Gene info: ID 6515

Gene: SLC2A3

GENE ID: 6515

Synonyms: GLUT3

Description: solute carrier family 2 member 3

Gene type: protein-coding

Location: 12p13.31

dbXrefs: Ensembl:ENSG00000059804 MIM:138170 Vega:OTTHUMG00000133685 UniprotKB:P11169

RefSeq: NC_000012.12

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: AD

# Publications: 1

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 4.800e-1 (AD) 7.692e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
ETS2	0.776
BHLHE40	0.767
STAT6	0.752
LDHA	0.749
BTN2A1	0.741
TNFAIP1	0.737
CTSB	0.731
HEXB	0.726
NUMB	0.726
ATP1B3	0.725

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
OR4F5	-0.51
OR4F29	-0.497
ACOT6	-0.27
HKDC1	-0.27
SLC22A6	-0.27
EYA1	-0.267
TPPP2	-0.262
DIAPH3	-0.26
SOX3	-0.259
NXNL1	-0.258

ID	Drug Name	Drug Type	CAS Num	Status	Role
DB01914	D-glucose	Small Molecule	50-99-7	Approved	Transporter
DB09341	Glucose	Small Molecule	50-99-7	Approved	Transporter
DB09502	Fludeoxyglucose F-18	Small Molecule	63503-12-8	Approved\|Investigational	Transporter

ID	Drug Name	Action	PubMed
C031763	1,3-butadiene	"1,3-butadiene results in decreased expression of SLC2A3 mRNA"	21147608
C511295	2,2',4,4'-tetrabromodiphenyl ether	"2,2',4,4'-tetrabromodiphenyl ether results in increased expression of SLC2A3 mRNA"	25614096
C111118	2',3,3',4',5-pentachloro-4-hydroxybiphenyl	"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of SLC2A3 mRNA"	19114083
C000589286	2-(4-methoxyphenyl)ethyl-2-acetamido-2-deoxyglucopyranoside	N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [[Oxygen co-treated with Glucose deficiency co-treated with 2-(4-methoxyphenyl)ethyl-2-acetamido-2-deoxyglucopyranoside] results in increased expression of SLC2A3 protein]	24726522
C000589286	2-(4-methoxyphenyl)ethyl-2-acetamido-2-deoxyglucopyranoside	[Oxygen co-treated with Glucose deficiency co-treated with 2-(4-methoxyphenyl)ethyl-2-acetamido-2-deoxyglucopyranoside] results in increased expression of SLC2A3 protein	24726522
C023035	3,4,5,3',4'-pentachlorobiphenyl	"3,4,5,3',4'-pentachlorobiphenyl results in increased expression of SLC2A3 mRNA"	23196670
C026137	3-hydroxyacetanilide	3-hydroxyacetanilide results in decreased expression of SLC2A3 mRNA	18544908
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in increased expression of SLC2A3 protein"	25670856
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SLC2A3 mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SLC2A3 mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with methylmercuric chloride co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SLC2A3 mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SLC2A3 mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SLC2A3 mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SLC2A3 mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SLC2A3 mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SLC2A3 mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SLC2A3 mRNA"	27188386
C029728	4-phenylenediamine	4-phenylenediamine results in increased expression of SLC2A3 mRNA	19371601
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SLC2A3 mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SLC2A3 mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with methylmercuric chloride co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SLC2A3 mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SLC2A3 mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SLC2A3 mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SLC2A3 mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SLC2A3 mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SLC2A3 mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SLC2A3 mRNA"	27188386
D000082	Acetaminophen	Acetaminophen results in decreased expression of SLC2A3 mRNA	17175557
D000082	Acetaminophen	Acetaminophen results in increased expression of SLC2A3 mRNA	21420995
D000082	Acetaminophen	Acetaminophen results in decreased expression of SLC2A3 mRNA	18544908
D000117	Acetylglucosamine	Acetylglucosamine results in decreased expression of SLC2A3 mRNA	18047607
D000117	Acetylglucosamine	Acetylglucosamine results in increased expression of SLC2A3 mRNA	18047607
D000447	Aldehydes	Aldehydes results in decreased expression of SLC2A3 mRNA	25014914
D000638	Amiodarone	Amiodarone results in decreased expression of SLC2A3 mRNA	15342952\|1756758
D000639	Amitriptyline	Amitriptyline results in decreased expression of SLC2A3 mRNA	15342952\|1717555
D000643	Ammonium Chloride	Ammonium Chloride affects the expression of SLC2A3 mRNA	16483693
D000667	Ampicillin	Ampicillin results in increased expression of SLC2A3 mRNA	21632981
D018501	Antirheumatic Agents	Antirheumatic Agents results in decreased expression of SLC2A3 mRNA	24449571
D047310	Apigenin	[Apigenin co-treated with Oxygen deficiency] results in decreased expression of SLC2A3 mRNA	20153296
C519728	archazolid B	archazolid B results in increased expression of SLC2A3 mRNA	25218289
C006632	arsenic trioxide	arsenic trioxide results in increased expression of SLC2A3 mRNA	22521957\|2525818
D017638	Asbestos, Crocidolite	"Asbestos, Crocidolite results in increased expression of SLC2A3 mRNA"	25351596
C547126	AZM551248	AZM551248 results in decreased expression of SLC2A3 mRNA	22323515
C022921	benzo(k)fluoranthene	benzo(k)fluoranthene results in increased expression of SLC2A3 mRNA	26377693
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of SLC2A3 mRNA	20106945\|2163298
D004958	Estradiol	Estradiol results in decreased expression of SLC2A3 mRNA	20106945\|2163298
C006780	bisphenol A	bisphenol A results in decreased expression of SLC2A3 mRNA	26779933
C006780	bisphenol A	bisphenol A results in decreased expression of SLC2A3 protein	25637671\|2677993
C006780	bisphenol A	bisphenol A results in increased expression of SLC2A3 mRNA	24909818\|2606340
C006780	bisphenol A	bisphenol A results in decreased expression of SLC2A3 mRNA	25181051
D000069286	Bortezomib	Bortezomib results in increased expression of SLC2A3 mRNA	20977926
D002084	Butylated Hydroxytoluene	Butylated Hydroxytoluene results in decreased expression of SLC2A3 mRNA	19925653
D020122	tert-Butylhydroperoxide	[pioglitazone co-treated with tert-Butylhydroperoxide] results in increased expression of SLC2A3 mRNA	20847119
D020122	tert-Butylhydroperoxide	[rosiglitazone co-treated with tert-Butylhydroperoxide] results in increased expression of SLC2A3 mRNA	20847119
D020122	tert-Butylhydroperoxide	rosiglitazone inhibits the reaction [tert-Butylhydroperoxide results in increased expression of SLC2A3 mRNA]	20847119
D020122	tert-Butylhydroperoxide	tert-Butylhydroperoxide results in increased expression of SLC2A3 mRNA	20847119
D020122	tert-Butylhydroperoxide	[troglitazone co-treated with tert-Butylhydroperoxide] results in increased expression of SLC2A3 mRNA	20847119
D020122	tert-Butylhydroperoxide	troglitazone inhibits the reaction [tert-Butylhydroperoxide results in increased expression of SLC2A3 mRNA]	20847119
C018475	butyraldehyde	butyraldehyde results in decreased expression of SLC2A3 mRNA	26079696
D002104	Cadmium	Cadmium results in decreased expression of SLC2A3 mRNA	21120746
D019256	Cadmium Chloride	Cadmium Chloride results in decreased expression of SLC2A3 mRNA	26314618
D019256	Cadmium Chloride	[sodium arsenite co-treated with Cadmium Chloride co-treated with chromic oxide co-treated with chromous chloride co-treated with lead acetate] results in decreased expression of SLC2A3 mRNA	12634122
D019256	Cadmium Chloride	Cadmium Chloride results in decreased expression of SLC2A3 mRNA	27984135
D019256	Cadmium Chloride	Cadmium Chloride results in decreased expression of SLC2A3 protein	27984135
D019256	Cadmium Chloride	Cadmium Chloride results in increased methylation of SLC2A3 promoter	27984135
D002110	Caffeine	Caffeine results in increased expression of SLC2A3 protein	25486098
D002220	Carbamazepine	Carbamazepine affects the expression of SLC2A3 mRNA	25979313
D002251	Carbon Tetrachloride	Carbon Tetrachloride affects the expression of SLC2A3 mRNA	12734012
D002251	Carbon Tetrachloride	Carbon Tetrachloride results in decreased expression of SLC2A3 mRNA	16644059
D002251	Carbon Tetrachloride	Carbon Tetrachloride results in increased expression of SLC2A3 mRNA	19224547
C084597	chlorcyclizine	chlorcyclizine results in decreased expression of SLC2A3 mRNA	15342952
D020245	p-Chloromercuribenzoic Acid	"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SLC2A3 mRNA"	27188386
D020245	p-Chloromercuribenzoic Acid	p-Chloromercuribenzoic Acid results in increased expression of SLC2A3 mRNA	26272509
D002746	Chlorpromazine	Chlorpromazine results in decreased expression of SLC2A3 mRNA	15342952
C023600	chromic oxide	[sodium arsenite co-treated with Cadmium Chloride co-treated with chromic oxide co-treated with chromous chloride co-treated with lead acetate] results in decreased expression of SLC2A3 mRNA	12634122
D002857	Chromium	Chromium inhibits the reaction [Dietary Fats results in decreased expression of SLC2A3 protein]	21120707
C017133	chromous chloride	[sodium arsenite co-treated with Cadmium Chloride co-treated with chromic oxide co-treated with chromous chloride co-treated with lead acetate] results in decreased expression of SLC2A3 mRNA	12634122
D015283	Citalopram	Citalopram results in decreased expression of SLC2A3 mRNA	17567588
D002997	Clomipramine	Clomipramine results in decreased expression of SLC2A3 mRNA	15342952\|1717555
D003024	Clozapine	Clozapine results in decreased expression of SLC2A3 mRNA	15342952
C018021	cobaltous chloride	cobaltous chloride results in increased expression of SLC2A3 mRNA	19320972\|1937684
D003300	Copper	[Organoselenium Compounds binds to Copper] which results in increased expression of SLC2A3 mRNA	25167922
D003474	Curcumin	Curcumin results in decreased expression of SLC2A3 mRNA	21397623
D016572	Cyclosporine	Cyclosporine results in decreased expression of SLC2A3 mRNA	20106945\|2163298
D016572	Cyclosporine	Cyclosporine results in increased expression of SLC2A3 mRNA	19224547
D003571	Cytochalasin B	Cytochalasin B inhibits the reaction [SLC2A3 protein results in increased transport of Deoxyglucose]	8457197
D015084	2,4-Dichlorophenoxyacetic Acid	"2,4-Dichlorophenoxyacetic Acid results in decreased expression of SLC2A3 mRNA"	23538319
D015084	2,4-Dichlorophenoxyacetic Acid	"2,4-Dichlorophenoxyacetic Acid results in decreased expression of SLC2A3 protein"	23538319
D015084	2,4-Dichlorophenoxyacetic Acid	"2,4-Dichlorophenoxyacetic Acid results in increased expression of SLC2A3 mRNA"	23538319
C010902	decabromobiphenyl ether	decabromobiphenyl ether results in decreased expression of SLC2A3 protein	28572024
C010902	decabromobiphenyl ether	decabromobiphenyl ether results in increased expression of SLC2A3 mRNA	23914054
D003683	Dehydroascorbic Acid	SLC2A3 protein affects the transport of Dehydroascorbic Acid	15590689
D003703	Demecolcine	Demecolcine results in increased expression of SLC2A3 mRNA	23649840
D003847	Deoxyglucose	Cytochalasin B inhibits the reaction [SLC2A3 protein results in increased transport of Deoxyglucose]	8457197
D003847	Deoxyglucose	Galactose inhibits the reaction [SLC2A3 protein results in increased transport of Deoxyglucose]	8457197
D003847	Deoxyglucose	Glucose inhibits the reaction [SLC2A3 protein results in increased transport of Deoxyglucose]	8457197
D003847	Deoxyglucose	Maltose inhibits the reaction [SLC2A3 protein results in increased transport of Deoxyglucose]	8457197
D003847	Deoxyglucose	SLC2A3 protein results in increased transport of Deoxyglucose	8457197
D003993	Dibutyl Phthalate	Dibutyl Phthalate results in increased expression of SLC2A3 mRNA	21266533
D002945	Cisplatin	Cisplatin results in increased expression of SLC2A3 mRNA	27594783
D002945	Cisplatin	Cisplatin results in increased phosphorylation of SLC2A3 protein	22006019
D004041	Dietary Fats	Chromium inhibits the reaction [Dietary Fats results in decreased expression of SLC2A3 protein]	21120707
D004041	Dietary Fats	Dietary Fats results in decreased expression of SLC2A3 protein	21120707
D002117	Calcitriol	Calcitriol results in increased expression of SLC2A3 mRNA	21592394
D002117	Calcitriol	[Testosterone co-treated with Calcitriol] results in increased expression of SLC2A3 mRNA	21592394
D004137	Dinitrochlorobenzene	Dinitrochlorobenzene results in decreased expression of SLC2A3 mRNA	19371601
D004137	Dinitrochlorobenzene	Dinitrochlorobenzene results in increased expression of SLC2A3 mRNA	17374397
D004139	Dinitrofluorobenzene	Dinitrofluorobenzene results in increased expression of SLC2A3 mRNA	21362464
D004316	Doxepin	Doxepin results in decreased expression of SLC2A3 mRNA	17567588
C118739	entinostat	entinostat results in increased expression of SLC2A3 mRNA	26272509
C118739	entinostat	"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SLC2A3 mRNA"	27188386
C045651	epigallocatechin gallate	[potassium chromate(VI) co-treated with epigallocatechin gallate] results in increased expression of SLC2A3 mRNA	22079256
C074283	estradiol 3-benzoate	estradiol 3-benzoate results in decreased methylation of SLC2A3 promoter	27415467
D000431	Ethanol	Ethanol results in decreased expression of SLC2A3 mRNA	23907025
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in increased expression of SLC2A3 mRNA	23550701
D005054	Eugenol	Eugenol results in increased expression of SLC2A3 mRNA	17374397
C017875	fisetin	[fisetin co-treated with Oxygen deficiency] results in decreased expression of SLC2A3 mRNA	20153296
D005424	Flecainide	Flecainide results in decreased expression of SLC2A3 mRNA	15342952
D005424	Flecainide	Flecainide results in increased expression of SLC2A3 mRNA	17175557
D005472	Fluorouracil	SLC2A3 protein affects the susceptibility to Fluorouracil	16217747
D005473	Fluoxetine	Fluoxetine results in decreased expression of SLC2A3 mRNA	15342952\|1756758
C061365	flusilazole	flusilazole results in increased expression of SLC2A3 mRNA	22382673
D005485	Flutamide	Flutamide results in increased expression of SLC2A3 mRNA	21126777
D005557	Formaldehyde	Formaldehyde results in increased expression of SLC2A3 mRNA	27664576
D005690	Galactose	Galactose inhibits the reaction [SLC2A3 protein results in increased transport of Deoxyglucose]	8457197
D005690	Galactose	Glucose inhibits the reaction [SLC2A3 protein results in increased transport of Galactose]	8457197
D005690	Galactose	Maltose inhibits the reaction [SLC2A3 protein results in increased transport of Galactose]	8457197
D005690	Galactose	SLC2A3 protein results in increased transport of Galactose	8457197
C056507	gemcitabine	gemcitabine results in increased expression of SLC2A3 mRNA	17039268
D019833	Genistein	Genistein results in decreased expression of SLC2A3 mRNA	21782745
D005947	Glucose	Glucose inhibits the reaction [SLC2A3 protein results in increased transport of Deoxyglucose]	8457197
D005947	Glucose	Glucose inhibits the reaction [SLC2A3 protein results in increased transport of Galactose]	8457197
D005947	Glucose	[INS protein co-treated with Glucose] results in decreased expression of SLC2A3 protein	28951307
D005947	Glucose	Kynurenic Acid inhibits the reaction [[INS protein co-treated with Glucose] results in decreased expression of SLC2A3 protein]	28951307
D005947	Glucose	N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [[Oxygen co-treated with Glucose deficiency co-treated with 2-(4-methoxyphenyl)ethyl-2-acetamido-2-deoxyglucopyranoside] results in increased expression of SLC2A3 protein]	24726522
D005947	Glucose	[Oxygen co-treated with Glucose deficiency co-treated with 2-(4-methoxyphenyl)ethyl-2-acetamido-2-deoxyglucopyranoside] results in increased expression of SLC2A3 protein	24726522
C082359	imidacloprid	imidacloprid results in increased expression of SLC2A3 mRNA	27782041
D007099	Imipramine	Imipramine results in decreased expression of SLC2A3 mRNA	15342952\|1756758
D015759	Ionomycin	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of SLC2A3 mRNA	25613284
C561695	(+)-JQ1 compound	(+)-JQ1 compound results in decreased expression of SLC2A3 mRNA	23086925
C410337	K 7174	K 7174 results in decreased expression of SLC2A3 mRNA	24086573
D007654	Ketoconazole	Ketoconazole results in decreased expression of SLC2A3 mRNA	15342952\|1756758
D007736	Kynurenic Acid	Kynurenic Acid inhibits the reaction [[INS protein co-treated with Glucose] results in decreased expression of SLC2A3 protein]	28951307
C008261	lead acetate	[sodium arsenite co-treated with Cadmium Chloride co-treated with chromic oxide co-treated with chromous chloride co-treated with lead acetate] results in decreased expression of SLC2A3 mRNA	12634122
D008070	Lipopolysaccharides	Lipopolysaccharides results in increased expression of SLC2A3 mRNA	21362464
D017336	Loratadine	Loratadine results in decreased expression of SLC2A3 mRNA	15342952\|1756758
D047311	Luteolin	[Luteolin co-treated with Oxygen deficiency] results in decreased expression of SLC2A3 mRNA	20153296
D008278	Magnesium Sulfate	Magnesium Sulfate results in increased expression of SLC2A3 protein	20517896
D008320	Maltose	Maltose inhibits the reaction [SLC2A3 protein results in increased transport of Deoxyglucose]	8457197
D008320	Maltose	Maltose inhibits the reaction [SLC2A3 protein results in increased transport of Galactose]	8457197
D015122	Mercaptopurine	Mercaptopurine results in decreased expression of SLC2A3 mRNA	23358152
C042720	mercuric bromide	mercuric bromide results in increased expression of SLC2A3 mRNA	26272509
C042720	mercuric bromide	"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SLC2A3 mRNA"	27188386
D008727	Methotrexate	Methotrexate results in decreased expression of SLC2A3 mRNA	24449571
D008727	Methotrexate	Methotrexate affects the expression of SLC2A3 mRNA	18502557
C004925	methylmercuric chloride	methylmercuric chloride results in decreased expression of SLC2A3 mRNA	23179753\|2718838
C004925	methylmercuric chloride	methylmercuric chloride results in increased expression of SLC2A3 mRNA	23179753\|2627250
C004925	methylmercuric chloride	"[NOG protein co-treated with methylmercuric chloride co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SLC2A3 mRNA"	27188386
D018817	N-Methyl-3,4-methylenedioxyamphetamine	"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of SLC2A3 mRNA"	20188158
C063509	N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide	N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [[Oxygen co-treated with Glucose deficiency co-treated with 2-(4-methoxyphenyl)ethyl-2-acetamido-2-deoxyglucopyranoside] results in increased expression of SLC2A3 protein]	24726522
C452423	N-(4-bromo-2-fluorophenyl)-6-methoxy-7-((1-methylpiperidin-4-yl)methoxy)quinazolin-4-amine	N-(4-bromo-2-fluorophenyl)-6-methoxy-7-((1-methylpiperidin-4-yl)methoxy)quinazolin-4-amine results in increased expression of SLC2A3 mRNA	16052530
C066471	NCS 382	NCS 382 results in decreased expression of SLC2A3 mRNA	28119166
D009532	Nickel	Nickel results in increased expression of SLC2A3 mRNA	24768652\|2558310
C022838	nickel chloride	nickel chloride results in increased expression of SLC2A3 mRNA	17312168
C029938	nickel sulfate	nickel sulfate results in increased expression of SLC2A3 mRNA	16780908\|1737439
D009534	Niclosamide	Niclosamide results in decreased expression of SLC2A3 mRNA	22576131
C572573	N-nitroso-tris-chloroethylurea	[N-nitroso-tris-chloroethylurea co-treated with XL147] results in increased expression of SLC2A3 mRNA	27935865
D016566	Organoselenium Compounds	[Organoselenium Compounds binds to Copper] which results in increased expression of SLC2A3 mRNA	25167922
C030110	oxaliplatin	oxaliplatin results in decreased expression of SLC2A3 mRNA	17762391
C030110	oxaliplatin	[oxaliplatin co-treated with Topotecan] results in increased expression of SLC2A3 mRNA	25729387
D010081	Oxazolone	Oxazolone results in increased expression of SLC2A3 mRNA	17374397
D010100	Oxygen	[Apigenin co-treated with Oxygen deficiency] results in decreased expression of SLC2A3 mRNA	20153296
D010100	Oxygen	[fisetin co-treated with Oxygen deficiency] results in decreased expression of SLC2A3 mRNA	20153296
D010100	Oxygen	HIF1A protein affects the reaction [Oxygen deficiency results in increased expression of SLC2A3 protein]	17442736
D010100	Oxygen	[Luteolin co-treated with Oxygen deficiency] results in decreased expression of SLC2A3 mRNA	20153296
D010100	Oxygen	Oxygen deficiency results in increased expression of SLC2A3 mRNA	20042640\|2651600
D010100	Oxygen	Oxygen deficiency results in increased expression of SLC2A3 protein	17442736
D010100	Oxygen	Oxygen deficiency results in increased expression of SLC2A3 mRNA	20880076
D010100	Oxygen	N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [[Oxygen co-treated with Glucose deficiency co-treated with 2-(4-methoxyphenyl)ethyl-2-acetamido-2-deoxyglucopyranoside] results in increased expression of SLC2A3 protein]	24726522
D010100	Oxygen	[Oxygen co-treated with Glucose deficiency co-treated with 2-(4-methoxyphenyl)ethyl-2-acetamido-2-deoxyglucopyranoside] results in increased expression of SLC2A3 protein	24726522
D010100	Oxygen	Oxygen deficiency results in increased expression of SLC2A3 mRNA	23307114
D010100	Oxygen	Progesterone promotes the reaction [Oxygen deficiency results in increased expression of SLC2A3 mRNA]	23307114
C496932	panobinostat	"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SLC2A3 mRNA"	27188386
C496932	panobinostat	panobinostat results in increased expression of SLC2A3 mRNA	26272509
D010269	Paraquat	Paraquat results in increased expression of SLC2A3 mRNA	18198484
D052638	Particulate Matter	Particulate Matter results in increased expression of SLC2A3 mRNA	21703343
C568608	PCI 5002	[PCI 5002 co-treated with Zinc] results in increased expression of SLC2A3 mRNA	18593933
D010419	Pentamidine	Pentamidine results in decreased expression of SLC2A3 mRNA	15342952
C046012	pentanal	pentanal results in decreased expression of SLC2A3 mRNA	26079696
C076994	perfluorooctane sulfonic acid	perfluorooctane sulfonic acid results in increased expression of SLC2A3 protein	26178269
C023036	perfluorooctanoic acid	perfluorooctanoic acid results in decreased expression of SLC2A3 protein	26879310
D010480	Perhexiline	Perhexiline results in decreased expression of SLC2A3 mRNA	15342952
D010480	Perhexiline	Perhexiline results in increased expression of SLC2A3 mRNA	17175557
D010662	Phenylmercuric Acetate	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SLC2A3 mRNA"	27188386
D010662	Phenylmercuric Acetate	Phenylmercuric Acetate results in increased expression of SLC2A3 mRNA	26272509
D010795	Phthalic Acids	Phthalic Acids results in increased expression of SLC2A3 mRNA	21061450
C060836	pioglitazone	[pioglitazone co-treated with tert-Butylhydroperoxide] results in increased expression of SLC2A3 mRNA	20847119
C027373	potassium chromate(VI)	[potassium chromate(VI) co-treated with epigallocatechin gallate] results in increased expression of SLC2A3 mRNA	22079256
C027373	potassium chromate(VI)	potassium chromate(VI) results in increased expression of SLC2A3 mRNA	22079256
D011192	Potassium Dichromate	Potassium Dichromate results in increased expression of SLC2A3 mRNA	23608068
D011374	Progesterone	Progesterone affects the expression of SLC2A3 mRNA	17251523
D011374	Progesterone	Progesterone results in increased expression of SLC2A3 mRNA	22238285
D011374	Progesterone	Progesterone promotes the reaction [Oxygen deficiency results in increased expression of SLC2A3 mRNA]	23307114
D011374	Progesterone	Progesterone results in decreased expression of SLC2A3	17510236
D011441	Propylthiouracil	Propylthiouracil results in increased expression of SLC2A3 mRNA	18077114
D011794	Quercetin	Quercetin results in decreased expression of SLC2A3 mRNA	21632981
D011802	Quinidine	Quinidine results in decreased expression of SLC2A3 mRNA	15342952\|1756758
D020849	Raloxifene Hydrochloride	Raloxifene Hydrochloride affects the expression of SLC2A3 mRNA	14699072
C031389	resorcinol	resorcinol results in increased expression of SLC2A3 mRNA	22623647
C089730	rosiglitazone	[rosiglitazone co-treated with tert-Butylhydroperoxide] results in increased expression of SLC2A3 mRNA	20847119
C089730	rosiglitazone	rosiglitazone inhibits the reaction [tert-Butylhydroperoxide results in increased expression of SLC2A3 mRNA]	20847119
C089730	rosiglitazone	rosiglitazone results in increased expression of SLC2A3 mRNA	21172411
C089730	rosiglitazone	rosiglitazone results in increased expression of SLC2A3 protein	21975308
D020280	Sertraline	Sertraline results in decreased expression of SLC2A3 mRNA	15342952\|1756758
D012822	Silicon Dioxide	Silicon Dioxide results in increased expression of SLC2A3 mRNA	25351596
C017947	sodium arsenite	[sodium arsenite co-treated with Cadmium Chloride co-treated with chromic oxide co-treated with chromous chloride co-treated with lead acetate] results in decreased expression of SLC2A3 mRNA	12634122
C017947	sodium arsenite	sodium arsenite results in decreased expression of SLC2A3 mRNA	12634122
C017947	sodium arsenite	sodium arsenite results in decreased expression of SLC2A3 mRNA	26876454
D012969	Sodium Fluoride	Sodium Fluoride results in increased expression of SLC2A3 protein	28918527
D013015	Sotalol	Sotalol results in increased expression of SLC2A3 mRNA	15342952
C016766	sulforafan	sulforafan results in increased expression of SLC2A3 mRNA	26833863
D013629	Tamoxifen	Tamoxifen affects the expression of SLC2A3 mRNA	14699072
D013629	Tamoxifen	Tamoxifen results in decreased expression of SLC2A3 mRNA	15342952\|1756758
D013629	Tamoxifen	Tamoxifen results in increased expression of SLC2A3 mRNA	19224547
D013739	Testosterone	[Testosterone co-treated with Calcitriol] results in increased expression of SLC2A3 mRNA	21592394
D013739	Testosterone	Testosterone results in increased expression of SLC2A3 mRNA	21592394
D013739	Testosterone	Testosterone inhibits the reaction [Testosterone deficiency results in decreased expression of SLC2A3 mRNA]	21045173
D013739	Testosterone	Testosterone results in increased expression of SLC2A3 mRNA	20403060
C045037	testosterone-3-carboxymethyloxime-bovine serum albumin conjugate	testosterone-3-carboxymethyloxime-bovine serum albumin conjugate affects the expression of SLC2A3 mRNA	20189893
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of SLC2A3 mRNA	16704738\|2010694
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of SLC2A3 mRNA	17872374\|2157046
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of SLC2A3 protein	17872374
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of SLC2A3 mRNA	11858732
D013752	Tetracycline	Tetracycline results in increased expression of SLC2A3 mRNA	19224547
D013755	Tetradecanoylphorbol Acetate	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of SLC2A3 mRNA	25613284
D013792	Thalidomide	Thalidomide results in increased expression of SLC2A3 mRNA	26217789
D013849	Thimerosal	Thimerosal results in decreased expression of SLC2A3 mRNA	27188386
D013881	Thioridazine	Thioridazine results in decreased expression of SLC2A3 mRNA	15342952
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution affects the expression of SLC2A3 mRNA	20133372
D019772	Topotecan	[oxaliplatin co-treated with Topotecan] results in increased expression of SLC2A3 mRNA	25729387
D019772	Topotecan	Topotecan results in increased expression of SLC2A3 mRNA	25729387
C483909	torcetrapib	torcetrapib results in increased expression of SLC2A3 mRNA	23228038
D001371	trans-1,4-Bis(2-chlorobenzaminomethyl)cyclohexane Dihydrochloride	"trans-1,4-Bis(2-chlorobenzaminomethyl)cyclohexane Dihydrochloride results in decreased expression of SLC2A3 mRNA"	15342952
D014212	Tretinoin	Tretinoin results in decreased expression of SLC2A3 mRNA	16168501
D014212	Tretinoin	Tretinoin results in increased expression of SLC2A3 mRNA	16054129
C011559	tributyltin	tributyltin results in decreased expression of SLC2A3 mRNA	19371601
C012589	trichostatin A	"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SLC2A3 mRNA"	27188386
C012589	trichostatin A	trichostatin A affects the expression of SLC2A3 mRNA	28542535
C012589	trichostatin A	trichostatin A results in increased expression of SLC2A3 mRNA	24935251\|2627250
C016805	tris(1,3-dichloro-2-propyl)phosphate	"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of SLC2A3 mRNA"	26179874
C057693	troglitazone	[troglitazone co-treated with tert-Butylhydroperoxide] results in increased expression of SLC2A3 mRNA	20847119
C057693	troglitazone	troglitazone inhibits the reaction [tert-Butylhydroperoxide results in increased expression of SLC2A3 mRNA]	20847119
D014415	Tunicamycin	Tunicamycin results in increased expression of SLC2A3 mRNA	24370435
D014501	Uranium	Uranium affects the expression of SLC2A3 mRNA	15672453
C005460	uranyl acetate	uranyl acetate affects the expression of SLC2A3 mRNA	15672453
D014520	Urethane	Urethane results in decreased expression of SLC2A3 mRNA	28818685
D014635	Valproic Acid	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SLC2A3 mRNA"	27188386
D014635	Valproic Acid	Valproic Acid results in increased expression of SLC2A3 mRNA	23179753\|2438349
D014638	Vanadates	Vanadates results in increased expression of SLC2A3 mRNA	22714537
C066075	vanadium pentoxide	vanadium pentoxide affects the expression of SLC2A3 mRNA	17459161
D024483	Vitamin K 3	Vitamin K 3 results in decreased expression of SLC2A3 mRNA	25270620
C111237	vorinostat	"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SLC2A3 mRNA"	27188386
C111237	vorinostat	vorinostat results in increased expression of SLC2A3 mRNA	26272509
C581157	XL147	[N-nitroso-tris-chloroethylurea co-treated with XL147] results in increased expression of SLC2A3 mRNA	27935865
D015215	Zidovudine	Zidovudine results in decreased expression of SLC2A3 mRNA	24292225
D015032	Zinc	[PCI 5002 co-treated with Zinc] results in increased expression of SLC2A3 mRNA	18593933

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005355	glucose transmembrane transporter activity	-	IDA	26176916
GO:0005536	glucose binding	-	IDA	26176916
GO:0033300	dehydroascorbic acid transmembrane transporter activity	-	EXP	9228080 10862609
GO:0055056	D-glucose transmembrane transporter activity	-	EXP	8457197

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005975	carbohydrate metabolic process	-	NAS	1695905
GO:0019852	L-ascorbic acid metabolic process	-	TAS	-
GO:0043312	neutrophil degranulation	-	TAS	-
GO:0070837	dehydroascorbic acid transport	-	IEA	-
GO:1904659	glucose transmembrane transport	-	IDA	26176916
GO:1904659	glucose transmembrane transport	-	TAS	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005886	plasma membrane	-	TAS	-
GO:0005887	integral component of plasma membrane	-	IMP	9477959
GO:0016021	integral component of membrane	-	IDA	26176916
GO:0030667	secretory granule membrane	-	TAS	-
GO:0035579	specific granule membrane	-	TAS	-
GO:0070062	extracellular exosome	-	HDA	20458337
GO:0070821	tertiary granule membrane	-	TAS	-
GO:0101003	ficolin-1-rich granule membrane	-	TAS	-

KEGG ID	KEGG Term

Reactome ID	Reactome Term	Evidence
R-HSA-1430728	Metabolism	TAS
R-HSA-168249	Innate Immune System	TAS
R-HSA-168256	Immune System	TAS
R-HSA-189200	Cellular hexose transport	TAS
R-HSA-196836	Vitamin C (ascorbate) metabolism	TAS
R-HSA-196849	Metabolism of water-soluble vitamins and cofactors	TAS
R-HSA-196854	Metabolism of vitamins and cofactors	TAS
R-HSA-382551	Transport of small molecules	TAS
R-HSA-425407	SLC-mediated transmembrane transport	TAS
R-HSA-6798695	Neutrophil degranulation	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
20589092	Ethanol and phencyclidine interact with respect to nucleus accumbens dopamine release: differential effects of administration order and pretreatment protocol. (2010)	Pickering C	Front Behav Neurosci