Gene: SLC6A9

6536
GCENSG|GLYT1
solute carrier family 6 member 9
protein-coding
1p34.1
Ensembl:ENSG00000196517 MIM:601019 Vega:OTTHUMG00000008294 UniprotKB:P48067
NG_050929.1
PubMed|SNP Mapped
1   ANCO-SNPs
AD
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.842e-1 (AD)  7.642e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs1362153chr1:44003359 (GRCh38.p7)T>Calcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg12133952chr1:44497352SLC6A91.170e-8Alcohol consumption per day27843151

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
LIPE0.788
SOX100.781
ELOVL10.768
TMC60.761
CPNE20.755
PRIMA10.753
BOK0.753
CLDN110.752
ZDHHC90.752
TJAP10.751

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.368
OR4F29-0.339
DIO2-0.269
VIP-0.26
CHRDL1-0.25
CUX2-0.242
RNF43-0.236
ACBD7-0.235
PADI4-0.221
GRB14-0.221

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00145GlycineSmall Molecule56-40-6Approved|NutraceuticalTarget
ID Drug Name Action PubMed
C5768821-(2-trifluoromethoxyphenyl)-2-nitroethanone1-(2-trifluoromethoxyphenyl)-2-nitroethanone affects the expression of SLC6A9 mRNA25596134
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased expression of SLC6A9 mRNA"21354444
C5486512-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in increased expression of SLC6A9 mRNA19933214
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in increased expression of SLC6A9 mRNA"27291303
C4049102,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane"2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane affects the expression of SLC6A9 mRNA"19414516
C0284513,4,3',4'-tetrachlorobiphenyl"3,4,3',4'-tetrachlorobiphenyl inhibits the reaction [Dietary Fats results in increased expression of SLC6A9 mRNA]"19467301
C5622493-biphenyl-4-yl-4-(2-fluorophenyl)-5-isopropyl-4H-1,2,4-triazole"3-biphenyl-4-yl-4-(2-fluorophenyl)-5-isopropyl-4H-1,2,4-triazole results in decreased activity of SLC6A9 protein"21141920
D000082AcetaminophenAcetaminophen results in decreased expression of SLC6A9 mRNA26690555
D000082AcetaminophenAcetaminophen results in increased expression of SLC6A9 mRNA29067470
D000082AcetaminophenAcetaminophen affects the expression of SLC6A9 mRNA17562736
C106812adefovir dipivoxiladefovir dipivoxil results in decreased expression of SLC6A9 mRNA25596134
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of SLC6A9 mRNA19770486
D000661AmphetamineSLC6A9 protein affects the susceptibility to Amphetamine15159536
D001151ArsenicArsenic affects the methylation of SLC6A9 gene25304211
C006632arsenic trioxidearsenic trioxide results in increased expression of SLC6A9 mRNA27829220
D001280AtrazineAtrazine results in decreased expression of SLC6A9 mRNA25929836
C037689benzamidebenzamide analog binds to and results in decreased activity of SLC6A9 protein18355687
C037689benzamidebenzamide analog binds to and results in decreased activity of SLC6A9 protein18355687
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of SLC6A9 mRNA26001963
D001564Benzo(a)pyrene"[Benzo(a)pyrene co-treated with dibenzo(a,l)pyrene] results in increased expression of SLC6A9 mRNA"17690111
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of SLC6A9 mRNA22316170
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of SLC6A9 mRNA21569818
C072553benzyloxycarbonylleucyl-leucyl-leucine aldehydebenzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of SLC6A9 mRNA25566086
C072553benzyloxycarbonylleucyl-leucyl-leucine aldehydeMYBPC3 protein affects the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of SLC6A9 mRNA]25566086
D001622BetaineBetaine results in decreased expression of SLC6A9 mRNA26391144
C006780bisphenol Abisphenol A results in increased expression of SLC6A9 mRNA29275510
C006780bisphenol Abisphenol A affects the expression of SLC6A9 mRNA21786754
C006780bisphenol Abisphenol A results in decreased expression of SLC6A9 mRNA25181051
C006780bisphenol Abisphenol A results in increased expression of SLC6A9 mRNA26982218
D0151248-Bromo Cyclic Adenosine Monophosphate8-Bromo Cyclic Adenosine Monophosphate results in increased expression of SLC6A9 mRNA20147733
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of SLC6A9 mRNA25596134
C055494caffeic acid phenethyl ester[Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of SLC6A9 mRNA20360939
D002185CannabidiolCannabidiol results in increased expression of SLC6A9 mRNA21542829
C054133casticincasticin results in decreased expression of SLC6A9 mRNA28444820
D002713Chlorine[Ozone co-treated with Chlorine] results in decreased expression of SLC6A9 mRNA18636392
C004656chloroacetaldehydechloroacetaldehyde results in decreased expression of SLC6A9 mRNA25596134
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of SLC6A9 gene20938992
C059262cidofovircidofovir results in decreased expression of SLC6A9 mRNA25596134
D002922CiguatoxinsCiguatoxins affects the expression of SLC6A9 mRNA18353800
D004002Clodronic AcidClodronic Acid results in decreased expression of SLC6A9 mRNA25596134
D002995Clofibric AcidClofibric Acid affects the expression of SLC6A9 mRNA17602206
D060729Coal AshCoal Ash results in decreased expression of SLC6A9 mRNA19000753
C018021cobaltous chloridecobaltous chloride results in increased expression of SLC6A9 mRNA24386269
D003300Copper[Disulfiram binds to Copper] which results in increased expression of SLC6A9 mRNA24690739
C030123coumarincoumarin results in increased expression of SLC6A9 mRNA18480146
D003471CuprizoneCuprizone results in decreased expression of SLC6A9 mRNA27523638
D003471CuprizoneCuprizone results in increased expression of SLC6A9 mRNA26577399
D016572CyclosporineCyclosporine results in increased expression of SLC6A9 mRNA25596134
D016572CyclosporineCyclosporine results in increased expression of SLC6A9 mRNA25596134
C010902decabromobiphenyl etherdecabromobiphenyl ether results in increased expression of SLC6A9 mRNA23640034|2391405
D013759DronabinolDronabinol results in increased expression of SLC6A9 mRNA21542829
D003907DexamethasoneDexamethasone results in decreased expression of SLC6A9 mRNA25047013
D003976DiazinonDiazinon results in increased methylation of SLC6A9 gene22964155
C041517dibenzo(a,l)pyrene"[Benzo(a)pyrene co-treated with dibenzo(a,l)pyrene] results in increased expression of SLC6A9 mRNA"17690111
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of SLC6A9 mRNA21266533
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in increased expression of SLC6A9 mRNA27392435
D002945CisplatinCisplatin results in decreased expression of SLC6A9 mRNA25596134
D004041Dietary Fats"3,4,3',4'-tetrachlorobiphenyl inhibits the reaction [Dietary Fats results in increased expression of SLC6A9 mRNA]"19467301
D004041Dietary FatsDietary Fats results in increased expression of SLC6A9 mRNA19467301
D004051Diethylhexyl PhthalateDiethylhexyl Phthalate results in increased expression of SLC6A9 mRNA19850644
D004051Diethylhexyl PhthalatePPARA protein promotes the reaction [Diethylhexyl Phthalate results in increased expression of SLC6A9 mRNA]19850644
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of SLC6A9 mRNA20360939
D004221Disulfiram[Disulfiram binds to Copper] which results in increased expression of SLC6A9 mRNA24690739
D004237DiuronDiuron results in increased expression of SLC6A9 mRNA21551480
D000431EthanolEthanol results in increased expression of SLC6A9 mRNA20655511
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of SLC6A9 mRNA17942748
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of SLC6A9 mRNA17942748
D011345FenofibrateFenofibrate results in increased expression of SLC6A9 mRNA25596134
D011345FenofibrateFenofibrate results in decreased expression of SLC6A9 mRNA25596134
C082360fipronilfipronil results in decreased expression of SLC6A9 mRNA23962444
D005419FlavonoidsFlavonoids results in decreased expression of SLC6A9 mRNA18035473
D005485FlutamideFlutamide results in decreased expression of SLC6A9 mRNA21126777
D005485FlutamideFlutamide results in increased expression of SLC6A9 mRNA24136188
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of SLC6A9 gene20938992
D017313FenretinideFenretinide results in increased expression of SLC6A9 mRNA28973697
D007052IbuprofenIbuprofen results in increased expression of SLC6A9 mRNA25596134
C492448ICG 001ICG 001 results in increased expression of SLC6A9 mRNA26191083
D007069IfosfamideIfosfamide results in decreased expression of SLC6A9 mRNA25596134
C544151jinfukang[Cisplatin co-treated with jinfukang] results in increased expression of SLC6A9 mRNA27392435
C544151jinfukangjinfukang results in increased expression of SLC6A9 mRNA27392435
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of SLC6A9 mRNA26752646
C008261lead acetatelead acetate results in increased expression of SLC6A9 mRNA11578147
D058185Magnetite NanoparticlesMagnetite Nanoparticles results in decreased expression of SLC6A9 mRNA24525745
D008627Mercuric ChlorideMercuric Chloride results in increased expression of SLC6A9 mRNA16507785
D008687MetforminMetformin results in increased expression of SLC6A9 mRNA25596134
D008694MethamphetamineSLC6A9 gene SNP results in increased susceptibility to Methamphetamine17582620
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of SLC6A9 gene20938992
D008727MethotrexateMethotrexate affects the expression of SLC6A9 mRNA18502557
D0156551-Methyl-4-phenylpyridinium1-Methyl-4-phenylpyridinium results in increased expression of SLC6A9 mRNA22776087
D008985MonensinMonensin affects the localization of SLC6A9 protein19473961
D008985MonensinTetradecanoylphorbol Acetate promotes the reaction [Monensin affects the localization of SLC6A9 protein]19473961
D009151Mustard GasMustard Gas results in decreased expression of SLC6A9 mRNA15674843
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of SLC6A9 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of SLC6A9 mRNA"25620056
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of SLC6A9 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of SLC6A9 mRNA"25620056
C017096n-butoxyethanoln-butoxyethanol results in increased expression of SLC6A9 mRNA19812364
C051752nefazodonenefazodone results in increased expression of SLC6A9 mRNA24136188
C012655nimesulidenimesulide results in increased expression of SLC6A9 mRNA24136188
C520612N-methyl-N-(6-methoxy-1-phenyl-1,2,3,4-tetrahydronaphthalen-2-ylmethyl)aminomethylcarboxylic acid"N-methyl-N-(6-methoxy-1-phenyl-1,2,3,4-tetrahydronaphthalen-2-ylmethyl)aminomethylcarboxylic acid results in decreased activity of SLC6A9 protein"20655511
C008661nobiletinnobiletin results in increased expression of SLC6A9 mRNA23321314
C008661nobiletinnobiletin results in increased expression of SLC6A9 mRNA23321314
C570897NSC668394NSC668394 results in increased expression of SLC6A9 mRNA27137931
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in decreased expression of SLC6A9 mRNA25729387
C030110oxaliplatinoxaliplatin results in decreased expression of SLC6A9 mRNA25729387
D010098OxycodoneOxycodone results in decreased expression of SLC6A9 mRNA23439660
D010100OxygenOxygen deficiency results in decreased expression of SLC6A9 mRNA25596134
D010100OxygenOxygen deficiency results in increased expression of SLC6A9 mRNA22629407
D010100OxygenOxygen inhibits the reaction [Oxygen deficiency results in increased expression of SLC6A9 mRNA]22629407
D010126Ozone[Ozone co-treated with Chlorine] results in decreased expression of SLC6A9 mRNA18636392
D010269ParaquatParaquat results in increased expression of SLC6A9 mRNA17077588|1819848
D010416PentachlorophenolPentachlorophenol results in increased expression of SLC6A9 mRNA23892564
D010634PhenobarbitalNR1I3 protein affects the reaction [Phenobarbital results in increased expression of SLC6A9 mRNA]19482888
D010634PhenobarbitalPhenobarbital affects the expression of SLC6A9 mRNA23091169
D010634PhenobarbitalPhenobarbital results in increased expression of SLC6A9 mRNA19482888
C018637phoronephorone affects the expression of SLC6A9 mRNA18198479
C006253pirinixic acidpirinixic acid results in increased expression of SLC6A9 mRNA18301758
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in decreased expression of SLC6A9 mRNA19162173
D011441PropylthiouracilPropylthiouracil results in decreased expression of SLC6A9 mRNA24780913
D012293RifampinRifampin results in increased expression of SLC6A9 mRNA27199754
C089730rosiglitazonerosiglitazone results in decreased expression of SLC6A9 mRNA25596134
C009250sevofluranesevoflurane affects the expression of SLC6A9 mRNA15967596
D012822Silicon DioxideSilicon Dioxide analog results in increased expression of SLC6A9 mRNA25895662
D012822Silicon DioxideSilicon Dioxide results in decreased expression of SLC6A9 mRNA25351596
D012969Sodium FluorideSodium Fluoride results in increased expression of SLC6A9 mRNA27862939
D018038Sodium SeleniteSodium Selenite results in increased expression of SLC6A9 mRNA24383545
D013629TamoxifenTamoxifen results in decreased expression of SLC6A9 mRNA25123088
C031655tauroursodeoxycholic acidtauroursodeoxycholic acid results in increased expression of SLC6A9 mRNA15885361
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of SLC6A9 mRNA21570461|2468072
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of SLC6A9 mRNA17942748
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of SLC6A9 mRNA19933214
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of SLC6A9 mRNA21215274
D013750TetrachloroethyleneTetrachloroethylene results in increased expression of SLC6A9 mRNA28973375
D013755Tetradecanoylphorbol AcetateTetradecanoylphorbol Acetate affects the localization of SLC6A9 protein19473961
D013755Tetradecanoylphorbol AcetateTetradecanoylphorbol Acetate promotes the reaction [Monensin affects the localization of SLC6A9 protein]19473961
D019284ThapsigarginThapsigargin results in increased expression of SLC6A9 mRNA22378314
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of SLC6A9 mRNA28065790
D014050TolueneToluene affects the expression of SLC6A9 mRNA18653662
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in decreased expression of SLC6A9 mRNA25729387
D019772TopotecanTopotecan results in decreased expression of SLC6A9 mRNA25729387
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of SLC6A9 mRNA"26179874
C013320tris(2-butoxyethyl) phosphatetris(2-butoxyethyl) phosphate affects the expression of SLC6A9 mRNA29024780
C057693troglitazonetroglitazone results in decreased expression of SLC6A9 mRNA25596134
D014415TunicamycinTunicamycin results in increased expression of SLC6A9 mRNA22378314
D014520UrethaneUrethane results in decreased expression of SLC6A9 mRNA28818685
D014639VanadiumVanadium results in decreased expression of SLC6A9 mRNA19000753
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of SLC6A9 gene25560391

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005215transporter activity-IBA21873635  
GO:0015187glycine transmembrane transporter activity-IBA21873635  
GO:0015375glycine:sodium symporter activity-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0003333amino acid transmembrane transport-IEA-  
GO:0035725sodium ion transmembrane transport-IBA21873635  
GO:0060092regulation of synaptic transmission, glycinergic-IBA21873635  
GO:0061537glycine secretion, neurotransmission-IBA21873635  
GO:0061537glycine secretion, neurotransmission-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005886plasma membrane-IBA21873635  
GO:0005886plasma membrane-TAS-  
GO:0016020membrane-TAS8183239  
GO:0098793presynapse-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-382551Transport of small moleculesTAS
R-HSA-425366Transport of bile salts and organic acids, metal ions and amine compoundsTAS
R-HSA-425407SLC-mediated transmembrane transportTAS
R-HSA-442660Na+/Cl- dependent neurotransmitter transportersTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
19650813No association of alcohol dependence with SLC6A5 and SLC6A9 glycine transporter polymorphisms. (2009 Sep)Koller GAddict Biol