Gene: SLC1A5

6510
AAAT|ASCT2|ATBO|M7V1|M7VS1|R16|RDRC
solute carrier family 1 member 5
protein-coding
19q13.32
Ensembl:ENSG00000105281 MIM:109190 Vega:OTTHUMG00000183434 UniprotKB:Q15758
NC_000019.10
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
3.225e-1 (AD)  3.825e-1 (ND)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg07626482chr19:47289503SLC1A54.100e-16Smoking27651444
cg22304262chr19:47287778SLC1A58.570e-9Alcohol consumption per day27843151
cg02711608chr19:47287964SLC1A53.970e-8Alcohol consumption per day27843151
cg02711608chr19:47287964SLC1A52.430e-11Alcohol consumption der day27843151
cg03359362chr19:47289611SLC1A51.870e-10Alcohol consumption der day27843151
cg07626482chr19:47289503SLC1A58.390e-8Alcohol consumption der day27843151

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SIGLEC90.894
CD140.888
HCK0.888
EBI30.885
ABI30.881
CD300A0.881
ALOX5AP0.88
SERPINA10.88
CD930.879
LCP10.877

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
NEUROD6-0.52
KCNIP3-0.488
EXTL1-0.481
MARCH4-0.48
ST6GAL2-0.478
CHRM1-0.466
ABCC12-0.461
BCL11A-0.46
TMEM179-0.459
SPRN-0.457

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00130L-GlutamineSmall Molecule56-85-9Approved|Investigational|NutraceuticalTransporter
DB00174L-AsparagineSmall Molecule70-47-3Approved|Investigational|NutraceuticalTarget
DB13146Fluciclovine (18F)Small Molecule222727-39-1ApprovedTarget
ID Drug Name Action PubMed
C5321622-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine"[PIK3CA gene mutant form results in increased susceptibility to 2-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine] which results in decreased expression of SLC1A5 mRNA"20453058
C0297902,2',3',4,4',5-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of SLC1A5 mRNA"25510870
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in increased expression of SLC1A5 mRNA"25614096
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of SLC1A5 mRNA"19114083
C0817662,4,4'-trichlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of SLC1A5 mRNA"25510870
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of SLC1A5 mRNA"25510870
C0098282,4,5,2',5'-pentachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of SLC1A5 mRNA"25510870
C0094072,5,2',5'-tetrachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of SLC1A5 mRNA"25510870
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of SLC1A5 mRNA"23196670
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in decreased expression of SLC1A5 mRNA"18648102
C5258724'-cyanobiphenyl-4-sulfonic acid (6-aminopyridin-2-yl)amide4'-cyanobiphenyl-4-sulfonic acid (6-aminopyridin-2-yl)amide results in decreased expression of SLC1A5 mRNA23264615
D000082AcetaminophenAcetaminophen results in increased expression of SLC1A5 mRNA29067470
D000082AcetaminophenAcetaminophen affects the expression of SLC1A5 mRNA17562736
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of SLC1A5 mRNA22100608
D000535Aluminum[APP protein modified form binds to Aluminum] which results in decreased expression of SLC1A5 mRNA21298039
D000643Ammonium ChlorideAmmonium Chloride affects the expression of SLC1A5 mRNA16483693
D001151ArsenicArsenic affects the methylation of SLC1A5 gene25304211
D001507BeclomethasoneBeclomethasone results in increased expression of SLC1A5 mRNA23656298
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of SLC1A5 mRNA20106945|2163298
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of SLC1A5 mRNA22228805
D004958EstradiolEstradiol results in increased expression of SLC1A5 mRNA23019147|2751499
C006780bisphenol Abisphenol A affects the expression of SLC1A5 mRNA20170705
C006780bisphenol Abisphenol A results in increased expression of SLC1A5 mRNA19371625|2927551
C006780bisphenol Abisphenol A affects the expression of SLC1A5 mRNA21786754
C006780bisphenol Abisphenol A results in decreased expression of SLC1A5 mRNA25181051
C006780bisphenol Abisphenol A results in increased expression of SLC1A5 mRNA17010207
C584509C646 compoundC646 compound results in decreased expression of SLC1A5 mRNA26191083
D019256Cadmium ChlorideCadmium Chloride results in increased expression of SLC1A5 mRNA25596134
C055494caffeic acid phenethyl ester[Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of SLC1A5 mRNA20360939
D002251Carbon TetrachlorideCarbon Tetrachloride affects the expression of SLC1A5 mRNA17484886
D002509CephaloridineCephaloridine results in increased expression of SLC1A5 mRNA18500788
C004656chloroacetaldehydechloroacetaldehyde affects the expression of SLC1A5 mRNA25596134
C100187chloropicrinchloropicrin results in decreased expression of SLC1A5 mRNA26352163
D002746ChlorpromazineChlorpromazine results in increased expression of SLC1A5 mRNA25596134
D004390Chlorpyrifos[Chlorpyrifos co-treated with NGF protein] results in increased expression of SLC1A5 mRNA20600679
D004390ChlorpyrifosChlorpyrifos results in increased expression of SLC1A5 mRNA20600679
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of SLC1A5 mRNA20938992
C059262cidofovircidofovir results in increased expression of SLC1A5 mRNA25596134
D004002Clodronic AcidClodronic Acid results in decreased expression of SLC1A5 mRNA25596134
D060729Coal AshCoal Ash results in decreased expression of SLC1A5 mRNA19000753
C018021cobaltous chloridecobaltous chloride results in decreased expression of SLC1A5 mRNA19320972
D003078ColchicineColchicine results in decreased expression of SLC1A5 mRNA24211769
D003300CopperCopper deficiency results in increased expression of SLC1A5 mRNA26033743
D003471CuprizoneCuprizone results in increased expression of SLC1A5 mRNA26577399
D016572CyclosporineCyclosporine results in increased expression of SLC1A5 mRNA20106945|2163298
D013759DronabinolDronabinol results in increased expression of SLC1A5 mRNA16616335
D003907Dexamethasone[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS protein] results in increased expression of SLC1A5 mRNA24848799
D003976Diazinon[Diazinon co-treated with NGF protein] results in increased expression of SLC1A5 mRNA20600679
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of SLC1A5 mRNA21266533
D002945CisplatinCisplatin results in decreased expression of SLC1A5 mRNA24211769
D002945CisplatinCisplatin results in increased expression of SLC1A5 mRNA25596134
D002945CisplatinCisplatin results in increased expression of SLC1A5 mRNA21080177
D019259Lamivudine[Zidovudine co-treated with Lamivudine] results in increased expression of SLC1A5 mRNA15784690
D004026Dieldrin[Dieldrin co-treated with NGF protein] results in increased expression of SLC1A5 mRNA20600679
D004041Dietary FatsDietary Fats results in decreased expression of SLC1A5 mRNA18042831
D019422Dietary SucroseDietary Sucrose results in increased expression of SLC1A5 mRNA26033743
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of SLC1A5 mRNA20360939
D0151279,10-Dimethyl-1,2-benzanthracene"9,10-Dimethyl-1,2-benzanthracene results in increased expression of SLC1A5 mRNA"22485181
D004226DithioerythritolDithioerythritol inhibits the reaction [Thiazoles analog results in decreased activity of SLC1A5 protein]23010140
D004791Enzyme Inhibitors[Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of SLC1A5 protein23301498
D000431EthanolEthanol results in increased expression of SLC1A5 mRNA19167417
D000431EthanolEthanol results in decreased expression of SLC1A5 mRNA20655511
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of SLC1A5 mRNA20170705
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of SLC1A5 mRNA18936297
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of SLC1A5 mRNA20170705
D005047EtoposideEtoposide results in decreased expression of SLC1A5 mRNA24211769
D015025ZearalenoneZearalenone results in increased expression of SLC1A5 mRNA19371625
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of SLC1A5 mRNA20938992
D019833GenisteinGenistein results in increased expression of SLC1A5 mRNA19371625|2301914
D019833GenisteinGenistein results in increased expression of SLC1A5 mRNA17010207
D005839GentamicinsGentamicins results in decreased expression of SLC1A5 mRNA22061828
D006854HydrocortisoneHydrocortisone results in increased expression of SLC1A5 mRNA23264615
D006918HydroxyureaHydroxyurea results in decreased expression of SLC1A5 mRNA24211769
D007069IfosfamideIfosfamide results in increased expression of SLC1A5 mRNA25596134
C041508indeno(1,2,3-cd)pyrene"indeno(1,2,3-cd)pyrene results in decreased expression of SLC1A5 mRNA"26377693
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of SLC1A5 mRNA25613284
D0150561-Methyl-3-isobutylxanthine[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS protein] results in increased expression of SLC1A5 mRNA24848799
C410337K 7174K 7174 results in increased expression of SLC1A5 mRNA24086573
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of SLC1A5 mRNA12057914
D008345ManganeseManganese promotes the reaction [PRKCD protein binds to SLC1A5 protein]21812036
D008345ManganeseManganese results in decreased expression of SLC1A5 protein20737472
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of SLC1A5 mRNA20938992
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of SLC1A5 mRNA28001369
D008767Methylmercury CompoundsMethylmercury Compounds affects the expression of SLC1A5 mRNA21664453
D008767Methylmercury CompoundsMethylmercury Compounds affects the expression of SLC1A5 mRNA21664453
D016685MitomycinMitomycin results in decreased expression of SLC1A5 mRNA24211769
D009151Mustard GasMustard Gas results in increased expression of SLC1A5 mRNA15674843
D0150581-Naphthylisothiocyanate1-Naphthylisothiocyanate results in increased expression of SLC1A5 mRNA20551477
D009532Nickel[Nickel co-treated with NGF protein] results in increased expression of SLC1A5 mRNA20600679
C025256nonylphenolnonylphenol results in increased expression of SLC1A5 mRNA17010207
C570897NSC668394NSC668394 results in increased expression of SLC1A5 mRNA27137931
C016340o,p'-DDT"o,p'-DDT results in increased expression of SLC1A5 mRNA"19371625
D010100OxygenOxygen deficiency results in decreased expression of SLC1A5 mRNA25596134
D000073878Palm OilPalm Oil results in decreased expression of SLC1A5 mRNA18042831
C410127PCB 180"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of SLC1A5 mRNA"25510870
C086401pentabromodiphenyl etherpentabromodiphenyl ether results in increased expression of SLC1A5 mRNA26705709
D010416PentachlorophenolPentachlorophenol results in increased expression of SLC1A5 mRNA23892564
D010634PhenobarbitalNR1I3 protein affects the reaction [Phenobarbital results in increased expression of SLC1A5 mRNA]19482888
D010634PhenobarbitalPhenobarbital results in increased expression of SLC1A5 mRNA19482888
C045362prochlorazprochloraz results in increased expression of SLC1A5 mRNA21470553
D011374ProgesteroneProgesterone results in decreased expression of SLC1A5 mRNA23012394|2301818
D011374ProgesteroneIFNE protein promotes the reaction [Progesterone results in increased expression of SLC1A5 mRNA]19176878
D011374ProgesteroneProgesterone results in increased expression of SLC1A5 mRNA19176878
C059514resveratrolresveratrol results in increased expression of SLC1A5 mRNA19371625
C089730rosiglitazonerosiglitazone results in increased expression of SLC1A5 mRNA24848799
D018038Sodium SeleniteSodium Selenite results in increased expression of SLC1A5 mRNA24383545
D013629TamoxifenTamoxifen results in increased expression of SLC1A5 mRNA25123088
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of SLC1A5 mRNA21570461|2637764
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of SLC1A5 mRNA26290441|2756255
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of SLC1A5 mRNA25613284
D013755Tetradecanoylphorbol AcetateTetradecanoylphorbol Acetate results in decreased expression of SLC1A5 protein21812036
D013844ThiazolesDithioerythritol inhibits the reaction [Thiazoles analog results in decreased activity of SLC1A5 protein]23010140
D013844ThiazolesThiazoles analog results in decreased activity of SLC1A5 protein23010140
D013853ThioacetamideThioacetamide results in increased expression of SLC1A5 mRNA23411599
C066340tolcaponetolcapone binds to SLC1A5 protein19783845
C011559tributyltintributyltin results in increased expression of SLC1A5 mRNA24848799
C012589trichostatin Atrichostatin A results in increased expression of SLC1A5 mRNA15901671
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of SLC1A5 mRNA"26743178
D014635Valproic AcidValproic Acid results in increased methylation of SLC1A5 gene29154799
D014635Valproic AcidValproic Acid affects the expression of SLC1A5 mRNA17963808
D014635Valproic AcidValproic Acid results in increased expression of SLC1A5 mRNA15901671
D000225AdenineAdenine results in decreased expression of SLC1A5 mRNA24211769
D015215Zidovudine[Zidovudine co-treated with Lamivudine] results in increased expression of SLC1A5 mRNA15784690
C016837zinc chloridezinc chloride results in decreased expression of SLC1A5 mRNA18947441
C088658zoledronic acidzoledronic acid results in decreased expression of SLC1A5 mRNA25596134

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0001618virus receptor activity-IEA-  
GO:0005515protein binding-IPI23492904  25759021  
GO:0015171amino acid transmembrane transporter activity-TAS-  
GO:0015175neutral amino acid transmembrane transporter activity-TAS10051606  
GO:0015186L-glutamine transmembrane transporter activity-TAS21757002  
GO:0015194L-serine transmembrane transporter activity-IEA-  
GO:0015293symporter activity-IEA-  
GO:0038023signaling receptor activity-TAS10051606  
GO ID GO Term Qualifier Evidence PubMed
GO:0006865amino acid transport-TAS-  
GO:0006868glutamine transport-TAS21757002  
GO:0007165signal transduction-IEA-  
GO:0010585glutamine secretion-IEA-  
GO:0015804neutral amino acid transport-TAS10051606  
GO:0015825L-serine transport-IEA-  
GO:0046718viral entry into host cell-IEA-  
GO:1903803L-glutamine import across plasma membrane-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005886plasma membrane-IDA23492904  
GO:0005886plasma membrane-TAS-  
GO:0005887integral component of plasma membrane-TAS8702519  
GO:0016020membrane-HDA19946888  
GO:0042470melanosome-IEA-  
GO:0070062extracellular exosome-HDA20458337  
KEGG ID KEGG Term
hsa04974Protein digestion and absorption
Reactome ID Reactome Term Evidence
R-HSA-352230Amino acid transport across the plasma membraneTAS
R-HSA-382551Transport of small moleculesTAS
R-HSA-425393Transport of inorganic cations/anions and amino acids/oligopeptidesTAS
R-HSA-425407SLC-mediated transmembrane transportTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
25821004Targeting SLC1a5-mediated glutamine dependence in non-small cell lung cancer. (2015 Oct 1)Hassanein MInt J Cancer