Gene: SLC6A1

6529
GABATHG|GABATR|GAT1|MAE
solute carrier family 6 member 1
protein-coding
3p25.3
Ensembl:ENSG00000157103 MIM:137165 Vega:OTTHUMG00000044208 UniprotKB:P30531
NG_053003.1
PubMed
0   ANCO-SNPs
AD
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
4.045e-2 (AD)  6.576e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ERBB40.856
ACSL60.851
ABAT0.839
GABBR10.836
ALDH5A10.817
NLGN30.813
CSPG50.811
WASF30.807
ARNT20.806
SLC23A20.805

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.652
OR4F29-0.63
CHI3L2-0.487
SFN-0.477
ANGPT2-0.453
STC1-0.443
GBP2-0.442
S100A3-0.442
SPINK8-0.438
SERPINA5-0.431

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00349ClobazamSmall Molecule22316-47-8Approved|IllicitTransporter
DB00906TiagabineSmall Molecule115103-54-3Approved|InvestigationalTarget
DB08848GuvacineSmall Molecule498-96-4ExperimentalTarget
ID Drug Name Action PubMed
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in decreased expression of SLC6A1 mRNA"25614096
D016604Aflatoxin B1Aflatoxin B1 affects the expression of SLC6A1 protein20106945
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of SLC6A1 mRNA27153756
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of SLC6A1 gene27153756
D005680gamma-Aminobutyric AcidNiflumic Acid inhibits the reaction [SLC6A1 protein results in increased uptake of gamma-Aminobutyric Acid]15981712
D005680gamma-Aminobutyric AcidSLC6A1 protein results in increased uptake of gamma-Aminobutyric Acid15981712
D005680gamma-Aminobutyric AcidSLC6A1 results in increased export of gamma-Aminobutyric Acid21748804
D005680gamma-Aminobutyric AcidSLC6A1 protein results in increased uptake of gamma-Aminobutyric Acid28621878
D005680gamma-Aminobutyric AcidWasp Venoms inhibits the reaction [SLC6A1 protein results in increased uptake of gamma-Aminobutyric Acid]28621878
D000643Ammonium ChlorideAmmonium Chloride affects the expression of SLC6A1 mRNA16483693
D018501Antirheumatic AgentsAntirheumatic Agents results in increased expression of SLC6A1 mRNA24449571
D004958EstradiolEstradiol results in decreased expression of SLC6A1 mRNA20106945
C006780bisphenol Abisphenol A results in decreased expression of SLC6A1 mRNA25181051
D060729Coal AshCoal Ash results in decreased expression of SLC6A1 mRNA19000753
D016572CyclosporineCyclosporine results in decreased expression of SLC6A1 mRNA20106945
D013759DronabinolDronabinol results in decreased expression of SLC6A1 mRNA16616335
D003907DexamethasoneDexamethasone affects the expression of SLC6A1 mRNA15102944
C036042dicyclohexyl phthalatedicyclohexyl phthalate affects the expression of SLC6A1 mRNA26924002
D004041Dietary FatsDietary Fats results in increased expression of SLC6A1 mRNA25016146
C118739entinostatentinostat results in increased expression of SLC6A1 mRNA27188386
C074283estradiol 3-benzoateestradiol 3-benzoate results in decreased expression of SLC6A1 mRNA15664431
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of SLC6A1 mRNA15664431
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of SLC6A1 mRNA23550701
C039281furanfuran results in decreased expression of SLC6A1 mRNA26194646
C010974glyphosate[Surface-Active Agents co-treated with glyphosate] results in increased expression of SLC6A1 mRNA22467014
D007501Iron[Iron deficiency co-treated with manganese chloride] results in decreased expression of SLC6A1 mRNA18771689
D007501Iron[Iron deficiency co-treated with manganese chloride] results in decreased expression of SLC6A1 protein18771689
D007501Iron[Iron deficiency co-treated with manganese chloride] results in increased expression of SLC6A1 mRNA18771689
D007501IronIron deficiency results in decreased expression of SLC6A1 protein18771689
D007501IronIron deficiency results in increased expression of SLC6A1 mRNA18771689
C099406L 742694L 742694 affects the expression of SLC6A1 mRNA15102944
D007854LeadLead affects the expression of SLC6A1 mRNA28903495
D007854LeadLead results in increased expression of SLC6A1 protein15149801
D008070LipopolysaccharidesLipopolysaccharides results in decreased expression of SLC6A1 mRNA21219332
C025340manganese chloride[Iron deficiency co-treated with manganese chloride] results in decreased expression of SLC6A1 mRNA18771689
C025340manganese chloride[Iron deficiency co-treated with manganese chloride] results in decreased expression of SLC6A1 protein18771689
C025340manganese chloride[Iron deficiency co-treated with manganese chloride] results in increased expression of SLC6A1 mRNA18771689
C025340manganese chloridemanganese chloride results in decreased expression of SLC6A1 mRNA18771689
C025340manganese chloridemanganese chloride results in decreased expression of SLC6A1 protein18771689
C025340manganese chloridemanganese chloride results in increased expression of SLC6A1 mRNA18771689
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of SLC6A1 protein25809596
C517284monomethyl phthalatemonomethyl phthalate affects the expression of SLC6A1 mRNA26924002
D009020Morphine[NNC 711 results in decreased activity of SLC6A1 protein] which affects the susceptibility to Morphine14598306
D009020MorphineSLC6A1 protein affects the susceptibility to Morphine14598306
D009544Niflumic AcidNiflumic Acid inhibits the reaction [SLC6A1 protein results in increased uptake of gamma-Aminobutyric Acid]15981712
C078793NNC 711[NNC 711 results in decreased activity of SLC6A1 protein] which affects the susceptibility to Morphine14598306
C078793NNC 711NNC 711 results in decreased activity of SLC6A1 protein14598306
D010862PilocarpinePilocarpine results in decreased expression of SLC6A1 mRNA21219332
D010862PilocarpinePilocarpine results in decreased expression of SLC6A1 protein12183020
D011374ProgesteroneProgesterone results in decreased expression of SLC6A1 mRNA20631399
D013501Surface-Active Agents[Surface-Active Agents co-treated with glyphosate] results in increased expression of SLC6A1 mRNA22467014
D013619TacrineTacrine results in increased expression of SLC6A1 mRNA12832660
C059205tiagabinetiagabine results in decreased activity of SLC6A1 protein15788781
D014050TolueneToluene affects the expression of SLC6A1 mRNA21827849
C057693troglitazonetroglitazone results in decreased expression of SLC6A1 mRNA25572481
D014635Valproic AcidValproic Acid affects the expression of SLC6A1 mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of SLC6A1 mRNA23179753|2718838
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of SLC6A1 gene25560391
D014862Wasp VenomsWasp Venoms inhibits the reaction [SLC6A1 protein results in increased uptake of gamma-Aminobutyric Acid]28621878

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005215transporter activity-IBA21873635  
GO:0005332gamma-aminobutyric acid:sodium symporter activity-IBA21873635  
GO:0005332gamma-aminobutyric acid:sodium symporter activity-TAS-  
GO:0042165neurotransmitter binding-IBA21873635  
GO:0046872metal ion binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0007268chemical synaptic transmission-TAS8530094  
GO:0035725sodium ion transmembrane transport-IBA21873635  
GO:0055085transmembrane transport-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005886plasma membrane-IBA21873635  
GO:0005886plasma membrane-TAS-  
GO:0009986cell surface-IBA21873635  
GO:0016020membrane-TAS2387399  
GO:0016021integral component of membrane-TAS8530094  
GO:0030424axon-IBA21873635  
GO:0043005neuron projection-IBA21873635  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-112310Neurotransmitter release cycleTAS
R-HSA-112315Transmission across Chemical SynapsesTAS
R-HSA-112316Neuronal SystemTAS
R-HSA-382551Transport of small moleculesTAS
R-HSA-425366Transport of bile salts and organic acids, metal ions and amine compoundsTAS
R-HSA-425407SLC-mediated transmembrane transportTAS
R-HSA-442660Na+/Cl- dependent neurotransmitter transportersTAS
R-HSA-888590GABA synthesis, release, reuptake and degradationTAS
R-HSA-888593Reuptake of GABATAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
26727527GABBR1 and SLC6A1, Two Genes Involved in Modulation of GABA Synaptic Transmission, Influence Risk for Alcoholism: Results from Three Ethnically Diverse Populations. (2016 Jan)Enoch MAAlcohol Clin Exp Res
20589092Ethanol and phencyclidine interact with respect to nucleus accumbens dopamine release: differential effects of administration order and pretreatment protocol. (2010)Pickering CFront Behav Neurosci