Gene: BMP3

651
BMP-3A
bone morphogenetic protein 3
protein-coding
4q21.21
Ensembl:ENSG00000152785 MIM:112263 Vega:OTTHUMG00000130292 UniprotKB:P12645
NC_000004.12
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
7.367e-2 (AD)  5.091e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
AFF20.714
PRKAA20.711
SLC6A150.706
EPHA50.704
ROBO20.694
PCDH70.691
CSRNP30.689
CHM0.687
EIF5A20.686
BBS70.685

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
FCGRT-0.428
RHOD-0.424
CSAG1-0.422
IMPA2-0.418
SYDE1-0.401
ACOX2-0.396
EYA2-0.392
SOD3-0.389
TCF7L1-0.388
ACSF2-0.386

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0131862,3-pentanedione"2,3-pentanedione results in decreased expression of BMP3 mRNA"25710175
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of BMP3 gene27153756
D000517alpha-Chlorohydrinalpha-Chlorohydrin results in decreased expression of BMP3 mRNA28522335
D000643Ammonium ChlorideAmmonium Chloride affects the expression of BMP3 mRNA16483693
D001205Ascorbic Acid[Ascorbic Acid co-treated with beta-glycerophosphoric acid] results in increased expression of BMP3 mRNA15994055
D004958Estradiol[bisphenol A co-treated with Estradiol] results in increased expression of BMP3 mRNA26496021
C031463beta-glycerophosphoric acid[Ascorbic Acid co-treated with beta-glycerophosphoric acid] results in increased expression of BMP3 mRNA15994055
C006780bisphenol A[bisphenol A co-treated with Estradiol] results in increased expression of BMP3 mRNA26496021
C006780bisphenol Abisphenol A results in increased expression of BMP3 mRNA25181051
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of BMP3 mRNA17032414
C014347decitabinedecitabine results in decreased expression of BMP3 mRNA27915011
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of BMP3 mRNA21266533
D004128DimethylnitrosamineDimethylnitrosamine results in increased expression of BMP3 mRNA17032414
C070609EMD 53998EMD 53998 analog results in decreased expression of BMP3 mRNA24977338
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of BMP3 mRNA17351261
C008261lead acetatelead acetate results in decreased expression of BMP3 mRNA22641619
D008627Mercuric ChlorideMercuric Chloride affects the expression of BMP3 mRNA20353558
C406082monomethylarsonous acidmonomethylarsonous acid results in increased expression of BMP3 mRNA22108045
D037742Nanotubes, Carbon"Nanotubes, Carbon analog affects the expression of BMP3 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of BMP3 mRNA"25554681
C005274naringinnaringin results in decreased expression of BMP3 mRNA18495116
C028007nickel monoxidenickel monoxide results in decreased expression of BMP3 mRNA19167457
D010047Ovalbumin[Ovalbumin affects the susceptibility to Particulate Matter] which results in decreased expression of BMP3 mRNA19176365
D052638Particulate Matter[Ovalbumin affects the susceptibility to Particulate Matter] which results in decreased expression of BMP3 mRNA19176365
D011441PropylthiouracilPropylthiouracil results in decreased expression of BMP3 mRNA24780913
D011794QuercetinQuercetin affects the expression of BMP3 mRNA18178720
C017947sodium arsenitesodium arsenite affects the methylation of BMP3 gene28589171
D053260SootSoot results in decreased expression of BMP3 mRNA26551751
C015559trimellitic anhydridetrimellitic anhydride results in decreased expression of BMP3 mRNA19042947
D014635Valproic AcidValproic Acid results in decreased methylation of BMP3 gene29154799

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005102signaling receptor binding-TAS3201241  
GO:0005125cytokine activity-IBA21873635  
GO:0005160transforming growth factor beta receptor binding-IBA21873635  
GO:0008083growth factor activity-IEA-  
GO:0070700BMP receptor binding-IDA7811286  
GO ID GO Term Qualifier Evidence PubMed
GO:0001501skeletal system development-TAS3201241  
GO:0001649osteoblast differentiation-IEA-  
GO:0007267cell-cell signaling-TAS3201241  
GO:0010469regulation of signaling receptor activity-IEA-  
GO:0010862positive regulation of pathway-restricted SMAD protein phosphorylation-IBA21873635  
GO:0042981regulation of apoptotic process-IBA21873635  
GO:0043408regulation of MAPK cascade-IBA21873635  
GO:0048468cell development-IBA21873635  
GO:0051216cartilage development-IEA-  
GO:0060395SMAD protein signal transduction-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0005615extracellular space-IBA21873635  
GO:0070062extracellular exosome-HDA19199708  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
22083596Stool DNA testing for the detection of pancreatic cancer: assessment of methylation marker candidates. (2012 May 15)Kisiel JBCancer