Gene: GSTT2B

653689
GSTT2P
glutathione S-transferase theta 2B (gene/pseudogene)
protein-coding
22q11.23
Ensembl:ENSG00000133433 Vega:OTTHUMG00000150774 UniprotKB:P0CG30
NC_000022.11
PubMed
0   ANCO-SNPs
ND
2   
2.544e-1 (AD)  6.308e-1 (ND)   (Frontal_Cortex)
NA (AD)  NA (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
GSTT20.764
NOXO10.369
DDTL0.333
BCKDK0.324
PEX70.317
NIT10.311
CHPF0.31
POLR2J30.308
FAM162A0.304
DBH0.304

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
GSTT1-0.324
C19orf33-0.292
UNC45B-0.229
PPP1R14D-0.227
FOXB2-0.225
SLC52A1-0.217
HIST1H2BL-0.204
ERVFRD-1-0.199
OCLN-0.191
HRH4-0.187

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
D000117AcetylglucosamineAcetylglucosamine results in increased expression of GSTT2B mRNA18047607
D016604Aflatoxin B1Aflatoxin B1 results in increased methylation of GSTT2B gene27153756
C561695(+)-JQ1 compound(+)-JQ1 compound results in increased expression of GSTT2B mRNA24796395
D010695PhlorhizinPhlorhizin results in decreased expression of GSTT2B mRNA22538082
D014635Valproic AcidValproic Acid results in increased methylation of GSTT2B gene29154799

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004364glutathione transferase activity-IBA21873635  
GO:0004364glutathione transferase activity-NAS7789971  
GO:0004364glutathione transferase activity-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006749glutathione metabolic process-IBA21873635  
GO:1901687glutathione derivative biosynthetic process-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005654nucleoplasm-IDA-  
GO:0005737cytoplasm-IBA21873635  
GO:0005829cytosol-IDA-  
GO:0005829cytosol-TAS-  
GO:0070062extracellular exosome-HDA23533145  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-1430728MetabolismTAS
R-HSA-156580Phase II - Conjugation of compoundsTAS
R-HSA-156590Glutathione conjugationTAS
R-HSA-211859Biological oxidationsTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
22216261Association of a deletion of GSTT2B with an altered risk of oesophageal squamous cell carcinoma in a South African population: a case-control study. (2011)Matejcic MPLoS One
21349909Glutathione S-transferase copy number variation alters lung gene expression. (2011 Jul)Butler MWEur Respir J