Gene: WNK4

65266
PHA2B|PRKWNK4
WNK lysine deficient protein kinase 4
protein-coding
17q21.2
Ensembl:ENSG00000126562 MIM:601844 Vega:OTTHUMG00000180650 UniprotKB:Q96J92
NG_016227.1
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
9.455e-2 (AD)  6.135e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CRIP10.592
MAP3K7CL0.59
SGMS20.587
RAI140.571
FOXC20.571
HEY20.568
UACA0.564
SRPX0.563
SFRP40.561
ROR10.56

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
RORB-0.408
INSM2-0.388
EFNA5-0.374
KCNH6-0.372
CTXN2-0.372
RTBDN-0.363
GRM7-0.362
TTC39C-0.358
LRFN5-0.358
ZMAT4-0.358

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C5486512-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in decreased expression of WNK4 mRNA19933214
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in increased expression of WNK4 mRNA"23196670
C0179063-dinitrobenzene3-dinitrobenzene results in increased expression of WNK4 mRNA21983209
D000082AcetaminophenAcetaminophen results in increased expression of WNK4 mRNA29067470
D000082AcetaminophenAcetaminophen affects the expression of WNK4 mRNA17562736
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of WNK4 gene27153756
D000643Ammonium ChlorideAmmonium Chloride affects the expression of WNK4 mRNA16483693
D019324beta-Naphthoflavone[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of WNK4 mRNA18164116
D001622BetaineBetaine results in decreased expression of WNK4 mRNA26391144
C006780bisphenol Abisphenol A results in decreased methylation of WNK4 promoter27312807
C006780bisphenol Abisphenol A results in increased methylation of WNK4 promoter27312807
C006780bisphenol Abisphenol A results in decreased expression of WNK4 mRNA25181051
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of WNK4 gene20938992
C031180chrysenechrysene results in increased expression of WNK4 mRNA26377693
C018021cobaltous chloridecobaltous chloride results in decreased expression of WNK4 mRNA24386269
D019327Copper SulfateCopper Sulfate results in decreased expression of WNK4 mRNA19549813
D016572CyclosporineCyclosporine results in decreased expression of WNK4 mRNA25562108
D003907DexamethasoneDexamethasone results in increased expression of WNK4 mRNA19344079
D002945CisplatinWNK4 results in decreased susceptibility to Cisplatin21652733
C000944dicrotophosdicrotophos results in increased expression of WNK4 mRNA28302478
D004052DiethylnitrosamineDiethylnitrosamine results in increased expression of WNK4 mRNA24535843
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of WNK4 mRNA18164116
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of WNK4 gene20938992
C069837fullerene C60fullerene C60 results in increased expression of WNK4 mRNA19167457
C508665gold (III) porphyrin 1agold (III) porphyrin 1a results in increased expression of WNK4 mRNA16206274
D017313FenretinideFenretinide results in increased expression of WNK4 mRNA28973697
D006861Hydrogen PeroxideHydrogen Peroxide affects the expression of WNK4 mRNA20044591
C045463leflunomideleflunomide results in increased expression of WNK4 mRNA28988120
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of WNK4 gene20938992
D008727MethotrexateMethotrexate affects the expression of WNK4 mRNA18502557
D008777MethyltestosteroneMethyltestosterone results in increased expression of WNK4 mRNA29191790
C022838nickel chloridenickel chloride affects the expression of WNK4 mRNA22110744
C028007nickel monoxidenickel monoxide results in increased expression of WNK4 mRNA19167457
C029938nickel sulfatenickel sulfate results in increased expression of WNK4 mRNA22714537
D010426Pentosan Sulfuric PolyesterPentosan Sulfuric Polyester results in increased expression of WNK4 mRNA28973697
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of WNK4 mRNA19710929
D011374ProgesteroneProgesterone results in decreased expression of WNK4 mRNA23012394
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of WNK4 mRNA25895662
C016104sodium bichromatesodium bichromate affects the expression of WNK4 mRNA22110744
D016559TacrolimusTacrolimus results in increased phosphorylation of WNK4 protein21963515
C057693troglitazonetroglitazone results in decreased expression of WNK4 mRNA28973697
D014415TunicamycinTunicamycin results in increased expression of WNK4 mRNA17127020
D014635Valproic AcidValproic Acid results in increased methylation of WNK4 gene29154799
D014635Valproic AcidValproic Acid affects the expression of WNK4 mRNA17963808
D014638VanadatesVanadates results in decreased expression of WNK4 mRNA22714537

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004674protein serine/threonine kinase activity-IBA21873635  
GO:0004674protein serine/threonine kinase activity-ISS-  
GO:0005515protein binding-IPI17721439  23453970  23576762  
GO:0005524ATP binding-ISS-  
GO:0019869chloride channel inhibitor activity-IDA17673510  
GO ID GO Term Qualifier Evidence PubMed
GO:0006468protein phosphorylation-IBA21873635  
GO:0006468protein phosphorylation-ISS-  
GO:0006811ion transport-ISS-  
GO:0006821chloride transport-IEA-  
GO:0008104protein localization-IEA-  
GO:0010766negative regulation of sodium ion transport-ISS-  
GO:0032414positive regulation of ion transmembrane transporter activity-IBA21873635  
GO:0035556intracellular signal transduction-IBA21873635  
GO:0035556intracellular signal transduction-ISS-  
GO:0050794regulation of cellular process-ISS-  
GO:0050801ion homeostasis-IMP23453970  23576762  
GO:0070294renal sodium ion absorption-IBA21873635  
GO:0070294renal sodium ion absorption-IMP23453970  23576762  
GO:0072156distal tubule morphogenesis-IMP23453970  23576762  
GO:0090188negative regulation of pancreatic juice secretion-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005829cytosol-IBA21873635  
GO:0005829cytosol-ISS-  
GO:0005923bicellular tight junction-ISS-  
GO:0016020membrane-ISS-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-2672351Stimuli-sensing channelsTAS
R-HSA-382551Transport of small moleculesTAS
R-HSA-983712Ion channel transportTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
15309683Identification of 108 SNPs in TSC, WNK1, and WNK4 and their association with hypertension in a Japanese general population. (2004)Kokubo YJ Hum Genet