Gene info: ID 652

Gene: BMP4

GENE ID: 652

Synonyms: BMP2B|BMP2B1|MCOPS6|OFC11|ZYME

Description: bone morphogenetic protein 4

Gene type: protein-coding

Location: 14q22.2

dbXrefs: Ensembl:ENSG00000125378 MIM:112262 Vega:OTTHUMG00000140303 UniprotKB:P12644

RefSeq: NG_009215.1

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: ND

# Publications: 8

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 7.015e-2 (AD) 3.237e-1 (ND)

DNA Methylation

Probe	Locus(GRCh37)	Gene	Region	p-val	Trait	PubMed ID
cg05928290	chr14:54418728	BMP4		4.320e-14	Maternal smoking in pregnancy	27040690
cg05923197	chr14:54418804	BMP4		4.000e-14	Maternal smoking in pregnancy	27040690
cg09367901	chr14:54418851	BMP4		2.230e-13	Maternal smoking in pregnancy	27040690
cg08046044	chr14:54419614	BMP4		2.310e-8	Maternal smoking in pregnancy	27040690
cg05928290	chr14:54418728	BMP4		1.480e-19	Maternal smoking in pregnancy	27040690
cg05923197	chr14:54418804	BMP4		1.080e-18	Maternal smoking in pregnancy	27040690
cg09367901	chr14:54418851	BMP4		3.980e-17	Maternal smoking in pregnancy	27040690
cg08046044	chr14:54419614	BMP4		2.700e-9	Maternal smoking in pregnancy	27040690
cg05928290	chr14:54418728	BMP4		1.820e-20	Maternal smoking in pregnancy	27040690
cg05923197	chr14:54418804	BMP4		1.640e-20	Maternal smoking in pregnancy	27040690
cg09367901	chr14:54418851	BMP4		2.010e-17	Maternal smoking in pregnancy	27040690
cg08046044	chr14:54419614	BMP4		1.190e-10	Maternal smoking in pregnancy	27040690
cg04937184	chr14:54423845	BMP4		1.600e-8	Smoking	27651444

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
DEDD2	0.647
TMEM243	0.631
SIRT7	0.626
NHLH1	0.62
TMEM81	0.619
NAB2	0.619
SIAH2	0.617
IER5	0.616
PCID2	0.614
GLIS1	0.61

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
ALDH1L1-AS2	-0.382
PDE11A	-0.359
ZNF98	-0.355
RMDN1	-0.347
PON1	-0.344
SOX3	-0.333
ZFHX4-AS1	-0.318
FNDC7	-0.312
MYOM1	-0.308
C16orf74	-0.308

ID	Drug Name	Drug Type	CAS Num	Status	Role
DB01373	Calcium	Small Molecule	7440-70-2	Approved\|Nutraceutical	Target

ID	Drug Name	Action	PubMed
C548651	2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester	2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in decreased expression of BMP4 mRNA	19933214
C094210	2,2'-(hydroxynitrosohydrazono)bis-ethanamine	"2,2'-(hydroxynitrosohydrazono)bis-ethanamine results in increased expression of BMP4 mRNA"	15991191
C023035	3,4,5,3',4'-pentachlorobiphenyl	"3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of BMP4 mRNA"	23196670
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide co-treated with BMP4 protein] results in decreased methylation of ELF5 promoter"	25670856
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of BMP4 mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of BMP4 mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of BMP4 mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of BMP4 mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of BMP4 mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of BMP4 mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of BMP4 mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of BMP4 mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of BMP4 mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of BMP4 mRNA"	27188386
D000082	Acetaminophen	Acetaminophen affects the expression of BMP4 mRNA	17562736
D000537	Aluminum Oxide	Aluminum Oxide results in increased expression of BMP4 mRNA	19464052
D000643	Ammonium Chloride	Ammonium Chloride affects the expression of BMP4 mRNA	16483693
D003913	Dextroamphetamine	Dextroamphetamine results in decreased expression of BMP4 mRNA	12205029
D003913	Dextroamphetamine	SOD1 inhibits the reaction [Dextroamphetamine results in decreased expression of BMP4 mRNA]	12205029
C061374	antimonite	antimonite results in decreased expression of BMP4 mRNA	17400267
C061374	antimonite	tyrphostin AG 1478 inhibits the reaction [antimonite results in decreased expression of BMP4 mRNA]	17400267
D001149	Arsenates	Arsenates results in increased expression of BMP4 mRNA	12773770
D001151	Arsenic	Arsenic results in increased expression of BMP4 mRNA	12773770
C015001	arsenite	arsenite results in decreased expression of BMP4 mRNA	17400267
C015001	arsenite	tyrphostin AG 1478 inhibits the reaction [arsenite results in decreased expression of BMP4 mRNA]	17400267
D001205	Ascorbic Acid	Ascorbic Acid affects the expression of BMP4 mRNA	21281732
C547126	AZM551248	AZM551248 results in decreased expression of BMP4 mRNA	22323515
D001414	Bacitracin	Bacitracin results in decreased expression of BMP4 mRNA	18289764
D001564	Benzo(a)pyrene	[Benzo(a)pyrene co-treated with fluoranthene] results in decreased expression of BMP4 mRNA	25412620
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of BMP4 mRNA	22228805
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of BMP4 mRNA	21839799
D004958	Estradiol	Estradiol affects the expression of BMP4 mRNA	14699072\|2257421
D004958	Estradiol	[Estradiol binds to ESR2 protein] which results in increased expression of BMP4 mRNA	20404318
D004958	Estradiol	Estradiol results in decreased expression of BMP4 mRNA	26921789
D004958	Estradiol	Estradiol results in decreased expression of BMP4 mRNA	23144751
D004958	Estradiol	BMP4 protein inhibits the reaction [IGF1 protein promotes the reaction [FSHB protein results in increased abundance of Estradiol]]	22067323
D004958	Estradiol	[BMP4 protein results in increased expression of CYP19A1 mRNA] promotes the reaction [FSHB protein results in increased abundance of Estradiol]	22067323
D001623	Betamethasone	"Betamethasone inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in decreased expression of BMP4 protein]"	22693607
D001647	Bile Acids and Salts	Bile Acids and Salts results in increased expression of BMP4 mRNA	25973022
C006780	bisphenol A	bisphenol A results in decreased expression of BMP4 mRNA	27685785
C006780	bisphenol A	bisphenol A results in decreased expression of BMP4 mRNA	22718145
C006780	bisphenol A	bisphenol A results in decreased expression of BMP4 mRNA	25181051
D015124	8-Bromo Cyclic Adenosine Monophosphate	8-Bromo Cyclic Adenosine Monophosphate results in decreased expression of BMP4 mRNA	22079614
D002066	Busulfan	Busulfan results in decreased expression of BMP4 mRNA	15786497
D020122	tert-Butylhydroperoxide	tert-Butylhydroperoxide results in decreased expression of BMP4 mRNA	12419474
D019256	Cadmium Chloride	[sodium arsenite co-treated with Cadmium Chloride co-treated with chromic oxide co-treated with chromous chloride co-treated with lead acetate] results in increased expression of BMP4 mRNA	12634122
D019256	Cadmium Chloride	Cadmium Chloride results in increased expression of BMP4 mRNA	21297351
D002118	Calcium	[Calcium binds to MGP protein] which binds to and results in decreased activity of BMP4 protein	18369157
D002118	Calcium	[Edetic Acid inhibits the reaction [Calcium binds to MGP protein]] inhibits the reaction [MGP protein binds to BMP4 protein]	18369157
D002118	Calcium	Calcium affects the expression of BMP4 mRNA	15913539
D002220	Carbamazepine	Carbamazepine affects the expression of BMP4 mRNA	24752500
C054133	casticin	casticin results in increased expression of BMP4 mRNA	27862857
C084597	chlorcyclizine	chlorcyclizine results in increased expression of BMP4 mRNA	21058326
D002713	Chlorine	[Ozone co-treated with Chlorine] results in increased expression of BMP4 mRNA	18636392
D002794	Choline	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of BMP4 gene	20938992
C023600	chromic oxide	[sodium arsenite co-treated with Cadmium Chloride co-treated with chromic oxide co-treated with chromous chloride co-treated with lead acetate] results in increased expression of BMP4 mRNA	12634122
C017133	chromous chloride	[sodium arsenite co-treated with Cadmium Chloride co-treated with chromic oxide co-treated with chromous chloride co-treated with lead acetate] results in increased expression of BMP4 mRNA	12634122
C007076	citral	citral results in decreased expression of BMP4 mRNA	15581867
C018021	cobaltous chloride	cobaltous chloride results in decreased expression of BMP4 mRNA	19320972
D003300	Copper	Copper results in decreased expression of BMP4 mRNA	22465980
D016572	Cyclosporine	Cyclosporine results in decreased expression of BMP4 mRNA	25562108\|2798913
D016572	Cyclosporine	Cyclosporine results in decreased expression of BMP4 mRNA	21865292
D003561	Cytarabine	Cytarabine results in decreased expression of BMP4 mRNA	21198554
C014347	decitabine	decitabine results in increased expression of BMP4 mRNA	27915011
D003907	Dexamethasone	Dexamethasone inhibits the reaction [RX3 gene mutant form affects the expression of BMP4 mRNA]	27941970
D003907	Dexamethasone	Dexamethasone results in decreased expression of BMP4 mRNA	28453788
D003907	Dexamethasone	Dexamethasone inhibits the reaction [BMP4 protein results in increased expression of GREM1 mRNA]	15268896
D003907	Dexamethasone	Dexamethasone inhibits the reaction [BMP4 protein results in increased expression of SOST mRNA]	15268896
D003907	Dexamethasone	Dexamethasone affects the expression of BMP4 mRNA	21277400
D003907	Dexamethasone	[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in decreased expression of BMP4 mRNA	16054899
D003993	Dibutyl Phthalate	Dibutyl Phthalate results in decreased expression of BMP4 mRNA	19464577\|2202756
D003993	Dibutyl Phthalate	Dibutyl Phthalate results in decreased expression of BMP4 protein	28341571
D003993	Dibutyl Phthalate	Dibutyl Phthalate results in increased expression of BMP4 mRNA	15829613
D003994	Bucladesine	Bucladesine inhibits the reaction [BMP4 protein results in increased expression of SMAD6 mRNA]	20522807
D002945	Cisplatin	Cisplatin results in increased expression of BMP4 mRNA	21674241
D004008	Diclofenac	Diclofenac affects the expression of BMP4 mRNA	24752500
C027118	didecyldimethylammonium	didecyldimethylammonium results in decreased expression of BMP4 mRNA	23537712
D004051	Diethylhexyl Phthalate	Diethylhexyl Phthalate results in increased expression of BMP4 mRNA	22677342
D002117	Calcitriol	Calcitriol promotes the reaction [BMP4 protein results in increased expression of SOST mRNA]	15268896
D004147	Dioxins	Dioxins affects the expression of BMP4 mRNA	20463971
C001082	diphenylcresyl phosphate	diphenylcresyl phosphate affects the expression of BMP4 mRNA	25661707
D004317	Doxorubicin	Doxorubicin results in decreased expression of BMP4 mRNA	23956100
D004317	Doxorubicin	Doxorubicin affects the expression of BMP4 protein	17415656
D004492	Edetic Acid	[Edetic Acid inhibits the reaction [Calcium binds to MGP protein]] inhibits the reaction [MGP protein binds to BMP4 protein]	18369157
C070609	EMD 53998	EMD 53998 analog results in decreased expression of BMP4 mRNA	24977338
C045651	epigallocatechin gallate	[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of BMP4 mRNA	22079256
D000431	Ethanol	Ethanol results in decreased expression of BMP4 mRNA	28919490
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in decreased expression of BMP4 mRNA	16551644
D005031	Ethylenethiourea	Ethylenethiourea results in decreased expression of BMP4 mRNA	17161201\|1808271
D005231	Fatty Acids, Unsaturated	"Fatty Acids, Unsaturated results in increased expression of BMP4 mRNA"	16571146
D005419	Flavonoids	Flavonoids results in increased expression of BMP4 mRNA	18035473
C007738	fluoranthene	[Benzo(a)pyrene co-treated with fluoranthene] results in decreased expression of BMP4 mRNA	25412620
D005492	Folic Acid	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of BMP4 gene	20938992
D005620	Freund's Adjuvant	[Urethane co-treated with Freund's Adjuvant] results in increased expression of BMP4 mRNA	12400877
C039281	furan	furan results in decreased methylation of BMP4 gene	27387713
C039281	furan	furan results in increased expression of BMP4 mRNA	27387713
D019833	Genistein	Genistein results in increased expression of BMP4 mRNA	16169203
D005944	Glucosamine	Glucosamine promotes the reaction [IL1B results in decreased expression of BMP4 mRNA]	17109745
D005944	Glucosamine	Glucosamine results in decreased expression of BMP4 mRNA	17109745
C004312	glycidol	glycidol results in decreased expression of BMP4 mRNA	24915197
D017313	Fenretinide	Fenretinide results in increased expression of BMP4 mRNA	28973697
D006861	Hydrogen Peroxide	Hydrogen Peroxide results in decreased expression of BMP4 mRNA	12419474
D006861	Hydrogen Peroxide	Hydrogen Peroxide results in decreased expression of BMP4 mRNA	23562911
C056599	icariin	icariin results in increased expression of BMP4 mRNA	18295595
C056599	icariin	icariin results in increased expression of BMP4 mRNA	20019778
D016285	Iloprost	Iloprost inhibits the reaction [BMP4 protein results in increased expression of SMAD6 mRNA]	20522807
D016285	Iloprost	Iloprost promotes the reaction [BMP4 protein results in increased expression of ID1 mRNA]	20522807
D016285	Iloprost	Iloprost promotes the reaction [BMP4 protein results in increased expression of ID1 protein]	20522807
C082359	imidacloprid	imidacloprid results in decreased expression of BMP4 mRNA	27444676\|2779232
C016517	indole-3-carbinol	indole-3-carbinol affects the expression of BMP4 mRNA	21396975
D015759	Ionomycin	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of BMP4 mRNA	25613284
D015056	1-Methyl-3-isobutylxanthine	[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in decreased expression of BMP4 mRNA	16054899
C544151	jinfukang	jinfukang results in increased expression of BMP4 mRNA	27392435
C410337	K 7174	K 7174 results in decreased expression of BMP4 mRNA	24086573
C006552	kaempferol	kaempferol results in increased expression of BMP4 mRNA	23989061
C008261	lead acetate	[sodium arsenite co-treated with Cadmium Chloride co-treated with chromic oxide co-treated with chromous chloride co-treated with lead acetate] results in increased expression of BMP4 mRNA	12634122
C008261	lead acetate	lead acetate results in decreased expression of BMP4 mRNA	22613225
D008044	Linuron	Linuron results in decreased expression of BMP4 mRNA	12730624
C482199	lipopolysaccharide, E coli O55-B5	"Betamethasone inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in decreased expression of BMP4 protein]"	22693607
C482199	lipopolysaccharide, E coli O55-B5	"lipopolysaccharide, E coli O55-B5 results in decreased expression of BMP4 mRNA"	22693607
C482199	lipopolysaccharide, E coli O55-B5	"lipopolysaccharide, E coli O55-B5 results in decreased expression of BMP4 protein"	22693607
D018021	Lithium Chloride	Lithium Chloride results in increased expression of BMP4 mRNA	15711924
D008344	Maneb	[LRRK2 protein mutant form co-treated with Maneb co-treated with Paraquat] results in decreased expression of BMP4 mRNA	23017109
D008344	Maneb	[SNCA protein co-treated with Maneb co-treated with Paraquat] results in decreased expression of BMP4 mRNA	23017109
C025340	manganese chloride	manganese chloride results in increased expression of BMP4 mRNA	17467022
C042720	mercuric bromide	mercuric bromide results in increased expression of BMP4 mRNA	26272509
C042720	mercuric bromide	"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of BMP4 mRNA"	27188386
D019216	Metals, Heavy	"Metals, Heavy results in increased expression of BMP4 mRNA"	12773770
D008715	Methionine	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of BMP4 gene	20938992
D008727	Methotrexate	BMP4 mRNA results in decreased susceptibility to Methotrexate	20008919
D008727	Methotrexate	Methotrexate affects the expression of BMP4 mRNA	18502557
D008748	Methylcholanthrene	Methylcholanthrene results in decreased expression of BMP4 mRNA	29094188
C004925	methylmercuric chloride	methylmercuric chloride results in decreased expression of BMP4 mRNA	23179753
C004925	methylmercuric chloride	methylmercuric chloride results in increased expression of BMP4 mRNA	28001369
D008741	Methyl Methanesulfonate	Methyl Methanesulfonate results in decreased expression of BMP4 mRNA	26011545
D008769	Methylnitronitrosoguanidine	Methylnitronitrosoguanidine results in decreased expression of BMP4 mRNA	12773770
C008493	methylselenic acid	methylselenic acid results in increased expression of BMP4 mRNA	12517777
D016685	Mitomycin	Mitomycin results in decreased expression of BMP4 mRNA	12760830
D037742	Nanotubes, Carbon	"Nanotubes, Carbon analog results in decreased expression of BMP4 mRNA"	25554681
D037742	Nanotubes, Carbon	"Nanotubes, Carbon results in decreased expression of BMP4 mRNA"	25554681
C005274	naringin	naringin results in increased expression of BMP4 mRNA	24915843
C029938	nickel sulfate	nickel sulfate results in increased expression of BMP4 mRNA	22714537
D009538	Nicotine	Nicotine results in decreased expression of BMP4 mRNA	20339300
C007350	nitrofen	nitrofen results in decreased expression of BMP4 mRNA	17270562\|1828029
C025589	ochratoxin A	ochratoxin A results in increased acetylation of BMP4 promoter	29098329
C025589	ochratoxin A	[ochratoxin A results in increased acetylation of BMP4 promoter] which results in increased expression of BMP4 mRNA	29098329\|2909832
C025589	ochratoxin A	ochratoxin A results in increased expression of BMP4 mRNA	29098329
D015282	Octreotide	Octreotide promotes the reaction [BMP4 protein results in increased expression of ID1 mRNA]	23137853
D009966	Orphenadrine	Orphenadrine affects the expression of BMP4 mRNA	23665939
C030110	oxaliplatin	[oxaliplatin co-treated with Topotecan] results in increased expression of BMP4 mRNA	25729387
C030110	oxaliplatin	oxaliplatin results in increased expression of BMP4 mRNA	25729387
D010126	Ozone	[Ozone co-treated with Chlorine] results in increased expression of BMP4 mRNA	18636392
D017239	Paclitaxel	Paclitaxel results in decreased expression of BMP4 mRNA	23956100
C496932	panobinostat	"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of BMP4 mRNA"	27188386
C496932	panobinostat	panobinostat results in increased expression of BMP4 mRNA	26272509
D010269	Paraquat	[LRRK2 protein mutant form co-treated with Maneb co-treated with Paraquat] results in decreased expression of BMP4 mRNA	23017109
D010269	Paraquat	[SNCA protein co-treated with Maneb co-treated with Paraquat] results in decreased expression of BMP4 mRNA	23017109
D010269	Paraquat	Paraquat results in decreased expression of BMP4 mRNA	18198484
C084656	paricalcitol	[Phosphorus co-treated with paricalcitol] results in increased expression of BMP4 mRNA	17715259
D052638	Particulate Matter	Particulate Matter results in decreased expression of BMP4 mRNA	23085030
C517782	pasireotide	pasireotide promotes the reaction [BMP4 protein results in increased expression of ID1 mRNA]	23137853
D010416	Pentachlorophenol	Pentachlorophenol results in increased expression of BMP4 mRNA	24642059
C076994	perfluorooctane sulfonic acid	perfluorooctane sulfonic acid results in increased expression of BMP4 mRNA	23562911
D010662	Phenylmercuric Acetate	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of BMP4 mRNA"	27188386
D010662	Phenylmercuric Acetate	Phenylmercuric Acetate results in increased expression of BMP4 mRNA	26272509
D010672	Phenytoin	Phenytoin results in increased expression of BMP4 mRNA	16141649
D010758	Phosphorus	[Phosphorus co-treated with paricalcitol] results in increased expression of BMP4 mRNA	17715259
D010862	Pilocarpine	Pilocarpine results in decreased expression of BMP4 mRNA	17971868
D010862	Pilocarpine	Pilocarpine results in increased expression of BMP4 mRNA	17971868
C049032	pinosylvin	[pinosylvin affects the localization of and results in decreased activity of CTNNB1 protein] which results in decreased expression of BMP4 mRNA	23333577
C027373	potassium chromate(VI)	[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of BMP4 mRNA	22079256
C027373	potassium chromate(VI)	potassium chromate(VI) results in decreased expression of BMP4 mRNA	22079256
C045362	prochloraz	prochloraz results in decreased expression of BMP4 mRNA	21470553
D011374	Progesterone	BMP4 protein results in decreased abundance of Progesterone	21072679
D011374	Progesterone	BMP4 protein inhibits the reaction [FSHB protein results in increased secretion of Progesterone]	15591037
D011374	Progesterone	BMP4 protein results in decreased secretion of Progesterone	15591037
D011374	Progesterone	[BMP4 protein results in decreased expression of STAR mRNA] inhibits the reaction [FSHB protein results in increased abundance of Progesterone]	22067323
D011374	Progesterone	GH1 protein inhibits the reaction [BMP4 protein inhibits the reaction [FSHB protein results in increased abundance of Progesterone]]	22067323
D011374	Progesterone	IGF1 protein inhibits the reaction [BMP4 protein inhibits the reaction [FSHB protein results in increased abundance of Progesterone]]	22067323
C043680	ptaquiloside	[ptaquiloside co-treated with Sodium Selenite] results in decreased expression of BMP4 mRNA	23274088
C513428	pyrachlostrobin	pyrachlostrobin results in increased expression of BMP4 mRNA	27029645
D011794	Quercetin	Quercetin results in decreased expression of BMP4 mRNA	21632981
C059514	resveratrol	resveratrol results in increased expression of BMP4 mRNA	25888808
C059514	resveratrol	resveratrol inhibits the reaction [BMP4 protein results in increased expression of VEGFA mRNA]	24435444
C059514	resveratrol	resveratrol inhibits the reaction [BMP4 protein results in increased secretion of VEGFA protein]	24435444
C009166	retinol acetate	retinol acetate results in increased expression of BMP4 mRNA	16772331
D012293	Rifampin	[Rifampin co-treated with NR1I2 protein] results in increased expression of BMP4 mRNA	21127053
C089730	rosiglitazone	[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in decreased expression of BMP4 mRNA	16054899
C025759	saikosaponin	saikosaponin inhibits the reaction [BMP4 protein results in increased expression of ACTA2 protein]	23969230
C025759	saikosaponin	saikosaponin results in decreased expression of BMP4 mRNA	23969230
C025759	saikosaponin	saikosaponin results in decreased expression of BMP4 protein	23969230
D012715	Sesame Oil	Sesame Oil results in decreased expression of BMP4 mRNA	29191790
D012822	Silicon Dioxide	Silicon Dioxide analog results in decreased expression of BMP4 mRNA	25895662
D012834	Silver	Silver results in decreased expression of BMP4 mRNA	26014281
D012834	Silver	Silver results in increased expression of BMP4 mRNA	27131904
C017947	sodium arsenite	[sodium arsenite co-treated with Cadmium Chloride co-treated with chromic oxide co-treated with chromous chloride co-treated with lead acetate] results in increased expression of BMP4 mRNA	12634122
C017947	sodium arsenite	sodium arsenite results in decreased expression of BMP4 mRNA	19615344
C017947	sodium arsenite	sodium arsenite results in increased expression of BMP4 mRNA	12634122\|1276083
C017947	sodium arsenite	sodium arsenite results in increased expression of BMP4 mRNA	16014739
C016104	sodium bichromate	sodium bichromate results in decreased expression of BMP4 mRNA	12760830
C032706	sodium chlorate	sodium chlorate results in decreased expression of BMP4 mRNA	12922982
D018038	Sodium Selenite	Sodium Selenite results in decreased expression of BMP4 mRNA	24383545
D018038	Sodium Selenite	[ptaquiloside co-treated with Sodium Selenite] results in decreased expression of BMP4 mRNA	23274088
D018038	Sodium Selenite	Sodium Selenite results in decreased expression of BMP4 mRNA	23274088
C525422	SRT1720	SRT1720 inhibits the reaction [BMP4 protein results in increased expression of VEGFA mRNA]	24435444
C525422	SRT1720	SRT1720 inhibits the reaction [BMP4 protein results in increased secretion of VEGFA protein]	24435444
C105686	SU 5402	SU 5402 results in increased expression of BMP4 mRNA	12421715
D013739	Testosterone	Testosterone affects the expression of BMP4 mRNA	20403060
D013739	Testosterone	Testosterone results in decreased expression of BMP4 mRNA	22138414
C020806	tetrabromobisphenol A	tetrabromobisphenol A results in decreased expression of BMP4 mRNA	25172293
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the localization of BMP4 protein	18477685
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of BMP4 mRNA	19684285
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of BMP4 mRNA	19684285\|2010694
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of BMP4 mRNA	21570461
D013749	Tetrachlorodibenzodioxin	[Tetrachlorodibenzodioxin co-treated with EGF protein] results in increased expression of BMP4 mRNA	16054899
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of BMP4 mRNA	18691609\|1977048
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased secretion of BMP4 protein	26572662
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of BMP4 mRNA	16054899\|1758670
D013755	Tetradecanoylphorbol Acetate	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of BMP4 mRNA	25613284
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution results in increased expression of BMP4 mRNA	28065790
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution results in increased expression of BMP4 mRNA	28111298
D019772	Topotecan	[oxaliplatin co-treated with Topotecan] results in increased expression of BMP4 mRNA	25729387
D019772	Topotecan	Topotecan results in increased expression of BMP4 mRNA	25729387
D014212	Tretinoin	Tretinoin promotes the reaction [BMP4 protein results in increased expression of SOST mRNA]	15268896
D014212	Tretinoin	Tretinoin results in increased expression of BMP4 mRNA	17196394
D014212	Tretinoin	Tretinoin affects the expression of BMP4	10862743
D014212	Tretinoin	Tretinoin results in decreased activity of BMP4 protein	16818722
D014212	Tretinoin	Tretinoin results in decreased expression of BMP4 mRNA	15996115\|1660451
D014212	Tretinoin	Tretinoin results in increased expression of BMP4 mRNA	16195406\|1870356
D014212	Tretinoin	Tretinoin results in increased expression of BMP4 protein	16195406
C011559	tributyltin	tributyltin results in increased expression of BMP4 mRNA	27614199
C012589	trichostatin A	"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of BMP4 mRNA"	27188386
C012589	trichostatin A	trichostatin A results in increased expression of BMP4 mRNA	24935251\|2627250
C012589	trichostatin A	trichostatin A results in increased expression of BMP4 mRNA	23562654
C005445	triphenyl phosphate	triphenyl phosphate results in decreased expression of BMP4 mRNA	25661707
C016805	tris(1,3-dichloro-2-propyl)phosphate	"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of BMP4 mRNA"	26179874
C101044	tyrphostin AG 1478	tyrphostin AG 1478 inhibits the reaction [antimonite results in decreased expression of BMP4 mRNA]	17400267
C101044	tyrphostin AG 1478	tyrphostin AG 1478 inhibits the reaction [arsenite results in decreased expression of BMP4 mRNA]	17400267
D014520	Urethane	Urethane results in decreased expression of BMP4 mRNA	28818685
D014520	Urethane	[Urethane co-treated with Freund's Adjuvant] results in increased expression of BMP4 mRNA	12400877
D014635	Valproic Acid	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of BMP4 mRNA"	27188386
D014635	Valproic Acid	Valproic Acid results in increased expression of BMP4 mRNA	23179753\|2438349
D014635	Valproic Acid	Valproic Acid results in increased expression of BMP4 mRNA	19136453
D014635	Valproic Acid	Valproic Acid results in increased expression of BMP4 mRNA	23562654
D000068756	Valsartan	Valsartan inhibits the reaction [AGT protein results in decreased expression of BMP4 mRNA]	19225232
C025643	vinclozolin	vinclozolin affects the expression of BMP4 mRNA	19015723
D014800	Vitallium	Vitallium analog results in decreased expression of BMP4 mRNA	23825117
D014801	Vitamin A	Vitamin A results in increased expression of BMP4 mRNA	16571146
D014801	Vitamin A	Vitamin A affects the expression of BMP4 mRNA	16120438
D014810	Vitamin E	Vitamin E results in increased expression of BMP4 mRNA	19244175
C111237	vorinostat	vorinostat results in increased expression of BMP4 mRNA	26272509

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005125	cytokine activity	-	IBA	21873635
GO:0005125	cytokine activity	-	IDA	14749725
GO:0005160	transforming growth factor beta receptor binding	-	IBA	21873635
GO:0005515	protein binding	-	IPI	8413626 8752214 12045205 18339631 20505824 20860622 21054789
GO:0008083	growth factor activity	-	IEA	-
GO:0008201	heparin binding	-	IEA	-
GO:0039706	co-receptor binding	-	IPI	16604073
GO:0042056	chemoattractant activity	-	IDA	12631064
GO:0070700	BMP receptor binding	-	IBA	21873635
GO:0070700	BMP receptor binding	-	IDA	7811286

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0000122	negative regulation of transcription by RNA polymerase II	-	IBA	21873635
GO:0000122	negative regulation of transcription by RNA polymerase II	-	IDA	9187146
GO:0000122	negative regulation of transcription by RNA polymerase II	-	ISS	-
GO:0000186	activation of MAPKK activity	-	IDA	17600318 17992660
GO:0001649	osteoblast differentiation	-	IDA	17720811
GO:0001657	ureteric bud development	-	IDA	12141440
GO:0001658	branching involved in ureteric bud morphogenesis	-	IDA	12631064
GO:0001822	kidney development	-	IMP	18305125
GO:0001823	mesonephros development	-	IEP	18437684
GO:0001843	neural tube closure	-	IEA	-
GO:0001934	positive regulation of protein phosphorylation	-	IDA	14749725
GO:0001938	positive regulation of endothelial cell proliferation	-	IDA	17992660
GO:0001958	endochondral ossification	-	ISS	-
GO:0002043	blood vessel endothelial cell proliferation involved in sprouting angiogenesis	-	IDA	18787191
GO:0002062	chondrocyte differentiation	-	ISS	-
GO:0002244	hematopoietic progenitor cell differentiation	-	IDA	15451575
GO:0002320	lymphoid progenitor cell differentiation	-	IMP	12421925
GO:0003014	renal system process	-	IEA	-
GO:0003130	BMP signaling pathway involved in heart induction	-	IMP	20702560
GO:0003139	secondary heart field specification	-	IMP	20702560
GO:0003148	outflow tract septum morphogenesis	-	ISS	-
GO:0003149	membranous septum morphogenesis	-	ISS	-
GO:0003150	muscular septum morphogenesis	NOT	ISS	-
GO:0003180	aortic valve morphogenesis	-	ISS	-
GO:0003184	pulmonary valve morphogenesis	-	ISS	-
GO:0003197	endocardial cushion development	-	ISS	-
GO:0003198	epithelial to mesenchymal transition involved in endocardial cushion formation	NOT	ISS	-
GO:0003215	cardiac right ventricle morphogenesis	NOT	ISS	-
GO:0003277	apoptotic process involved in endocardial cushion morphogenesis	NOT	ISS	-
GO:0003279	cardiac septum development	-	TAS	18076106
GO:0003323	type B pancreatic cell development	-	IDA	11865031
GO:0003337	mesenchymal to epithelial transition involved in metanephros morphogenesis	-	IDA	10706139
GO:0007182	common-partner SMAD protein phosphorylation	-	IDA	20573232
GO:0007224	smoothened signaling pathway	-	IEP	17850284
GO:0007281	germ cell development	-	IEA	-
GO:0007492	endoderm development	-	IEA	-
GO:0007500	mesodermal cell fate determination	-	IEA	-
GO:0008284	positive regulation of cell proliferation	-	IDA	15516325
GO:0008285	negative regulation of cell proliferation	-	IDA	9187146
GO:0009791	post-embryonic development	-	IDA	8674409
GO:0009948	anterior/posterior axis specification	-	IEA	-
GO:0010159	specification of animal organ position	-	IEA	-
GO:0010453	regulation of cell fate commitment	-	IDA	18823971
GO:0010469	regulation of signaling receptor activity	-	IEA	-
GO:0010595	positive regulation of endothelial cell migration	-	IDA	17992660
GO:0010628	positive regulation of gene expression	-	IDA	24906886 28124060
GO:0010629	negative regulation of gene expression	-	IDA	28124060
GO:0010718	positive regulation of epithelial to mesenchymal transition	-	IEA	-
GO:0010862	positive regulation of pathway-restricted SMAD protein phosphorylation	-	IBA	21873635
GO:0010862	positive regulation of pathway-restricted SMAD protein phosphorylation	-	IDA	9389648 16816361 17244894 20559569
GO:0010862	positive regulation of pathway-restricted SMAD protein phosphorylation	-	IMP	17992660
GO:0010942	positive regulation of cell death	-	IDA	8674409
GO:0021537	telencephalon development	-	IDA	9187146
GO:0021904	dorsal/ventral neural tube patterning	-	IEA	-
GO:0021978	telencephalon regionalization	-	IEA	-
GO:0021983	pituitary gland development	-	IEA	-
GO:0030218	erythrocyte differentiation	-	IEA	-
GO:0030224	monocyte differentiation	-	IDA	21149635
GO:0030225	macrophage differentiation	-	IDA	21149635
GO:0030501	positive regulation of bone mineralization	-	IDA	14749725 18436533
GO:0030509	BMP signaling pathway	-	IBA	21873635
GO:0030509	BMP signaling pathway	-	IDA	9389648 18436533
GO:0030509	BMP signaling pathway	-	IMP	17472960 18326817
GO:0030513	positive regulation of BMP signaling pathway	-	ISS	-
GO:0032092	positive regulation of protein binding	-	IDA	23610558
GO:0032331	negative regulation of chondrocyte differentiation	-	IEA	-
GO:0032967	positive regulation of collagen biosynthetic process	-	IDA	17720811
GO:0033085	negative regulation of T cell differentiation in thymus	-	IMP	12421925
GO:0033088	negative regulation of immature T cell proliferation in thymus	-	IMP	12421925
GO:0034504	protein localization to nucleus	-	IDA	17244894
GO:0035116	embryonic hindlimb morphogenesis	-	IEA	-
GO:0035990	tendon cell differentiation	-	ISS	-
GO:0035993	deltoid tuberosity development	-	ISS	-
GO:0042306	regulation of protein import into nucleus	-	IDA	22529382
GO:0042326	negative regulation of phosphorylation	-	IDA	17244894
GO:0042475	odontogenesis of dentin-containing tooth	-	IEA	-
GO:0042476	odontogenesis	-	IGI	11023873
GO:0042487	regulation of odontogenesis of dentin-containing tooth	-	IEA	-
GO:0042733	embryonic digit morphogenesis	-	IEA	-
GO:0042981	regulation of apoptotic process	-	IBA	21873635
GO:0043065	positive regulation of apoptotic process	-	IDA	9187146 10706139
GO:0043066	negative regulation of apoptotic process	-	IBA	21873635
GO:0043066	negative regulation of apoptotic process	-	IDA	17992660
GO:0043401	steroid hormone mediated signaling pathway	-	IMP	17244894
GO:0043407	negative regulation of MAP kinase activity	-	IDA	17244894
GO:0043408	regulation of MAPK cascade	-	IBA	21873635
GO:0043687	post-translational protein modification	-	TAS	-
GO:0044267	cellular protein metabolic process	-	TAS	-
GO:0045603	positive regulation of endothelial cell differentiation	-	IEA	-
GO:0045606	positive regulation of epidermal cell differentiation	-	IDA	18823971
GO:0045662	negative regulation of myoblast differentiation	-	IDA	14749725
GO:0045666	positive regulation of neuron differentiation	-	IEA	-
GO:0045669	positive regulation of osteoblast differentiation	-	IDA	14749725 18436533
GO:0045778	positive regulation of ossification	-	IDA	14749725
GO:0045786	negative regulation of cell cycle	-	IDA	11502704
GO:0045839	negative regulation of mitotic nuclear division	-	IDA	17244894
GO:0045843	negative regulation of striated muscle tissue development	-	IDA	14749725
GO:0045892	negative regulation of transcription, DNA-templated	-	IDA	10706139 12631064 17244894
GO:0045893	positive regulation of transcription, DNA-templated	-	IDA	10021330 17600318 17992660
GO:0045944	positive regulation of transcription by RNA polymerase II	-	IDA	9187146 15516325
GO:0045944	positive regulation of transcription by RNA polymerase II	-	IGI	18326817
GO:0045944	positive regulation of transcription by RNA polymerase II	-	ISS	-
GO:0048286	lung alveolus development	-	IDA	8674409
GO:0048392	intermediate mesodermal cell differentiation	-	IDA	10021330
GO:0048468	cell development	-	IBA	21873635
GO:0048661	positive regulation of smooth muscle cell proliferation	-	IDA	10706139 17600318
GO:0048663	neuron fate commitment	-	IEA	-
GO:0048701	embryonic cranial skeleton morphogenesis	-	IEA	-
GO:0048745	smooth muscle tissue development	-	ISS	-
GO:0048754	branching morphogenesis of an epithelial tube	-	IDA	10706139
GO:0050679	positive regulation of epithelial cell proliferation	-	IDA	11865031
GO:0050680	negative regulation of epithelial cell proliferation	-	IEA	-
GO:0050918	positive chemotaxis	-	IEA	-
GO:0051150	regulation of smooth muscle cell differentiation	-	IEA	-
GO:0055007	cardiac muscle cell differentiation	-	IEA	-
GO:0055020	positive regulation of cardiac muscle fiber development	-	IMP	20702560
GO:0060113	inner ear receptor cell differentiation	-	IEA	-
GO:0060197	cloacal septation	-	IEA	-
GO:0060235	lens induction in camera-type eye	-	IEA	-
GO:0060272	embryonic skeletal joint morphogenesis	-	IEA	-
GO:0060363	cranial suture morphogenesis	-	IEA	-
GO:0060391	positive regulation of SMAD protein signal transduction	-	IDA	9389648
GO:0060393	regulation of pathway-restricted SMAD protein phosphorylation	-	IDA	18787191
GO:0060395	SMAD protein signal transduction	-	IBA	21873635
GO:0060395	SMAD protein signal transduction	-	IDA	17244894
GO:0060425	lung morphogenesis	-	IDA	8674409
GO:0060433	bronchus development	-	IDA	8674409
GO:0060438	trachea development	-	IDA	8674409
GO:0060440	trachea formation	-	IEA	-
GO:0060441	epithelial tube branching involved in lung morphogenesis	-	IDA	8674409
GO:0060442	branching involved in prostate gland morphogenesis	-	IEA	-
GO:0060449	bud elongation involved in lung branching	-	IEA	-
GO:0060502	epithelial cell proliferation involved in lung morphogenesis	-	IDA	8674409
GO:0060503	bud dilation involved in lung branching	-	IDA	8674409
GO:0060548	negative regulation of cell death	-	IDA	12631064
GO:0060592	mammary gland formation	-	IEA	-
GO:0060684	epithelial-mesenchymal cell signaling	-	IEA	-
GO:0060686	negative regulation of prostatic bud formation	-	IEA	-
GO:0060687	regulation of branching involved in prostate gland morphogenesis	-	IEA	-
GO:0060976	coronary vasculature development	-	ISS	-
GO:0061036	positive regulation of cartilage development	-	IDA	3201241
GO:0061047	positive regulation of branching involved in lung morphogenesis	-	ISS	-
GO:0061149	BMP signaling pathway involved in ureter morphogenesis	-	ISS	-
GO:0061151	BMP signaling pathway involved in renal system segmentation	-	ISS	-
GO:0061155	pulmonary artery endothelial tube morphogenesis	-	IDA	17992660
GO:0061312	BMP signaling pathway involved in heart development	-	ISS	-
GO:0061626	pharyngeal arch artery morphogenesis	-	ISS	-
GO:0070244	negative regulation of thymocyte apoptotic process	-	IMP	12421925
GO:0070374	positive regulation of ERK1 and ERK2 cascade	-	IEA	-
GO:0071773	cellular response to BMP stimulus	-	IMP	18326817
GO:0071893	BMP signaling pathway involved in nephric duct formation	-	IDA	10021330
GO:0072001	renal system development	-	IEP	17850284
GO:0072015	glomerular visceral epithelial cell development	-	IEA	-
GO:0072097	negative regulation of branch elongation involved in ureteric bud branching by BMP signaling pathway	-	IDA	10706139 17118062
GO:0072101	specification of ureteric bud anterior/posterior symmetry by BMP signaling pathway	-	IDA	10706139 17118062
GO:0072104	glomerular capillary formation	-	ISS	-
GO:0072125	negative regulation of glomerular mesangial cell proliferation	-	IDA	17244894
GO:0072138	mesenchymal cell proliferation involved in ureteric bud development	-	IEA	-
GO:0072161	mesenchymal cell differentiation involved in kidney development	-	IEA	-
GO:0072192	ureter epithelial cell differentiation	-	ISS	-
GO:0072193	ureter smooth muscle cell differentiation	-	ISS	-
GO:0072198	mesenchymal cell proliferation involved in ureter development	-	IEA	-
GO:0072200	negative regulation of mesenchymal cell proliferation involved in ureter development	-	IDA	12399320
GO:0072205	metanephric collecting duct development	-	ISS	-
GO:0090184	positive regulation of kidney development	-	IDA	10021330
GO:0090191	negative regulation of branching involved in ureteric bud morphogenesis	-	IDA	12141440 17118062
GO:0090194	negative regulation of glomerulus development	-	IDA	12141440
GO:1901964	positive regulation of cell proliferation involved in outflow tract morphogenesis	-	ISS	-
GO:1902893	regulation of pri-miRNA transcription by RNA polymerase II	NOT	IMP	18548003
GO:1902894	negative regulation of pri-miRNA transcription by RNA polymerase II	-	IDA	28124060
GO:1903800	positive regulation of production of miRNAs involved in gene silencing by miRNA	-	IDA	18548003
GO:1905072	cardiac jelly development	NOT	ISS	-
GO:1905312	positive regulation of cardiac neural crest cell migration involved in outflow tract morphogenesis	-	IEA	-
GO:2000005	negative regulation of metanephric S-shaped body morphogenesis	-	IDA	12141440
GO:2000007	negative regulation of metanephric comma-shaped body morphogenesis	-	IDA	12141440
GO:2000137	negative regulation of cell proliferation involved in heart morphogenesis	-	IMP	20702560
GO:2001237	negative regulation of extrinsic apoptotic signaling pathway	-	ISS	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005576	extracellular region	-	ISS	-
GO:0005576	extracellular region	-	TAS	-
GO:0005615	extracellular space	-	IBA	21873635
GO:0005615	extracellular space	-	IDA	16604073
GO:0005615	extracellular space	-	ISS	-
GO:0005788	endoplasmic reticulum lumen	-	TAS	-

KEGG ID	KEGG Term
hsa04340	Hedgehog signaling pathway
hsa04350	TGF-beta signaling pathway
hsa05200	Pathways in cancer
hsa05217	Basal cell carcinoma

Reactome ID	Reactome Term	Evidence
R-HSA-1474244	Extracellular matrix organization	TAS
R-HSA-1566948	Elastic fibre formation	TAS
R-HSA-2129379	Molecules associated with elastic fibres	TAS
R-HSA-381426	Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)	TAS
R-HSA-392499	Metabolism of proteins	TAS
R-HSA-597592	Post-translational protein modification	TAS
R-HSA-8957275	Post-translational protein phosphorylation	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
25303326	Joint testing of genotypic and gene-environment interaction identified novel association for BMP4 with non-syndromic CL/P in an Asian population using data from an International Cleft Consortium. (2014)	Chen Q	PLoS One
24977008	Remodeling of rat pulmonary artery induced by chronic smoking exposure. (2014 Jun)	Zhao L	J Thorac Dis
28852126	Decrease of FSTL1-BMP4-Smad signaling predicts poor prognosis in lung adenocarcinoma but not in squamous cell carcinoma. (2017 Aug 29)	Chiou J	Sci Rep
23232839	Endothelial dysfunction in diabetes and hypertension: cross talk in RAS, BMP4, and ROS-dependent COX-2-derived prostanoids. (2013 Mar)	Wong WT	J Cardiovasc Pharmacol
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