Gene: SLC6A6

6533
TAUT
solute carrier family 6 member 6
protein-coding
3p25.1
Ensembl:ENSG00000131389 MIM:186854 Vega:OTTHUMG00000155525 UniprotKB:P31641
NC_000003.12
SNP Mapped
8   ANCO-SNPs
ND|AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
7.624e-1 (AD)  7.466e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs3773165chr3:14482762 (GRCh38.p7)G>Aalcohol dependenceSNV(Single Nucleotide Variation)
rs9834678chr3:14475607 (GRCh38.p7)T>Calcohol dependenceSNV(Single Nucleotide Variation)
rs2289128chr3:14472187 (GRCh38.p7)G>A / G>Calcohol dependenceSNV(Single Nucleotide Variation)
rs3773171chr3:14470585 (GRCh38.p7)C>Talcohol dependenceSNV(Single Nucleotide Variation)
rs3773172chr3:14470191 (GRCh38.p7)G>Aalcohol dependenceSNV(Single Nucleotide Variation)
rs12489456chr3:14459666 (GRCh38.p7)G>Aalcohol dependenceSNV(Single Nucleotide Variation)
rs17237132chr3:14457512 (GRCh38.p7)C>Tnicotine dependenceSNV(Single Nucleotide Variation)
rs12638941chr3:14419407 (GRCh38.p7)C>Tnicotine dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
NFATC2IP0.714
DENND30.711
GTPBP20.707
FNBP40.702
ASXL10.699
ESYT20.698
HGSNAT0.698
MYO190.693
OSBPL50.693
NAA400.69

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
WDR38-0.354
DIAPH3-0.346
FOXJ1-0.344
OR4F5-0.334
OR4F29-0.325
EYA2-0.291
EVC2-0.289
LRAT-0.283
S100A1-0.272
AKR1C3-0.27

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB01956TaurineSmall Molecule107-35-7Approved|NutraceuticalTransporter
ID Drug Name Action PubMed
C0780921-piperonylpiperazine1-piperonylpiperazine results in increased expression of SLC6A6 mRNA26821219
C0291412,2,5,7,8-pentamethyl-1-hydroxychroman"2,2,5,7,8-pentamethyl-1-hydroxychroman results in decreased expression of SLC6A6 mRNA"21920950
C0142112,3,7,8-tetrachlorodibenzofuran"2,3,7,8-tetrachlorodibenzofuran results in increased expression of SLC6A6 mRNA"25768209
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[3,4,5,3',4'-pentachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl] results in decreased expression of SLC6A6 mRNA"16984957
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of SLC6A6 mRNA"21346803
C0230353,4,5,3',4'-pentachlorobiphenyl"[3,4,5,3',4'-pentachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl] results in decreased expression of SLC6A6 mRNA"16984957
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of SLC6A6 mRNA"16984957|2095900
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in increased expression of SLC6A6 mRNA"18648102
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SLC6A6 mRNA"27188386
C0293704-toluidine4-toluidine results in decreased expression of SLC6A6 mRNA27638505
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SLC6A6 mRNA"27188386
D000082AcetaminophenAcetaminophen results in increased expression of SLC6A6 mRNA29067470
D000082AcetaminophenAcetaminophen affects the expression of SLC6A6 mRNA17562736
D000082AcetaminophenAcetaminophen results in decreased expression of SLC6A6 mRNA17202762
D000111Acetylcysteine[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of SLC6A6 mRNA22129741
D020106AcrylamideAcrylamide results in decreased expression of SLC6A6 mRNA28959563
D016604Aflatoxin B1Aflatoxin B1 affects the expression of SLC6A6 protein20106945
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of SLC6A6 mRNA19770486
D000638AmiodaroneAmiodarone affects the expression of SLC6A6 mRNA18355885|1948338
D000639AmitriptylineAmitriptyline affects the expression of SLC6A6 mRNA18355885
D000643Ammonium ChlorideAmmonium Chloride affects the expression of SLC6A6 mRNA16483693
D001151ArsenicArsenic affects the expression of SLC6A6 mRNA18414638
D001151ArsenicArsenic affects the methylation of SLC6A6 gene25304211
D017638Asbestos, Crocidolite"Asbestos, Crocidolite results in increased expression of SLC6A6 mRNA"25351596
D001379AzathioprineAzathioprine results in increased expression of SLC6A6 mRNA22623647
D001553BenzbromaroneBenzbromarone affects the expression of SLC6A6 mRNA19483382
D019324beta-Naphthoflavone[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in decreased expression of SLC6A6 mRNA18164116
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of SLC6A6 mRNA20106945|2163298
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of SLC6A6 mRNA19770486
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of SLC6A6 mRNA"19150397
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased expression of SLC6A6 mRNA"20382639
D004958Estradiol[Estradiol co-treated with Tetrachlorodibenzodioxin] results in increased expression of SLC6A6 mRNA19619570
D004958EstradiolEstradiol promotes the reaction [ESR2 protein affects the expression of SLC6A6 mRNA]20404318
D004958EstradiolEstradiol results in increased expression of SLC6A6 mRNA19619570|2301914
C095105bexarotenebexarotene results in increased expression of SLC6A6 mRNA16648578
C006780bisphenol Abisphenol A results in increased expression of SLC6A6 mRNA23019147|2927551
C018475butyraldehydebutyraldehyde results in increased expression of SLC6A6 mRNA26079696
D002101Cacodylic AcidCacodylic Acid results in increased expression of SLC6A6 mRNA17720352
D019256Cadmium ChlorideCadmium Chloride results in increased expression of SLC6A6 mRNA25596134
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of SLC6A6 mRNA25993096
C037123cadmium sulfate[cadmium sulfate co-treated with cobaltous chloride co-treated with lead chloride] results in increased expression of SLC6A6 mRNA18654764
D002251Carbon TetrachlorideCarbon Tetrachloride results in decreased expression of SLC6A6 protein17544377
C004656chloroacetaldehydechloroacetaldehyde affects the expression of SLC6A6 mRNA25596134
D002737ChloropreneChloroprene results in increased expression of SLC6A6 mRNA23125180
D002746ChlorpromazineChlorpromazine results in increased expression of SLC6A6 mRNA25596134
C059262cidofovircidofovir affects the expression of SLC6A6 mRNA25596134
D002994ClofibrateClofibrate affects the expression of SLC6A6 mRNA19483382
D002997ClomipramineClomipramine affects the expression of SLC6A6 mRNA18355885
D060729Coal AshCoal Ash results in decreased expression of SLC6A6 mRNA19000753
C018021cobaltous chloride[cadmium sulfate co-treated with cobaltous chloride co-treated with lead chloride] results in increased expression of SLC6A6 mRNA18654764
D019327Copper SulfateCopper Sulfate results in increased expression of SLC6A6 mRNA19549813
C029892cupric chloridecupric chloride results in decreased expression of SLC6A6 mRNA24650576
D016572CyclosporineCyclosporine results in decreased expression of SLC6A6 mRNA25596134
D016572CyclosporineCyclosporine results in increased expression of SLC6A6 mRNA20106945|2556210
D000069439DasatinibDasatinib results in increased expression of SLC6A6 mRNA20579391
C010902decabromobiphenyl etherdecabromobiphenyl ether results in decreased expression of SLC6A6 mRNA23640034
D013759DronabinolDronabinol results in decreased expression of SLC6A6 mRNA16616335
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of SLC6A6 mRNA21266533
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of SLC6A6 mRNA21266533
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in increased expression of SLC6A6 mRNA27392435
D002945CisplatinCisplatin results in decreased expression of SLC6A6 mRNA27594783
D002945CisplatinCisplatin results in increased expression of SLC6A6 mRNA27392435
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in decreased expression of SLC6A6 mRNA18164116
D004052Diethylnitrosamine[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of SLC6A6 mRNA22129741
D004054DiethylstilbestrolDiethylstilbestrol results in increased expression of SLC6A6 mRNA19371625
C015835dimethyl-4-toluidinedimethyl-4-toluidine results in decreased expression of SLC6A6 mRNA27638505
D004317DoxorubicinDoxorubicin results in decreased expression of SLC6A6 mRNA17105721
C045651epigallocatechin gallate[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of SLC6A6 mRNA22079256
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of SLC6A6 mRNA26865667
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of SLC6A6 mRNA18936297
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of SLC6A6 mRNA17555576
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of SLC6A6 mRNA17942748
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in decreased expression of SLC6A6 mRNA17942748
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of SLC6A6 mRNA26865667
D005001EthionineEthionine affects the expression of SLC6A6 mRNA19483382
D015025ZearalenoneZearalenone results in increased expression of SLC6A6 mRNA19371625
D005411Flame RetardantsFlame Retardants results in increased expression of SLC6A6 mRNA27219277
D019833GenisteinGenistein affects the expression of SLC6A6 mRNA26865667
D019833GenisteinGenistein results in increased expression of SLC6A6 mRNA19371625|2301914
D055768Halogenated Diphenyl EthersHalogenated Diphenyl Ethers results in increased expression of SLC6A6 mRNA27219277
D017313FenretinideFenretinide results in increased expression of SLC6A6 mRNA28973697
D007099ImipramineImipramine affects the expression of SLC6A6 mRNA18355885
C016517indole-3-carbinolindole-3-carbinol affects the expression of SLC6A6 mRNA21396975
C016517indole-3-carbinol[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of SLC6A6 mRNA22129741
C544151jinfukang[Cisplatin co-treated with jinfukang] results in increased expression of SLC6A6 mRNA27392435
C544151jinfukangjinfukang results in increased expression of SLC6A6 mRNA27392435
D007654KetoconazoleKetoconazole affects the expression of SLC6A6 mRNA18355885
C008261lead acetatelead acetate results in decreased expression of SLC6A6 mRNA11578147
C029891lead chloride[cadmium sulfate co-treated with cobaltous chloride co-treated with lead chloride] results in increased expression of SLC6A6 mRNA18654764
D008345ManganeseManganese results in increased expression of SLC6A6 mRNA20832424
D008687MetforminMetformin results in increased expression of SLC6A6 mRNA25596134
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of SLC6A6 mRNA"25554681|2562005
C461488N-benzylpiperazineN-benzylpiperazine results in increased expression of SLC6A6 mRNA26821219
C051752nefazodonenefazodone results in decreased expression of SLC6A6 mRNA24136188
D009532NickelNickel results in increased expression of SLC6A6 mRNA24768652|2558310
C029938nickel sulfatenickel sulfate results in increased expression of SLC6A6 mRNA22714537
D009853OmeprazoleOmeprazole affects the expression of SLC6A6 mRNA19483382
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in increased expression of SLC6A6 mRNA25729387
D010100OxygenOxygen deficiency results in increased expression of SLC6A6 mRNA25596134|2651600
C016030pantogabpantogab results in decreased expression of SLC6A6 mRNA17379144
D010416PentachlorophenolPentachlorophenol results in increased expression of SLC6A6 mRNA23892564
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in decreased expression of SLC6A6 mRNA19162173
C023036perfluorooctanoic acidperfluorooctanoic acid results in decreased expression of SLC6A6 mRNA19162173
D010634PhenobarbitalPhenobarbital affects the expression of SLC6A6 mRNA23091169
D010862PilocarpinePilocarpine results in increased expression of SLC6A6 mRNA21219332
C006253pirinixic acidpirinixic acid results in decreased expression of SLC6A6 mRNA23811191
C006253pirinixic acidpirinixic acid affects the expression of SLC6A6 mRNA19483382
C006253pirinixic acidpirinixic acid results in decreased expression of SLC6A6 mRNA19162173
C027373potassium chromate(VI)[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of SLC6A6 mRNA22079256
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of SLC6A6 mRNA22079256
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in decreased expression of SLC6A6 mRNA28903501
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in decreased expression of SLC6A6 mRNA19162173
D011441PropylthiouracilPropylthiouracil affects the expression of SLC6A6 mRNA19483382
D011441PropylthiouracilPropylthiouracil results in increased expression of SLC6A6 mRNA24780913
C502851quinocetonequinocetone results in decreased expression of SLC6A6 mRNA27046791
C059514resveratrol[resveratrol co-treated with Streptozocin] results in increased expression of SLC6A6 mRNA25905778
D012402RotenoneRotenone results in increased expression of SLC6A6 mRNA19013527
D017632Asbestos, Serpentine"Asbestos, Serpentine results in decreased expression of SLC6A6 mRNA"21148743
D012822Silicon DioxideSilicon Dioxide analog results in increased expression of SLC6A6 mRNA25895662
D012822Silicon DioxideSilicon Dioxide results in increased expression of SLC6A6 mRNA25351596
C009277sodium arsenatesodium arsenate results in increased expression of SLC6A6 mRNA21795629
C017947sodium arsenitesodium arsenite results in increased expression of SLC6A6 mRNA21281968|2451658
C016104sodium bichromatesodium bichromate results in decreased expression of SLC6A6 mRNA25993096
D013311Streptozocin[resveratrol co-treated with Streptozocin] results in increased expression of SLC6A6 mRNA25905778
C041711St. Thomas' Hospital cardioplegic solutionSt. Thomas' Hospital cardioplegic solution results in decreased expression of SLC6A6 mRNA16214533
D013629TamoxifenTamoxifen affects the expression of SLC6A6 mRNA17555576
D013654TaurineSLC6A6 protein affects the transport of Taurine16318624
C020806tetrabromobisphenol Atetrabromobisphenol A results in increased expression of SLC6A6 mRNA28300664
D013749Tetrachlorodibenzodioxin[Estradiol co-treated with Tetrachlorodibenzodioxin] results in increased expression of SLC6A6 mRNA19619570
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of SLC6A6 mRNA22298810
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of SLC6A6 mRNA19619570|2010694
D013749TetrachlorodibenzodioxinAHR gene mutant form inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of SLC6A6 mRNA]16984957
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of SLC6A6 mRNA21570461
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in decreased expression of SLC6A6 mRNA17942748
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with TIPARP gene mutant form] results in increased expression of SLC6A6 mRNA25975270
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of SLC6A6 mRNA16984957
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of SLC6A6 mRNA15328365|1661135
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of SLC6A6 mRNA16984957
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of SLC6A6 mRNA21215274
D013853ThioacetamideThioacetamide affects the expression of SLC6A6 mRNA19483382
D013853ThioacetamideThioacetamide results in decreased expression of SLC6A6 mRNA23411599
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased expression of SLC6A6 mRNA28065790
D014028Tobacco Smoke PollutionTobacco Smoke Pollution affects the expression of SLC6A6 mRNA20133372
C052342topiramatetopiramate results in decreased expression of SLC6A6 mRNA16979414
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in increased expression of SLC6A6 mRNA25729387
D019772TopotecanTopotecan results in increased expression of SLC6A6 mRNA25729387
D014212TretinoinTretinoin results in increased expression of SLC6A6 mRNA23830798
C012589trichostatin A"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SLC6A6 mRNA"27188386
C012589trichostatin Atrichostatin A results in increased expression of SLC6A6 mRNA24935251|2627250
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of SLC6A6 mRNA"26179874
D014635Valproic AcidValproic Acid results in increased expression of SLC6A6 mRNA24383497|2493525
D014635Valproic AcidValproic Acid results in increased methylation of SLC6A6 gene29154799
D001335Vehicle EmissionsVehicle Emissions affects the methylation of SLC6A6 gene25560391
D000069470Venlafaxine HydrochlorideVenlafaxine Hydrochloride results in increased expression of SLC6A6 mRNA25423262
C025643vinclozolinvinclozolin results in decreased expression of SLC6A6 mRNA23034163
C025643vinclozolinvinclozolin results in increased expression of SLC6A6 mRNA23034163
C111237vorinostatvorinostat results in decreased expression of SLC6A6 mRNA27188386

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005215transporter activity-IBA21873635  
GO:0005328neurotransmitter:sodium symporter activity-IEA-  
GO:0005369taurine:sodium symporter activity-IBA21873635  
GO:0015171amino acid transmembrane transporter activity-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006520cellular amino acid metabolic process-TAS8010975  
GO:0006836neurotransmitter transport-IEA-  
GO:0006865amino acid transport-TAS-  
GO:0015734taurine transport-IBA21873635  
GO:0035725sodium ion transmembrane transport-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0005886plasma membrane-IBA21873635  
GO:0005886plasma membrane-TAS-  
GO:0016021integral component of membrane-TAS8010975  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-352230Amino acid transport across the plasma membraneTAS
R-HSA-382551Transport of small moleculesTAS
R-HSA-425366Transport of bile salts and organic acids, metal ions and amine compoundsTAS
R-HSA-425393Transport of inorganic cations/anions and amino acids/oligopeptidesTAS
R-HSA-425407SLC-mediated transmembrane transportTAS
R-HSA-442660Na+/Cl- dependent neurotransmitter transportersTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal