	N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide	N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Raloxifene Hydrochloride results in increased expression of SLC1A2 protein]	24782323
D037742	Nanotubes, Carbon	"Nanotubes, Carbon results in decreased expression of SLC1A2 mRNA"	25620056
C066471	NCS 382	NCS 382 results in increased expression of SLC1A2 mRNA	29031482
D009543	Nifedipine	Nifedipine inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of SLC1A2 protein]	26988466
C520612	N-methyl-N-(6-methoxy-1-phenyl-1,2,3,4-tetrahydronaphthalen-2-ylmethyl)aminomethylcarboxylic acid	"N-methyl-N-(6-methoxy-1-phenyl-1,2,3,4-tetrahydronaphthalen-2-ylmethyl)aminomethylcarboxylic acid inhibits the reaction [Ethanol results in decreased expression of SLC1A2 mRNA]"	20655511
C002741	N-nitrosomorpholine	N-nitrosomorpholine results in increased expression of SLC1A2 mRNA	19716841
C025589	ochratoxin A	ochratoxin A affects the expression of SLC1A2 protein	20558201
C118580	octylmethoxycinnamate	[bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben] results in increased expression of SLC1A2 mRNA	25607892
D016627	Oxidopamine	[Levodopa co-treated with Oxidopamine] results in increased expression of SLC1A2 mRNA	17329435
D010098	Oxycodone	Oxycodone results in increased expression of SLC1A2 mRNA	23439660
D010100	Oxygen	Oxygen deficiency affects the expression of SLC1A2 protein	15927375
D010100	Oxygen	[Oxygen deficiency co-treated with Blood Glucose deficiency] results in decreased expression of SLC1A2 protein	25727173
D010100	Oxygen	resveratrol inhibits the reaction [[Oxygen deficiency co-treated with Blood Glucose deficiency] results in decreased expression of SLC1A2 protein]	25727173
D017239	Paclitaxel	Paclitaxel results in decreased expression of SLC1A2 protein	16361064
D010261	Paraoxon	Paraoxon results in increased expression of SLC1A2 mRNA	27769869
D010261	Paraoxon	Paraoxon results in increased expression of SLC1A2 protein	27769869
D010406	Penicillins	Penicillins results in increased expression of SLC1A2 protein	17138558
D010416	Pentachlorophenol	Pentachlorophenol results in increased expression of SLC1A2 mRNA	23892564
C046012	pentanal	pentanal results in increased expression of SLC1A2 mRNA	26079696
C076994	perfluorooctane sulfonic acid	perfluorooctane sulfonic acid results in decreased expression of SLC1A2 mRNA	27825932
D037342	Pertussis Toxin	"Pertussis Toxin inhibits the reaction [[1-(4-(6-bromobenzo(1,3)dioxol-5-yl)-3a,4,5,9b-tetrahydro-3H-cyclopenta(c)quinolin-8-yl)ethanone binds to and results in increased activity of GPER1 protein] which results in increased activity of SLC1A2 protein]"	22645130
D037342	Pertussis Toxin	"Pertussis Toxin inhibits the reaction [[1-(4-(6-bromobenzo(1,3)dioxol-5-yl)-3a,4,5,9b-tetrahydro-3H-cyclopenta(c)quinolin-8-yl)ethanone binds to and results in increased activity of GPER1 protein] which results in increased expression of SLC1A2 protein]"	22645130
D037342	Pertussis Toxin	Pertussis Toxin inhibits the reaction [Estradiol results in increased expression of SLC1A2 protein]	22645130
D010634	Phenobarbital	NR1I3 protein affects the reaction [Phenobarbital results in increased expression of SLC1A2 mRNA]	19482888
D010634	Phenobarbital	Phenobarbital results in decreased expression of SLC1A2 mRNA	23091169
D010634	Phenobarbital	Phenobarbital results in increased expression of SLC1A2 mRNA	19482888
D010662	Phenylmercuric Acetate	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SLC1A2 mRNA"	27188386
D010662	Phenylmercuric Acetate	Phenylmercuric Acetate results in decreased expression of SLC1A2 mRNA	26272509
C006253	pirinixic acid	pirinixic acid results in decreased expression of SLC1A2 mRNA	20813756\|2381119
C006253	pirinixic acid	pirinixic acid results in increased expression of SLC1A2 mRNA	12832660
D011192	Potassium Dichromate	Potassium Dichromate affects the expression of SLC1A2 mRNA	23608068
C045362	prochloraz	[Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in decreased expression of SLC1A2 mRNA	25607892
C035988	procymidone	[Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in decreased expression of SLC1A2 mRNA	25607892
D011374	Progesterone	[Estradiol co-treated with Progesterone] results in increased expression of SLC1A2 mRNA	22154832
C005556	propionaldehyde	propionaldehyde results in increased expression of SLC1A2 mRNA	26079696
D011441	Propylthiouracil	Propylthiouracil results in decreased expression of SLC1A2 mRNA	24780913
C020972	pyrrolidine dithiocarbamic acid	pyrrolidine dithiocarbamic acid results in increased expression of SLC1A2 protein	17409235
C020972	pyrrolidine dithiocarbamic acid	"pyrrolidine dithiocarbamic acid inhibits the reaction [[1-(4-(6-bromobenzo(1,3)dioxol-5-yl)-3a,4,5,9b-tetrahydro-3H-cyclopenta(c)quinolin-8-yl)ethanone binds to and results in increased activity of GPER1 protein] which results in increased expression of SLC1A2 protein]"	22645130
C020972	pyrrolidine dithiocarbamic acid	pyrrolidine dithiocarbamic acid inhibits the reaction [Raloxifene Hydrochloride results in increased expression of SLC1A2 mRNA]	24782323
C020972	pyrrolidine dithiocarbamic acid	pyrrolidine dithiocarbamic acid inhibits the reaction [Raloxifene Hydrochloride results in increased expression of SLC1A2 protein]	24782323
D011794	Quercetin	Quercetin results in decreased expression of SLC1A2 mRNA	21632981
D011799	Quinazolines	"Quinazolines inhibits the reaction [[1-(4-(6-bromobenzo(1,3)dioxol-5-yl)-3a,4,5,9b-tetrahydro-3H-cyclopenta(c)quinolin-8-yl)ethanone binds to and results in increased activity of GPER1 protein] which results in increased expression of SLC1A2 protein]"	22645130
D020849	Raloxifene Hydrochloride	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Raloxifene Hydrochloride results in increased expression of SLC1A2 mRNA]	24782323
D020849	Raloxifene Hydrochloride	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Raloxifene Hydrochloride results in increased expression of SLC1A2 protein]	24782323
D020849	Raloxifene Hydrochloride	"[4-(6-bromo-1,3-benzodioxol-5-yl)-3a,4,5,9b-3H-cyclopenta(c)quinoline binds to and results in decreased activity of GPER1 protein] inhibits the reaction [[Raloxifene Hydrochloride results in increased activity of GPER1 protein] which results in increased expression of SLC1A2 protein]"	24782323
D020849	Raloxifene Hydrochloride	ESR1 protein promotes the reaction [Raloxifene Hydrochloride results in increased expression of SLC1A2 mRNA]	24782323
D020849	Raloxifene Hydrochloride	ESR2 protein promotes the reaction [Raloxifene Hydrochloride results in increased expression of SLC1A2 mRNA]	24782323
D020849	Raloxifene Hydrochloride	N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Raloxifene Hydrochloride results in increased expression of SLC1A2 mRNA]	24782323
D020849	Raloxifene Hydrochloride	N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Raloxifene Hydrochloride results in increased expression of SLC1A2 protein]	24782323
D020849	Raloxifene Hydrochloride	pyrrolidine dithiocarbamic acid inhibits the reaction [Raloxifene Hydrochloride results in increased expression of SLC1A2 mRNA]	24782323
D020849	Raloxifene Hydrochloride	pyrrolidine dithiocarbamic acid inhibits the reaction [Raloxifene Hydrochloride results in increased expression of SLC1A2 protein]	24782323
D020849	Raloxifene Hydrochloride	Raloxifene Hydrochloride inhibits the reaction [manganese chloride results in decreased expression of SLC1A2 mRNA]	24782323
D020849	Raloxifene Hydrochloride	Raloxifene Hydrochloride inhibits the reaction [manganese chloride results in decreased expression of SLC1A2 protein]	24782323
D020849	Raloxifene Hydrochloride	Raloxifene Hydrochloride promotes the reaction [NFKB1 protein binds to SLC1A2 promoter]	24782323
D020849	Raloxifene Hydrochloride	Raloxifene Hydrochloride promotes the reaction [RELA protein binds to SLC1A2 promoter]	24782323
D020849	Raloxifene Hydrochloride	[Raloxifene Hydrochloride results in increased activity of GPER1 protein] which results in increased expression of SLC1A2 protein	24782323
D020849	Raloxifene Hydrochloride	Raloxifene Hydrochloride results in increased expression of SLC1A2 mRNA	24782323
D020849	Raloxifene Hydrochloride	Raloxifene Hydrochloride results in increased expression of SLC1A2 protein	24782323
D020849	Raloxifene Hydrochloride	tyrphostin AG 1478 inhibits the reaction [Raloxifene Hydrochloride results in increased expression of SLC1A2 mRNA]	24782323
D020849	Raloxifene Hydrochloride	tyrphostin AG 1478 inhibits the reaction [Raloxifene Hydrochloride results in increased expression of SLC1A2 protein]	24782323
C059514	resveratrol	resveratrol inhibits the reaction [[Oxygen deficiency co-treated with Blood Glucose deficiency] results in decreased expression of SLC1A2 protein]	25727173
C059514	resveratrol	resveratrol results in increased expression of SLC1A2 mRNA	25905778
D012293	Rifampin	Rifampin results in decreased expression of SLC1A2 mRNA	27199754
D019782	Riluzole	Riluzole inhibits the reaction [manganese chloride results in decreased expression of SLC1A2 mRNA]	19615351
D019782	Riluzole	Riluzole inhibits the reaction [manganese chloride results in decreased expression of SLC1A2 protein]	19615351
D019782	Riluzole	Riluzole inhibits the reaction [methylmercuric chloride results in decreased expression of and results in decreased activity of SLC1A2 protein]	22966415
D019782	Riluzole	Riluzole inhibits the reaction [methylmercuric chloride results in decreased expression of SLC1A2 mRNA]	22966415
D019782	Riluzole	Riluzole results in increased expression of SLC1A2 mRNA	22966415
D019782	Riluzole	Riluzole results in increased expression of SLC1A2 protein	22966415
C087123	romidepsin	romidepsin inhibits the reaction [Manganese results in decreased expression of SLC1A2 mRNA]	24469401
C087123	romidepsin	romidepsin results in increased expression of SLC1A2 mRNA	24469401
C017947	sodium arsenite	sodium arsenite results in decreased expression of SLC1A2	29204679
C017947	sodium arsenite	sodium arsenite results in decreased expression of and results in decreased activity of SLC1A2 protein	22020379
C025451	sodium bisulfide	sodium bisulfide inhibits the reaction [cobaltous chloride results in decreased expression of SLC1A2 protein]	22895544
D012999	Soman	Soman results in increased expression of SLC1A2 mRNA	19281266
D019311	Staurosporine	Staurosporine inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of SLC1A2 protein]	26988466
D014284	Triiodothyronine	Triiodothyronine results in increased expression of SLC1A2 mRNA	25172293
D013629	Tamoxifen	Tamoxifen results in decreased expression of SLC1A2 mRNA	25123088
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of SLC1A2 mRNA	22298810
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of SLC1A2 mRNA	20106945\|2163298
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of SLC1A2 mRNA	21998131
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of SLC1A2 mRNA	21570461\|2637764
D013749	Tetrachlorodibenzodioxin	[Tetrachlorodibenzodioxin co-treated with decitabine] results in increased expression of SLC1A2 mRNA	15251184
D013749	Tetrachlorodibenzodioxin	[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of SLC1A2 mRNA	17942748
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to SLC1A2 gene]	28213091
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of SLC1A2 mRNA	19933214
D013749	Tetrachlorodibenzodioxin	2-(1-(3-dimethylaminopropyl)-5-methoxyindol-3-yl)-3-(1H-indol-3-yl)maleimide inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of SLC1A2 protein]	26988466
D013749	Tetrachlorodibenzodioxin	Nifedipine inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of SLC1A2 protein]	26988466
D013749	Tetrachlorodibenzodioxin	Staurosporine inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of SLC1A2 protein]	26988466
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of SLC1A2 mRNA	22298810
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of SLC1A2 mRNA	21215274
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of SLC1A2 protein	26988466
D013755	Tetradecanoylphorbol Acetate	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of SLC1A2 mRNA	25613284
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution affects the expression of SLC1A2 mRNA	20133372
D014050	Toluene	Toluene affects the expression of SLC1A2 mRNA	18653662
D014212	Tretinoin	Tretinoin results in decreased expression of SLC1A2 mRNA	21934132
D014212	Tretinoin	Tretinoin results in increased expression of SLC1A2 mRNA	23724009
D014241	Trichloroethylene	Trichloroethylene results in decreased expression of SLC1A2 mRNA	25549359
C012589	trichostatin A	trichostatin A results in decreased expression of SLC1A2 mRNA	15901671
C012589	trichostatin A	trichostatin A results in decreased expression of SLC1A2 mRNA	24935251
C012589	trichostatin A	trichostatin A results in increased expression of SLC1A2 mRNA	19924110\|2493525
C012589	trichostatin A	trichostatin A inhibits the reaction [Manganese results in decreased expression of SLC1A2 mRNA]	24469401
C012589	trichostatin A	trichostatin A results in increased expression of SLC1A2 mRNA	24469401
C013320	tris(2-butoxyethyl) phosphate	tris(2-butoxyethyl) phosphate affects the expression of SLC1A2 mRNA	29024780
C002802	tungsten carbide	[tungsten carbide co-treated with Cobalt] results in decreased expression of SLC1A2 mRNA	18078969
C101044	tyrphostin AG 1478	"tyrphostin AG 1478 inhibits the reaction [[1-(4-(6-bromobenzo(1,3)dioxol-5-yl)-3a,4,5,9b-tetrahydro-3H-cyclopenta(c)quinolin-8-yl)ethanone binds to and results in increased activity of GPER1 protein] which results in increased expression of SLC1A2 protein]"	22645130
C101044	tyrphostin AG 1478	"tyrphostin AG 1478 inhibits the reaction [4,4',4''-(4-propyl-((1)H)-pyrazole-1,3,5-triyl) tris-phenol results in increased expression of SLC1A2 protein]"	24782323
C101044	tyrphostin AG 1478	tyrphostin AG 1478 inhibits the reaction [diarylpropionitrile results in increased expression of SLC1A2 protein]	24782323
C101044	tyrphostin AG 1478	tyrphostin AG 1478 inhibits the reaction [Raloxifene Hydrochloride results in increased expression of SLC1A2 mRNA]	24782323
C101044	tyrphostin AG 1478	tyrphostin AG 1478 inhibits the reaction [Raloxifene Hydrochloride results in increased expression of SLC1A2 protein]	24782323
C113580	U 0126	U 0126 inhibits the reaction [cobaltous chloride results in decreased expression of SLC1A2 protein]	22895544
D017974	Uranium Compounds	Uranium Compounds results in increased expression of SLC1A2 mRNA	19654044
D014635	Valproic Acid	Valproic Acid results in decreased expression of SLC1A2 mRNA	15901671
D014635	Valproic Acid	Valproic Acid promotes the reaction [HIST4H4 protein modified form binds to SLC1A2 promoter]	19924110
D014635	Valproic Acid	Valproic Acid results in decreased expression of SLC1A2 mRNA	24383497\|2800136
D014635	Valproic Acid	Valproic Acid results in decreased methylation of SLC1A2 gene	29154799
D014635	Valproic Acid	Valproic Acid results in increased expression of SLC1A2 mRNA	19924110\|2493525
D014635	Valproic Acid	Valproic Acid inhibits the reaction [Manganese results in decreased expression of SLC1A2 mRNA]	28610743
D014635	Valproic Acid	Valproic Acid inhibits the reaction [Manganese results in decreased expression of SLC1A2 protein]	28610743
D014635	Valproic Acid	Valproic Acid inhibits the reaction [Manganese results in decreased expression of SLC1A2 mRNA]	24469401
D014635	Valproic Acid	Valproic Acid results in decreased methylation of SLC1A2 promoter	19924110
D014635	Valproic Acid	[Valproic Acid results in decreased methylation of SLC1A2 promoter] which results in increased expression of SLC1A2 mRNA	19924110\|1992411
D014635	Valproic Acid	Valproic Acid results in increased expression of SLC1A2 mRNA	19924110\|2446940
D001335	Vehicle Emissions	Vehicle Emissions results in decreased methylation of SLC1A2 gene	25560391
C025643	vinclozolin	[Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in decreased expression of SLC1A2 mRNA	25607892
D014801	Vitamin A	Vitamin A promotes the reaction [Corticosterone results in increased expression of SLC1A2 protein]	17138558
D014801	Vitamin A	Vitamin A results in increased expression of SLC1A2 protein	17138558
D014801	Vitamin A	Vitamin A results in increased expression of SLC1A2 protein	17138558
C111237	vorinostat	vorinostat inhibits the reaction [Manganese results in decreased expression of SLC1A2 mRNA]	24469401
C111237	vorinostat	vorinostat results in increased expression of SLC1A2 mRNA	24469401
C070417	Win 55212-2	Win 55212-2 results in increased expression of SLC1A2 protein	17631920
D015032	Zinc	Zinc deficiency results in increased expression of SLC1A2 protein	18755231
C016837	zinc chloride	[Kainic Acid co-treated with zinc chloride] results in decreased expression of SLC1A2 protein	19061913

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005313	L-glutamate transmembrane transporter activity	-	IDA	7521911
GO:0005314	high-affinity glutamate transmembrane transporter activity	-	IDA	26690923
GO:0005314	high-affinity glutamate transmembrane transporter activity	-	TAS	-
GO:0005515	protein binding	-	IPI	19527721
GO:0015171	amino acid transmembrane transporter activity	-	TAS	-
GO:0015501	glutamate:sodium symporter activity	-	IDA	15265858
GO:0046872	metal ion binding	-	IEA	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0006811	ion transport	-	TAS	-
GO:0007268	chemical synaptic transmission	-	TAS	7521911
GO:0007632	visual behavior	-	IEA	-
GO:0009611	response to wounding	-	IEA	-
GO:0010259	multicellular organism aging	-	IEA	-
GO:0014047	glutamate secretion	-	TAS	-
GO:0015813	L-glutamate transmembrane transport	-	IDA	26690923
GO:0021537	telencephalon development	-	IEA	-
GO:0030534	adult behavior	-	IEA	-
GO:0031668	cellular response to extracellular stimulus	-	IEA	-
GO:0035264	multicellular organism growth	-	IEA	-
GO:0043200	response to amino acid	-	IEA	-
GO:0046326	positive regulation of glucose import	-	IEA	-
GO:0070207	protein homotrimerization	-	IDA	15265858 15483603
GO:0070779	D-aspartate import across plasma membrane	-	IDA	7521911
GO:0098712	L-glutamate import across plasma membrane	-	IDA	7521911 15265858 26690923

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005886	plasma membrane	-	TAS	-
GO:0005887	integral component of plasma membrane	-	IMP	15265858 26690923
GO:0009986	cell surface	-	IDA	21399631
GO:0016020	membrane	-	TAS	7521911
GO:0030673	axolemma	-	IEA	-

KEGG ID	KEGG Term
hsa05014	Amyotrophic lateral sclerosis (ALS)

Reactome ID	Reactome Term	Evidence
R-HSA-112310	Neurotransmitter release cycle	TAS
R-HSA-112313	Neurotransmitter uptake and metabolism In glial cells	TAS
R-HSA-112315	Transmission across Chemical Synapses	TAS
R-HSA-112316	Neuronal System	TAS
R-HSA-210455	Astrocytic Glutamate-Glutamine Uptake And Metabolism	TAS
R-HSA-210500	Glutamate Neurotransmitter Release Cycle	TAS
R-HSA-382551	Transport of small molecules	TAS
R-HSA-425393	Transport of inorganic cations/anions and amino acids/oligopeptides	TAS
R-HSA-425407	SLC-mediated transmembrane transport	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
16766085	GABA(A) receptor beta isoform protein expression in human alcoholic brain: interaction with genotype. (2006 Nov)	Buckley ST	Neurochem Int
19268276	Genome-wide association study of smoking initiation and current smoking. (2009 Mar)	Vink JM	Am J Hum Genet
22719919	Glutamate and synaptic plasticity systems and smoking behavior: results from a genetic association study. (2012)	dos Santos VA	PLoS One
25972039	GLAST But Not Least--Distribution, Function, Genetics and Epigenetics of L-Glutamate Transport in Brain--Focus on GLAST/EAAT1. (2015 Dec)	Sery O	Neurochem Res
20589092	Ethanol and phencyclidine interact with respect to nucleus accumbens dopamine release: differential effects of administration order and pretreatment protocol. (2010)	Pickering C	Front Behav Neurosci