Gene: NBEAL1

65065
A530083I02Rik|ALS2CR16|ALS2CR17
neurobeachin like 1
protein-coding
2q33.2
Ensembl:ENSG00000144426 MIM:609816 Vega:OTTHUMG00000154129 UniprotKB:Q6ZS30
NC_000002.12
SNP Mapped
2   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
2.542e-1 (AD)  7.299e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs2117266chr2:203195425 (GRCh38.p7)G>Talcohol dependenceSNV(Single Nucleotide Variation)
rs10182274chr2:203186286 (GRCh38.p7)G>A / G>Talcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ZBTB200.798
ZNF4600.775
CXCR60.705
PCDHGA80.677
TAS2R300.671
C17orf780.665
MTRNR2L50.664
NKAIN30.663
LMX1B0.662
PRAMEF170.658

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
TMEM191C-0.375
HENMT1-0.37
DLK2-0.368
SFTPD-0.367
CHST8-0.362
ACRV1-0.355
CCDC175-0.337
C11orf80-0.334
CRYBA2-0.332
SPAG8-0.328

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased expression of NBEAL1 mRNA"28903501
C0294972,3-bis(3'-hydroxybenzyl)butyrolactone"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in decreased expression of NBEAL1 mRNA"19167446
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in increased expression of NBEAL1 mRNA"28973690
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in increased expression of NBEAL1 mRNA"18648102
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of NBEAL1 mRNA22100608
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of NBEAL1 mRNA19770486
D000393Air PollutantsAir Pollutants analog results in decreased expression of NBEAL1 mRNA21757418
D018501Antirheumatic AgentsAntirheumatic Agents results in increased expression of NBEAL1 mRNA24449571
C547126AZM551248AZM551248 results in increased expression of NBEAL1 mRNA22323515
C030935benz(a)anthracenebenz(a)anthracene results in decreased expression of NBEAL1 mRNA26377693
C006703benzo(b)fluoranthenebenzo(b)fluoranthene results in decreased expression of NBEAL1 mRNA26377693
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of NBEAL1 mRNA19770486
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of NBEAL1 mRNA27339419
C031180chrysenechrysene results in decreased expression of NBEAL1 mRNA26377693
D003033Coal TarCoal Tar results in decreased expression of NBEAL1 mRNA27858113
D003375Coumestrol"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in decreased expression of NBEAL1 mRNA"19167446
D016572CyclosporineCyclosporine results in increased expression of NBEAL1 mRNA25562108
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in decreased expression of NBEAL1 mRNA27392435
D002945CisplatinCisplatin results in decreased expression of NBEAL1 mRNA27392435
C045651epigallocatechin gallate[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of NBEAL1 mRNA22079256
D000431EthanolEthanol results in decreased expression of NBEAL1 mRNA29018328
D006830Hydralazine[Hydralazine co-treated with Valproic Acid] results in increased expression of NBEAL1 mRNA17183730
D006861Hydrogen Peroxide[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of NBEAL1 protein18951874
C544151jinfukang[Cisplatin co-treated with jinfukang] results in decreased expression of NBEAL1 mRNA27392435
C544151jinfukangjinfukang results in decreased expression of NBEAL1 mRNA27392435
D058185Magnetite Nanoparticles[Succimer binds to Magnetite Nanoparticles] which results in decreased expression of NBEAL1 mRNA21641980
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of NBEAL1 mRNA23649840
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in decreased expression of NBEAL1 mRNA"26251327
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of NBEAL1 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of NBEAL1 mRNA"25554681
D010634PhenobarbitalPhenobarbital affects the expression of NBEAL1 mRNA23091169
D010936Plant ExtractsPlant Extracts results in increased expression of NBEAL1 mRNA23557933
C027373potassium chromate(VI)[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of NBEAL1 mRNA22079256
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of NBEAL1 mRNA22079256
D011374ProgesteroneProgesterone results in increased expression of NBEAL1 mRNA23018184
C045950propiconazolepropiconazole results in decreased expression of NBEAL1 mRNA21278054
C009277sodium arsenatesodium arsenate results in increased expression of NBEAL1 mRNA21795629
D004113Succimer[Succimer binds to Magnetite Nanoparticles] which results in decreased expression of NBEAL1 mRNA21641980
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of NBEAL1 mRNA21570461
D013806Theophylline[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of NBEAL1 protein18951874
C057693troglitazonetroglitazone results in decreased expression of NBEAL1 mRNA28973697
D014635Valproic Acid[Hydralazine co-treated with Valproic Acid] results in increased expression of NBEAL1 mRNA17183730
D014635Valproic AcidValproic Acid affects the expression of NBEAL1 mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of NBEAL1 mRNA28001369
D014635Valproic AcidValproic Acid affects the expression of NBEAL1 mRNA17963808

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO ID GO Term Qualifier Evidence PubMed
GO ID GO Term Qualifier Evidence PubMed
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal