Gene: SLC4A1

6521
AE1|BND3|CD233|CHC|DI|EMPB3|EPB3|FR|RTA1A|SAO|SPH4|SW|WD|WD1|WR
solute carrier family 4 member 1 (Diego blood group)
protein-coding
17q21.31
Ensembl:ENSG00000004939 MIM:109270 Vega:OTTHUMG00000156843 UniprotKB:P02730
NG_007498.1
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
6.428e-1 (AD)  6.793e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CA10.919
SPTA10.859
ALAS20.858
AHSP0.776
TRIM100.765
LILRA50.725
IL18RAP0.719
IFIT1B0.712
RETN0.709
LILRB20.708

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
MAGIX-0.535
SVOP-0.492
MYADML2-0.489
KCNC2-0.477
PRKCZ-0.475
CHRNA4-0.471
NEUROD6-0.471
EXTL1-0.47
FAM71E1-0.469
SLC32A1-0.469

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0067181,12-benzoperylene"1,12-benzoperylene results in decreased expression of SLC4A1 mRNA"26377693
C0264861,2,5,6-dibenzanthracene"1,2,5,6-dibenzanthracene results in decreased expression of SLC4A1 mRNA"26377693
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of SLC4A1 mRNA"20959002
C0223064,4'-dinitro-2,2'-stilbenedisulfonic acid"4,4'-dinitro-2,2'-stilbenedisulfonic acid inhibits the reaction [SLC4A1 protein results in increased transport of Chlorides]"2511191
D000082AcetaminophenAcetaminophen results in decreased expression of SLC4A1 mRNA26690555
D000082AcetaminophenAcetaminophen results in decreased expression of SLC4A1 mRNA17585979
D000111Acetylcysteine[Acetylcysteine co-treated with Atorvastatin Calcium] inhibits the reaction [sodium arsenite affects the localization of SLC4A1 protein]20946910
D000535Aluminum[APP protein modified form binds to Aluminum] which results in decreased expression of SLC4A1 mRNA21298039
D000643Ammonium ChlorideAmmonium Chloride affects the expression of SLC4A1 mRNA16483693
C059765amphotericin B, deoxycholate drug combination"amphotericin B, deoxycholate drug combination results in decreased expression of SLC4A1 mRNA"22863853
D000069059Atorvastatin Calcium[Acetylcysteine co-treated with Atorvastatin Calcium] inhibits the reaction [sodium arsenite affects the localization of SLC4A1 protein]20946910
D001280AtrazineAtrazine results in decreased expression of SLC4A1 mRNA25929836
C006703benzo(b)fluoranthenebenzo(b)fluoranthene results in increased expression of SLC4A1 mRNA26377693
C022921benzo(k)fluoranthenebenzo(k)fluoranthene results in increased expression of SLC4A1 mRNA26377693
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of SLC4A1 mRNA21569818|2222880
C110772benzoylcarbonyl-aspartyl-glutamyl-valyl-aspartyl-fluoromethyl ketonebenzoylcarbonyl-aspartyl-glutamyl-valyl-aspartyl-fluoromethyl ketone inhibits the reaction [[Hydrogen Peroxide co-treated with Cholesterol] affects the localization of SLC4A1 protein]20946910
C006780bisphenol Abisphenol A results in decreased expression of SLC4A1 mRNA25181051
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in increased degradation of SLC4A1 protein15040847
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of SLC4A1 mRNA25993096
D002712Chlorides"4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid inhibits the reaction [SLC4A1 protein results in increased transport of Chlorides]"2511191
D002712Chlorides"4,4'-dinitro-2,2'-stilbenedisulfonic acid inhibits the reaction [SLC4A1 protein results in increased transport of Chlorides]"2511191
D002712ChloridesDipyridamole inhibits the reaction [SLC4A1 protein results in increased transport of Chlorides]2511191
D002712ChloridesNiflumic Acid inhibits the reaction [SLC4A1 protein results in increased transport of Chlorides]2511191
D002712ChloridesSLC4A1 protein polymorphism affects the transport of Chlorides16227998
D002712ChloridesSLC4A1 protein results in increased transport of Chlorides2511191
D002712ChloridesSLC4A1 protein mutant form results in increased transport of Chlorides18480299
D002712ChloridesSLC4A1 protein results in increased transport of Chlorides18480299
D002784Cholesterolbenzoylcarbonyl-aspartyl-glutamyl-valyl-aspartyl-fluoromethyl ketone inhibits the reaction [[Hydrogen Peroxide co-treated with Cholesterol] affects the localization of SLC4A1 protein]20946910
D002784Cholesterol[Hydrogen Peroxide co-treated with Cholesterol] affects the localization of SLC4A1 protein20946910
D002994ClofibrateClofibrate results in increased expression of SLC4A1 mRNA17585979
D019327Copper SulfateCopper Sulfate results in increased expression of SLC4A1 mRNA19549813
D003907DexamethasoneDexamethasone results in decreased expression of SLC4A1 mRNA20032058
D003907DexamethasoneTestosterone inhibits the reaction [Dexamethasone results in decreased expression of SLC4A1 mRNA]20032058
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of SLC4A1 mRNA17361019|2126653
D003999Dichloroacetic AcidDichloroacetic Acid results in decreased expression of SLC4A1 mRNA28962523
D004008DiclofenacDiclofenac results in increased expression of SLC4A1 mRNA26934552
D004026DieldrinDieldrin results in increased expression of SLC4A1 mRNA20438755
D0178784,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid"4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid binds to SLC4A1 protein"2511191
D0178784,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid"4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid inhibits the reaction [SLC4A1 protein results in increased transport of Chlorides]"2511191
D004121Dimethyl SulfoxideDimethyl Sulfoxide affects the localization of and results in increased activity of SLC4A1 protein mutant form23460825
D004121Dimethyl SulfoxideDimethyl Sulfoxide results in increased expression of SLC4A1 protein mutant form23460825
D004176DipyridamoleDipyridamole inhibits the reaction [SLC4A1 protein results in increased transport of Chlorides]2511191
D005038EthylnitrosoureaEthylnitrosourea results in increased mutagenesis of SLC4A1 gene16724327
C069837fullerene C60fullerene C60 results in decreased expression of SLC4A1 mRNA19167457
C039281furanfuran results in decreased expression of SLC4A1 mRNA26194646
D005663FuransFurans analog inhibits the reaction [Glucose results in increased expression of SLC4A1 protein]28911973
D005839GentamicinsGentamicins results in decreased expression of SLC4A1 mRNA22061828
D005947GlucoseFurans analog inhibits the reaction [Glucose results in increased expression of SLC4A1 protein]28911973
D005947GlucoseGlucose results in increased expression of SLC4A1 protein28911973
D005990GlycerolGlycerol affects the localization of SLC4A1 protein mutant form23460825
D006861Hydrogen Peroxidebenzoylcarbonyl-aspartyl-glutamyl-valyl-aspartyl-fluoromethyl ketone inhibits the reaction [[Hydrogen Peroxide co-treated with Cholesterol] affects the localization of SLC4A1 protein]20946910
D006861Hydrogen Peroxide[Hydrogen Peroxide co-treated with Cholesterol] affects the localization of SLC4A1 protein20946910
C008261lead acetatelead acetate results in increased expression of SLC4A1 mRNA22641619
C569105lumacaftorlumacaftor affects the localization of SLC4A1 protein mutant form23460825
C569105lumacaftorlumacaftor results in increased expression of SLC4A1 protein mutant form23460825
D008727MethotrexateMethotrexate results in decreased expression of SLC4A1 mRNA24136188
D008731MethoxychlorMethoxychlor results in increased methylation of SLC4A1 gene23303685
C008461methyl isocyanatemethyl isocyanate binds to and results in increased degradation of SLC4A1 protein8935787
D037742Nanotubes, Carbon"Nanotubes, Carbon affects the expression of SLC4A1 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon affects the expression of SLC4A1 protein"21135415
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of SLC4A1 mRNA"25554681
C017096n-butoxyethanoln-butoxyethanol results in increased expression of SLC4A1 mRNA19812364
C028007nickel monoxidenickel monoxide results in decreased expression of SLC4A1 mRNA19167457
D009544Niflumic AcidNiflumic Acid inhibits the reaction [SLC4A1 protein results in increased transport of Chlorides]2511191
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in decreased expression of SLC4A1 mRNA25729387
C030110oxaliplatinoxaliplatin results in decreased expression of SLC4A1 mRNA25729387
D010396PenicillaminePenicillamine results in decreased expression of SLC4A1 mRNA19575532
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in decreased expression of SLC4A1 mRNA17560707
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in increased expression of SLC4A1 mRNA18692542
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of SLC4A1 mRNA19710929
D011188PotassiumSLC4A1 protein polymorphism affects the transport of Potassium16227998
D011192Potassium DichromatePotassium Dichromate results in decreased expression of SLC4A1 mRNA23608068
D011441PropylthiouracilPropylthiouracil results in decreased expression of SLC4A1 mRNA24780913
D011522ProtonsSLC4A1 protein results in increased transport of Protons18480299
C059514resveratrol[resveratrol results in increased activity of CASP3 protein] which affects the activity of SLC4A1 protein20536388
C059514resveratrolresveratrol results in increased expression of SLC4A1 protein24526417
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of SLC4A1 mRNA25895662
D012964SodiumSLC4A1 protein polymorphism affects the transport of Sodium16227998
C017947sodium arsenite[Acetylcysteine co-treated with Atorvastatin Calcium] inhibits the reaction [sodium arsenite affects the localization of SLC4A1 protein]20946910
C017947sodium arsenitesodium arsenite affects the localization of SLC4A1 protein20946910
D053260SootSoot affects the expression of SLC4A1 mRNA26551751
D013431SulfatesSLC4A1 protein polymorphism results in decreased transport of Sulfates16227998
D013431SulfatesSLC4A1 protein mutant form results in increased transport of Sulfates18480299
D013431SulfatesSLC4A1 protein results in increased transport of Sulfates18480299
D013739TestosteroneTestosterone inhibits the reaction [Dexamethasone results in decreased expression of SLC4A1 mRNA]20032058
C020806tetrabromobisphenol Atetrabromobisphenol A results in decreased expression of SLC4A1 mRNA27914987
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of SLC4A1 mRNA22298810
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of SLC4A1 mRNA20959002
C009495titanium dioxidetitanium dioxide results in decreased expression of SLC4A1 mRNA23409001
C009495titanium dioxidetitanium dioxide results in increased expression of SLC4A1 mRNA23557971
D014028Tobacco Smoke PollutionTobacco Smoke Pollution affects the expression of SLC4A1 mRNA20133372
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in decreased expression of SLC4A1 mRNA25729387
D019772TopotecanTopotecan results in decreased expression of SLC4A1 mRNA25729387
D014212TretinoinTretinoin results in decreased expression of SLC4A1 mRNA23724009
C012589trichostatin Atrichostatin A results in decreased expression of SLC4A1 mRNA15901671
C406224valdecoxibvaldecoxib results in decreased expression of SLC4A1 mRNA24136188
D014635Valproic AcidValproic Acid results in decreased expression of SLC4A1 mRNA15901671
D014635Valproic AcidValproic Acid results in increased methylation of SLC4A1 gene29154799
D014640VancomycinVancomycin results in increased expression of SLC4A1 mRNA18930951

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005452inorganic anion exchanger activity-IDA24121512  
GO:0005452inorganic anion exchanger activity-TAS-  
GO:0005515protein binding-IPI15811326  16669616  19438409  25012180  26049106  26823170  
GO:0008509anion transmembrane transporter activity-IBA21873635  
GO:0008509anion transmembrane transporter activity-TAS4027230  
GO:0015106bicarbonate transmembrane transporter activity-IDA24121512  
GO:0015108chloride transmembrane transporter activity-ISS-  
GO:0015301anion:anion antiporter activity-IDA14734552  
GO:0030506ankyrin binding-IPI379653  
GO:0042803protein homodimerization activity-IPI379653  
GO:0043495protein membrane anchor-TAS10950304  
GO ID GO Term Qualifier Evidence PubMed
GO:0006820anion transport-IDA14734552  
GO:0006821chloride transport-ISS-  
GO:0006873cellular ion homeostasis-TAS8841202  
GO:0015701bicarbonate transport-IBA21873635  
GO:0015701bicarbonate transport-IDA24121512  
GO:0015701bicarbonate transport-TAS-  
GO:0051453regulation of intracellular pH-IBA21873635  
GO:1902476chloride transmembrane transport-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005886plasma membrane-TAS-  
GO:0005887integral component of plasma membrane-IBA21873635  
GO:0005887integral component of plasma membrane-IDA379653  24121512  
GO:0016021integral component of membrane-NAS1527044  
GO:0016323basolateral plasma membrane-IDA12539048  14734552  
GO:0030018Z disc-ISS-  
GO:0030863cortical cytoskeleton-IDA16669616  
GO:0070062extracellular exosome-HDA19056867  
GO:0072562blood microparticle-HDA22516433  
KEGG ID KEGG Term
hsa04966Collecting duct acid secretion
Reactome ID Reactome Term Evidence
R-HSA-1237044Erythrocytes take up carbon dioxide and release oxygenTAS
R-HSA-1247673Erythrocytes take up oxygen and release carbon dioxideTAS
R-HSA-1480926O2/CO2 exchange in erythrocytesTAS
R-HSA-1643685DiseaseTAS
R-HSA-382551Transport of small moleculesTAS
R-HSA-425381Bicarbonate transportersTAS
R-HSA-425393Transport of inorganic cations/anions and amino acids/oligopeptidesTAS
R-HSA-425407SLC-mediated transmembrane transportTAS
R-HSA-5619050Defective SLC4A1 causes hereditary spherocytosis type 4 (HSP4), distal renal tubular acidosis (dRTA) and dRTA with hemolytic anemia (dRTA-HA)TAS
R-HSA-5619102SLC transporter disordersTAS
R-HSA-5619115Disorders of transmembrane transportersTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
17137217Association of sixty-one non-synonymous polymorphisms in forty-one hypertension candidate genes with blood pressure variation and hypertension. (2006 Aug)Kokubo YHypertens Res