Gene: PCDH15

65217
CDHR15|DFNB23|USH1F
protocadherin related 15
protein-coding
10q21.1
Ensembl:ENSG00000150275 MIM:605514 Vega:OTTHUMG00000018259 UniprotKB:Q96QU1
NG_009191.3
PubMed|SNP Mapped
1   ANCO-SNPs
ND|AD
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
2.520e-2 (AD)  4.357e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs1935468chr10:54323965 (GRCh38.p7)T>Cnicotine dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
PDGFRA0.853
LHFPL30.762
SEMA5A0.757
MYT10.755
VCAN0.737
FERMT10.733
BCHE0.716
COL9A10.715
STK32A0.71
KIF26B0.699

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
FAM83D-0.331
GNB1L-0.319
BCL2L10-0.311
ULBP2-0.303
CHAC1-0.3
S100A5-0.292
PTTG1-0.287
ADPRHL1-0.283
B9D2-0.277
CRYBA2-0.275

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of PCDH15 gene27153756
D000535Aluminum[APP protein modified form binds to Aluminum] which results in decreased expression of PCDH15 mRNA21298039
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of PCDH15 mRNA24449571
D001151ArsenicArsenic affects the methylation of PCDH15 gene25304211
C006780bisphenol Abisphenol A results in decreased expression of PCDH15 mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of PCDH15 gene28505145
D019259Lamivudine[Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in increased expression of PCDH15 mRNA16931933
D019259Lamivudine[Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in increased expression of PCDH15 mRNA16931933
D019259Lamivudine[Zidovudine co-treated with Lamivudine] results in increased expression of PCDH15 mRNA16931933
D004041Dietary FatsDietary Fats results in decreased expression of PCDH15 mRNA25016146
D004041Dietary FatsDietary Fats results in increased expression of PCDH15 mRNA21852083
D004051Diethylhexyl PhthalateDiethylhexyl Phthalate results in increased expression of PCDH15 mRNA28085963
D005038EthylnitrosoureaEthylnitrosourea results in increased mutagenesis of PCDH15 gene15811708
D006830Hydralazine[Hydralazine co-treated with Valproic Acid] results in increased expression of PCDH15 mRNA17183730
D019469Indinavir[Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in increased expression of PCDH15 mRNA16931933
C028577monobutyl phthalatemonobutyl phthalate results in decreased expression of PCDH15 mRNA29162477
C043680ptaquilosideptaquiloside results in decreased expression of PCDH15 mRNA23274088
D019258Saquinavir[Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in increased expression of PCDH15 mRNA16931933
D053260SootSoot results in increased expression of PCDH15 mRNA26551751
D014635Valproic Acid[Hydralazine co-treated with Valproic Acid] results in increased expression of PCDH15 mRNA17183730
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of PCDH15 gene25560391
C025643vinclozolinvinclozolin results in decreased expression of PCDH15 mRNA23869203
C025643vinclozolinvinclozolin results in increased expression of PCDH15 mRNA23869203
D015215Zidovudine[Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in increased expression of PCDH15 mRNA16931933
D015215Zidovudine[Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in increased expression of PCDH15 mRNA16931933
D015215Zidovudine[Zidovudine co-treated with Lamivudine] results in increased expression of PCDH15 mRNA16931933

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005509calcium ion binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0007155cell adhesion-IBA21873635  
GO:0007156homophilic cell adhesion via plasma membrane adhesion molecules-IEA-  
GO:0007267cell-cell signaling-IBA21873635  
GO:0007605sensory perception of sound-IMP11398101  15537665  
GO:0045494photoreceptor cell maintenance-IMP11398101  
GO:0048839inner ear development-IEA-  
GO:0050953sensory perception of light stimulus-IMP11398101  
GO:0050957equilibrioception-IMP16679490  
GO ID GO Term Qualifier Evidence PubMed
GO:0001750photoreceptor outer segment-IDA14570705  
GO:0005576extracellular region-IEA-  
GO:0005887integral component of plasma membrane-IBA21873635  
GO:0032420stereocilium-ISS14570705  
GO:0045202synapse-IDA11487575  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
25462672Genetic variations in protocadherin 15 and their interactions with noise exposure associated with noise-induced hearing loss in Chinese population. (2014 Nov)Zhang XEnviron Res
28056266[Association between variations in protocadherin 15 gene and occupational noise-induced hearing loss]. (2017 Jan 6)Xu XRZhonghua Yu Fang Yi Xue Za Zhi