Gene: SLC6A3

6531
DAT|DAT1|PKDYS
solute carrier family 6 member 3
protein-coding
5p15.33
Ensembl:ENSG00000142319 MIM:126455 Vega:OTTHUMG00000131016 UniprotKB:Q01959
NG_015885.1
PubMed
0   ANCO-SNPs
CD|OD|ND|AD
67   
NA (AD)  NA (ND)   (Frontal_Cortex)
6.271e-1 (AD)  9.815e-1 (ND)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg26924408chr5:1394484SLC6A33'UTR1.387e-4Alcohol use disorders26763658

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
DEFB1150.596
OPN1MW20.572
CALCB0.568
GSC0.564
ASIP0.563
CCDC1400.553
OXT0.55
GALR20.549
TRH0.547
C22orf420.545

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SLC6A12-0.205
RIMS2-0.202
RGS5-0.198
RAPGEF4-0.195
ITIH5-0.191
UNC13C-0.19
SYTL2-0.187
RIMS1-0.185
CYTH3-0.176
SMYD1-0.17

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00215CitalopramSmall Molecule59729-33-8ApprovedTransporter
DB01454MidomafetamineSmall Molecule42542-10-9Experimental|Illicit|InvestigationalTransporter
DB08824Ioflupane I-123Small Molecule155798-07-5ApprovedTransporter
DB09194EtoperidoneSmall Molecule52942-31-1WithdrawnTransporter
DB00182AmphetamineSmall Molecule300-62-9Approved|Illicit|InvestigationalTarget
DB00191PhentermineSmall Molecule122-09-8Approved|IllicitTarget
DB00245BenzatropineSmall Molecule86-13-5ApprovedTarget
DB00285VenlafaxineSmall Molecule93413-69-5ApprovedTarget
DB00289AtomoxetineSmall Molecule83015-26-3ApprovedTarget
DB00370MirtazapineSmall Molecule85650-52-8ApprovedTarget
DB00408LoxapineSmall Molecule1977-10-2ApprovedTarget
DB00422MethylphenidateSmall Molecule113-45-1Approved|InvestigationalTarget
DB00454PethidineSmall Molecule57-42-1ApprovedTarget
DB00458ImipramineSmall Molecule50-49-7ApprovedTarget
DB00476DuloxetineSmall Molecule116539-59-4ApprovedTarget
DB00543AmoxapineSmall Molecule14028-44-5ApprovedTarget
DB00579MazindolSmall Molecule22232-71-9Approved|InvestigationalTarget
DB00721ProcaineSmall Molecule59-46-1Approved|InvestigationalTarget
DB00726TrimipramineSmall Molecule739-71-9ApprovedTarget
DB00745ModafinilSmall Molecule68693-11-8Approved|InvestigationalTarget
DB00830PhenmetrazineSmall Molecule134-49-6Approved|IllicitTarget
DB00852PseudoephedrineSmall Molecule90-82-4ApprovedTarget
DB00865BenzphetamineSmall Molecule156-08-1Approved|IllicitTarget
DB00907CocaineSmall Molecule50-36-2Approved|IllicitTarget
DB00937DiethylpropionSmall Molecule90-84-6Approved|IllicitTarget
DB00988DopamineSmall Molecule51-61-6ApprovedTarget
DB01104SertralineSmall Molecule79617-96-2ApprovedTarget
DB01105SibutramineSmall Molecule106650-56-0Approved|Illicit|Investigational|WithdrawnTarget
DB01114ChlorphenamineSmall Molecule132-22-9ApprovedTarget
DB01146DiphenylpyralineSmall Molecule147-20-6Approved|InvestigationalTarget
DB01149NefazodoneSmall Molecule83366-66-9Approved|WithdrawnTarget
DB01156BupropionSmall Molecule34911-55-2ApprovedTarget
DB01161ChloroprocaineSmall Molecule133-16-4ApprovedTarget
DB01175EscitalopramSmall Molecule128196-01-0Approved|InvestigationalTarget
DB01255LisdexamfetamineSmall Molecule608137-32-2Approved|InvestigationalTarget
DB01363EphedraSmall Molecule-Approved|Nutraceutical|WithdrawnTarget
DB01442MMDASmall Molecule13674-05-0Experimental|IllicitTarget
DB01454MidomafetamineSmall Molecule42542-10-9Experimental|Illicit|InvestigationalTarget
DB01463FencamfamineSmall Molecule1209-98-9Approved|Illicit|WithdrawnTarget
DB014724-MethoxyamphetamineSmall Molecule64-13-1Experimental|IllicitTarget
DB01576DextroamphetamineSmall Molecule51-64-9Approved|IllicitTarget
DB01577MethamphetamineSmall Molecule537-46-2Approved|IllicitTarget
DB03701VanoxerineSmall Molecule67469-69-6InvestigationalTarget
DB04821NomifensineSmall Molecule24526-64-5WithdrawnTarget
DB04947AltropaneSmall Molecule180468-34-2InvestigationalTarget
DB06148MianserinSmall Molecule24219-97-4Approved|InvestigationalTarget
DB06156TesofensineSmall Molecule195875-84-4InvestigationalTarget
DB06333TrodusquemineBiotechDrug186139-09-3InvestigationalTarget
DB06413ArmodafinilSmall Molecule112111-43-0Approved|InvestigationalTarget
DB06701DexmethylphenidateSmall Molecule40431-64-9Approved|InvestigationalTarget
DB12305DasotralineSmall Molecule675126-05-3InvestigationalTarget
ID Drug Name Action PubMed
C5348801,1-bis(3'-indolyl)-1-(4-chlorophenyl)methane"1,1-bis(3'-indolyl)-1-(4-chlorophenyl)methane inhibits the reaction [[1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine co-treated with Probenecid] results in decreased expression of SLC6A3 protein]"25406165
C5525301,1-bis(3'-indolyl)-1-(4-hydroxyphenyl)methane"1,1-bis(3'-indolyl)-1-(4-hydroxyphenyl)methane inhibits the reaction [[1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine co-treated with Probenecid] results in decreased expression of SLC6A3 protein]"25406165
C5452551,1-bis(3'-indolyl)-1-(p-anisyl)methane"1,1-bis(3'-indolyl)-1-(p-anisyl)methane inhibits the reaction [[1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine co-treated with Probenecid] results in decreased expression of SLC6A3 protein]"25406165
C461261(1-(2-(bis(4-fluorophenyl)methoxy)ethyl)-4-(3-hydroxy-3-phenylpropyl) piperazinyl decanoate)(1-(2-(bis(4-fluorophenyl)methoxy)ethyl)-4-(3-hydroxy-3-phenylpropyl) piperazinyl decanoate) results in decreased activity of SLC6A3 protein12105088
C0397371-(2-(diphenylmethoxy)ethyl)-4-(3-phenyl-2-propenyl)piperazine1-(2-(diphenylmethoxy)ethyl)-4-(3-phenyl-2-propenyl)piperazine results in decreased activity of SLC6A3 protein14556232
C0446301-(2 (diphenylmethoxy)ethyl)-4-(3-phenylpropyl)piperazine1-(2 (diphenylmethoxy)ethyl)-4-(3-phenylpropyl)piperazine binds to SLC6A3 protein11226678
C0446301-(2 (diphenylmethoxy)ethyl)-4-(3-phenylpropyl)piperazine1-(2 (diphenylmethoxy)ethyl)-4-(3-phenylpropyl)piperazine inhibits the reaction [Dextroamphetamine results in increased activity of SLC6A3 protein]12716422
C0446301-(2 (diphenylmethoxy)ethyl)-4-(3-phenylpropyl)piperazineNR3C1 protein inhibits the reaction [1-(2 (diphenylmethoxy)ethyl)-4-(3-phenylpropyl)piperazine binds to SLC6A3 protein]11226678
C0446301-(2 (diphenylmethoxy)ethyl)-4-(3-phenylpropyl)piperazine1-(2 (diphenylmethoxy)ethyl)-4-(3-phenylpropyl)piperazine binds to SLC6A3 protein15985715|1619088
C0446301-(2 (diphenylmethoxy)ethyl)-4-(3-phenylpropyl)piperazineParaquat inhibits the reaction [1-(2 (diphenylmethoxy)ethyl)-4-(3-phenylpropyl)piperazine binds to SLC6A3 protein]15985715|1619088
C4524241-(4-(2-(bis(4-fluorophenyl)methoxy)ethyl)piperazinyl)-3-phenylpropan-2-ol1-(4-(2-(bis(4-fluorophenyl)methoxy)ethyl)piperazinyl)-3-phenylpropan-2-ol binds to SLC6A3 protein11882001
C4524251-(4-(2-(diphenylmethoxy)ethyl)piperazinyl)-3-phenylpropan-2-ol1-(4-(2-(diphenylmethoxy)ethyl)piperazinyl)-3-phenylpropan-2-ol binds to SLC6A3 protein11882001
C47781915-deoxyprostaglandin J215-deoxyprostaglandin J2 inhibits the reaction [Methamphetamine results in decreased expression of SLC6A3 protein]18946735
C0005922731-phenyl-2-(1-pyrrolidinyl)-1-pentanone1-phenyl-2-(1-pyrrolidinyl)-1-pentanone inhibits the reaction [SLC6A3 protein results in increased import of Biogenic Monoamines analog]28506818
C0005922731-phenyl-2-(1-pyrrolidinyl)-1-pentanone1-phenyl-2-(1-pyrrolidinyl)-1-pentanone inhibits the reaction [SLC6A3 protein results in increased import of Fluorescent Dyes]28506818
C021279(1R-(exo,exo))-3-(4-fluorophenyl)-8-methyl-8- azabicyclo(3.2.1)octane-2-carboxylic acid, methyl ester"1-Methyl-4-phenylpyridinium inhibits the reaction [(1R-(exo,exo))-3-(4-fluorophenyl)-8-methyl-8- azabicyclo(3.2.1)octane-2-carboxylic acid, methyl ester binds to SLC6A3 protein]"17250655
C021279(1R-(exo,exo))-3-(4-fluorophenyl)-8-methyl-8- azabicyclo(3.2.1)octane-2-carboxylic acid, methyl ester"(1R-(exo,exo))-3-(4-fluorophenyl)-8-methyl-8- azabicyclo(3.2.1)octane-2-carboxylic acid, methyl ester binds to SLC6A3 protein"12064476|1611027
C021279(1R-(exo,exo))-3-(4-fluorophenyl)-8-methyl-8- azabicyclo(3.2.1)octane-2-carboxylic acid, methyl ester"Cocaine promotes the reaction [(1R-(exo,exo))-3-(4-fluorophenyl)-8-methyl-8- azabicyclo(3.2.1)octane-2-carboxylic acid, methyl ester binds to SLC6A3 protein]"12064476|1611027
C021279(1R-(exo,exo))-3-(4-fluorophenyl)-8-methyl-8- azabicyclo(3.2.1)octane-2-carboxylic acid, methyl ester"(1R-(exo,exo))-3-(4-fluorophenyl)-8-methyl-8- azabicyclo(3.2.1)octane-2-carboxylic acid, methyl ester binds to SLC6A3 protein"18769473
C021279(1R-(exo,exo))-3-(4-fluorophenyl)-8-methyl-8- azabicyclo(3.2.1)octane-2-carboxylic acid, methyl ester"Cocaine affects the reaction [(1R-(exo,exo))-3-(4-fluorophenyl)-8-methyl-8- azabicyclo(3.2.1)octane-2-carboxylic acid, methyl ester binds to SLC6A3 protein]"18769473
C021279(1R-(exo,exo))-3-(4-fluorophenyl)-8-methyl-8- azabicyclo(3.2.1)octane-2-carboxylic acid, methyl ester"(1R-(exo,exo))-3-(4-fluorophenyl)-8-methyl-8- azabicyclo(3.2.1)octane-2-carboxylic acid, methyl ester binds to SLC6A3 protein"16897726|8891593
C021279(1R-(exo,exo))-3-(4-fluorophenyl)-8-methyl-8- azabicyclo(3.2.1)octane-2-carboxylic acid, methyl ester"Methamphetamine inhibits the reaction [(1R-(exo,exo))-3-(4-fluorophenyl)-8-methyl-8- azabicyclo(3.2.1)octane-2-carboxylic acid, methyl ester binds to SLC6A3 protein]"16897726
C021279(1R-(exo,exo))-3-(4-fluorophenyl)-8-methyl-8- azabicyclo(3.2.1)octane-2-carboxylic acid, methyl ester"(1R-(exo,exo))-3-(4-fluorophenyl)-8-methyl-8- azabicyclo(3.2.1)octane-2-carboxylic acid, methyl ester binds to SLC6A3 protein"12672245|2393324
C021279(1R-(exo,exo))-3-(4-fluorophenyl)-8-methyl-8- azabicyclo(3.2.1)octane-2-carboxylic acid, methyl ester"2,3,3',4',6-pentachlorobiphenyl inhibits the reaction [(1R-(exo,exo))-3-(4-fluorophenyl)-8-methyl-8- azabicyclo(3.2.1)octane-2-carboxylic acid, methyl ester binds to SLC6A3 protein]"23933243
C021279(1R-(exo,exo))-3-(4-fluorophenyl)-8-methyl-8- azabicyclo(3.2.1)octane-2-carboxylic acid, methyl ester"aroclor 1242 inhibits the reaction [(1R-(exo,exo))-3-(4-fluorophenyl)-8-methyl-8- azabicyclo(3.2.1)octane-2-carboxylic acid, methyl ester binds to SLC6A3 protein]"23933243
C021279(1R-(exo,exo))-3-(4-fluorophenyl)-8-methyl-8- azabicyclo(3.2.1)octane-2-carboxylic acid, methyl ester"aroclor 1260 inhibits the reaction [(1R-(exo,exo))-3-(4-fluorophenyl)-8-methyl-8- azabicyclo(3.2.1)octane-2-carboxylic acid, methyl ester binds to SLC6A3 protein]"23933243
C021279(1R-(exo,exo))-3-(4-fluorophenyl)-8-methyl-8- azabicyclo(3.2.1)octane-2-carboxylic acid, methyl ester"Chlorodiphenyl (54% Chlorine) inhibits the reaction [(1R-(exo,exo))-3-(4-fluorophenyl)-8-methyl-8- azabicyclo(3.2.1)octane-2-carboxylic acid, methyl ester binds to SLC6A3 protein]"23933243
C021279(1R-(exo,exo))-3-(4-fluorophenyl)-8-methyl-8- azabicyclo(3.2.1)octane-2-carboxylic acid, methyl ester"Cocaine inhibits the reaction [(1R-(exo,exo))-3-(4-fluorophenyl)-8-methyl-8- azabicyclo(3.2.1)octane-2-carboxylic acid, methyl ester binds to SLC6A3 protein]"23933243
C021279(1R-(exo,exo))-3-(4-fluorophenyl)-8-methyl-8- azabicyclo(3.2.1)octane-2-carboxylic acid, methyl ester"[rimcazole analog binds to SLC6A3 protein] inhibits the reaction [(1R-(exo,exo))-3-(4-fluorophenyl)-8-methyl-8- azabicyclo(3.2.1)octane-2-carboxylic acid, methyl ester binds to SLC6A3 protein]"9435903
C0329032,3,3',4',6-pentachlorobiphenyl"2,3,3',4',6-pentachlorobiphenyl inhibits the reaction [(1R-(exo,exo))-3-(4-fluorophenyl)-8-methyl-8- azabicyclo(3.2.1)octane-2-carboxylic acid, methyl ester binds to SLC6A3 protein]"23933243
C0930262,3,5,4'-tetrahydroxystilbene 2-O-glucopyranoside"2,3,5,4'-tetrahydroxystilbene 2-O-glucopyranoside inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of SLC6A3 protein]"23911879
C5691132-(3-methoxyphenyl)-2-(ethylamino)cyclohexanone2-(3-methoxyphenyl)-2-(ethylamino)cyclohexanone inhibits the reaction [SLC6A3 protein results in increased import of Biogenic Monoamines analog]28506818
C5691132-(3-methoxyphenyl)-2-(ethylamino)cyclohexanone2-(3-methoxyphenyl)-2-(ethylamino)cyclohexanone inhibits the reaction [SLC6A3 protein results in increased import of Fluorescent Dyes]28506818
C0140242,4,5,2',4',5'-hexachlorobiphenyl"2,4,5,2',4',5'-hexachlorobiphenyl results in decreased expression of SLC6A3 protein"26215117
C0793212-(4-bromo-2,5-dimethoxyphenyl)ethylamine"2-(4-bromo-2,5-dimethoxyphenyl)ethylamine inhibits the reaction [SLC6A3 protein results in increased import of Biogenic Monoamines analog]"28506818
C0793212-(4-bromo-2,5-dimethoxyphenyl)ethylamine"2-(4-bromo-2,5-dimethoxyphenyl)ethylamine inhibits the reaction [SLC6A3 protein results in increased import of Fluorescent Dyes]"28506818
C0005959262-(4-bromo-2,5-dimethoxyphenyl)-N-((2-methoxyphenyl)methyl)ethanamine"2-(4-bromo-2,5-dimethoxyphenyl)-N-((2-methoxyphenyl)methyl)ethanamine inhibits the reaction [SLC6A3 protein results in increased import of Biogenic Monoamines analog]"28506818
C0005959262-(4-bromo-2,5-dimethoxyphenyl)-N-((2-methoxyphenyl)methyl)ethanamine"2-(4-bromo-2,5-dimethoxyphenyl)-N-((2-methoxyphenyl)methyl)ethanamine inhibits the reaction [SLC6A3 protein results in increased import of Fluorescent Dyes]"28506818
C5541812-(4-iodo-2,5-dimethoxyphenyl)-N-(2-methoxybenzyl)ethanamine"2-(4-iodo-2,5-dimethoxyphenyl)-N-(2-methoxybenzyl)ethanamine inhibits the reaction [SLC6A3 protein results in increased import of Biogenic Monoamines analog]"28506818
C5541812-(4-iodo-2,5-dimethoxyphenyl)-N-(2-methoxybenzyl)ethanamine"2-(4-iodo-2,5-dimethoxyphenyl)-N-(2-methoxybenzyl)ethanamine inhibits the reaction [SLC6A3 protein results in increased import of Fluorescent Dyes]"28506818
C0697232beta-carbomethoxy-3beta-(4-iodophenyl)tropane2beta-carbomethoxy-3beta-(4-iodophenyl)tropane binds to and results in decreased activity of SLC6A3 protein20969853
C0697232beta-carbomethoxy-3beta-(4-iodophenyl)tropaneMelitten inhibits the reaction [2beta-carbomethoxy-3beta-(4-iodophenyl)tropane binds to SLC6A3 protein]20969853
C0312782-chloroethyl ethyl sulfide2-chloroethyl ethyl sulfide results in decreased expression of SLC6A3 protein21898719
C0406394-fluoroamphetamine4-fluoroamphetamine inhibits the reaction [SLC6A3 protein results in increased import of Biogenic Monoamines analog]28506818
C0406394-fluoroamphetamine4-fluoroamphetamine inhibits the reaction [SLC6A3 protein results in increased import of Fluorescent Dyes]28506818
C0601694-methoxymethamphetamine4-methoxymethamphetamine inhibits the reaction [SLC6A3 protein results in increased import of Biogenic Monoamines analog]28506818
C0601694-methoxymethamphetamine4-methoxymethamphetamine inhibits the reaction [SLC6A3 protein results in increased import of Fluorescent Dyes]28506818
C0175724-nitrotoluene4-nitrotoluene results in decreased expression of SLC6A3 mRNA15265578
C0006082505-(2-aminopropyl)benzofuran5-(2-aminopropyl)benzofuran inhibits the reaction [SLC6A3 protein results in increased import of Biogenic Monoamines analog]28506818
C0006082505-(2-aminopropyl)benzofuran5-(2-aminopropyl)benzofuran inhibits the reaction [SLC6A3 protein results in increased import of Fluorescent Dyes]28506818
C4853836,7-dihydroxyflavone"6,7-dihydroxyflavone inhibits the reaction [Methamphetamine results in decreased expression of SLC6A3]"23934209
C4853836,7-dihydroxyflavone"ANA 12 compound inhibits the reaction [6,7-dihydroxyflavone inhibits the reaction [Methamphetamine results in decreased expression of SLC6A3]]"23934209
C0106436-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid"6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid inhibits the reaction [[Dopamine co-treated with SLC6A3 protein] results in increased expression of FOS protein]"12112414
C0801227-nitroindazole7-nitroindazole inhibits the reaction [Methamphetamine results in decreased expression of SLC6A3 protein]20575850
D020106AcrylamideAcrylamide results in decreased expression of SLC6A325943760
D020106AcrylamideAcrylamide results in decreased expression of SLC6A3 mRNA28959563
D000336AerosolsAerosols results in decreased expression of SLC6A3 mRNA25265048
C014959albiflorinalbiflorin affects the expression of SLC6A326475043
D000438Alcohols[Alcohols co-treated with Cocaine] results in increased activity of SLC6A3 protein11165777
D000438AlcoholsAlcohols results in increased activity of SLC6A3 protein11165777
D000438AlcoholsSLC6A3 protein affects the reaction [Alcohols results in increased uptake of Dopamine]11165777
D000438AlcoholsSLC6A3 protein affects the reaction [[Cocaine co-treated with Alcohols] results in increased uptake of Dopamine]11165777
C006733alpha-benzyl-N-methylphenethylaminealpha-benzyl-N-methylphenethylamine binds to SLC6A3 protein8891593
D000535Aluminum[APP protein modified form binds to Aluminum] which results in increased expression of SLC6A3 mRNA21298039
D000643Ammonium ChlorideAmmonium Chloride affects the expression of SLC6A3 mRNA16483693
D003913Dextroamphetamine1-(2 (diphenylmethoxy)ethyl)-4-(3-phenylpropyl)piperazine inhibits the reaction [Dextroamphetamine results in increased activity of SLC6A3 protein]12716422
D003913DextroamphetamineDextroamphetamine results in increased activity of SLC6A3 protein12716422
D003913DextroamphetamineSLC6A3 protein affects the susceptibility to Dextroamphetamine11797063
D003913DextroamphetamineDextroamphetamine results in decreased expression of SLC6A3 protein15900317
D000661AmphetamineAmphetamine affects the localization of SLC6A3 protein16684900
D000661Amphetamine[Amphetamine co-treated with SLC6A3 protein] results in increased expression of FOS mRNA12112414
D000661Amphetamine[Amphetamine co-treated with SLC6A3 protein] results in increased expression of FOS protein12112414
D000661Amphetamine[Amphetamine co-treated with Zinc] results in decreased localization of SLC6A3 protein16684900
D000661AmphetamineAmphetamine inhibits the reaction [SLC6A3 protein mutant form results in increased export of Dopamine]18614672
D000661AmphetamineAmphetamine inhibits the reaction [SLC6A3 protein results in increased import of Biogenic Monoamines analog]28506818
D000661AmphetamineAmphetamine inhibits the reaction [SLC6A3 protein results in increased import of Fluorescent Dyes]28506818
D000661AmphetamineSLC6A3 3' UTR polymorphism affects the susceptibility to Amphetamine19462300
D000661AmphetamineSLC6A3 3' UTR polymorphism results in decreased susceptibility to Amphetamine15602501
D000661AmphetamineSLC6A3 protein results in increased susceptibility to Amphetamine15602501
D000661AmphetamineSOD1 protein inhibits the reaction [Amphetamine results in decreased expression of SLC6A3 protein]11731100
D000661AmphetamineSLC6A3 protein promotes the reaction [Amphetamine results in increased activity of TAAR1 protein]15764732
D000661AmphetamineAmphetamine results in decreased expression of SLC6A3 protein11731100
D000661AmphetamineSLC6A3 protein affects the reaction [Amphetamine results in increased expression of FOS protein]12699766
D000661AmphetamineAmphetamine results in increased expression of SLC6A3 mRNA16126238
C559317ANA 12 compound"ANA 12 compound inhibits the reaction [6,7-dihydroxyflavone inhibits the reaction [Methamphetamine results in decreased expression of SLC6A3]]"23934209
C027386Aroclor 1016Aroclor 1016 results in decreased expression of SLC6A3 protein15019086
C027423aroclor 1242[aroclor 1242 co-treated with aroclor 1248 co-treated with Chlorodiphenyl (54% Chlorine) co-treated with aroclor 1260] results in decreased expression of SLC6A3 protein17324953
C027423aroclor 1242"aroclor 1242 inhibits the reaction [(1R-(exo,exo))-3-(4-fluorophenyl)-8-methyl-8- azabicyclo(3.2.1)octane-2-carboxylic acid, methyl ester binds to SLC6A3 protein]"23933243
C028617aroclor 1248[aroclor 1242 co-treated with aroclor 1248 co-treated with Chlorodiphenyl (54% Chlorine) co-treated with aroclor 1260] results in decreased expression of SLC6A3 protein17324953
C026987aroclor 1260aroclor 1260 results in decreased expression of SLC6A3 protein15019086
C026987aroclor 1260[Chlorodiphenyl (54% Chlorine) co-treated with aroclor 1260] inhibits the reaction [SLC6A3 protein results in increased uptake of Dopamine]16702228
C026987aroclor 1260[Chlorodiphenyl (54% Chlorine) co-treated with aroclor 1260] results in decreased expression of SLC6A3 protein16702228
C026987aroclor 1260[aroclor 1242 co-treated with aroclor 1248 co-treated with Chlorodiphenyl (54% Chlorine) co-treated with aroclor 1260] results in decreased expression of SLC6A3 protein17324953
C026987aroclor 1260"aroclor 1260 inhibits the reaction [(1R-(exo,exo))-3-(4-fluorophenyl)-8-methyl-8- azabicyclo(3.2.1)octane-2-carboxylic acid, methyl ester binds to SLC6A3 protein]"23933243
D001280AtrazineAtrazine results in decreased expression of SLC6A3 mRNA23123945|2486396
D001280AtrazineAtrazine results in decreased expression of SLC6A3 protein24863964
D001280AtrazineAtrazine results in increased expression of SLC6A3 mRNA28341570
D001590BenztropineBenztropine inhibits the reaction [SLC6A3 protein results in increased uptake of Dopamine]17250655
D001590BenztropineBenztropine analog binds to SLC6A3 protein17879975
C072553benzyloxycarbonylleucyl-leucyl-leucine aldehydebenzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [NDFIP1 protein results in decreased expression of SLC6A3 protein]26300475
D004958Estradiol[Estradiol binds to ESR2 protein] which results in increased expression of SLC6A3 mRNA20404318
D004958Estradiol"Estradiol inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased activity of SLC6A3 protein]"16011487
D004958Estradiol[bisphenol A co-treated with Estradiol] inhibits the reaction [SLC6A3 protein affects the export of Dopamine]19479021
D004958Estradiol[Dichlorodiphenyl Dichloroethylene co-treated with Estradiol] promotes the reaction [SLC6A3 protein affects the export of Dopamine]19479021
D004958EstradiolESR2 protein affects the reaction [Estradiol results in increased expression of SLC6A3 protein]16451217
D004958EstradiolEstradiol affects the reaction [SLC6A3 protein affects the export of Dopamine]19479021
D004958EstradiolEstradiol results in increased expression of SLC6A3 protein16451217
D015306Biogenic Monoamines1-phenyl-2-(1-pyrrolidinyl)-1-pentanone inhibits the reaction [SLC6A3 protein results in increased import of Biogenic Monoamines analog]28506818
D015306Biogenic Monoamines2-(3-methoxyphenyl)-2-(ethylamino)cyclohexanone inhibits the reaction [SLC6A3 protein results in increased import of Biogenic Monoamines analog]28506818
D015306Biogenic Monoamines"2-(4-bromo-2,5-dimethoxyphenyl)ethylamine inhibits the reaction [SLC6A3 protein results in increased import of Biogenic Monoamines analog]"28506818
D015306Biogenic Monoamines"2-(4-bromo-2,5-dimethoxyphenyl)-N-((2-methoxyphenyl)methyl)ethanamine inhibits the reaction [SLC6A3 protein results in increased import of Biogenic Monoamines analog]"28506818
D015306Biogenic Monoamines"2-(4-iodo-2,5-dimethoxyphenyl)-N-(2-methoxybenzyl)ethanamine inhibits the reaction [SLC6A3 protein results in increased import of Biogenic Monoamines analog]"28506818
D015306Biogenic Monoamines4-fluoroamphetamine inhibits the reaction [SLC6A3 protein results in increased import of Biogenic Monoamines analog]28506818
D015306Biogenic Monoamines4-methoxymethamphetamine inhibits the reaction [SLC6A3 protein results in increased import of Biogenic Monoamines analog]28506818
D015306Biogenic Monoamines5-(2-aminopropyl)benzofuran inhibits the reaction [SLC6A3 protein results in increased import of Biogenic Monoamines analog]28506818
D015306Biogenic MonoaminesAmphetamine inhibits the reaction [SLC6A3 protein results in increased import of Biogenic Monoamines analog]28506818
D015306Biogenic MonoaminesCocaine inhibits the reaction [SLC6A3 protein results in increased import of Biogenic Monoamines analog]28506818
D015306Biogenic MonoaminesFluoxetine inhibits the reaction [SLC6A3 protein results in increased import of Biogenic Monoamines analog]28506818
D015306Biogenic Monoamines"N-Methyl-3,4-methylenedioxyamphetamine inhibits the reaction [SLC6A3 protein results in increased import of Biogenic Monoamines analog]"28506818
D015306Biogenic MonoaminesSLC6A3 protein results in increased import of Biogenic Monoamines analog28506818
C070515bisindolylmaleimide Ibisindolylmaleimide I inhibits the reaction [[Dopamine co-treated with SLC6A3 protein] results in increased expression of FOS protein]12112414
C006780bisphenol Abisphenol A affects the expression of SLC6A3 mRNA21786754
C006780bisphenol Abisphenol A results in increased expression of SLC6A3 protein27494678
C006780bisphenol Abisphenol A affects the localization of SLC6A3 protein19479021
C006780bisphenol Abisphenol A affects the reaction [SLC6A3 protein affects the export of Dopamine]19479021
C006780bisphenol A[bisphenol A co-treated with Estradiol] inhibits the reaction [SLC6A3 protein affects the export of Dopamine]19479021
C006780bisphenol Abisphenol A results in decreased expression of SLC6A3 mRNA15079872|1768903
D016642Bupropion[Bupropion co-treated with SLC6A3 protein] results in increased expression of FOS protein12112414
D016642BupropionBupropion inhibits the reaction [[Dopamine co-treated with SLC6A3 protein] results in increased expression of FOS mRNA]12112414
D016642BupropionBupropion inhibits the reaction [[Dopamine co-treated with SLC6A3 protein] results in increased expression of FOS protein]12112414
D016642BupropionBupropion inhibits the reaction [SLC6A3 protein mutant form results in decreased import of Dopamine]27555326
D016642BupropionBupropion promotes the reaction [SLC6A3 protein results in increased import of Dopamine]27555326
D016642BupropionBupropion results in increased expression of SLC6A3 protein27555326
D002087ButyratesButyrates inhibits the reaction [Cocaine inhibits the reaction [SLC6A3 protein results in increased uptake of Dopamine]]17250655
D002087ButyratesButyrates inhibits the reaction [Mazindol inhibits the reaction [SLC6A3 protein results in increased uptake of Dopamine]]17250655
D002087ButyratesButyrates results in increased expression of SLC6A3 protein17250655
D020148Butyric AcidButyric Acid results in increased expression of SLC6A3 mRNA28743636
D019256Cadmium ChlorideCadmium Chloride results in increased expression of SLC6A3 mRNA12160620
D002110CaffeineSLC6A3 gene polymorphism affects the susceptibility to Caffeine24403155
D002110CaffeineSLC6A3 gene mutant form results in increased susceptibility to Caffeine11222668
D002220CarbamazepineCarbamazepine affects the expression of SLC6A3 mRNA25979313
D002243CarbolinesSLC6A3 protein results in increased susceptibility to Carbolines analog15086525
D002251Carbon TetrachlorideCarbon Tetrachloride affects the expression of SLC6A3 mRNA17805973
C023665cathinonecathinone analog results in decreased expression of SLC6A3 mRNA28173643
D020111Chlorodiphenyl (54% Chlorine)[Chlorodiphenyl (54% Chlorine) co-treated with aroclor 1260] inhibits the reaction [SLC6A3 protein results in increased uptake of Dopamine]16702228
D020111Chlorodiphenyl (54% Chlorine)[Chlorodiphenyl (54% Chlorine) co-treated with aroclor 1260] results in decreased expression of SLC6A3 protein16702228
D020111Chlorodiphenyl (54% Chlorine)Chlorodiphenyl (54% Chlorine) results in decreased expression of SLC6A3 protein22094459|2439449
D020111Chlorodiphenyl (54% Chlorine)[Plant Extracts co-treated with Terpenes co-treated with ginsenoside Rg3] inhibits the reaction [Chlorodiphenyl (54% Chlorine) results in decreased expression of SLC6A3 protein]24394491
D020111Chlorodiphenyl (54% Chlorine)[aroclor 1242 co-treated with aroclor 1248 co-treated with Chlorodiphenyl (54% Chlorine) co-treated with aroclor 1260] results in decreased expression of SLC6A3 protein17324953
D020111Chlorodiphenyl (54% Chlorine)"Chlorodiphenyl (54% Chlorine) inhibits the reaction [(1R-(exo,exo))-3-(4-fluorophenyl)-8-methyl-8- azabicyclo(3.2.1)octane-2-carboxylic acid, methyl ester binds to SLC6A3 protein]"23933243
D004390ChlorpyrifosChlorpyrifos affects the expression of SLC6A3 mRNA18812211
D015283CitalopramSLC6A3 mutant form promotes the reaction [Citalopram results in increased abundance of Dopamine]14691264
D003024ClozapineSLC6A3 5' UTR affects the susceptibility to Clozapine20580759
D003042CocaineCocaine results in decreased expression of SLC6A3 mRNA17622340
D003042CocaineMelatonin affects the reaction [Cocaine affects the expression of SLC6A3 mRNA]17622340
D003042CocaineButyrates inhibits the reaction [Cocaine inhibits the reaction [SLC6A3 protein results in increased uptake of Dopamine]]17250655
D003042CocaineCocaine binds to SLC6A3 protein9372557
D003042Cocaine[Cocaine co-treated with SLC6A3 protein] results in increased expression of FOS protein12112414
D003042CocaineCocaine inhibits the reaction [[Dopamine co-treated with SLC6A3 protein] results in increased expression of FOS mRNA]12112414
D003042CocaineCocaine inhibits the reaction [[Dopamine co-treated with SLC6A3 protein] results in increased expression of FOS protein]12112414
D003042CocaineCocaine inhibits the reaction [Melitten results in increased localization of SLC6A3 protein]20969853|2268384
D003042CocaineCocaine inhibits the reaction [SLC6A3 protein results in increased import of Biogenic Monoamines analog]28506818
D003042CocaineCocaine inhibits the reaction [SLC6A3 protein results in increased import of Fluorescent Dyes]28506818
D003042CocaineCocaine inhibits the reaction [SLC6A3 protein results in increased transport of phenethylamine]15764732
D003042CocaineCocaine inhibits the reaction [SLC6A3 protein results in increased uptake of Dopamine]17250655
D003042Cocaine"Cocaine promotes the reaction [(1R-(exo,exo))-3-(4-fluorophenyl)-8-methyl-8- azabicyclo(3.2.1)octane-2-carboxylic acid, methyl ester binds to SLC6A3 protein]"12064476|1611027
D003042CocaineCocaine results in decreased expression of SLC6A3 mRNA10581411|1116577
D003042CocaineCocaine results in increased expression of SLC6A3 protein16110277|1856569
D003042CocaineSLC6A3 gene polymorphism results in increased susceptibility to Cocaine8825631
D003042Cocaine"Cocaine affects the reaction [(1R-(exo,exo))-3-(4-fluorophenyl)-8-methyl-8- azabicyclo(3.2.1)octane-2-carboxylic acid, methyl ester binds to SLC6A3 protein]"18769473
D003042CocaineCocaine binds to SLC6A3 protein11746736
D003042CocaineCocaine results in increased expression of SLC6A3 mRNA11165777
D003042Cocaine[Alcohols co-treated with Cocaine] results in increased activity of SLC6A3 protein11165777
D003042CocaineCocaine results in increased activity of SLC6A3 protein11165777
D003042CocaineSLC6A3 gene mutant form results in decreased susceptibility to Cocaine22034972
D003042CocaineSLC6A3 mutant form affects the reaction [Cocaine affects the abundance of and affects the uptake of Dopamine]14691264
D003042CocaineSLC6A3 mutant form affects the susceptibility to Cocaine11320258
D003042CocaineSLC6A3 protein affects the reaction [[Cocaine co-treated with Alcohols] results in increased uptake of Dopamine]11165777
D003042CocaineSLC6A3 protein affects the reaction [Cocaine results in increased uptake of Dopamine]11165777
D003042CocaineSLC6A3 protein affects the susceptibility to Cocaine11312315|1219319
D003042CocaineCocaine affects the expression of SLC6A3 mRNA11072100
D003042CocaineCocaine affects the expression of SLC6A3 protein11249581
D003042CocaineCocaine promotes the reaction [SLC6A3 protein affects the uptake of Dopamine]20035724
D003042CocaineCocaine results in decreased expression of SLC6A3 protein16179556
D003042CocaineCocaine results in increased phosphorylation of and results in increased activity of SLC6A3 protein20035724
D003042Cocainevanoxerine affects the reaction [Cocaine affects the expression of SLC6A3 protein]11249581
D003042CocaineCocaine binds to SLC6A3 protein11223167
D003042CocaineCocaine binds to SLC6A3 protein mutant form11223167
D003042CocaineCocaine binds to SLC6A3 protein9435903
D003042Cocaine"Cocaine inhibits the reaction [(1R-(exo,exo))-3-(4-fluorophenyl)-8-methyl-8- azabicyclo(3.2.1)octane-2-carboxylic acid, methyl ester binds to SLC6A3 protein]"23933243
C037304cyhalothrincyhalothrin results in decreased expression of SLC6A3 protein28495607
C532102D-161 compoundD-161 compound results in decreased activity of SLC6A3 protein18561912
C017180decamethrindecamethrin affects the activity of SLC6A3 protein16005927
C017180decamethrindecamethrin inhibits the reaction [SLC6A3 protein results in increased uptake of Dopamine]16005927
C017180decamethrindecamethrin results in increased expression of SLC6A3 protein16005927|2563097
C017180decamethrin[decamethrin results in increased expression of SLC6A3 protein] which results in increased uptake of Dopamine25630971
D003976DiazinonDiazinon affects the expression of SLC6A3 mRNA18812211
D003976DiazinonDiazinon results in increased expression of SLC6A3 mRNA29108742
D003633Dichlorodiphenyl Dichloroethylene[Dichlorodiphenyl Dichloroethylene co-treated with Estradiol] promotes the reaction [SLC6A3 protein affects the export of Dopamine]19479021
D003633Dichlorodiphenyl DichloroethyleneDichlorodiphenyl Dichloroethylene inhibits the reaction [SLC6A3 protein affects the export of Dopamine]19479021
D004026DieldrinDieldrin results in decreased expression of SLC6A3 protein17291500
D004026DieldrinDieldrin results in increased expression of SLC6A3 mRNA16809432
D004026DieldrinDieldrin results in increased expression of SLC6A3 protein16809432
D004026DieldrinDieldrin inhibits the reaction [SLC6A3 protein affects the export of Dopamine]19479021
D004026DieldrinDieldrin results in increased expression of SLC6A3 mRNA18812211
D004026DieldrinDieldrin results in increased expression of SLC6A3 protein11719704
D004041Dietary FatsDietary Fats results in increased expression of SLC6A3 mRNA18457598
D004054DiethylstilbestrolDiethylstilbestrol affects the reaction [SLC6A3 protein affects the export of Dopamine]19479021
D004079Dihydro-beta-ErythroidineDihydro-beta-Erythroidine affects the reaction [Nicotine results in decreased activity of SLC6A3 protein]23999947
D002117CalcitriolCalcitriol results in increased expression of SLC6A3 mRNA21592394
D002117Calcitriol[Testosterone co-treated with Calcitriol] results in increased expression of SLC6A3 mRNA21592394
D004050DitiocarbDitiocarb results in increased expression of SLC6A3 protein22874009
D007980LevodopaLevodopa results in decreased activity of SLC6A3 protein17664021
D004298Dopamine"6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid inhibits the reaction [[Dopamine co-treated with SLC6A3 protein] results in increased expression of FOS protein]"12112414
D004298DopamineAmphetamine inhibits the reaction [SLC6A3 protein mutant form results in increased export of Dopamine]18614672
D004298DopamineBenztropine inhibits the reaction [SLC6A3 protein results in increased uptake of Dopamine]17250655
D004298Dopaminebisindolylmaleimide I inhibits the reaction [[Dopamine co-treated with SLC6A3 protein] results in increased expression of FOS protein]12112414
D004298DopamineBupropion inhibits the reaction [[Dopamine co-treated with SLC6A3 protein] results in increased expression of FOS mRNA]12112414
D004298DopamineBupropion inhibits the reaction [[Dopamine co-treated with SLC6A3 protein] results in increased expression of FOS protein]12112414
D004298DopamineBupropion inhibits the reaction [SLC6A3 protein mutant form results in decreased import of Dopamine]27555326
D004298DopamineBupropion promotes the reaction [SLC6A3 protein results in increased import of Dopamine]27555326
D004298DopamineButyrates inhibits the reaction [Cocaine inhibits the reaction [SLC6A3 protein results in increased uptake of Dopamine]]17250655
D004298DopamineButyrates inhibits the reaction [Mazindol inhibits the reaction [SLC6A3 protein results in increased uptake of Dopamine]]17250655
D004298DopamineCocaine inhibits the reaction [[Dopamine co-treated with SLC6A3 protein] results in increased expression of FOS mRNA]12112414
D004298DopamineCocaine inhibits the reaction [[Dopamine co-treated with SLC6A3 protein] results in increased expression of FOS protein]12112414
D004298DopamineCocaine inhibits the reaction [SLC6A3 protein results in increased uptake of Dopamine]17250655
D004298Dopaminedecamethrin inhibits the reaction [SLC6A3 protein results in increased uptake of Dopamine]16005927
D004298DopamineDopamine affects the localization of SLC6A3 protein20875051
D004298Dopamine[Dopamine co-treated with SLC6A3 protein] results in increased expression of FOS mRNA12112414
D004298Dopamine[Dopamine co-treated with SLC6A3 protein] results in increased expression of FOS protein12112414
D004298DopamineIbogaine inhibits the reaction [SLC6A3 protein mutant form results in decreased import of Dopamine]27555326
D004298DopamineIbogaine promotes the reaction [SLC6A3 protein results in increased import of Dopamine]27555326
D004298Dopamineindatraline inhibits the reaction [SLC6A3 protein promotes the reaction [Dopamine results in increased activity of TAAR1 protein]]17234900
D004298DopamineLRRK2 mutant form results in increased susceptibility to [Dopamine co-treated with SLC6A3 protein]23628791
D004298DopamineMazindol inhibits the reaction [SLC6A3 protein results in increased uptake of Dopamine]17250655
D004298DopamineMelitten inhibits the reaction [SLC6A3 protein results in increased uptake of Dopamine]20969853
D004298DopamineMethylphenidate inhibits the reaction [[Dopamine co-treated with SLC6A3 protein] results in increased expression of FOS mRNA]12112414
D004298DopamineMethylphenidate inhibits the reaction [[Dopamine co-treated with SLC6A3 protein] results in increased expression of FOS protein]12112414
D004298DopamineMethylphenidate inhibits the reaction [SLC6A3 protein mutant form results in increased export of Dopamine]18614672
D004298DopamineMethylphenidate inhibits the reaction [SLC6A3 protein promotes the reaction [Dopamine results in increased activity of TAAR1 protein]]17234900
D004298DopamineNomifensine inhibits the reaction [SLC6A3 protein results in increased uptake of Dopamine]20875051
D004298DopaminePermethrin inhibits the reaction [SLC6A3 protein results in increased uptake of Dopamine]16005927
D004298DopamineSLC6A3 protein mutant form results in decreased import of Dopamine27555326
D004298DopamineSLC6A3 protein mutant form results in increased export of Dopamine18614672
D004298DopamineSLC6A3 protein promotes the reaction [Dopamine results in increased activity of TAAR1 protein]17234900
D004298DopamineSLC6A3 protein results in increased import of Dopamine27555326
D004298DopamineSLC6A3 protein results in increased susceptibility to Dopamine23313730
D004298DopamineSLC6A3 protein results in increased transport of Dopamine11707631
D004298DopamineSLC6A3 protein results in increased uptake of Dopamine16005927|1725065
D004298Dopamine[SNCA protein affects the localization of SLC6A3 protein] which affects the uptake of Dopamine19032594
D004298DopamineSulpiride inhibits the reaction [Dopamine affects the localization of SLC6A3 protein]20875051
D004298DopamineSulpiride inhibits the reaction [SLC6A3 protein results in increased uptake of Dopamine]20875051
D004298Dopaminevanoxerine inhibits the reaction [SLC6A3 protein results in increased uptake of Dopamine]17250655
D004298Dopaminewortmannin inhibits the reaction [SLC6A3 protein results in increased uptake of Dopamine]20875051
D004298Dopamine[Chlorodiphenyl (54% Chlorine) co-treated with aroclor 1260] inhibits the reaction [SLC6A3 protein results in increased uptake of Dopamine]16702228
D004298Dopamine[decamethrin results in increased expression of SLC6A3 protein] which results in increased uptake of Dopamine25630971
D004298DopamineHeptachlor promotes the reaction [SLC6A3 protein results in increased uptake of Dopamine]11294980
D004298DopamineSLC6A3 mutant form affects the reaction [Cocaine affects the abundance of and affects the uptake of Dopamine]14691264
D004298DopamineSLC6A3 mutant form affects the reaction [Fluoxetine affects the abundance of Dopamine]14691264
D004298DopamineSLC6A3 mutant form promotes the reaction [Citalopram results in increased abundance of Dopamine]14691264
D004298DopamineSLC6A3 protein affects the abundance of Dopamine18690110
D004298DopamineSLC6A3 protein affects the reaction [Alcohols results in increased uptake of Dopamine]11165777
D004298DopamineSLC6A3 protein affects the reaction [[Cocaine co-treated with Alcohols] results in increased uptake of Dopamine]11165777
D004298DopamineSLC6A3 protein affects the reaction [Cocaine results in increased uptake of Dopamine]11165777
D004298DopamineSLC6A3 protein affects the reaction [Methamphetamine affects the abundance of Dopamine]9634552
D004298Dopamine"SLC6A3 protein promotes the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased abundance of Dopamine]"22342763
D004298Dopamine"vanoxerine inhibits the reaction [SLC6A3 protein promotes the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased abundance of Dopamine]]"22342763
D004298Dopaminebisphenol A affects the reaction [SLC6A3 protein affects the export of Dopamine]19479021
D004298Dopamine[bisphenol A co-treated with Estradiol] inhibits the reaction [SLC6A3 protein affects the export of Dopamine]19479021
D004298DopamineCocaine promotes the reaction [SLC6A3 protein affects the uptake of Dopamine]20035724
D004298Dopamine[Dichlorodiphenyl Dichloroethylene co-treated with Estradiol] promotes the reaction [SLC6A3 protein affects the export of Dopamine]19479021
D004298DopamineDichlorodiphenyl Dichloroethylene inhibits the reaction [SLC6A3 protein affects the export of Dopamine]19479021
D004298DopamineDieldrin inhibits the reaction [SLC6A3 protein affects the export of Dopamine]19479021
D004298DopamineDiethylstilbestrol affects the reaction [SLC6A3 protein affects the export of Dopamine]19479021
D004298DopamineEndosulfan inhibits the reaction [SLC6A3 protein affects the export of Dopamine]19479021
D004298DopamineEstradiol affects the reaction [SLC6A3 protein affects the export of Dopamine]19479021
D004298Dopaminemodafinil inhibits the reaction [SLC6A3 protein affects the uptake of Dopamine]19197004
D004298Dopaminenonylphenol affects the reaction [SLC6A3 protein affects the export of Dopamine]19479021
D004298DopamineSLC6A3 protein affects the export of Dopamine19479021
D004298DopamineSLC6A3 protein affects the transport of Dopamine11223167
D004298DopamineSLC6A3 protein mutant form results in decreased transport of Dopamine11223167
D004298DopamineSLC6A3 protein results in increased uptake of Dopamine11719704
D004726EndosulfanEndosulfan inhibits the reaction [SLC6A3 protein affects the export of Dopamine]19479021
C074283estradiol 3-benzoateestradiol 3-benzoate inhibits the reaction [Methamphetamine results in decreased expression of SLC6A3 mRNA]15249736
C074283estradiol 3-benzoateestradiol 3-benzoate inhibits the reaction [Methamphetamine results in decreased expression of SLC6A3 protein]15249736
D004967EstrogensEstrogens results in decreased activity of SLC6A3 protein11424955
D004970Estrone"Estrone inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased activity of SLC6A3 protein]"16011487
D000431EthanolEthanol promotes the reaction [mephedrone results in decreased expression of SLC6A3 protein]26747301
D005038EthylnitrosoureaEthylnitrosourea results in increased mutagenesis of SLC6A3 gene16495775
D005456Fluorescent Dyes1-phenyl-2-(1-pyrrolidinyl)-1-pentanone inhibits the reaction [SLC6A3 protein results in increased import of Fluorescent Dyes]28506818
D005456Fluorescent Dyes2-(3-methoxyphenyl)-2-(ethylamino)cyclohexanone inhibits the reaction [SLC6A3 protein results in increased import of Fluorescent Dyes]28506818
D005456Fluorescent Dyes"2-(4-bromo-2,5-dimethoxyphenyl)ethylamine inhibits the reaction [SLC6A3 protein results in increased import of Fluorescent Dyes]"28506818
D005456Fluorescent Dyes"2-(4-bromo-2,5-dimethoxyphenyl)-N-((2-methoxyphenyl)methyl)ethanamine inhibits the reaction [SLC6A3 protein results in increased import of Fluorescent Dyes]"28506818
D005456Fluorescent Dyes"2-(4-iodo-2,5-dimethoxyphenyl)-N-(2-methoxybenzyl)ethanamine inhibits the reaction [SLC6A3 protein results in increased import of Fluorescent Dyes]"28506818
D005456Fluorescent Dyes4-fluoroamphetamine inhibits the reaction [SLC6A3 protein results in increased import of Fluorescent Dyes]28506818
D005456Fluorescent Dyes4-methoxymethamphetamine inhibits the reaction [SLC6A3 protein results in increased import of Fluorescent Dyes]28506818
D005456Fluorescent Dyes5-(2-aminopropyl)benzofuran inhibits the reaction [SLC6A3 protein results in increased import of Fluorescent Dyes]28506818
D005456Fluorescent DyesAmphetamine inhibits the reaction [SLC6A3 protein results in increased import of Fluorescent Dyes]28506818
D005456Fluorescent DyesCocaine inhibits the reaction [SLC6A3 protein results in increased import of Fluorescent Dyes]28506818
D005456Fluorescent DyesFluoxetine inhibits the reaction [SLC6A3 protein results in increased import of Fluorescent Dyes]28506818
D005456Fluorescent Dyes"N-Methyl-3,4-methylenedioxyamphetamine inhibits the reaction [SLC6A3 protein results in increased import of Fluorescent Dyes]"28506818
D005456Fluorescent DyesSLC6A3 protein results in increased import of Fluorescent Dyes28506818
D005473FluoxetineFluoxetine inhibits the reaction [SLC6A3 protein results in increased import of Biogenic Monoamines analog]28506818
D005473FluoxetineFluoxetine inhibits the reaction [SLC6A3 protein results in increased import of Fluorescent Dyes]28506818
D005473FluoxetineSLC6A3 mutant form affects the reaction [Fluoxetine affects the abundance of Dopamine]14691264
D005473FluoxetineSLC6A3 protein affects the susceptibility to Fluoxetine11797063
D005473FluoxetineFluoxetine affects the expression of SLC6A326475043
C097367ginsenoside Rg3[Plant Extracts co-treated with Terpenes co-treated with ginsenoside Rg3] inhibits the reaction [Chlorodiphenyl (54% Chlorine) results in decreased expression of SLC6A3 protein]24394491
D005905Glyburide"Glyburide promotes the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of SLC6A3 protein]"16725203
D006220HaloperidolSLC6A3 protein promotes the reaction [Haloperidol results in increased expression of NTS mRNA]14698760
D006220HaloperidolHaloperidol results in increased expression of SLC6A3 protein17069804
D006533HeptachlorHeptachlor promotes the reaction [SLC6A3 protein results in increased uptake of Dopamine]11294980
D006533HeptachlorHeptachlor results in increased expression of SLC6A3 mRNA18577399
D006533HeptachlorHeptachlor results in increased expression of SLC6A3 protein10499361|1129498
D006533HeptachlorHeptachlor results in increased expression of SLC6A3 protein11719704
D006540HerbicidesHerbicides results in decreased expression of SLC6A3 mRNA23123945
C089796hexabromocyclododecanehexabromocyclododecane results in decreased expression of SLC6A3 protein26073293|2821474
D012701SerotoninSLC6A3 protein promotes the reaction [Serotonin results in increased activity of TAAR1 protein]17234900
D012701SerotoninSLC6A3 protein results in increased uptake of Serotonin17250655
D007052IbuprofenIbuprofen inhibits the reaction [Methamphetamine results in decreased expression of SLC6A3 protein]18946735
C418119indatralineindatraline inhibits the reaction [SLC6A3 protein promotes the reaction [Dopamine results in increased activity of TAAR1 protein]]17234900
C418119indatralineindatraline inhibits the reaction [SLC6A3 protein promotes the reaction [Methamphetamine results in increased activity of TAAR1 protein]]17234900
C418119indatralineindatraline inhibits the reaction [SLC6A3 protein promotes the reaction [Octopamine results in increased activity of TAAR1 protein]]17234900
C418119indatralineindatraline inhibits the reaction [SLC6A3 protein promotes the reaction [tryptamine results in increased activity of TAAR1 protein]]17234900
C418119indatralineindatraline inhibits the reaction [SLC6A3 protein promotes the reaction [Tyramine results in increased activity of TAAR1 protein]]17234900
D007501Iron[manganese chloride co-treated with Iron deficiency] results in decreased expression of SLC6A3 protein22479410
C040920isoliquiritigeninisoliquiritigenin inhibits the reaction [Methamphetamine results in decreased expression of SLC6A3 protein]19834288
C029310lardlard results in increased expression of SLC6A3 mRNA26115784
D016308Enkephalin, Leucine-2-Alanine"Enkephalin, Leucine-2-Alanine inhibits the reaction [Methamphetamine results in decreased expression of SLC6A3 protein]"9765353
D016308Enkephalin, Leucine-2-Alanine"Naltrexone inhibits the reaction [Enkephalin, Leucine-2-Alanine inhibits the reaction [Methamphetamine results in decreased expression of SLC6A3 protein]]"9765353
C018584linaloollinalool results in decreased expression of SLC6A3 mRNA20536181
C482199lipopolysaccharide, E coli O55-B5"lipopolysaccharide, E coli O55-B5 promotes the reaction [Rotenone results in increased expression of SLC6A3 protein]"23567316
C482199lipopolysaccharide, E coli O55-B5"lipopolysaccharide, E coli O55-B5 results in increased expression of SLC6A3 protein"23567316
C482199lipopolysaccharide, E coli O55-B5"Rotenone promotes the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of SLC6A3 protein]"23567316
D008344ManebSLC6A3 gene polymorphism affects the susceptibility to Maneb19590691
D008344Maneb[Paraquat co-treated with Maneb] results in decreased expression of SLC6A3 mRNA18386188
D008344Maneb[Paraquat co-treated with Maneb] results in decreased expression of SLC6A3 protein11124998
D008345ManganeseLRRK2 mutant form results in increased susceptibility to [Manganese co-treated with SLC6A3 protein]23628791
D008345ManganeseManganese affects the localization of SLC6A3 protein23313730
D008345ManganeseSLC6A3 protein results in increased susceptibility to Manganese18206288
D008345ManganeseManganese results in decreased expression of SLC6A3 protein16571372
D008345ManganeseManganese results in decreased expression of SLC6A323313730
C025340manganese chloridemanganese chloride results in decreased expression of SLC6A3 protein24969583
C025340manganese chlorideMelatonin inhibits the reaction [manganese chloride results in decreased expression of SLC6A3 protein]24969583
C025340manganese chloride[manganese chloride co-treated with Iron deficiency] results in decreased expression of SLC6A3 protein22479410
C025340manganese chloridemanganese chloride results in decreased expression of SLC6A323458069
C025340manganese chloridemanganese chloride results in decreased expression of SLC6A3 protein16571372|2247941
D008454MazindolButyrates inhibits the reaction [Mazindol inhibits the reaction [SLC6A3 protein results in increased uptake of Dopamine]]17250655
D008454MazindolMazindol inhibits the reaction [SLC6A3 protein results in increased uptake of Dopamine]17250655
D008454Mazindol[Mazindol results in decreased activity of SLC6A3 protein] which results in decreased susceptibility to 1-Methyl-4-phenylpyridinium18206288
D008454MazindolMazindol binds to SLC6A3 protein11085313|1594506
D008454MazindolMethamphetamine inhibits the reaction [Mazindol binds to SLC6A3 protein]11085313
D008454MazindolNOS1 protein affects the reaction [Methamphetamine inhibits the reaction [Mazindol binds to SLC6A3 protein]]11085313
D008454MazindolMazindol binds to SLC6A3 protein11719704|9132989
D008454MazindolMethamphetamine inhibits the reaction [Mazindol binds to SLC6A3 protein]9132989
D008454MazindolMazindol results in decreased activity of SLC6A3 protein18206288
D008464MecamylamineMecamylamine affects the reaction [Nicotine results in decreased activity of SLC6A3 protein]23999947
D008550MelatoninMelatonin affects the reaction [Cocaine affects the expression of SLC6A3 mRNA]17622340
D008550MelatoninMelatonin inhibits the reaction [manganese chloride results in decreased expression of SLC6A3 protein]24969583
D008550MelatoninMelatonin inhibits the reaction [Rotenone results in decreased expression of SLC6A3 protein]18289173
D008555MelittenCocaine inhibits the reaction [Melitten results in increased localization of SLC6A3 protein]20969853|2268384
D008555MelittenMelitten inhibits the reaction [2beta-carbomethoxy-3beta-(4-iodophenyl)tropane binds to SLC6A3 protein]20969853
D008555MelittenMelitten inhibits the reaction [SLC6A3 protein results in increased uptake of Dopamine]20969853
D008555MelittenMelitten results in increased localization of SLC6A3 protein20969853|2268384
D008555MelittenMelitten results in increased localization of [SLC6A3 protein co-treated with RAB5A protein]22683840
C548233mephedroneEthanol promotes the reaction [mephedrone results in decreased expression of SLC6A3 protein]26747301
C548233mephedronemephedrone results in decreased expression of SLC6A3 protein26747301
C548233mephedronemephedrone results in decreased expression of SLC6A3 protein25817894
D008694MethamphetamineMethamphetamine results in decreased expression of SLC6A3 protein10958525
D008694Methamphetamineindatraline inhibits the reaction [SLC6A3 protein promotes the reaction [Methamphetamine results in increased activity of TAAR1 protein]]17234900
D008694MethamphetamineMethamphetamine results in decreased activity of SLC6A3 protein16842981
D008694MethamphetamineMethamphetamine results in decreased expression of SLC6A3 protein12944350|1554272
D008694MethamphetamineMethylphenidate inhibits the reaction [SLC6A3 protein promotes the reaction [Methamphetamine results in increased activity of TAAR1 protein]]17234900
D008694MethamphetamineSLC6A3 3' UTR polymorphism results in increased susceptibility to Methamphetamine12931138
D008694MethamphetamineSLC6A3 protein affects the abundance of Methamphetamine11027249
D008694MethamphetamineSLC6A3 protein promotes the reaction [Methamphetamine results in increased activity of TAAR1 protein]17234900
D008694Methamphetamine15-deoxyprostaglandin J2 inhibits the reaction [Methamphetamine results in decreased expression of SLC6A3 protein]18946735
D008694Methamphetamine"6,7-dihydroxyflavone inhibits the reaction [Methamphetamine results in decreased expression of SLC6A3]"23934209
D008694Methamphetamine7-nitroindazole inhibits the reaction [Methamphetamine results in decreased expression of SLC6A3 protein]20575850
D008694Methamphetamine"ANA 12 compound inhibits the reaction [6,7-dihydroxyflavone inhibits the reaction [Methamphetamine results in decreased expression of SLC6A3]]"23934209
D008694Methamphetamine"Enkephalin, Leucine-2-Alanine inhibits the reaction [Methamphetamine results in decreased expression of SLC6A3 protein]"9765353
D008694Methamphetamineestradiol 3-benzoate inhibits the reaction [Methamphetamine results in decreased expression of SLC6A3 mRNA]15249736
D008694Methamphetamineestradiol 3-benzoate inhibits the reaction [Methamphetamine results in decreased expression of SLC6A3 protein]15249736
D008694MethamphetamineFOS protein affects the reaction [Methamphetamine results in decreased expression of SLC6A3 protein]10559418
D008694MethamphetamineIbuprofen inhibits the reaction [Methamphetamine results in decreased expression of SLC6A3 protein]18946735
D008694MethamphetamineIFNG protein inhibits the reaction [Methamphetamine results in decreased expression of SLC6A3 protein]18282668
D008694MethamphetamineIL6 protein affects the reaction [Methamphetamine results in decreased expression of SLC6A3 protein]11093760
D008694Methamphetamineisoliquiritigenin inhibits the reaction [Methamphetamine results in decreased expression of SLC6A3 protein]19834288
D008694MethamphetamineMethamphetamine inhibits the reaction [Mazindol binds to SLC6A3 protein]11085313
D008694MethamphetamineMethamphetamine results in decreased expression of SLC6A323934209
D008694MethamphetamineMethamphetamine results in decreased expression of SLC6A3 mRNA15249736
D008694MethamphetamineMethamphetamine results in decreased expression of SLC6A3 protein10559418|1109376
D008694MethamphetamineMinocycline inhibits the reaction [Methamphetamine results in decreased expression of SLC6A3 protein]16839653
D008694Methamphetamine"Naltrexone inhibits the reaction [Enkephalin, Leucine-2-Alanine inhibits the reaction [Methamphetamine results in decreased expression of SLC6A3 protein]]"9765353
D008694MethamphetamineNOS1 protein affects the reaction [Methamphetamine inhibits the reaction [Mazindol binds to SLC6A3 protein]]11085313
D008694MethamphetamineNOS1 protein affects the reaction [Methamphetamine results in decreased expression of SLC6A3 protein]20575850
D008694MethamphetamineNR4A2 protein affects the reaction [Methamphetamine results in decreased expression of SLC6A3 protein]21151937
D008694MethamphetamineSLC6A3 gene mutant form results in decreased susceptibility to Methamphetamine11222668
D008694MethamphetamineSLC6A3 protein affects the reaction [Methamphetamine affects the abundance of Dopamine]9634552
D008694MethamphetamineSLC6A3 protein affects the reaction [Methamphetamine results in increased expression of GFAP mRNA]9634552
D008694MethamphetamineSLC6A3 protein affects the reaction [Methamphetamine results in increased expression of GFAP protein]9634552
D008694MethamphetamineSLC6A3 protein affects the susceptibility to Methamphetamine12050851|2055820
D008694Methamphetamine"Methamphetamine inhibits the reaction [(1R-(exo,exo))-3-(4-fluorophenyl)-8-methyl-8- azabicyclo(3.2.1)octane-2-carboxylic acid, methyl ester binds to SLC6A3 protein]"16897726
D008694MethamphetamineMethamphetamine inhibits the reaction [Mazindol binds to SLC6A3 protein]9132989
D008694MethamphetamineMethamphetamine results in decreased activity of SLC6A3 protein11032899|1904638
D008694MethamphetamineMethamphetamine results in decreased expression of SLC6A3 protein15900317|1964846
D008694MethamphetamineMethamphetamine results in increased expression of SLC6A3 protein15986185
D008731MethoxychlorMethoxychlor results in decreased expression of SLC6A3 protein19459224
D007050IbogaineIbogaine inhibits the reaction [SLC6A3 protein mutant form results in decreased import of Dopamine]27555326
D007050IbogaineIbogaine promotes the reaction [SLC6A3 protein results in increased import of Dopamine]27555326
D007050IbogaineIbogaine results in increased expression of SLC6A3 protein27555326
D008767Methylmercury CompoundsMethylmercury Compounds results in decreased expression of SLC6A3 mRNA26056851|2655846
D008767Methylmercury CompoundsMethylmercury Compounds results in decreased expression of SLC6A3 protein26056851
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine inhibits the reaction [SLC6A3 protein results in increased import of Biogenic Monoamines analog]"28506818
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine inhibits the reaction [SLC6A3 protein results in increased import of Fluorescent Dyes]"28506818
D018817N-Methyl-3,4-methylenedioxyamphetamine"SLC6A3 protein promotes the reaction [N-Methyl-3,4-methylenedioxyamphetamine results in increased activity of TAAR1 protein]"15764732
D008774MethylphenidateMethylphenidate results in decreased activity of SLC6A3 protein25912032
D008774Methylphenidate[Methylphenidate co-treated with SLC6A3 protein] results in increased expression of FOS protein12112414
D008774MethylphenidateMethylphenidate inhibits the reaction [[Dopamine co-treated with SLC6A3 protein] results in increased expression of FOS mRNA]12112414
D008774MethylphenidateMethylphenidate inhibits the reaction [[Dopamine co-treated with SLC6A3 protein] results in increased expression of FOS protein]12112414
D008774MethylphenidateMethylphenidate inhibits the reaction [SLC6A3 protein mutant form results in increased export of Dopamine]18614672
D008774MethylphenidateMethylphenidate inhibits the reaction [SLC6A3 protein promotes the reaction [Dopamine results in increased activity of TAAR1 protein]]17234900
D008774MethylphenidateMethylphenidate inhibits the reaction [SLC6A3 protein promotes the reaction [Methamphetamine results in increased activity of TAAR1 protein]]17234900
D008774MethylphenidateMethylphenidate inhibits the reaction [SLC6A3 protein promotes the reaction [Octopamine results in increased activity of TAAR1 protein]]17234900
D008774MethylphenidateMethylphenidate inhibits the reaction [SLC6A3 protein promotes the reaction [tryptamine results in increased activity of TAAR1 protein]]17234900
D008774MethylphenidateMethylphenidate inhibits the reaction [SLC6A3 protein promotes the reaction [Tyramine results in increased activity of TAAR1 protein]]17234900
D008774MethylphenidateMethylphenidate results in decreased expression of SLC6A3 protein15059031|1613973
D008774MethylphenidateSLC6A3 3' UTR polymorphism affects the susceptibility to Methylphenidate19462300
D008774MethylphenidateMethylphenidate results in decreased expression of SLC6A3 mRNA22470460
D008774MethylphenidateSLC6A3 protein affects the reaction [Methylphenidate results in increased expression of FOS protein]12699766
D008774MethylphenidateSLC6A3 protein results in increased susceptibility to Methylphenidate12699766
D008774MethylphenidateMethylphenidate results in decreased activity of SLC6A3 protein15059031
D0156551-Methyl-4-phenylpyridinium"1-Methyl-4-phenylpyridinium inhibits the reaction [(1R-(exo,exo))-3-(4-fluorophenyl)-8-methyl-8- azabicyclo(3.2.1)octane-2-carboxylic acid, methyl ester binds to SLC6A3 protein]"17250655
D0156551-Methyl-4-phenylpyridinium[Mazindol results in decreased activity of SLC6A3 protein] which results in decreased susceptibility to 1-Methyl-4-phenylpyridinium18206288
D0156551-Methyl-4-phenylpyridinium[Nomifensine results in decreased activity of SLC6A3 protein] which results in decreased susceptibility to 1-Methyl-4-phenylpyridinium18206288
D0156551-Methyl-4-phenylpyridiniumSLC6A3 protein affects the susceptibility to 1-Methyl-4-phenylpyridinium12151787
D0156551-Methyl-4-phenylpyridiniumSLC6A3 protein results in increased susceptibility to 1-Methyl-4-phenylpyridinium12151787|1508652
D0156551-Methyl-4-phenylpyridiniumSLC6A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium17250655
D0156551-Methyl-4-phenylpyridiniumSNCA protein affects the reaction [SLC6A3 protein results in increased susceptibility to 1-Methyl-4-phenylpyridinium]12151787
D0156551-Methyl-4-phenylpyridiniumSNCA protein mutant form promotes the reaction [SLC6A3 protein results in increased susceptibility to 1-Methyl-4-phenylpyridinium]12151787
D0156551-Methyl-4-phenylpyridinium[vanoxerine results in decreased activity of SLC6A3 protein] which results in decreased susceptibility to 1-Methyl-4-phenylpyridinium18206288
D0156551-Methyl-4-phenylpyridinium1-Methyl-4-phenylpyridinium binds to SLC6A3 protein23665943
D0156551-Methyl-4-phenylpyridinium1-Methyl-4-phenylpyridinium results in decreased expression of SLC6A3 mRNA23665943|2605685
D0156551-Methyl-4-phenylpyridinium1-Methyl-4-phenylpyridinium results in decreased expression of SLC6A3 protein23665943|2605685
D0156551-Methyl-4-phenylpyridinium1-Methyl-4-phenylpyridinium results in increased expression of SLC6A3 mRNA26558463
D0156551-Methyl-4-phenylpyridinium1-Methyl-4-phenylpyridinium results in decreased expression of SLC6A3 protein19794909
D0156551-Methyl-4-phenylpyridiniumSLC6A3 protein results in increased susceptibility to 1-Methyl-4-phenylpyridinium10881039
D0156321-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine"1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of SLC6A3 protein"15514976
D0156321-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine"1,1-bis(3'-indolyl)-1-(4-chlorophenyl)methane inhibits the reaction [[1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine co-treated with Probenecid] results in decreased expression of SLC6A3 protein]"25406165
D0156321-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine"1,1-bis(3'-indolyl)-1-(4-hydroxyphenyl)methane inhibits the reaction [[1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine co-treated with Probenecid] results in decreased expression of SLC6A3 protein]"25406165
D0156321-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine"1,1-bis(3'-indolyl)-1-(p-anisyl)methane inhibits the reaction [[1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine co-treated with Probenecid] results in decreased expression of SLC6A3 protein]"25406165
D0156321-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine"[1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine co-treated with Probenecid] results in decreased expression of SLC6A3 protein"19653878|2540616
D0156321-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine"1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased activity of SLC6A3 protein"16011487
D0156321-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine"1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of SLC6A3"24995576
D0156321-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine"1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of SLC6A3 mRNA"15329391|2007914
D0156321-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine"1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of SLC6A3 protein"15329391|1672520
D0156321-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine"2,3,5,4'-tetrahydroxystilbene 2-O-glucopyranoside inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of SLC6A3 protein]"23911879
D0156321-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine"Estradiol inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased activity of SLC6A3 protein]"16011487
D0156321-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine"Estrone inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased activity of SLC6A3 protein]"16011487
D0156321-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine"Glyburide promotes the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of SLC6A3 protein]"16725203
D0156321-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine"[Probenecid co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of SLC6A3 protein"25064079
D0156321-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine"SLC6A3 protein promotes the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased abundance of Dopamine]"22342763
D0156321-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine"telmisartan inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of SLC6A3 mRNA]"23747572
D0156321-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine"telmisartan inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of SLC6A3 protein]"23747572
D0156321-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine"Trehalose inhibits the reaction [[Probenecid co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of SLC6A3 protein]"25064079
D0156321-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine"vanoxerine inhibits the reaction [SLC6A3 protein promotes the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased abundance of Dopamine]]"22342763
D008911MinocyclineMinocycline inhibits the reaction [Methamphetamine results in decreased expression of SLC6A3 protein]16839653
C048833modafinilSLC6A3 gene polymorphism affects the susceptibility to modafinil24403155
C048833modafinilSLC6A3 gene mutant form results in decreased susceptibility to modafinil11222668
C048833modafinilmodafinil inhibits the reaction [SLC6A3 protein affects the uptake of Dopamine]19197004
C047806monomethylpropionmonomethylpropion results in decreased expression of SLC6A3 protein9763484
D005677G(M1) GangliosideG(M1) Ganglioside results in increased expression of SLC6A3 mRNA14552908
D009151Mustard GasMustard Gas results in increased expression of SLC6A3 mRNA15674844
C534983N-(2-amino-3-methyl-n-butyl)-3-((bis-4-fluorophenyl)methoxy)tropaneSLC6A3 protein binds to N-(2-amino-3-methyl-n-butyl)-3-((bis-4-fluorophenyl)methoxy)tropane18425847
D009271NaltrexoneSLC6A3 gene polymorphism affects the susceptibility to Naltrexone18552399
D009271Naltrexone"Naltrexone inhibits the reaction [Enkephalin, Leucine-2-Alanine inhibits the reaction [Methamphetamine results in decreased expression of SLC6A3 protein]]"9765353
D009538NicotineNicotine inhibits the reaction [Paraquat results in decreased expression of SLC6A3 protein]17227438
D009538NicotineDihydro-beta-Erythroidine affects the reaction [Nicotine results in decreased activity of SLC6A3 protein]23999947
D009538NicotineMecamylamine affects the reaction [Nicotine results in decreased activity of SLC6A3 protein]23999947
D009538NicotineNicotine results in decreased activity of SLC6A3 protein23999947
C464560N-methyl-3-(bis(4'-fluorophenyl)methoxy)tropaneN-methyl-3-(bis(4'-fluorophenyl)methoxy)tropane binds to SLC6A3 protein16586462
D009627NomifensineNomifensine inhibits the reaction [SLC6A3 protein results in increased uptake of Dopamine]20875051
D009627Nomifensine[Nomifensine results in decreased activity of SLC6A3 protein] which results in decreased susceptibility to 1-Methyl-4-phenylpyridinium18206288
D009627NomifensineNomifensine inhibits the reaction [Rotenone results in decreased expression of SLC6A3 protein]18289173
D009627NomifensineNomifensine results in decreased activity of SLC6A3 protein11719704|1820628
C025256nonylphenolnonylphenol affects the reaction [SLC6A3 protein affects the export of Dopamine]19479021
D009638NorepinephrineSLC6A3 protein promotes the reaction [Norepinephrine results in increased activity of TAAR1 protein]17234900
D009638NorepinephrineSLC6A3 protein results in increased uptake of Norepinephrine17250655
D019301Oleic AcidPPARA protein promotes the reaction [Oleic Acid results in increased expression of SLC6A3 mRNA]18489776
D009655Octopamineindatraline inhibits the reaction [SLC6A3 protein promotes the reaction [Octopamine results in increased activity of TAAR1 protein]]17234900
D009655OctopamineMethylphenidate inhibits the reaction [SLC6A3 protein promotes the reaction [Octopamine results in increased activity of TAAR1 protein]]17234900
D009655OctopamineSLC6A3 protein promotes the reaction [Octopamine results in increased activity of TAAR1 protein]17234900
D016627OxidopamineOxidopamine results in decreased expression of SLC6A3 mRNA15518916
D016627OxidopamineOxidopamine results in decreased expression of SLC6A3 protein20200117
D016627OxidopamineOxidopamine results in increased expression of SLC6A3 mRNA15303306
D016627OxidopamineSLC6A3 protein results in increased susceptibility to Oxidopamine10881039
D010269ParaquatSLC6A3 gene polymorphism affects the susceptibility to Paraquat19590691
D010269ParaquatNicotine inhibits the reaction [Paraquat results in decreased expression of SLC6A3 protein]17227438
D010269Paraquat[Paraquat co-treated with Maneb] results in decreased expression of SLC6A3 mRNA18386188
D010269Paraquat[Paraquat co-treated with Maneb] results in decreased expression of SLC6A3 protein11124998
D010269ParaquatParaquat results in decreased expression of SLC6A3 mRNA20079141
D010269ParaquatParaquat results in decreased expression of SLC6A3 protein17227438|2007914
D010269ParaquatParaquat inhibits the reaction [1-(2 (diphenylmethoxy)ethyl)-4-(3-phenylpropyl)piperazine binds to SLC6A3 protein]15985715|1619088
D010269ParaquatParaquat promotes the reaction [Zinc Sulfate results in increased expression of SLC6A3 mRNA]20553223
D010269ParaquatParaquat promotes the reaction [Zinc Sulfate results in increased expression of SLC6A3 protein]20553223
D010269ParaquatParaquat results in increased expression of SLC6A3 mRNA20553223
D010269ParaquatParaquat results in increased expression of SLC6A3 protein20553223
D010269ParaquatZinc Sulfate promotes the reaction [Paraquat results in increased expression of SLC6A3 mRNA]20553223
D010269ParaquatZinc Sulfate promotes the reaction [Paraquat results in increased expression of SLC6A3 protein]20553223
D052638Particulate Matter[Particulate Matter co-treated with Volatile Organic Compounds] results in decreased expression of SLC6A3 mRNA25265048
C086401pentabromodiphenyl etherpentabromodiphenyl ether results in decreased expression of SLC6A3 protein23916505
D026023PermethrinPermethrin affects the activity of SLC6A3 protein16005927
D026023PermethrinPermethrin inhibits the reaction [SLC6A3 protein results in increased uptake of Dopamine]16005927
D026023PermethrinPermethrin results in decreased expression of SLC6A3 protein14555407
D026023PermethrinPermethrin results in increased expression of SLC6A3 protein12428726|1457564
C029261phenethylamineCocaine inhibits the reaction [SLC6A3 protein results in increased transport of phenethylamine]15764732
C029261phenethylamineSLC6A3 protein promotes the reaction [phenethylamine results in increased activity of TAAR1 protein]17234900
C029261phenethylamineSLC6A3 protein results in increased transport of phenethylamine15764732
C029261phenethylamineSLC6A3 protein promotes the reaction [phenethylamine results in increased activity of TAAR1 protein]15764732
D010879PiperazinesPiperazines analog binds to and affects the activity of SLC6A3 protein11931612
D010880PiperidinesPiperidines analog binds to SLC6A3 protein12413863
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of SLC6A3 mRNA19710929
C006253pirinixic acidpirinixic acid results in increased expression of SLC6A3 mRNA17426115
C006253pirinixic acidpirinixic acid results in decreased expression of SLC6A3 mRNA19162173
D010936Plant Extracts[Plant Extracts co-treated with Terpenes co-treated with ginsenoside Rg3] inhibits the reaction [Chlorodiphenyl (54% Chlorine) results in decreased expression of SLC6A3 protein]24394491
D010936Plant ExtractsPlant Extracts results in decreased expression of SLC6A3 mRNA23999947
D010936Plant ExtractsPlant Extracts results in increased activity of SLC6A3 protein23999947
D011339Probenecid"1,1-bis(3'-indolyl)-1-(4-chlorophenyl)methane inhibits the reaction [[1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine co-treated with Probenecid] results in decreased expression of SLC6A3 protein]"25406165
D011339Probenecid"1,1-bis(3'-indolyl)-1-(4-hydroxyphenyl)methane inhibits the reaction [[1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine co-treated with Probenecid] results in decreased expression of SLC6A3 protein]"25406165
D011339Probenecid"1,1-bis(3'-indolyl)-1-(p-anisyl)methane inhibits the reaction [[1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine co-treated with Probenecid] results in decreased expression of SLC6A3 protein]"25406165
D011339Probenecid"[1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine co-treated with Probenecid] results in decreased expression of SLC6A3 protein"19653878|2540616
D011339Probenecid"[Probenecid co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of SLC6A3 protein"25064079
D011339Probenecid"Trehalose inhibits the reaction [[Probenecid co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of SLC6A3 protein]"25064079
D011738PyrilaminePyrilamine analog binds to and affects the activity of SLC6A3 protein11931612
D017378Quinolinic AcidQuinolinic Acid results in decreased expression of SLC6A3 protein12207953
D017378Quinolinic AcidQuinolinic Acid results in increased expression of SLC6A3 protein12207953
D019257QuinpiroleQuinpirole affects the localization of SLC6A3 protein20875051
D019257QuinpiroleQuinpirole results in increased expression of SLC6A3 mRNA20875051
D020849Raloxifene HydrochlorideRaloxifene Hydrochloride results in increased expression of SLC6A3 protein16451217
C074679reboxetineSLC6A3 protein affects the susceptibility to reboxetine11312315
D012110ReserpineReserpine results in decreased activity of SLC6A3 protein17664021
D012110ReserpineSLC6A3 gene mutant form affects the susceptibility to Reserpine19615345
C034931rimcazolerimcazole analog binds to SLC6A3 protein9435903
C034931rimcazole"[rimcazole analog binds to SLC6A3 protein] inhibits the reaction [(1R-(exo,exo))-3-(4-fluorophenyl)-8-methyl-8- azabicyclo(3.2.1)octane-2-carboxylic acid, methyl ester binds to SLC6A3 protein]"9435903
C034931rimcazolerimcazole binds to SLC6A3 protein12801223|9435903
D012402RotenoneSLC6A3 protein results in increased susceptibility to Rotenone18206288
D012402Rotenone"lipopolysaccharide, E coli O55-B5 promotes the reaction [Rotenone results in increased expression of SLC6A3 protein]"23567316
D012402RotenoneMelatonin inhibits the reaction [Rotenone results in decreased expression of SLC6A3 protein]18289173
D012402RotenoneNomifensine inhibits the reaction [Rotenone results in decreased expression of SLC6A3 protein]18289173
D012402Rotenone"Rotenone promotes the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of SLC6A3 protein]"23567316
D012402RotenoneRotenone results in decreased expression of SLC6A3 protein18289173
D012402RotenoneRotenone results in increased expression of SLC6A3 protein18579341|2356731
C114870RTI-113RTI-113 binds to SLC6A3 protein11746736
C079213RTI 121RTI 121 binds to SLC6A3 protein16451217
D019311StaurosporineSNCA protein affects the reaction [Staurosporine results in increased activity of SLC6A3 protein]19032594
D019311StaurosporineStaurosporine results in increased activity of SLC6A3 protein19032594
D013469SulpirideSulpiride inhibits the reaction [Dopamine affects the localization of SLC6A3 protein]20875051
D013469SulpirideSulpiride inhibits the reaction [SLC6A3 protein results in increased uptake of Dopamine]20875051
D013629TamoxifenTamoxifen results in increased expression of SLC6A3 protein16451217
C084178telmisartan"telmisartan inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of SLC6A3 mRNA]"23747572
C084178telmisartan"telmisartan inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of SLC6A3 protein]"23747572
D013729Terpenes[Plant Extracts co-treated with Terpenes co-treated with ginsenoside Rg3] inhibits the reaction [Chlorodiphenyl (54% Chlorine) results in decreased expression of SLC6A3 protein]24394491
D013739Testosterone[Testosterone co-treated with Calcitriol] results in increased expression of SLC6A3 mRNA21592394
D013739TestosteroneTestosterone results in increased expression of SLC6A3 mRNA21592394
D013755Tetradecanoylphorbol AcetateTetradecanoylphorbol Acetate results in increased localization of [SLC6A3 protein co-treated with EEA1 protein]22683840
D013755Tetradecanoylphorbol Acetate[Tretinoin co-treated with Tetradecanoylphorbol Acetate] results in increased expression of SLC6A3 protein24101030
D014050TolueneToluene affects the expression of SLC6A3 mRNA18653662
D014199Trehalose"Trehalose inhibits the reaction [[Probenecid co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of SLC6A3 protein]"25064079
D014212Tretinoin[Tretinoin co-treated with Tetradecanoylphorbol Acetate] results in increased expression of SLC6A3 protein24101030
C012589trichostatin Atrichostatin A results in increased expression of SLC6A3 mRNA28743636
C030820tryptamineindatraline inhibits the reaction [SLC6A3 protein promotes the reaction [tryptamine results in increased activity of TAAR1 protein]]17234900
C030820tryptamineMethylphenidate inhibits the reaction [SLC6A3 protein promotes the reaction [tryptamine results in increased activity of TAAR1 protein]]17234900
C030820tryptamineSLC6A3 protein promotes the reaction [tryptamine results in increased activity of TAAR1 protein]17234900
D014439Tyramineindatraline inhibits the reaction [SLC6A3 protein promotes the reaction [Tyramine results in increased activity of TAAR1 protein]]17234900
D014439TyramineMethylphenidate inhibits the reaction [SLC6A3 protein promotes the reaction [Tyramine results in increased activity of TAAR1 protein]]17234900
D014439TyramineSLC6A3 protein promotes the reaction [Tyramine results in increased activity of TAAR1 protein]17234900
D014635Valproic AcidValproic Acid results in increased methylation of SLC6A3 gene29154799
D014635Valproic AcidValproic Acid promotes the reaction [NR4A2 protein binds to SLC6A3 promoter]28743636
D014635Valproic AcidValproic Acid results in increased expression of SLC6A3 mRNA28743636
D014635Valproic AcidValproic Acid results in increased expression of SLC6A3 protein28743636
C043425vanoxerinevanoxerine binds to SLC6A3 protein11249581
C043425vanoxerinevanoxerine inhibits the reaction [SLC6A3 protein results in increased uptake of Dopamine]17250655
C043425vanoxerine[vanoxerine results in decreased activity of SLC6A3 protein] which results in decreased susceptibility to 1-Methyl-4-phenylpyridinium18206288
C043425vanoxerineSLC6A3 gene mutant form results in decreased susceptibility to vanoxerine11222668
C043425vanoxerineSLC6A3 protein affects the susceptibility to vanoxerine11312315
C043425vanoxerine"vanoxerine inhibits the reaction [SLC6A3 protein promotes the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased abundance of Dopamine]]"22342763
C043425vanoxerinevanoxerine results in decreased activity of SLC6A3 protein19616025|2234276
C043425vanoxerinevanoxerine affects the reaction [Cocaine affects the expression of SLC6A3 protein]11249581
C043425vanoxerinevanoxerine results in decreased activity of SLC6A3 protein18561912
C043425vanoxerinevanoxerine binds to and results in decreased activity of SLC6A3 protein27026709
C043425vanoxerinevanoxerine results in decreased activity of SLC6A3 protein11312315|1750501
D055549Volatile Organic Compounds[Particulate Matter co-treated with Volatile Organic Compounds] results in decreased expression of SLC6A3 mRNA25265048
C111237vorinostatvorinostat results in increased expression of SLC6A3 mRNA27188386
C009687wortmanninwortmannin inhibits the reaction [SLC6A3 protein results in increased uptake of Dopamine]20875051
D015032Zinc[Amphetamine co-treated with Zinc] results in decreased localization of SLC6A3 protein16684900
D015032ZincZinc results in decreased activity of SLC6A3 protein16684900
D019287Zinc SulfateParaquat promotes the reaction [Zinc Sulfate results in increased expression of SLC6A3 mRNA]20553223
D019287Zinc SulfateParaquat promotes the reaction [Zinc Sulfate results in increased expression of SLC6A3 protein]20553223
D019287Zinc SulfateZinc Sulfate promotes the reaction [Paraquat results in increased expression of SLC6A3 mRNA]20553223
D019287Zinc SulfateZinc Sulfate promotes the reaction [Paraquat results in increased expression of SLC6A3 protein]20553223
D019287Zinc SulfateZinc Sulfate results in increased expression of SLC6A3 mRNA20553223
D019287Zinc SulfateZinc Sulfate results in increased expression of SLC6A3 protein20553223

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0002020protease binding-IEA-  
GO:0005102signaling receptor binding-IEA-  
GO:0005215transporter activity-IBA21873635  
GO:0005328neurotransmitter:sodium symporter activity-IEA-  
GO:0005329dopamine transmembrane transporter activity-IBA21873635  
GO:0005329dopamine transmembrane transporter activity-IDA15505207  
GO:0005330dopamine:sodium symporter activity-IBA21873635  
GO:0005515protein binding-IPI11343649  12958153  15505207  17380124  17519329  20018661  
21957239  22163275  
GO:0008504monoamine transmembrane transporter activity-IDA16024787  
GO:0008504monoamine transmembrane transporter activity-TAS-  
GO:0035240dopamine binding-IBA21873635  
GO:0035240dopamine binding-IEA-  
GO:0044877protein-containing complex binding-IEA-  
GO:0046872metal ion binding-IEA-  
GO:0047485protein N-terminus binding-IEA-  
GO:0051721protein phosphatase 2A binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0007568aging-IEA-  
GO:0007595lactation-IEA-  
GO:0007608sensory perception of smell-IEA-  
GO:0007626locomotory behavior-IEA-  
GO:0010039response to iron ion-IEA-  
GO:0015844monoamine transport-IDA16024787  
GO:0015872dopamine transport-IDA15505207  
GO:0021984adenohypophysis development-IEA-  
GO:0035094response to nicotine-IEA-  
GO:0035725sodium ion transmembrane transport-IBA21873635  
GO:0040018positive regulation of multicellular organism growth-IEA-  
GO:0042053regulation of dopamine metabolic process-IEA-  
GO:0042136neurotransmitter biosynthetic process-TAS-  
GO:0042220response to cocaine-IEA-  
GO:0042416dopamine biosynthetic process-IEA-  
GO:0042420dopamine catabolic process-IEA-  
GO:0045471response to ethanol-IEA-  
GO:0051591response to cAMP-IEA-  
GO:0055085transmembrane transport-IEA-  
GO:0060134prepulse inhibition-IEA-  
GO:0090494dopamine uptake-IDA21957239  
GO ID GO Term Qualifier Evidence PubMed
GO:0005737cytoplasm-TAS10823899  
GO:0005886plasma membrane-IBA21873635  
GO:0005886plasma membrane-IDA11343649  12958153  21957239  
GO:0005886plasma membrane-TAS-  
GO:0009986cell surface-IBA21873635  
GO:0009986cell surface-IDA21399631  
GO:0016021integral component of membrane-TAS8628395  
GO:0016600flotillin complex-IDA21399631  
GO:0030424axon-IBA21873635  
GO:0030424axon-IDA12958153  
GO:0043005neuron projection-IBA21873635  
GO:0043005neuron projection-IDA21957239  
GO:0043025neuronal cell body-IDA12958153  
GO:0045121membrane raft-IDA21957239  
GO:0098793presynapse-IEA-  
KEGG ID KEGG Term
hsa05012Parkinson's disease
Reactome ID Reactome Term Evidence
R-HSA-112311Neurotransmitter clearanceTAS
R-HSA-112315Transmission across Chemical SynapsesTAS
R-HSA-112316Neuronal SystemTAS
R-HSA-1643685DiseaseTAS
R-HSA-379401Dopamine clearance from the synaptic cleftTAS
R-HSA-382551Transport of small moleculesTAS
R-HSA-425366Transport of bile salts and organic acids, metal ions and amine compoundsTAS
R-HSA-425407SLC-mediated transmembrane transportTAS
R-HSA-442660Na+/Cl- dependent neurotransmitter transportersTAS
R-HSA-5619081Defective SLC6A3 causes Parkinsonism-dystonia infantile (PKDYS)TAS
R-HSA-5619102SLC transporter disordersTAS
R-HSA-5619115Disorders of transmembrane transportersTAS
R-HSA-5660724Defective SLC6A3 causes Parkinsonism-dystonia infantile (PKDYS)TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
18690118Dopamine and opioid gene variants are associated with increased smoking reward and reinforcement owing to negative mood. (2008 Sep)Perkins KABehav Pharmacol
23032071Interacting effects of naltrexone and OPRM1 and DAT1 variation on the neural response to alcohol cues. (2013 Feb)Schacht JPNeuropsychopharmacology
19450132Polymorphisms in the dopamine transporter gene (SLC6A3/DAT1) and alcohol dependence in humans: a systematic review. (2009 May)van der Zwaluw CSPharmacogenomics
15148564Pharmacogenetic insights to monoaminergic dysfunction in alcohol dependence. (2004 Aug)Heinz APsychopharmacology (Berl)
18704100DAT genotype modulates brain and behavioral responses elicited by cigarette cues. (2009 Feb)Franklin TRNeuropsychopharmacology
23061530Neural correlates of attentional bias for smoking cues: modulation by variance in the dopamine transporter gene. (2014 Mar)Wetherill RRAddict Biol
21078357Genetic influences of dopamine transport gene on alcohol dependence: a pooled analysis of 13 studies with 2483 cases and 1753 controls. (2011 Jul 1)Xu MProg Neuropsychopharmacol Biol Psychiatry
17654295Pharmacogenetic clinical trial of sustained-release bupropion for smoking cessation. (2007 Aug)David SPNicotine Tob Res
15996968Association of the dopamine transporter gene with alcoholism. (2005 Sep-Oct)Kohnke MDAlcohol Alcohol
25545355Genetic variants and early cigarette smoking and nicotine dependence phenotypes in adolescents. (2014)O'Loughlin JPLoS One
19761593Influences of polymorphic variants of DRD2 and SLC6A3 genes, and their combinations on smoking in Polish population. (2009 Sep 17)Sieminska ABMC Med Genet
17135598No evidence for a major role of polymorphisms during bupropion treatment. (2006 Nov)Hu JObesity (Silver Spring)
22028400Cigarette experimentation in Mexican origin youth: psychosocial and genetic determinants. (2012 Jan)Wilkinson AVCancer Epidemiol Biomarkers Prev
24421289Interactive effects of OPRM1 and DAT1 genetic variation on subjective responses to alcohol. (2014 May-Jun)Ray LAAlcohol Alcohol
17449448Association in alcoholic patients between psychopathic traits and the additive effect of allelic forms of the CNR1 and FAAH endocannabinoid genes, and the 3' region of the DRD2 gene. (2007 Jan)Hoenicka JNeurotox Res
9925040A genetic association for cigarette smoking behavior. (1999 Jan)Sabol SZHealth Psychol
9925041Evidence suggesting the role of specific genetic factors in cigarette smoking. (1999 Jan)Lerman CHealth Psychol
28862750Erratum: Meta-Analysis Reveals Significant Association of the 3'-UTR VNTR in SLC6A3 With Alcohol Dependence. (2017 Sep)Ma YAlcohol Clin Exp Res
17466074Genetic polymorphisms in dopamine-related genes and smoking cessation in women: a prospective cohort study. (2007 Apr 28)Ton TGBehav Brain Funct
27490263The association of dopamine pathway gene score, nicotine dependence and smoking cessation in a rural male population of Shandong, China. (2016 Sep)Li SAm J Addict
18070248The 3' part of the dopamine transporter gene DAT1/SLC6A3 is associated with withdrawal seizures in patients with alcohol dependence. (2008 Jan)Le Strat YAlcohol Clin Exp Res
17264803Dopamine transporter polymorphisms are associated with short-term response to smoking cessation treatment. (2007 Jan)O'Gara CPharmacogenet Genomics
20801583Could the inter-individual variability in cocaine-induced psychotic effects influence the development of cocaine addiction? Towards a new pharmacogenetic approach to addictions. (2010 Dec)Brousse GMed Hypotheses
19183461SLC6A3 and body mass index in the Prostate, Lung, Colorectal and Ovarian Cancer Screening Trial. (2009 Jan 30)Azzato EMBMC Med Genet
18444252Neurotransmission and bipolar disorder: a systematic family-based association study. (2008 Oct 5)Shi JAm J Med Genet B Neuropsychiatr Genet
28300812[A pharmacogenetic analysis of dopaminergic and opioidergic genes in opioid addicts treated with the combination of naltrexone and guanfacine]. (2016)Kibitov capital A, Cyrilliccapital O, CyrillicZh Nevrol Psikhiatr Im S S Korsakova
19462300Pharmacogenetic treatments for drug addiction: cocaine, amphetamine and methamphetamine. (2009)Haile CNAm J Drug Alcohol Abuse
20505554Association study between the DAT1, DBH and DRD2 genes and cocaine dependence in a Spanish sample. (2010 Dec)Fernandez-Castillo NPsychiatr Genet
18197080Effect of genetic polymorphisms on smoking cessation: a trial of bupropion in Korean male smokers. (2008 Feb)Han DHPsychiatr Genet
22745713Molecular variation at the SLC6A3 locus predicts lifetime risk of PTSD in the Detroit Neighborhood Health Study. (2012)Chang SCPLoS One
14570538Effects of dopamine transporter and receptor polymorphisms on smoking cessation in a bupropion clinical trial. (2003 Sep)Lerman CHealth Psychol
17175058Polymorphisms of dopamine receptor/transporter genes and risk of non-small cell lung cancer. (2007 Apr)Campa DLung Cancer
21083670Limited associations of dopamine system genes with alcohol dependence and related traits in the Irish Affected Sib Pair Study of Alcohol Dependence (IASPSAD). (2011 Feb)Hack LMAlcohol Clin Exp Res
15229055Interacting effects of genetic predisposition and depression on adolescent smoking progression. (2004 Jul)Audrain-McGovern JAm J Psychiatry
17500623Joint effect of dopaminergic genes on likelihood of smoking following treatment with bupropion SR. (2007 May)Swan GEHealth Psychol
18563706The impact of genetic variation in DRD2 and SLC6A3 on smoking cessation in a cohort of participants 1 year after enrollment in a lung cancer screening study. (2009 Mar 5)Styn MAAm J Med Genet B Neuropsychiatr Genet
28182634The SLC6A3 gene possibly affects susceptibility to late-onset alcohol dependence but not specific personality traits in a Han Chinese population. (2017)Huang CCPLoS One
26149737Meta-analysis reveals significant association of 3'-UTR VNTR in SLC6A3 with smoking cessation in Caucasian populations. (2016 Feb)Ma YPharmacogenomics J
25526961Genetic influence of dopamine receptor, dopamine transporter, and nicotine metabolism on smoking cessation and nicotine dependence in a Japanese population. (2014 Dec 20)Ohmoto MBMC Genet
20603187Smoking, genes encoding dopamine pathway and risk for Parkinson's disease. (2010 Sep 20)Gu ZNeurosci Lett
23273726Functional genomics of attention-deficit/hyperactivity disorder (ADHD) risk alleles on dopamine transporter binding in ADHD and healthy control subjects. (2013 Jul 15)Spencer TJBiol Psychiatry
16585473Effect of team sport participation on genetic predisposition to adolescent smoking progression. (2006 Apr)Audrain-McGovern JArch Gen Psychiatry
26058807A 40-bp VNTR polymorphism in the 3'-untranslated region of DAT1/SLC6A3 is associated with ADHD but not with alcoholism. (2015 Jun 11)Sery OBehav Brain Funct
29030974Dopamine Transporter Gene Methylation is Associated with Nucleus Accumbens Activation During Reward Processing in Healthy but not Alcohol-Dependent Individuals. (2018 Jan)Muench CAlcohol Clin Exp Res
18690117Gene and gene by sex associations with initial sensitivity to nicotine in nonsmokers. (2008 Sep)Perkins KABehav Pharmacol
23504072Association of VMAT2 gene polymorphisms with alcohol dependence. (2013 Aug)Fehr CJ Neural Transm (Vienna)
15542698Association studies of neurotransmitter gene polymorphisms in alcoholic Caucasians. (2004 Oct)Foley PFAnn N Y Acad Sci
10088054DAT1 gene polymorphism in alcoholism: a family-based association study. (1999 Mar 1)Franke PBiol Psychiatry
14732864Stress-induced cigarette craving: effects of the DRD2 TaqI RFLP and SLC6A3 VNTR polymorphisms. (2004)Erblich JPharmacogenomics J
16881528[Epidemiology, treatment and prevention of attention deficit/hyperactivity disorder: a review]. (2006 Jun)Yoshimasu KNihon Koshu Eisei Zasshi
22698582DRD2/ANKK1 TaqIA and SLC6A3 VNTR polymorphisms in alcohol dependence: association and gene-gene interaction study in a population of Central Italy. (2012 Aug 1)Mignini FNeurosci Lett
12215242Smoking status and the human dopamine transporter variable number of tandem repeats (VNTR) polymorphism: failure to replicate and finding that never-smokers may be different. (2002 Aug)Vandenbergh DJNicotine Tob Res
21806388Dopamine-related genes and spontaneous smoking cessation in ever-heavy smokers. (2011 Aug)Breitling LPPharmacogenomics
21299752Dopamine transporter genotype modulation of neural responses to smoking cues: confirmation in a new cohort. (2011 Apr)Franklin TRAddict Biol
10649826Genotype influences in vivo dopamine transporter availability in human striatum. (2000 Feb)Heinz ANeuropsychopharmacology
27219321Meta-Analysis Reveals Significant Association of the 3'-UTR VNTR in SLC6A3 with Alcohol Dependence. (2016 Jul)Ma YAlcohol Clin Exp Res
18552399Association between the Stin2 VNTR polymorphism of the serotonin transporter gene and treatment outcome in alcohol-dependent patients. (2008 Sep-Oct)Florez GAlcohol Alcohol
15213032Relation between food reinforcement and dopamine genotypes and its effect on food intake in smokers. (2004 Jul)Epstein LHAm J Clin Nutr
23128675Genetic analysis of polymorphisms in dopamine receptor and transporter genes for association with smoking among cancer patients. (2013)Gordiev MEur Addict Res
15381926Effects of dopamine D2 receptor (DRD2) and transporter (SLC6A3) polymorphisms on smoking cue-induced cigarette craving among African-American smokers. (2005 Apr)Erblich JMol Psychiatry
23941313Influence of a dopamine pathway additive genetic efficacy score on smoking cessation: results from two randomized clinical trials of bupropion. (2013 Dec)David SPAddiction
27287604Meta-analysis update of association between dopamine transporter SLC6A3 gene polymorphism and smoking cessation. (2016 Jun 1)Duck CHJ Health Psychol
25247548Crack cocaine users show differences in genotype frequencies of the 3' UTR variable number of tandem repeats of the dopamine transporter gene (DAT1/SLC6A3). (2014)Stolf ARNeuropsychobiology
24892317Genetic variants associated with addictive behavior in Colombian addicted and non-addicted to heroin or cocaine. (2013 Jan)Isaza CColomb Med (Cali)
19494806Dopamine genes and nicotine dependence in treatment-seeking and community smokers. (2009 Sep)Bergen AWNeuropsychopharmacology
22551036Naltrexone modification of drinking effects in a subacute treatment and bar-lab paradigm: influence of OPRM1 and dopamine transporter (SLC6A3) genes. (2012 Nov)Anton RFAlcohol Clin Exp Res
14685824Association between polymorphism of the dopamine transporter gene and early smoking onset: an interaction risk on nicotine dependence. (2004)Ling DJ Hum Genet