Gene: SLC4A2

6522
AE2|BND3L|EPB3L1|HKB3|NBND3
solute carrier family 4 member 2
protein-coding
7q36.1
Ensembl:ENSG00000164889 MIM:109280 Vega:OTTHUMG00000158443 UniprotKB:P04920
NG_051947.1
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.029e-1 (AD)  4.410e-2 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CERS20.864
PREX10.838
MICALL10.838
ARHGEF100.833
RRBP10.83
DNM20.827
SH3BP40.826
NOTCH10.823
HIP10.821
TLN10.816

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
FBLN7-0.417
CRH-0.415
KCNB2-0.408
ADRA1D-0.397
SMIM18-0.392
PPEF1-0.388
VGF-0.387
MARCH4-0.387
ABCC12-0.385
CNTN5-0.383

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C5471242,3-dibromopropyl-2,4,6-tribromophenyl ether"2,3-dibromopropyl-2,4,6-tribromophenyl ether results in decreased expression of SLC4A2 mRNA"26318274
C0352074-amino-2,6-dinitrotoluene"4-amino-2,6-dinitrotoluene affects the expression of SLC4A2 mRNA"21346803
D000242Cyclic AMPNitric Oxide inhibits the reaction [SLC4A2 protein promotes the reaction [Cyclic AMP results in increased transport of Bicarbonates]]12612912
D000242Cyclic AMPSLC4A2 protein promotes the reaction [Cyclic AMP results in increased transport of Bicarbonates]12612912
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of SLC4A2 mRNA19770486
C000188alachloralachlor results in increased expression of SLC4A2 mRNA12419858
D000643Ammonium ChlorideAmmonium Chloride affects the expression of SLC4A2 mRNA16483693
D016718Arachidonic AcidArachidonic Acid results in increased expression of SLC4A2 mRNA16623957
D001151ArsenicArsenic affects the methylation of SLC4A2 gene25304211
C006632arsenic trioxidearsenic trioxide results in increased stability of and results in increased expression of SLC4A2 protein17018029
D019817Benzoic Acid"4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid inhibits the reaction [SLC4A2 protein results in increased uptake of Benzoic Acid]"9563070
D019817Benzoic AcidBicarbonates inhibits the reaction [SLC4A2 protein results in increased uptake of Benzoic Acid]9563070
D019817Benzoic AcidChlorides inhibits the reaction [SLC4A2 protein results in increased uptake of Benzoic Acid]9563070
D019817Benzoic AcidSLC4A2 protein results in increased uptake of Benzoic Acid9563070
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of SLC4A2 mRNA21715664
D001639BicarbonatesSLC4A2 protein affects the transport of [Chlorides co-treated with Bicarbonates]11852051
D001639BicarbonatesBicarbonates inhibits the reaction [SLC4A2 protein results in increased uptake of Benzoic Acid]9563070
D001639BicarbonatesNitric Oxide inhibits the reaction [SLC4A2 protein promotes the reaction [Cyclic AMP results in increased transport of Bicarbonates]]12612912
D001639BicarbonatesSLC4A2 protein promotes the reaction [Cyclic AMP results in increased transport of Bicarbonates]12612912
C006780bisphenol Abisphenol A affects the expression of SLC4A2 mRNA25181051
C011686boldineboldine results in increased expression of SLC4A2 mRNA25771127
C032688boric acidboric acid results in increased expression of SLC4A2 mRNA22576912
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in decreased expression of SLC4A2 mRNA18804290
D020148Butyric AcidSLC4A2 protein results in increased uptake of Butyric Acid9563070
C584509C646 compoundC646 compound results in decreased expression of SLC4A2 mRNA26191083
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of SLC4A2 mRNA18804290
D019256Cadmium ChlorideCadmium Chloride results in increased methylation of SLC4A2 promoter22457795
C055494caffeic acid phenethyl estercaffeic acid phenethyl ester inhibits the reaction [Diethylnitrosamine results in decreased expression of SLC4A2 mRNA]20360939
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of SLC4A2 mRNA16644059
D002712ChloridesSLC4A2 protein affects the transport of [Chlorides co-treated with Bicarbonates]11852051
D002712ChloridesChlorides inhibits the reaction [SLC4A2 protein results in increased uptake of Benzoic Acid]9563070
D002712ChloridesSLC4A2 protein results in increased export of Chlorides9563070
D002713Chlorine[Ozone co-treated with Chlorine] results in decreased expression of SLC4A2 mRNA18636392
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of SLC4A2 gene20938992
D002994ClofibrateClofibrate results in increased expression of SLC4A2 mRNA12851107
D003471CuprizoneCuprizone results in increased expression of SLC4A2 mRNA26577399
D016572CyclosporineCyclosporine results in decreased expression of SLC4A2 mRNA27989131
D003622DapsoneDapsone metabolite results in decreased expression of SLC4A2 protein15863252
D003907DexamethasoneDexamethasone promotes the reaction [EP300 protein binds to SLC4A2 promoter]18188457
D003907DexamethasoneDexamethasone promotes the reaction [HNF1A protein binds to SLC4A2 promoter]18188457
D003907Dexamethasone[glycoursodeoxycholic acid co-treated with Dexamethasone] results in increased expression of SLC4A2 mRNA alternative form18188457
D003907Dexamethasone[taurine-ursodeoxycholate conjugate co-treated with Dexamethasone] results in increased expression of SLC4A2 mRNA alternative form18188457
D003907Dexamethasone[Ursodeoxycholic Acid co-treated with Dexamethasone] promotes the reaction [EP300 protein binds to NR3C1 protein binds to HNF1A protein binds to SLC4A2 promoter alternative form]18188457
D003907Dexamethasone[Ursodeoxycholic Acid co-treated with Dexamethasone] promotes the reaction [EP300 protein binds to SLC4A2 promoter]18188457
D003907Dexamethasone[Ursodeoxycholic Acid co-treated with Dexamethasone] promotes the reaction [EP300 protein binds to SLC4A2 promoter alternative form]18188457
D003907Dexamethasone[Ursodeoxycholic Acid co-treated with Dexamethasone] promotes the reaction [HNF1A protein binds to NR3C1 protein binds to SLC4A2 promoter]18188457
D003907Dexamethasone[Ursodeoxycholic Acid co-treated with Dexamethasone] promotes the reaction [HNF1A protein binds to SLC4A2 promoter]18188457
D003907Dexamethasone[Ursodeoxycholic Acid co-treated with Dexamethasone] promotes the reaction [HNF1A protein binds to SLC4A2 promoter alternative form]18188457
D003907Dexamethasone[Ursodeoxycholic Acid co-treated with Dexamethasone] promotes the reaction [HNF1B protein binds to NR3C1 protein binds to EP300 protein binds to SLC4A2 promoter alternative form]18188457
D003907Dexamethasone[Ursodeoxycholic Acid co-treated with Dexamethasone] promotes the reaction [NR3C1 protein binds to SLC4A2 promoter alternative form]18188457
D003907Dexamethasone[Ursodeoxycholic Acid co-treated with Dexamethasone] results in increased activity of SLC4A2 protein18188457
D003907Dexamethasone[Ursodeoxycholic Acid co-treated with Dexamethasone] results in increased expression of SLC4A2 mRNA alternative form18188457
D003976DiazinonDiazinon results in increased methylation of SLC4A2 gene22964155
D002945CisplatinCisplatin results in increased expression of SLC4A2 mRNA27594783
D004052Diethylnitrosaminecaffeic acid phenethyl ester inhibits the reaction [Diethylnitrosamine results in decreased expression of SLC4A2 mRNA]20360939
D004052DiethylnitrosamineDiethylnitrosamine results in decreased expression of SLC4A2 mRNA20360939
D0178784,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid"4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid inhibits the reaction [SLC4A2 protein results in increased uptake of Benzoic Acid]"9563070
D0178784,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid"4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid promotes the reaction [SLC4A2 protein binds to SLC4A2 protein]"10387099
C070609EMD 53998EMD 53998 analog results in decreased expression of SLC4A2 mRNA24977338
D000431EthanolEthanol results in increased expression of SLC4A2 mRNA15353170
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of SLC4A2 mRNA17942748
C540355fenamidonefenamidone results in increased expression of SLC4A2 mRNA27029645
D018120FinasterideFinasteride results in increased expression of SLC4A2 mRNA24136188
D005485FlutamideFlutamide results in increased expression of SLC4A2 mRNA24136188
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of SLC4A2 gene20938992
C024033glycoursodeoxycholic acid[glycoursodeoxycholic acid co-treated with Dexamethasone] results in increased expression of SLC4A2 mRNA alternative form18188457
C492448ICG 001ICG 001 results in decreased expression of SLC4A2 mRNA26191083
D048628KetolidesKetolides analog results in increased expression of SLC4A2 mRNA24967691
D008627Mercuric ChlorideMercuric Chloride affects the expression of SLC4A2 mRNA20353558
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of SLC4A2 gene20938992
D008748MethylcholanthreneMethylcholanthrene results in increased expression of SLC4A2 mRNA18804290
C051752nefazodonenefazodone results in increased expression of SLC4A2 mRNA24136188
D009525NiacinSLC4A2 protein results in increased uptake of Niacin9563070
C022838nickel chloridenickel chloride affects the expression of SLC4A2 mRNA22110744
C028007nickel monoxidenickel monoxide results in increased expression of SLC4A2 mRNA19167457
D009569Nitric OxideNitric Oxide inhibits the reaction [SLC4A2 protein promotes the reaction [Cyclic AMP results in increased transport of Bicarbonates]]12612912
D010126Ozone[Ozone co-treated with Chlorine] results in decreased expression of SLC4A2 mRNA18636392
D010269ParaquatParaquat results in increased expression of SLC4A2 mRNA18198484
C086401pentabromodiphenyl etherpentabromodiphenyl ether results in decreased expression of SLC4A2 mRNA23948077
C029658propionic acidSLC4A2 protein results in increased uptake of propionic acid9563070
D011441PropylthiouracilPropylthiouracil results in decreased expression of SLC4A2 mRNA24780913
C513428pyrachlostrobinpyrachlostrobin results in increased expression of SLC4A2 mRNA27029645
C513635S-2-pentyl-4-pentynoic hydroxamic acidS-2-pentyl-4-pentynoic hydroxamic acid results in increased expression of SLC4A2 mRNA21427059
D012822Silicon DioxideSilicon Dioxide results in decreased expression of SLC4A2 mRNA25351596
C030141taurine-ursodeoxycholate conjugate[taurine-ursodeoxycholate conjugate co-treated with Dexamethasone] results in increased expression of SLC4A2 mRNA alternative form18188457
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of SLC4A2 mRNA21570461
D013853ThioacetamideThioacetamide results in decreased expression of SLC4A2 mRNA26222700
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of SLC4A2 mRNA28111298
D014580Ursodeoxycholic Acid[Ursodeoxycholic Acid co-treated with Dexamethasone] promotes the reaction [EP300 protein binds to NR3C1 protein binds to HNF1A protein binds to SLC4A2 promoter alternative form]18188457
D014580Ursodeoxycholic Acid[Ursodeoxycholic Acid co-treated with Dexamethasone] promotes the reaction [EP300 protein binds to SLC4A2 promoter]18188457
D014580Ursodeoxycholic Acid[Ursodeoxycholic Acid co-treated with Dexamethasone] promotes the reaction [EP300 protein binds to SLC4A2 promoter alternative form]18188457
D014580Ursodeoxycholic Acid[Ursodeoxycholic Acid co-treated with Dexamethasone] promotes the reaction [HNF1A protein binds to NR3C1 protein binds to SLC4A2 promoter]18188457
D014580Ursodeoxycholic Acid[Ursodeoxycholic Acid co-treated with Dexamethasone] promotes the reaction [HNF1A protein binds to SLC4A2 promoter]18188457
D014580Ursodeoxycholic Acid[Ursodeoxycholic Acid co-treated with Dexamethasone] promotes the reaction [HNF1A protein binds to SLC4A2 promoter alternative form]18188457
D014580Ursodeoxycholic Acid[Ursodeoxycholic Acid co-treated with Dexamethasone] promotes the reaction [HNF1B protein binds to NR3C1 protein binds to EP300 protein binds to SLC4A2 promoter alternative form]18188457
D014580Ursodeoxycholic Acid[Ursodeoxycholic Acid co-treated with Dexamethasone] promotes the reaction [NR3C1 protein binds to SLC4A2 promoter alternative form]18188457
D014580Ursodeoxycholic Acid[Ursodeoxycholic Acid co-treated with Dexamethasone] results in increased activity of SLC4A2 protein18188457
D014580Ursodeoxycholic Acid[Ursodeoxycholic Acid co-treated with Dexamethasone] results in increased expression of SLC4A2 mRNA alternative form18188457
D014580Ursodeoxycholic AcidUrsodeoxycholic Acid promotes the reaction [EP300 protein binds to SLC4A2 promoter]18188457
D014580Ursodeoxycholic AcidUrsodeoxycholic Acid promotes the reaction [HNF1A protein binds to SLC4A2 promoter]18188457
D014580Ursodeoxycholic AcidSLC4A2 affects the reaction [Ursodeoxycholic Acid analog results in increased activity of SCT]22194894
D014635Valproic AcidValproic Acid results in increased expression of SLC4A2 mRNA23179753|2800136
D014635Valproic AcidSLC4A2 protein results in increased uptake of Valproic Acid9563070
D014635Valproic AcidValproic Acid affects the expression of SLC4A2 mRNA17292431
D014635Valproic AcidValproic Acid results in increased expression of SLC4A2 mRNA21427059
C025643vinclozolinvinclozolin results in decreased expression of SLC4A2 mRNA23034163
D015215ZidovudineZidovudine results in increased expression of SLC4A2 mRNA24292225

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005452inorganic anion exchanger activity-TAS-  
GO:0008509anion transmembrane transporter activity-IBA21873635  
GO:0008509anion transmembrane transporter activity-TAS3015590  
GO:0015301anion:anion antiporter activity-IEA-  
GO:0019899enzyme binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006820anion transport-TAS3015590  
GO:0007283spermatogenesis-IEA-  
GO:0015698inorganic anion transport-IEA-  
GO:0015701bicarbonate transport-IBA21873635  
GO:0015701bicarbonate transport-TAS-  
GO:0048565digestive tract development-IEA-  
GO:0051453regulation of intracellular pH-IBA21873635  
GO:0098656anion transmembrane transport-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005886plasma membrane-TAS-  
GO:0005887integral component of plasma membrane-IBA21873635  
GO:0005925focal adhesion-HDA21423176  
GO:0016020membrane-HDA19946888  
GO:0016323basolateral plasma membrane-IEA-  
GO:0016324apical plasma membrane-IEA-  
KEGG ID KEGG Term
hsa04970Salivary secretion
hsa04971Gastric acid secretion
hsa04972Pancreatic secretion
hsa04976Bile secretion
Reactome ID Reactome Term Evidence
R-HSA-382551Transport of small moleculesTAS
R-HSA-425381Bicarbonate transportersTAS
R-HSA-425393Transport of inorganic cations/anions and amino acids/oligopeptidesTAS
R-HSA-425407SLC-mediated transmembrane transportTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
19562039Targeting 160 candidate genes for blood pressure regulation with a genome-wide genotyping array. (2009 Jun 29)Sober SPLoS One