Gene: UBE2Z

65264
HOYS7|USE1
ubiquitin conjugating enzyme E2 Z
protein-coding
17q21.32
Ensembl:ENSG00000159202 MIM:611362 Vega:OTTHUMG00000150521 UniprotKB:Q9H832
NC_000017.11
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
8.241e-1 (AD)  2.977e-1 (ND)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg24847230chr17:46986807UBE2Z1.300e-9Smoking27651444

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SARS0.961
MKRN10.96
CUL10.96
WDR820.96
CHMP70.958
ATXN7L3B0.957
TOX40.957
DDX240.957
UBQLN10.956
AARS0.955

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.667
OR4F29-0.628
MTRNR2L6-0.351
MTRNR2L10-0.341
KLRB1-0.333
IL18RAP-0.33
MTRNR2L9-0.33
ASB4-0.329
P2RY14-0.32
TFPI2-0.316

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in decreased expression of UBE2Z mRNA"27291303
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of UBE2Z mRNA"21346803
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in increased expression of UBE2Z mRNA"18648102
C0326424-aminophenylarsenoxide4-aminophenylarsenoxide binds to UBE2Z protein26598702
C0326424-aminophenylarsenoxidearsenic trioxide inhibits the reaction [4-aminophenylarsenoxide binds to UBE2Z protein]26598702
D000082AcetaminophenAcetaminophen results in increased expression of UBE2Z mRNA21420995|2223033
D000082AcetaminophenAcetaminophen affects the expression of UBE2Z mRNA17562736
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of UBE2Z mRNA24449571
C006632arsenic trioxidearsenic trioxide inhibits the reaction [4-aminophenylarsenoxide binds to UBE2Z protein]26598702
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of UBE2Z mRNA"20018196
C044887beta-methylcholinebeta-methylcholine affects the expression of UBE2Z mRNA21179406
C006780bisphenol Abisphenol A results in decreased expression of UBE2Z mRNA22576693
C006780bisphenol Abisphenol A results in increased methylation of UBE2Z gene22576693
C006780bisphenol Abisphenol A results in increased expression of UBE2Z mRNA25181051
C018475butyraldehydebutyraldehyde results in decreased expression of UBE2Z mRNA26079696
C584509C646 compoundC646 compound results in decreased expression of UBE2Z mRNA26191083
D019327Copper SulfateCopper Sulfate results in decreased expression of UBE2Z mRNA19549813
D016572CyclosporineCyclosporine results in increased expression of UBE2Z mRNA20106945
C010902decabromobiphenyl etherdecabromobiphenyl ether results in decreased expression of UBE2Z mRNA23640034
D003976DiazinonDiazinon results in increased methylation of UBE2Z gene22964155
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of UBE2Z mRNA21266533
C045651epigallocatechin gallate[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of UBE2Z mRNA22079256
D005485FlutamideFlutamide results in increased expression of UBE2Z mRNA24136188
D017313FenretinideFenretinide results in increased expression of UBE2Z mRNA28973697
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of UBE2Z mRNA25613284
D008627Mercuric ChlorideMercuric Chloride results in decreased expression of UBE2Z mRNA27188386
D008713MethimazoleMethimazole results in increased expression of UBE2Z mRNA22504374
C051752nefazodonenefazodone results in increased expression of UBE2Z mRNA24136188
D009532NickelNickel results in increased expression of UBE2Z mRNA25583101
D010261ParaoxonParaoxon results in decreased expression of UBE2Z mRNA24413757
D010269ParaquatParaquat results in increased expression of UBE2Z mRNA21371552
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of UBE2Z mRNA19710929
C027373potassium chromate(VI)[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of UBE2Z mRNA22079256
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of UBE2Z mRNA22079256
D011441PropylthiouracilPropylthiouracil results in increased expression of UBE2Z mRNA22504374
D012402RotenoneRotenone results in decreased expression of UBE2Z mRNA23186747
D012643Selenium[Selenium co-treated with Vitamin E] results in increased expression of UBE2Z mRNA19244175
D012643SeleniumSelenium results in increased expression of UBE2Z mRNA19244175
D012999SomanSoman results in increased expression of UBE2Z mRNA19281266
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of UBE2Z mRNA21570461
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with AHR gene mutant form] results in decreased expression of UBE2Z mRNA19465110
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of UBE2Z mRNA19770486
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of UBE2Z mRNA25613284
D014635Valproic AcidValproic Acid results in decreased methylation of UBE2Z gene29154799
D014810Vitamin E[Selenium co-treated with Vitamin E] results in increased expression of UBE2Z mRNA19244175
D014810Vitamin EVitamin E results in increased expression of UBE2Z mRNA19244175
C111237vorinostatvorinostat results in decreased expression of UBE2Z mRNA27188386

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004869cysteine-type endopeptidase inhibitor activity-IBA21873635  
GO:0005515protein binding-IPI16189514  24528925  25416956  
GO:0005524ATP binding-IEA-  
GO:0061631ubiquitin conjugating enzyme activity-IBA21873635  
GO:0061631ubiquitin conjugating enzyme activity-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006511ubiquitin-dependent protein catabolic process-IEA-  
GO:0006915apoptotic process-IEA-  
GO:0016567protein ubiquitination-IEA-  
GO:0016567protein ubiquitination-TAS-  
GO:0043065positive regulation of apoptotic process-IDA17464193  
GO:0043066negative regulation of apoptotic process-IBA21873635  
GO:1990001inhibition of cysteine-type endopeptidase activity involved in apoptotic process-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IBA21873635  
GO:0005634nucleus-IDA17464193  
GO:0005654nucleoplasm-IDA-  
GO:0005829cytosol-IDA-  
GO:0005829cytosol-TAS-  
KEGG ID KEGG Term
hsa04120Ubiquitin mediated proteolysis
Reactome ID Reactome Term Evidence
R-HSA-1280218Adaptive Immune SystemTAS
R-HSA-168256Immune SystemTAS
R-HSA-392499Metabolism of proteinsTAS
R-HSA-597592Post-translational protein modificationTAS
R-HSA-8852135Protein ubiquitinationTAS
R-HSA-8866652Synthesis of active ubiquitin: roles of E1 and E2 enzymesTAS
R-HSA-983168Antigen processing: Ubiquitination & Proteasome degradationTAS
R-HSA-983169Class I MHC mediated antigen processing & presentationTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
25524550Association of a polymorphism of the interleukin 6 receptor gene with chronic kidney disease in Japanese individuals. (2015 Apr)Horibe HNephrology (Carlton)