Gene: SLC1A3

6507
EA6|EAAT1|GLAST|GLAST1
solute carrier family 1 member 3
protein-coding
5p13.2
Ensembl:ENSG00000079215 MIM:600111 Vega:OTTHUMG00000090793 UniprotKB:P43003
NG_015890.1
PubMed
AD
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
5.166e-1 (AD)  1.471e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
GJA10.95
TP53BP20.94
ELOVL20.939
SLC39A120.928
SOX90.927
METTL7A0.926
NTRK20.922
ATP1B20.918
AQP40.916
LRIG10.915

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.472
OR4F29-0.441
DUSP27-0.357
SAMD5-0.357
QRFPR-0.35
CACNA1F-0.342
TRABD2A-0.338
AGMAT-0.337
SCARA5-0.335
NRG1-0.334

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00142Glutamic AcidSmall Molecule56-86-0Approved|NutraceuticalTarget
ID Drug Name Action PubMed
C5179431-(4-(6-bromobenzo(1,3)dioxol-5-yl)-3a,4,5,9b-tetrahydro-3H-cyclopenta(c)quinolin-8-yl)ethanone"[1-(4-(6-bromobenzo(1,3)dioxol-5-yl)-3a,4,5,9b-tetrahydro-3H-cyclopenta(c)quinolin-8-yl)ethanone binds to and results in increased activity of GPER1 protein] which results in increased expression of SLC1A3 mRNA"22645130
C5179431-(4-(6-bromobenzo(1,3)dioxol-5-yl)-3a,4,5,9b-tetrahydro-3H-cyclopenta(c)quinolin-8-yl)ethanone"[1-(4-(6-bromobenzo(1,3)dioxol-5-yl)-3a,4,5,9b-tetrahydro-3H-cyclopenta(c)quinolin-8-yl)ethanone binds to and results in increased activity of GPER1 protein] which results in increased expression of SLC1A3 protein"22645130
C5486512-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in decreased expression of SLC1A3 mRNA19933214
C0297902,2',3',4,4',5-hexachlorobiphenyl"2,2',3',4,4',5-hexachlorobiphenyl results in increased expression of SLC1A3 protein"21673325
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in increased expression of SLC1A3 mRNA"23146750
C0140242,4,5,2',4',5'-hexachlorobiphenyl"2,4,5,2',4',5'-hexachlorobiphenyl results in increased expression of SLC1A3 mRNA"23146750
C5532952-amino-4-(4-methoxyphenyl)-7-(naphthalen-1-yl)-5-oxo-5,6,7,8-tetrahydro-4H-chromene-3-carbonitrile"2-amino-4-(4-methoxyphenyl)-7-(naphthalen-1-yl)-5-oxo-5,6,7,8-tetrahydro-4H-chromene-3-carbonitrile results in decreased activity of SLC1A3 protein"22645130
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of SLC1A3 mRNA"23196670
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with belinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SLC1A3 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SLC1A3 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SLC1A3 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SLC1A3 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SLC1A3 mRNA"27188386
C5688624-(6-bromo-1,3-benzodioxol-5-yl)-3a,4,5,9b-3H-cyclopenta(c)quinoline"[4-(6-bromo-1,3-benzodioxol-5-yl)-3a,4,5,9b-3H-cyclopenta(c)quinoline results in decreased activity of GPER1 protein] inhibits the reaction [[Raloxifene Hydrochloride results in increased activity of GPER1 protein] which results in increased expression of SLC1A3 protein]"24782323
C5688624-(6-bromo-1,3-benzodioxol-5-yl)-3a,4,5,9b-3H-cyclopenta(c)quinoline"[4-(6-bromo-1,3-benzodioxol-5-yl)-3a,4,5,9b-3H-cyclopenta(c)quinoline results in decreased activity of GPER1 protein] which results in decreased expression of SLC1A3 protein"24782323
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with belinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SLC1A3 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SLC1A3 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SLC1A3 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SLC1A3 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SLC1A3 mRNA"27188386
D000082AcetaminophenAcetaminophen results in decreased expression of SLC1A3 mRNA29067470
D000082Acetaminophen[bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben co-treated with Androgen Antagonists co-treated with Acetaminophen] results in increased expression of SLC1A3 mRNA25607892
D020106AcrylamideAcrylamide results in increased expression of SLC1A3 mRNA12853321
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of SLC1A3 mRNA22100608
D000517alpha-Chlorohydrinalpha-Chlorohydrin results in increased expression of SLC1A3 mRNA28522335
D000535Aluminum[APP protein modified form binds to Aluminum] which results in increased expression of SLC1A3 mRNA21298039
D000602Amino Acids, Peptides, and Proteins"SLC1A3 affects the uptake of Amino Acids, Peptides, and Proteins"15608650
D000643Ammonium ChlorideAmmonium Chloride affects the expression of SLC1A3 mRNA16483693
D000643Ammonium ChlorideAmmonium Chloride results in increased oxidation of SLC1A3 mRNA18506841
D000726Androgen Antagonists[bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben co-treated with Androgen Antagonists co-treated with Acetaminophen] results in increased expression of SLC1A3 mRNA25607892
D017638Asbestos, Crocidolite"Asbestos, Crocidolite results in increased expression of SLC1A3 mRNA"19446018
D000069059Atorvastatin CalciumAtorvastatin Calcium inhibits the reaction [APP protein results in decreased expression of SLC1A3 protein]20816828
C487081belinostat"[NOG protein co-treated with belinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SLC1A3 mRNA"27188386
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of SLC1A3 mRNA22316170
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of SLC1A3 mRNA22300585
D004958Estradiol[Estradiol co-treated with Progesterone] results in increased expression of SLC1A3 mRNA20660070
D004958Estradiol[Estradiol co-treated with Progesterone] results in increased expression of SLC1A3 mRNA22154832
D004958EstradiolEstradiol results in increased expression of SLC1A3 mRNA22154832
D004958EstradiolEstradiol inhibits the reaction [Manganese results in decreased expression of SLC1A3 mRNA]19453300
D004958EstradiolEstradiol inhibits the reaction [Manganese results in decreased expression of SLC1A3 protein]19453300
D004958EstradiolEstradiol results in increased expression of SLC1A3 mRNA19453300
D004958EstradiolEstradiol results in increased expression of SLC1A3 protein19453300
C095105bexarotenebexarotene results in decreased expression of SLC1A3 mRNA16648578
C006780bisphenol Abisphenol A affects the expression of SLC1A3 mRNA20170705
C006780bisphenol Abisphenol A affects the expression of SLC1A3 mRNA25181051
C006780bisphenol A[bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben co-treated with Androgen Antagonists co-treated with Acetaminophen] results in increased expression of SLC1A3 mRNA25607892
C006780bisphenol A[bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben] results in increased expression of SLC1A3 mRNA25607892
C013418bromfenacoumbromfenacoum results in increased expression of SLC1A3 protein28903499
C038091butylparaben[bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben co-treated with Androgen Antagonists co-treated with Acetaminophen] results in increased expression of SLC1A3 mRNA25607892
C038091butylparaben[bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben] results in increased expression of SLC1A3 mRNA25607892
D020148Butyric AcidButyric Acid inhibits the reaction [Manganese results in decreased expression of SLC1A3 mRNA]28610743
D020148Butyric AcidButyric Acid inhibits the reaction [Manganese results in decreased expression of SLC1A3 protein]28610743
D002251Carbon TetrachlorideCarbon Tetrachloride results in decreased expression of SLC1A3 protein17544377
D005023Ethylene ChlorohydrinEthylene Chlorohydrin results in decreased expression of SLC1A3 mRNA27596522
D005023Ethylene ChlorohydrinEthylene Chlorohydrin results in decreased expression of SLC1A3 protein27596522
D002737ChloropreneChloroprene results in decreased expression of SLC1A3 mRNA23125180
D004390Chlorpyrifos[Chlorpyrifos co-treated with NGF protein] results in increased expression of SLC1A3 mRNA20600679
D004390ChlorpyrifosChlorpyrifos results in increased expression of SLC1A3 mRNA20600679
D002784CholesterolCholesterol results in increased expression of SLC1A3 mRNA26296894
C418118CI 1044CI 1044 results in increased expression of SLC1A3 mRNA17569694
D060729Coal AshCoal Ash results in decreased expression of SLC1A3 mRNA19000753
C018021cobaltous chloridecobaltous chloride results in decreased expression of SLC1A3 mRNA22941251
D003300Copper[NSC 689534 binds to Copper] which results in decreased expression of SLC1A3 mRNA20971185
D003300CopperCopper deficiency results in increased expression of SLC1A3 mRNA26033743
D003474CurcuminCurcumin inhibits the reaction [Streptozocin results in decreased expression of SLC1A3 mRNA]23267840
D003907DexamethasoneDexamethasone results in decreased expression of SLC1A3 mRNA25047013
D003907DexamethasoneDexamethasone results in decreased expression of SLC1A3 mRNA22733784
D003975DiazepamDiazepam results in increased oxidation of SLC1A3 mRNA18506841
D003976DiazinonDiazinon results in decreased expression of SLC1A3 mRNA17452286
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of SLC1A3 mRNA21266533
D002945CisplatinSLC1A3 mRNA affects the susceptibility to Cisplatin18610736
C036042dicyclohexyl phthalatedicyclohexyl phthalate affects the expression of SLC1A3 mRNA26924002
D004041Dietary FatsDietary Fats results in decreased expression of SLC1A3 mRNA18042831
D004041Dietary FatsDietary Fats results in increased expression of SLC1A3 mRNA19030233
D002117CalcitriolCalcitriol results in increased expression of SLC1A3 mRNA27107558
D0151279,10-Dimethyl-1,2-benzanthracene"9,10-Dimethyl-1,2-benzanthracene results in decreased expression of SLC1A3 mRNA"19480007
C024629dimethyl phthalatedimethyl phthalate affects the expression of SLC1A3 mRNA26924002
C061132diphenyldiselenidediphenyldiselenide results in increased expression of SLC1A3 protein19926633
D004785Environmental PollutantsEnvironmental Pollutants results in increased expression of SLC1A3 mRNA19118595
C038939enzacamene[bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben co-treated with Androgen Antagonists co-treated with Acetaminophen] results in increased expression of SLC1A3 mRNA25607892
C038939enzacamene[bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben] results in increased expression of SLC1A3 mRNA25607892
D000431EthanolEthanol affects the expression of SLC1A3 mRNA11772933
D000431EthanolEthanol results in increased expression of SLC1A3 mRNA20655511
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of SLC1A3 mRNA20170705|2686566
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of SLC1A3 mRNA15834898|1755790
D018683Excitatory Amino Acid AgentsMercuric Chloride inhibits the reaction [SLC1A3 protein results in increased uptake of Excitatory Amino Acid Agents]16632895
D018683Excitatory Amino Acid AgentsSLC1A3 protein results in increased uptake of Excitatory Amino Acid Agents16632895
C039281furanfuran results in increased expression of SLC1A3 mRNA27387713
D019833GenisteinGenistein results in decreased expression of SLC1A3 mRNA26865667
D005947GlucoseGlucose results in decreased expression of SLC1A3 mRNA26677078
D005947GlucoseGlucose results in decreased expression of SLC1A3 protein26677078
D005947Glucoseresveratrol inhibits the reaction [Glucose results in decreased expression of SLC1A3 mRNA]26677078
D005947Glucoseresveratrol inhibits the reaction [Glucose results in decreased expression of SLC1A3 protein]26677078
D006220HaloperidolHaloperidol results in decreased expression of SLC1A3 mRNA15860345
D017313FenretinideFenretinide results in decreased expression of SLC1A3 mRNA28973697
D017313FenretinideFenretinide results in increased expression of SLC1A3 mRNA28973697
D006861Hydrogen PeroxideHydrogen Peroxide affects the expression of SLC1A3 mRNA20044591
D002112CalcifediolCalcifediol deficiency results in decreased expression of SLC1A3 mRNA17293106
D007612KanamycinSLC1A3 affects the susceptibility to Kanamycin15862894
D007854LeadLead results in increased expression of SLC1A3 mRNA15955607
D007854LeadLead results in increased expression of SLC1A3 protein15955607
C008261lead acetatelead acetate affects the expression of SLC1A3 mRNA15985313
C008261lead acetatelead acetate results in increased expression of SLC1A3 mRNA11578147
D008345ManganeseButyric Acid inhibits the reaction [Manganese results in decreased expression of SLC1A3 mRNA]28610743
D008345ManganeseButyric Acid inhibits the reaction [Manganese results in decreased expression of SLC1A3 protein]28610743
D008345ManganeseManganese results in decreased expression of SLC1A3 mRNA28610743
D008345ManganeseManganese results in decreased expression of SLC1A3 protein28610743
D008345ManganeseValproic Acid inhibits the reaction [Manganese results in decreased expression of SLC1A3 mRNA]28610743
D008345ManganeseValproic Acid inhibits the reaction [Manganese results in decreased expression of SLC1A3 protein]28610743
D008345ManganeseEstradiol inhibits the reaction [Manganese results in decreased expression of SLC1A3 mRNA]19453300
D008345ManganeseEstradiol inhibits the reaction [Manganese results in decreased expression of SLC1A3 protein]19453300
D008345ManganeseManganese results in decreased expression of SLC1A3 mRNA19453300
D008345ManganeseManganese results in decreased expression of SLC1A3 protein19453300
D008345ManganeseTamoxifen inhibits the reaction [Manganese results in decreased expression of SLC1A3 mRNA]19453300
D008345ManganeseTamoxifen inhibits the reaction [Manganese results in decreased expression of SLC1A3 protein]19453300
C025340manganese chloridemanganese chloride results in decreased expression of SLC1A3 mRNA12387356|1961535
C025340manganese chloridemanganese chloride results in decreased expression of SLC1A3 protein19615351|2478232
C025340manganese chlorideRaloxifene Hydrochloride inhibits the reaction [manganese chloride results in decreased expression of SLC1A3 protein]24782323
C025340manganese chlorideRiluzole inhibits the reaction [manganese chloride results in decreased expression of SLC1A3 mRNA]19615351
C025340manganese chlorideRiluzole inhibits the reaction [manganese chloride results in decreased expression of SLC1A3 protein]19615351
C039798manganese sulfatemanganese sulfate results in decreased expression of SLC1A3 protein17347134
C039798manganese sulfatemanganese sulfate results in increased expression of SLC1A3 mRNA17347134
C039798manganese sulfatemanganese sulfate results in decreased expression of SLC1A3 mRNA12387356
D017258Medroxyprogesterone AcetateMedroxyprogesterone Acetate results in increased expression of SLC1A3 mRNA20843944
D008627Mercuric ChlorideMercuric Chloride inhibits the reaction [SLC1A3 protein results in increased uptake of Excitatory Amino Acid Agents]16632895
D008627Mercuric ChlorideMercuric Chloride results in decreased expression of SLC1A3 mRNA16632895
D008694MethamphetamineMethamphetamine results in increased expression of SLC1A3 mRNA18419818
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of and results in decreased activity of SLC1A3 protein22966415
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of SLC1A3 mRNA22966415
C004925methylmercuric chlorideRiluzole inhibits the reaction [methylmercuric chloride results in decreased expression of and results in decreased activity of SLC1A3 protein]22966415
C004925methylmercuric chlorideRiluzole inhibits the reaction [methylmercuric chloride results in decreased expression of SLC1A3 mRNA]22966415
D008767Methylmercury CompoundsMethylmercury Compounds results in decreased activity of SLC1A3 protein16286679
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of SLC1A3 mRNA"20188158
C517284monomethyl phthalatemonomethyl phthalate affects the expression of SLC1A3 mRNA26924002
D009151Mustard GasMustard Gas results in increased expression of SLC1A3 mRNA15674844
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of SLC1A3 mRNA"25554681
D0150581-Naphthylisothiocyanate1-Naphthylisothiocyanate results in increased expression of SLC1A3 mRNA12832660
C014707nitrosobenzylmethylaminenitrosobenzylmethylamine results in decreased expression of SLC1A3 mRNA17616710
C558013NSC 689534[NSC 689534 binds to Copper] which results in decreased expression of SLC1A3 mRNA20971185
C025589ochratoxin Aochratoxin A affects the expression of SLC1A3 protein20558201
C118580octylmethoxycinnamate[bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben co-treated with Androgen Antagonists co-treated with Acetaminophen] results in increased expression of SLC1A3 mRNA25607892
C118580octylmethoxycinnamate[bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben] results in increased expression of SLC1A3 mRNA25607892
D016627OxidopamineOxidopamine results in increased expression of SLC1A3 mRNA15518916
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in increased expression of SLC1A3 mRNA25729387
C030110oxaliplatinoxaliplatin results in increased expression of SLC1A3 mRNA25729387
D010100Oxygen[SCH 442416 co-treated with Oxygen deficiency] results in increased expression of SLC1A3 mRNA22969972
D010126OzoneOzone results in decreased expression of SLC1A3 mRNA17095637
D017239PaclitaxelPaclitaxel results in decreased expression of SLC1A3 protein16361064
D000073878Palm OilPalm Oil results in decreased expression of SLC1A3 mRNA18042831
C496932panobinostat"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SLC1A3 mRNA"27188386
C496932panobinostatpanobinostat results in increased expression of SLC1A3 mRNA26272509
D010261ParaoxonParaoxon results in increased expression of SLC1A3 mRNA27769869
D010261ParaoxonParaoxon results in increased expression of SLC1A3 protein27769869
D052638Particulate Matter[SLC1A3 gene mutant form affects the susceptibility to Particulate Matter] which results in increased expression of SLC1A3 mRNA21222557|2122255
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid affects the expression of SLC1A3 mRNA19429403
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in decreased expression of SLC1A3 mRNA18692542|2782593
C023036perfluorooctanoic acidperfluorooctanoic acid affects the expression of SLC1A3 mRNA19429403
D010578PetroleumPetroleum affects the expression of SLC1A3 mRNA25208076
D010656PhenylephrinePhenylephrine results in increased expression of SLC1A3 mRNA18158353
C006253pirinixic acidpirinixic acid results in increased expression of SLC1A3 mRNA12832660
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in decreased expression of SLC1A3 mRNA19162173
D011374Progesterone[Estradiol co-treated with Progesterone] results in increased expression of SLC1A3 mRNA20660070
D011374Progesterone[Estradiol co-treated with Progesterone] results in increased expression of SLC1A3 mRNA22154832
C020972pyrrolidine dithiocarbamic acidpyrrolidine dithiocarbamic acid inhibits the reaction [Raloxifene Hydrochloride results in increased expression of SLC1A3 mRNA]24782323
C020972pyrrolidine dithiocarbamic acidpyrrolidine dithiocarbamic acid inhibits the reaction [Raloxifene Hydrochloride results in increased expression of SLC1A3 protein]24782323
D020849Raloxifene Hydrochloride"[4-(6-bromo-1,3-benzodioxol-5-yl)-3a,4,5,9b-3H-cyclopenta(c)quinoline results in decreased activity of GPER1 protein] inhibits the reaction [[Raloxifene Hydrochloride results in increased activity of GPER1 protein] which results in increased expression of SLC1A3 protein]"24782323
D020849Raloxifene HydrochlorideESR1 protein promotes the reaction [Raloxifene Hydrochloride results in increased expression of SLC1A3 mRNA]24782323
D020849Raloxifene HydrochlorideESR2 protein promotes the reaction [Raloxifene Hydrochloride results in increased expression of SLC1A3 mRNA]24782323
D020849Raloxifene Hydrochloridepyrrolidine dithiocarbamic acid inhibits the reaction [Raloxifene Hydrochloride results in increased expression of SLC1A3 mRNA]24782323
D020849Raloxifene Hydrochloridepyrrolidine dithiocarbamic acid inhibits the reaction [Raloxifene Hydrochloride results in increased expression of SLC1A3 protein]24782323
D020849Raloxifene HydrochlorideRaloxifene Hydrochloride inhibits the reaction [manganese chloride results in decreased expression of SLC1A3 protein]24782323
D020849Raloxifene Hydrochloride[Raloxifene Hydrochloride results in increased activity of GPER1 protein] which results in increased expression of SLC1A3 protein24782323
D020849Raloxifene HydrochlorideRaloxifene Hydrochloride results in increased expression of SLC1A3 mRNA24782323
D020849Raloxifene HydrochlorideRaloxifene Hydrochloride results in increased expression of SLC1A3 protein24782323
C059514resveratrolresveratrol inhibits the reaction [Glucose results in decreased expression of SLC1A3 mRNA]26677078
C059514resveratrolresveratrol inhibits the reaction [Glucose results in decreased expression of SLC1A3 protein]26677078
C059514resveratrolresveratrol inhibits the reaction [Streptozocin results in decreased expression of SLC1A3 mRNA]26677078
C059514resveratrolresveratrol inhibits the reaction [Streptozocin results in decreased expression of SLC1A3 protein]26677078
D019782RiluzoleRiluzole inhibits the reaction [manganese chloride results in decreased expression of SLC1A3 mRNA]19615351
D019782RiluzoleRiluzole inhibits the reaction [manganese chloride results in decreased expression of SLC1A3 protein]19615351
D019782RiluzoleRiluzole inhibits the reaction [methylmercuric chloride results in decreased expression of and results in decreased activity of SLC1A3 protein]22966415
D019782RiluzoleRiluzole inhibits the reaction [methylmercuric chloride results in decreased expression of SLC1A3 mRNA]22966415
D019782RiluzoleRiluzole results in increased expression of SLC1A3 mRNA22966415
D019782RiluzoleRiluzole results in increased expression of SLC1A3 protein22966415
D012524SarinSarin results in increased expression of SLC1A3 protein25842371
C416650SCH 442416[SCH 442416 co-treated with Oxygen deficiency] results in increased expression of SLC1A3 mRNA22969972
C017947sodium arsenitesodium arsenite results in decreased activity of SLC1A3 promoter21602192
C017947sodium arsenitesodium arsenite results in decreased activity of SLC1A3 protein21602192
C017947sodium arsenitesodium arsenite results in decreased expression of SLC1A3 mRNA21602192
C017947sodium arsenitesodium arsenite results in increased expression of SLC1A3 mRNA22714537
C017947sodium arsenitesodium arsenite results in decreased expression of and results in decreased activity of SLC1A3 protein22020379
D013311StreptozocinCurcumin inhibits the reaction [Streptozocin results in decreased expression of SLC1A3 mRNA]23267840
D013311StreptozocinINS1 protein inhibits the reaction [Streptozocin results in decreased expression of SLC1A3 mRNA]23267840
D013311Streptozocinresveratrol inhibits the reaction [Streptozocin results in decreased expression of SLC1A3 mRNA]26677078
D013311Streptozocinresveratrol inhibits the reaction [Streptozocin results in decreased expression of SLC1A3 protein]26677078
D013311StreptozocinStreptozocin results in decreased expression of SLC1A3 mRNA23267840|2667707
D013311StreptozocinStreptozocin results in decreased expression of SLC1A3 protein26677078
D013629TamoxifenTamoxifen inhibits the reaction [Manganese results in decreased expression of SLC1A3 mRNA]19453300
D013629TamoxifenTamoxifen inhibits the reaction [Manganese results in decreased expression of SLC1A3 protein]19453300
D013629TamoxifenTamoxifen results in increased expression of SLC1A3 mRNA19453300
D013629TamoxifenTamoxifen results in increased expression of SLC1A3 protein19453300
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of SLC1A3 mRNA22298810
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of SLC1A3 mRNA21570461|2637764
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of SLC1A3 mRNA19933214
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of SLC1A3 mRNA22298810
C009495titanium dioxidetitanium dioxide results in increased expression of SLC1A3 mRNA23557971
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of SLC1A3 mRNA28065790
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in increased expression of SLC1A3 mRNA25729387
D014212TretinoinTretinoin results in increased expression of SLC1A3 mRNA21934132
C012589trichostatin A"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SLC1A3 mRNA"27188386
C012589trichostatin Atrichostatin A results in increased expression of SLC1A3 mRNA24935251|2627250
C012589trichostatin Atrichostatin A results in decreased expression of SLC1A3 mRNA15901671
C015559trimellitic anhydridetrimellitic anhydride results in decreased expression of SLC1A3 mRNA19042947
D014415TunicamycinTunicamycin results in increased expression of SLC1A3 mRNA17127020
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SLC1A3 mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of SLC1A3 mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of SLC1A3 mRNA23179753|2438349
D014635Valproic AcidValproic Acid inhibits the reaction [Manganese results in decreased expression of SLC1A3 mRNA]28610743
D014635Valproic AcidValproic Acid inhibits the reaction [Manganese results in decreased expression of SLC1A3 protein]28610743
D014635Valproic AcidValproic Acid results in decreased expression of SLC1A3 mRNA23665938
D014635Valproic AcidValproic Acid results in decreased expression of SLC1A3 mRNA15901671
D001335Vehicle Emissions[SLC1A3 gene mutant form affects the susceptibility to Vehicle Emissions] which results in increased expression of SLC1A3 mRNA21222557|2122255
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of SLC1A3 gene25560391
C025643vinclozolinvinclozolin results in increased expression of SLC1A3 mRNA22570695
C111237vorinostat"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SLC1A3 mRNA"27188386
C111237vorinostatvorinostat results in increased expression of SLC1A3 mRNA26272509
D014874Water Pollutants, Chemical"Water Pollutants, Chemical affects the expression of SLC1A3 mRNA"25208076
C088658zoledronic acidzoledronic acid results in increased expression of SLC1A3 mRNA24714768

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005313L-glutamate transmembrane transporter activity-IDA7521911  
GO:0005314high-affinity glutamate transmembrane transporter activity-IDA26690923  
GO:0005314high-affinity glutamate transmembrane transporter activity-IMP8123008  28032905  
GO:0005314high-affinity glutamate transmembrane transporter activity-TAS-  
GO:0015171amino acid transmembrane transporter activity-TAS-  
GO:0015501glutamate:sodium symporter activity-IDA20477940  
GO:0015501glutamate:sodium symporter activity-IMP8123008  
GO:0016595glutamate binding-IEA-  
GO:0046872metal ion binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0001504neurotransmitter uptake-TAS8647279  
GO:0006537glutamate biosynthetic process-IEA-  
GO:0006811ion transport-TAS-  
GO:0007268chemical synaptic transmission-TAS7521911  
GO:0007605sensory perception of sound-IEA-  
GO:0009416response to light stimulus-IEA-  
GO:0009449gamma-aminobutyric acid biosynthetic process-IEA-  
GO:0009611response to wounding-IEA-  
GO:0014047glutamate secretion-TAS-  
GO:0015813L-glutamate transmembrane transport-IDA26690923  
GO:0021545cranial nerve development-IEA-  
GO:0031223auditory behavior-IEA-  
GO:0046677response to antibiotic-IEA-  
GO:0048667cell morphogenesis involved in neuron differentiation-IEA-  
GO:0050806positive regulation of synaptic transmission-IEA-  
GO:0050885neuromuscular process controlling balance-IEA-  
GO:0051938L-glutamate import-IDA7521911  
GO:0070779D-aspartate import across plasma membrane-IDA7521911  
GO:0070779D-aspartate import across plasma membrane-IMP8123008  28032905  
GO:0071805potassium ion transmembrane transport-IDA20477940  
GO:0098712L-glutamate import across plasma membrane-IDA26690923  
GO:0098712L-glutamate import across plasma membrane-IMP8123008  28032905  
GO:0140009L-aspartate import across plasma membrane-IDA20477940  
GO:0140009L-aspartate import across plasma membrane-IMP8123008  
GO:1902476chloride transmembrane transport-IDA20477940  
GO ID GO Term Qualifier Evidence PubMed
GO:0005886plasma membrane-TAS-  
GO:0005887integral component of plasma membrane-IMP8123008  26690923  28032905  
GO:0009986cell surface-IEA-  
GO:0016020membrane-TAS7521911  
GO:0043005neuron projection-IEA-  
GO:0043025neuronal cell body-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-112310Neurotransmitter release cycleTAS
R-HSA-112313Neurotransmitter uptake and metabolism In glial cellsTAS
R-HSA-112315Transmission across Chemical SynapsesTAS
R-HSA-112316Neuronal SystemTAS
R-HSA-1643685DiseaseTAS
R-HSA-210455Astrocytic Glutamate-Glutamine Uptake And MetabolismTAS
R-HSA-210500Glutamate Neurotransmitter Release CycleTAS
R-HSA-382551Transport of small moleculesTAS
R-HSA-425393Transport of inorganic cations/anions and amino acids/oligopeptidesTAS
R-HSA-425407SLC-mediated transmembrane transportTAS
R-HSA-5619062Defective SLC1A3 causes episodic ataxia 6 (EA6)TAS
R-HSA-5619102SLC transporter disordersTAS
R-HSA-5619115Disorders of transmembrane transportersTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
25972039GLAST But Not Least--Distribution, Function, Genetics and Epigenetics of L-Glutamate Transport in Brain--Focus on GLAST/EAAT1. (2015 Dec)Sery ONeurochem Res
20589092Ethanol and phencyclidine interact with respect to nucleus accumbens dopamine release: differential effects of administration order and pretreatment protocol. (2010)Pickering CFront Behav Neurosci