Gene: ZSWIM4

65249
-
zinc finger SWIM-type containing 4
protein-coding
19p13.13-p13.12
Ensembl:ENSG00000132003 Vega:OTTHUMG00000181752 UniprotKB:Q9H7M6
NC_000019.10
SNP Mapped
1   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.211e-1 (AD)  1.025e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs12610873chr19:13831773 (GRCh38.p7)G>Aalcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
FURIN0.742
TRAF70.723
TRAF30.712
VARS0.71
ZNF5980.708
IRF2BPL0.705
FBRSL10.704
TNRC180.704
BRD40.701
ZNF8650.7

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.427
OR4F29-0.37
CTNNA3-0.358
MYOT-0.334
C5orf64-0.333
TSPAN8-0.325
LRRCC1-0.321
ZFHX4-AS1-0.313
PAIP2B-0.306
OMD-0.305

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0512461-methylanthracene[1-methylanthracene co-treated with fluoranthene] results in increased expression of ZSWIM4 mRNA28329830
D000082AcetaminophenAcetaminophen results in increased expression of ZSWIM4 mRNA29067470
D000082AcetaminophenAcetaminophen affects the expression of ZSWIM4 mRNA17562736
D000535Aluminum[APP protein modified form binds to Aluminum] which results in decreased expression of ZSWIM4 mRNA21298039
D001151ArsenicArsenic affects the methylation of ZSWIM4 gene25304211
D017638Asbestos, Crocidolite"Asbestos, Crocidolite affects the expression of ZSWIM4 mRNA"25757056
D001280AtrazineAtrazine results in increased expression of ZSWIM4 mRNA22378314
C044887beta-methylcholinebeta-methylcholine affects the expression of ZSWIM4 mRNA21179406
C006780bisphenol Abisphenol A results in decreased expression of ZSWIM4 mRNA27685785
C006780bisphenol Abisphenol A results in increased expression of ZSWIM4 mRNA25181051
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of ZSWIM4 gene20938992
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of ZSWIM4 mRNA21266533
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of ZSWIM4 mRNA21266533
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of ZSWIM4 mRNA23550701
C007738fluoranthene[1-methylanthracene co-treated with fluoranthene] results in increased expression of ZSWIM4 mRNA28329830
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of ZSWIM4 gene20938992
C492448ICG 001ICG 001 results in increased expression of ZSWIM4 mRNA26191083
C544151jinfukangjinfukang results in decreased expression of ZSWIM4 mRNA27392435
C045463leflunomideleflunomide results in increased expression of ZSWIM4 mRNA28988120
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of ZSWIM4 gene20938992
D008727MethotrexateMethotrexate results in increased expression of ZSWIM4 mRNA24449571
C020806tetrabromobisphenol Atetrabromobisphenol A results in increased expression of ZSWIM4 mRNA25172293
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of ZSWIM4 mRNA21570461
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of ZSWIM4 mRNA24680724
C012589trichostatin Atrichostatin A results in increased expression of ZSWIM4 mRNA15901671
D014520UrethaneUrethane results in increased expression of ZSWIM4 mRNA28818685
D014635Valproic AcidValproic Acid results in increased methylation of ZSWIM4 gene29154799
D014635Valproic AcidValproic Acid affects the expression of ZSWIM4 mRNA17963808
D014635Valproic AcidValproic Acid results in increased expression of ZSWIM4 mRNA15901671
C025643vinclozolinvinclozolin results in decreased expression of ZSWIM4 mRNA23034163

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0008270zinc ion binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:1902667regulation of axon guidance-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0031462Cul2-RING ubiquitin ligase complex-IBA21873635  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

There is no Interaction data for this gene.

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal