Gene: ANKRD33B

651746
-
ankyrin repeat domain 33B
protein-coding
5p15.2
Ensembl:ENSG00000164236 Vega:OTTHUMG00000162050 UniprotKB:A6NCL7
NC_000005.10
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
4.681e-1 (AD)  5.391e-1 (ND)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg14629055chr5:10562978ANKRD33B7.620e-8Maternal smoking in pregnancy27040690

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
KCNH10.84
PLEKHM30.836
SOCS70.834
GRM50.823
SLIT10.821
PCDH10.819
SMCR80.819
NCR3LG10.816
HRH20.815
SYN30.812

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
COPZ2-0.486
CSAG1-0.461
APOM-0.457
ROM1-0.456
MYL3-0.455
GNG11-0.449
RNF135-0.446
AKR1C3-0.446
HEY2-0.443
STON2-0.442

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased expression of ANKRD33B mRNA"28903501
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ANKRD33B mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ANKRD33B mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ANKRD33B mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ANKRD33B mRNA"27188386
D000082AcetaminophenAcetaminophen results in decreased expression of ANKRD33B mRNA22230336
D000082AcetaminophenAcetaminophen results in increased expression of ANKRD33B mRNA29067470
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of ANKRD33B mRNA27153756
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of ANKRD33B mRNA19770486
D000517alpha-Chlorohydrinalpha-Chlorohydrin results in increased expression of ANKRD33B mRNA28522335
D018501Antirheumatic AgentsAntirheumatic Agents results in increased expression of ANKRD33B mRNA24449571
D001151ArsenicArsenic affects the methylation of ANKRD33B gene25304211
C547126AZM551248AZM551248 results in increased expression of ANKRD33B mRNA22323515
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of ANKRD33B mRNA21569818
C006780bisphenol Abisphenol A affects the expression of ANKRD33B mRNA25181051
D002220CarbamazepineCarbamazepine affects the expression of ANKRD33B mRNA25979313
D003300CopperCopper results in decreased expression of ANKRD33B mRNA17205981
D003471CuprizoneCuprizone results in decreased expression of ANKRD33B mRNA26577399
D003703DemecolcineDemecolcine results in increased expression of ANKRD33B mRNA23649840
D002945CisplatinCisplatin results in decreased expression of ANKRD33B mRNA27594783
D004317DoxorubicinDoxorubicin results in decreased expression of ANKRD33B mRNA19277126
C118739entinostatentinostat results in increased expression of ANKRD33B mRNA27188386
D000431EthanolEthanol results in increased expression of ANKRD33B mRNA28986285
C024565ethylene dichlorideethylene dichloride results in decreased expression of ANKRD33B mRNA28189721
C069837fullerene C60fullerene C60 results in increased expression of ANKRD33B mRNA19167457
D017313FenretinideFenretinide results in increased expression of ANKRD33B mRNA28973697
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of ANKRD33B mRNA25613284
C544151jinfukangjinfukang results in decreased expression of ANKRD33B mRNA27392435
D048628KetolidesKetolides analog results in increased expression of ANKRD33B mRNA24967691
C008261lead acetatelead acetate results in increased expression of ANKRD33B mRNA25270620
C045463leflunomideleflunomide results in increased expression of ANKRD33B mRNA28988120
C042720mercuric bromidemercuric bromide results in increased expression of ANKRD33B mRNA26272509
C042720mercuric bromide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ANKRD33B mRNA"27188386
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of ANKRD33B mRNA28001369
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in decreased expression of ANKRD33B mRNA"20188158
C523799MRK 003ANKRD33B results in increased susceptibility to MRK 00319903844
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of ANKRD33B mRNA"25554681|2562005
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of ANKRD33B mRNA"25620056
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ANKRD33B mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in increased expression of ANKRD33B mRNA26272509
D010795Phthalic AcidsPhthalic Acids results in decreased expression of ANKRD33B mRNA21061450
D010795Phthalic AcidsPhthalic Acids results in increased expression of ANKRD33B mRNA21061450
D011374ProgesteroneProgesterone results in increased expression of ANKRD33B mRNA23012394
D011441PropylthiouracilPropylthiouracil results in decreased expression of ANKRD33B mRNA24780913
D012969Sodium FluorideSodium Fluoride results in increased expression of ANKRD33B mRNA27862939
D053260SootSoot results in decreased expression of ANKRD33B mRNA22461453
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of ANKRD33B mRNA25613284
D013853ThioacetamideThioacetamide results in decreased expression of ANKRD33B mRNA23411599
C009495titanium dioxidetitanium dioxide results in decreased expression of ANKRD33B mRNA23557971
D014212TretinoinTretinoin results in increased expression of ANKRD33B mRNA23830798
C057693troglitazonetroglitazone results in decreased expression of ANKRD33B mRNA28973697
D014520UrethaneUrethane results in increased expression of ANKRD33B mRNA28818685
D014635Valproic AcidValproic Acid affects the expression of ANKRD33B mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of ANKRD33B mRNA23179753|2800136
D014635Valproic AcidValproic Acid results in increased methylation of ANKRD33B gene29154799
D014635Valproic AcidValproic Acid affects the expression of ANKRD33B mRNA17292431
C025643vinclozolinvinclozolin affects the expression of ANKRD33B mRNA19015723
D014750VincristineVincristine results in increased expression of ANKRD33B mRNA23649840

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO ID GO Term Qualifier Evidence PubMed
GO ID GO Term Qualifier Evidence PubMed
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
25482056Fetal lung and placental methylation is associated with in utero nicotine exposure. (2014 Nov)Chhabra DEpigenetics