Gene: BMP6

654
VGR|VGR1
bone morphogenetic protein 6
protein-coding
6p24.3
Ensembl:ENSG00000153162 MIM:112266 Vega:OTTHUMG00000014217 UniprotKB:P22004
NC_000006.12
PubMed
0   ANCO-SNPs
ND
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.255e-1 (AD)  3.932e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SHE0.817
VWF0.81
THSD40.806
FOXC10.804
ERG0.794
PAQR50.791
PTPRB0.79
CDH50.79
CYYR10.788
ITGA10.786

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SMIM18-0.414
BCL11A-0.406
ASPDH-0.394
FBLL1-0.394
RTN4R-0.391
WNT7A-0.386
ABCC12-0.385
KCNIP3-0.385
KCNB2-0.383
NEUROD6-0.382

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C5486512-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in decreased expression of BMP6 mRNA19933214
C4086042-(4-nitrophenyl)-4-(4-fluorophenyl)-5-(4-pyridinyl)-1H-imidazole2-(4-nitrophenyl)-4-(4-fluorophenyl)-5-(4-pyridinyl)-1H-imidazole inhibits the reaction [(4-(7-chloroquinolin-4-yl)piperazino)(1-phenyl-5-(trifluoromethyl)-1H-pyrazol-4-yl)methanone promotes the reaction [BMP2 protein results in increased expression of BMP6 mRNA]]25789987
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of BMP6 mRNA"21346803
C0065512-amino-2-methyl-1-propanol2-amino-2-methyl-1-propanol results in increased expression of BMP6 mRNA25088246
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of BMP6 mRNA"23196670
C0144643,4-dichloroaniline"3,4-dichloroaniline results in increased expression of BMP6 mRNA"24172598
C0909424-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [(4-(7-chloroquinolin-4-yl)piperazino)(1-phenyl-5-(trifluoromethyl)-1H-pyrazol-4-yl)methanone promotes the reaction [BMP2 protein results in increased expression of BMP6 mRNA]]25789987
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of BMP6 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of BMP6 mRNA"27188386
C000603489(4-(7-chloroquinolin-4-yl)piperazino)(1-phenyl-5-(trifluoromethyl)-1H-pyrazol-4-yl)methanone2-(4-nitrophenyl)-4-(4-fluorophenyl)-5-(4-pyridinyl)-1H-imidazole inhibits the reaction [(4-(7-chloroquinolin-4-yl)piperazino)(1-phenyl-5-(trifluoromethyl)-1H-pyrazol-4-yl)methanone promotes the reaction [BMP2 protein results in increased expression of BMP6 mRNA]]25789987
C000603489(4-(7-chloroquinolin-4-yl)piperazino)(1-phenyl-5-(trifluoromethyl)-1H-pyrazol-4-yl)methanone4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [(4-(7-chloroquinolin-4-yl)piperazino)(1-phenyl-5-(trifluoromethyl)-1H-pyrazol-4-yl)methanone promotes the reaction [BMP2 protein results in increased expression of BMP6 mRNA]]25789987
C000603489(4-(7-chloroquinolin-4-yl)piperazino)(1-phenyl-5-(trifluoromethyl)-1H-pyrazol-4-yl)methanone(4-(7-chloroquinolin-4-yl)piperazino)(1-phenyl-5-(trifluoromethyl)-1H-pyrazol-4-yl)methanone promotes the reaction [BMP2 protein results in increased expression of BMP6 mRNA]25789987
C000603489(4-(7-chloroquinolin-4-yl)piperazino)(1-phenyl-5-(trifluoromethyl)-1H-pyrazol-4-yl)methanoneSB 203580 inhibits the reaction [(4-(7-chloroquinolin-4-yl)piperazino)(1-phenyl-5-(trifluoromethyl)-1H-pyrazol-4-yl)methanone promotes the reaction [BMP2 protein results in increased expression of BMP6 mRNA]]25789987
C5014744-OH-2',3,3',4',5'-pentachlorobiphenyl"4-OH-2',3,3',4',5'-pentachlorobiphenyl inhibits the reaction [Triiodothyronine results in decreased expression of BMP6 mRNA]"14761676
C5014744-OH-2',3,3',4',5'-pentachlorobiphenyl"4-OH-2',3,3',4',5'-pentachlorobiphenyl results in decreased expression of BMP6 mRNA"14761676
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine inhibits the reaction [BMP6 protein results in increased expression of HAMP mRNA]"25633564
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine inhibits the reaction [BMP6 protein results in increased secretion of HAMP protein modified form]"25633564
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of BMP6 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of BMP6 mRNA"27188386
C0524109-chloro-2-(2-furyl)-(1,2,4)triazolo(1,5-c)quinazolin-5-imine"9-chloro-2-(2-furyl)-(1,2,4)triazolo(1,5-c)quinazolin-5-imine inhibits the reaction [BMP6 protein results in increased expression of HAMP mRNA]"25633564
C0524109-chloro-2-(2-furyl)-(1,2,4)triazolo(1,5-c)quinazolin-5-imine"9-chloro-2-(2-furyl)-(1,2,4)triazolo(1,5-c)quinazolin-5-imine inhibits the reaction [BMP6 protein results in increased secretion of HAMP protein modified form]"25633564
D000082AcetaminophenAcetaminophen results in increased expression of BMP6 mRNA21420995
D000082AcetaminophenAcetaminophen affects the expression of BMP6 mRNA17562736
D000082AcetaminophenAcetaminophen results in decreased expression of BMP6 mRNA22610607
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of BMP6 mRNA19770486
D000395Air Pollutants, Occupational"Air Pollutants, Occupational results in increased expression of BMP6 mRNA"23195993
D000537Aluminum OxideAluminum Oxide results in decreased expression of BMP6 mRNA19464052
D000643Ammonium ChlorideAmmonium Chloride affects the expression of BMP6 mRNA16483693
D000966Antimony Potassium TartrateAntimony Potassium Tartrate inhibits the reaction [BMP6 protein results in increased expression of DUSP12 mRNA]28713220
D000966Antimony Potassium TartrateAntimony Potassium Tartrate inhibits the reaction [BMP6 protein results in increased expression of DUSP2 mRNA]28713220
D001058ApomorphineApomorphine inhibits the reaction [BMP6 protein results in increased expression of HAMP mRNA]25633564
D001058ApomorphineApomorphine inhibits the reaction [BMP6 protein results in increased secretion of HAMP protein modified form]25633564
C015001arsenitearsenite results in increased methylation of BMP6 promoter23974009
D001285AtropineAtropine inhibits the reaction [Carbon Tetrachloride results in increased expression of BMP6 mRNA]18472332
C013407benzamilbenzamil inhibits the reaction [BMP6 protein results in increased expression of HAMP mRNA]25633564
C006703benzo(b)fluoranthenebenzo(b)fluoranthene results in decreased expression of BMP6 mRNA26377693
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of BMP6 mRNA20064835
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of BMP6 mRNA19770486
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of BMP6 mRNA22228805|2261060
D004958Estradiol[Estradiol co-treated with EGF protein] results in increased expression of BMP6 mRNA24758408
D004958Estradiol[Estradiol co-treated with Progesterone] results in decreased expression of BMP6 mRNA20660070
D004958EstradiolEstradiol results in increased expression of BMP6 mRNA21795739
D004958Estradiol[bisphenol A co-treated with Estradiol] results in increased expression of BMP6 mRNA26496021
D004958EstradiolBMP6 protein inhibits the reaction [IGF1 protein promotes the reaction [FSHB protein results in increased abundance of Estradiol]]22067323
C543008bis(4-hydroxyphenyl)sulfone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of BMP6 mRNA28628672
C006780bisphenol Abisphenol A results in decreased expression of BMP6 mRNA27685785
C006780bisphenol A[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of BMP6 mRNA28628672
C006780bisphenol Abisphenol A affects the expression of BMP6 mRNA25181051
C006780bisphenol A[bisphenol A co-treated with Estradiol] results in increased expression of BMP6 mRNA26496021
C000611646bisphenol F[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of BMP6 mRNA28628672
D0151248-Bromo Cyclic Adenosine Monophosphate8-Bromo Cyclic Adenosine Monophosphate results in decreased expression of BMP6 mRNA22079614
D0151248-Bromo Cyclic Adenosine Monophosphate8-Bromo Cyclic Adenosine Monophosphate results in increased expression of BMP6 mRNA20147733
C027561butylbenzyl phthalatebutylbenzyl phthalate results in decreased expression of BMP6 mRNA19560483
C018475butyraldehydebutyraldehyde results in decreased expression of BMP6 mRNA26079696
D000001Calcimycinfulvic acid inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Calcimycin] results in increased expression of BMP6 mRNA]21331654
D000001Calcimycin[Tetradecanoylphorbol Acetate co-treated with Calcimycin] results in increased expression of BMP6 mRNA21331654
D002220CarbamazepineCarbamazepine affects the expression of BMP6 mRNA25979313
D002251Carbon TetrachlorideAtropine inhibits the reaction [Carbon Tetrachloride results in increased expression of BMP6 mRNA]18472332
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of BMP6 mRNA18472332
D020245p-Chloromercuribenzoic Acid"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of BMP6 mRNA"27188386
D020245p-Chloromercuribenzoic Acidp-Chloromercuribenzoic Acid results in increased expression of BMP6 mRNA26272509|2718838
C018021cobaltous chloridecobaltous chloride inhibits the reaction [BMP6 protein results in increased expression of HAMP mRNA]25633564
C018021cobaltous chloridecobaltous chloride results in decreased expression of BMP6 mRNA19320972
D005576ColforsinBMP6 protein inhibits the reaction [Colforsin results in increased expression of CYP11A1 mRNA]18936084
D005576ColforsinBMP6 protein inhibits the reaction [Colforsin results in increased expression of CYP19A1 mRNA]18936084
D005576ColforsinBMP6 protein inhibits the reaction [Colforsin results in increased expression of HSD3B1 mRNA]18936084
D005576ColforsinBMP6 protein inhibits the reaction [Colforsin results in increased expression of OXT mRNA]18936084
D005576ColforsinBMP6 protein inhibits the reaction [Colforsin results in increased expression of STAR mRNA]18936084
D005576ColforsinBMP6 protein inhibits the reaction [Colforsin results in increased secretion of Progesterone]18936084
D005576ColforsinFST protein inhibits the reaction [BMP6 protein inhibits the reaction [Colforsin results in increased secretion of Progesterone]]18936084
D003300CopperCopper deficiency results in increased expression of BMP6 mRNA20164366
D003345CorticosteroneCorticosterone results in increased expression of BMP6 mRNA15755911
D003471CuprizoneCuprizone results in increased expression of BMP6 mRNA26577399
D016572CyclosporineCyclosporine results in increased expression of BMP6 mRNA25562108
C010902decabromobiphenyl etherdecabromobiphenyl ether results in decreased expression of BMP6 mRNA23914054
C014347decitabine[decitabine affects the methylation of BMP6 promoter] which affects the expression of BMP6 mRNA18688853|1868885
C014347decitabinedecitabine results in increased expression of BMP6 mRNA27915011
D003676DeferoxamineDeferoxamine inhibits the reaction [BMP6 protein results in increased expression of HAMP mRNA]25633564
D003676Deferoxamineferric ammonium citrate affects the reaction [Deferoxamine inhibits the reaction [BMP6 protein results in increased expression of HAMP mRNA]]25633564
D003907DexamethasoneDexamethasone inhibits the reaction [BMP6 protein results in increased expression of GREM1 mRNA]15268896
D003907DexamethasoneDexamethasone inhibits the reaction [BMP6 protein results in increased expression of SOST mRNA]15268896
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of BMP6 mRNA28628672
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of BMP6 mRNA28628672
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of BMP6 mRNA28628672
D003976DiazinonDiazinon results in increased expression of BMP6 mRNA29108742
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of BMP6 mRNA19560483
D004008DiclofenacDiclofenac results in decreased expression of BMP6 mRNA26934552
C036042dicyclohexyl phthalatedicyclohexyl phthalate affects the expression of BMP6 mRNA26924002
D002117CalcitriolCalcitriol promotes the reaction [BMP6 protein results in increased expression of SOST mRNA]15268896
D002117CalcitriolCalcitriol results in increased expression of BMP6 mRNA16002434
D004137DinitrochlorobenzeneDinitrochlorobenzene results in increased expression of BMP6 mRNA17374397
C034171di-n-pentyl phthalatedi-n-pentyl phthalate results in decreased expression of BMP6 mRNA19560483
D004237DiuronDiuron metabolite results in increased expression of BMP6 mRNA24172598
D004237DiuronDiuron results in decreased expression of BMP6 mRNA21551480
D004610Ellagic AcidEllagic Acid results in decreased expression of BMP6 mRNA12002526
C007628esculetinesculetin inhibits the reaction [Streptozocin results in decreased expression of BMP6 mRNA]21450970
D000431EthanolBMP6 protein inhibits the reaction [Ethanol results in decreased expression of HAMP mRNA]24746831
D000431EthanolBMP6 protein inhibits the reaction [Ethanol results in decreased expression of SMAD4 mRNA]24746831
D000431EthanolBMP6 protein affects the reaction [Ethanol affects the localization of SMAD4 protein]24746831
D000431EthanolBMP6 protein affects the reaction [Ethanol inhibits the reaction [SMAD4 protein binds to HAMP promoter]]24746831
D000431EthanolEthanol inhibits the reaction [Iron Carbonyl Compounds results in increased expression of BMP6 mRNA]24746831
D000431EthanolEthanol inhibits the reaction [Iron Carbonyl Compounds results in increased expression of BMP6 protein]24746831
D000431EthanolEthanol results in decreased expression of BMP6 mRNA24746831
D000431EthanolEthanol results in decreased expression of BMP6 protein24746831
D000431EthanolQuercetin inhibits the reaction [Ethanol results in decreased expression of BMP6 mRNA]24746831
D000431EthanolQuercetin inhibits the reaction [Ethanol results in decreased expression of BMP6 protein]24746831
D000431EthanolQuercetin promotes the reaction [Ethanol inhibits the reaction [Iron Carbonyl Compounds results in increased expression of BMP6 mRNA]]24746831
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of BMP6 mRNA17555576
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of BMP6 mRNA23300682
D005047EtoposideEtoposide inhibits the reaction [BMP6 protein results in increased expression of HAMP mRNA]25633564
D005054EugenolEugenol results in increased expression of BMP6 mRNA17374397
C013531ferric ammonium citrateferric ammonium citrate affects the reaction [Deferoxamine inhibits the reaction [BMP6 protein results in increased expression of HAMP mRNA]]25633564
C013531ferric ammonium citrateferric ammonium citrate inhibits the reaction [BMP6 protein results in increased expression of HAMP mRNA]25633564
C005023fulvic acidfulvic acid inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Calcimycin] results in increased expression of BMP6 mRNA]21331654
D005839GentamicinsGentamicins results in decreased expression of BMP6 mRNA22061828
D005944GlucosamineGlucosamine inhibits the reaction [IL1B results in increased expression of BMP6 mRNA]17109745
D005944GlucosamineGlucosamine results in decreased expression of BMP6 mRNA17109745
D006493HeparinHeparin inhibits the reaction [BMP6 protein results in increased expression of HAMP mRNA]25633564
D006493HeparinHeparin inhibits the reaction [BMP6 protein results in increased secretion of HAMP protein modified form]25633564
D006493HeparinHeparin results in decreased expression of BMP6 mRNA25633564
D006497Heparitin SulfateHeparitin Sulfate analog binds to BMP6 protein14707131
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of BMP6 mRNA28628672
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of BMP6 mRNA28628672
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of BMP6 mRNA28628672
D007501IronBMP6 gene mutant form results in increased abundance of Iron19252486|1925248
D007501IronBMP6 protein results in decreased abundance of Iron19252486
D007501IronIron deficiency results in decreased expression of BMP6 mRNA20164366
D007501IronIron results in increased expression of BMP6 mRNA20164366
D054354Iron Carbonyl CompoundsEthanol inhibits the reaction [Iron Carbonyl Compounds results in increased expression of BMP6 mRNA]24746831
D054354Iron Carbonyl CompoundsEthanol inhibits the reaction [Iron Carbonyl Compounds results in increased expression of BMP6 protein]24746831
D054354Iron Carbonyl CompoundsIron Carbonyl Compounds results in increased expression of BMP6 mRNA24746831
D054354Iron Carbonyl CompoundsIron Carbonyl Compounds results in increased expression of BMP6 protein24746831
D054354Iron Carbonyl CompoundsQuercetin inhibits the reaction [Iron Carbonyl Compounds results in increased expression of BMP6 mRNA]24746831
D054354Iron Carbonyl CompoundsQuercetin inhibits the reaction [Iron Carbonyl Compounds results in increased expression of BMP6 protein]24746831
D054354Iron Carbonyl CompoundsQuercetin promotes the reaction [Ethanol inhibits the reaction [Iron Carbonyl Compounds results in increased expression of BMP6 mRNA]]24746831
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of BMP6 mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of BMP6 mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of BMP6 mRNA28628672
C119620kenpaullonekenpaullone inhibits the reaction [BMP6 protein results in increased secretion of HAMP protein modified form]25633564
C008261lead acetate[lead acetate co-treated with TGFB1 protein] results in increased expression of BMP6 mRNA12168672
D008070LipopolysaccharidesTriclosan promotes the reaction [Lipopolysaccharides results in increased expression of BMP6 mRNA]20507366
D008070LipopolysaccharidesBMP6 gene mutant form inhibits the reaction [Lipopolysaccharides results in increased expression of HAMP mRNA]19252488
D008070LipopolysaccharidesLipopolysaccharides results in decreased expression of BMP6 mRNA12057914
C042720mercuric bromidemercuric bromide results in increased expression of BMP6 mRNA26272509
C042720mercuric bromide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of BMP6 mRNA"27188386
D008713MethimazoleMethimazole results in decreased expression of BMP6 mRNA22504374
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of BMP6 mRNA"20188158
D008777MethyltestosteroneMethyltestosterone results in decreased expression of BMP6 mRNA29191790
C517284monomethyl phthalatemonomethyl phthalate affects the expression of BMP6 mRNA26924002
D009151Mustard GasMustard Gas results in increased expression of BMP6 mRNA15674843
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of BMP6 mRNA"25511174
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of BMP6 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of BMP6 mRNA"25554681
D009532NickelNickel results in increased expression of BMP6 mRNA23195993
C029938nickel sulfatenickel sulfate results in increased expression of BMP6 mRNA16780908|1737439
C419410N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester"N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester inhibits the reaction [BMP6 protein results in increased expression of KRT10 mRNA]"23566955
C419410N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester"N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester inhibits the reaction [BMP6 protein results in increased expression of KRT1 mRNA]"23566955
C570897NSC668394NSC668394 results in increased expression of BMP6 mRNA27137931
D015282OctreotideOctreotide promotes the reaction [BMP6 protein results in increased expression of ID1 mRNA]23137853
C510784ormosil[ormosil binds to Polyethylene Glycols] which results in increased expression of BMP6 mRNA24888373
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in increased expression of BMP6 mRNA25729387
C030110oxaliplatinoxaliplatin results in increased expression of BMP6 mRNA25729387
D052638Particulate MatterParticulate Matter results in decreased expression of BMP6 mRNA22178795
C517782pasireotidepasireotide promotes the reaction [BMP6 protein results in increased expression of ID1 mRNA]23137853
C086401pentabromodiphenyl etherpentabromodiphenyl ether results in decreased expression of BMP6 mRNA26705709
D010705PhosgenePhosgene affects the expression of BMP6 mRNA16300373
D011078Polychlorinated BiphenylsPolychlorinated Biphenyls inhibits the reaction [Triiodothyronine results in decreased expression of BMP6 mRNA]14761676
D011092Polyethylene Glycols[ormosil binds to Polyethylene Glycols] which results in increased expression of BMP6 mRNA24888373
D011374ProgesteroneBMP6 protein results in increased secretion of Progesterone17660239
D011374ProgesteroneBMP6 protein inhibits the reaction [Colforsin results in increased secretion of Progesterone]18936084
D011374Progesterone[Estradiol co-treated with Progesterone] results in decreased expression of BMP6 mRNA20660070
D011374ProgesteroneFST protein inhibits the reaction [BMP6 protein inhibits the reaction [Colforsin results in increased secretion of Progesterone]]18936084
D011374Progesterone[BMP6 protein results in decreased expression of STAR mRNA] inhibits the reaction [FSHB protein results in increased abundance of Progesterone]22067323
D011374ProgesteroneGH1 protein inhibits the reaction [BMP6 protein inhibits the reaction [FSHB protein results in increased abundance of Progesterone]]22067323
D011374ProgesteroneIGF1 protein inhibits the reaction [BMP6 protein inhibits the reaction [FSHB protein results in increased abundance of Progesterone]]22067323
D011374ProgesteroneProgesterone results in increased expression of BMP6 mRNA20726854
C005556propionaldehydepropionaldehyde results in decreased expression of BMP6 mRNA26079696
D011441PropylthiouracilPropylthiouracil results in decreased expression of BMP6 mRNA22504374
C513428pyrachlostrobinpyrachlostrobin results in increased expression of BMP6 mRNA27029645
D011794QuercetinQuercetin inhibits the reaction [Ethanol results in decreased expression of BMP6 mRNA]24746831
D011794QuercetinQuercetin inhibits the reaction [Ethanol results in decreased expression of BMP6 protein]24746831
D011794QuercetinQuercetin inhibits the reaction [Iron Carbonyl Compounds results in increased expression of BMP6 mRNA]24746831
D011794QuercetinQuercetin inhibits the reaction [Iron Carbonyl Compounds results in increased expression of BMP6 protein]24746831
D011794QuercetinQuercetin promotes the reaction [Ethanol inhibits the reaction [Iron Carbonyl Compounds results in increased expression of BMP6 mRNA]]24746831
C059514resveratrolresveratrol results in decreased expression of BMP6 mRNA12002526
C009172rhodiolosiderhodioloside results in increased expression of BMP6 mRNA24055767
C513635S-2-pentyl-4-pentynoic hydroxamic acidS-2-pentyl-4-pentynoic hydroxamic acid results in increased expression of BMP6 mRNA21427059
C093642SB 203580SB 203580 inhibits the reaction [(4-(7-chloroquinolin-4-yl)piperazino)(1-phenyl-5-(trifluoromethyl)-1H-pyrazol-4-yl)methanone promotes the reaction [BMP2 protein results in increased expression of BMP6 mRNA]]25789987
C078903seocalcitolseocalcitol results in increased expression of BMP6 mRNA12040012
D017632Asbestos, Serpentine"Asbestos, Serpentine results in decreased expression of BMP6 mRNA"16251409
D012715Sesame OilSesame Oil results in increased expression of BMP6 mRNA29191790
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of BMP6 mRNA25895662
C017947sodium arseniteEGF protein promotes the reaction [sodium arsenite inhibits the reaction [BMP6 protein results in increased phosphorylation of SMAD1 protein]]23566955
C017947sodium arseniteEGF protein promotes the reaction [sodium arsenite inhibits the reaction [BMP6 protein results in increased phosphorylation of SMAD5 protein]]23566955
C017947sodium arsenitesodium arsenite affects the methylation of BMP6 gene28589171
C017947sodium arsenitesodium arsenite inhibits the reaction [BMP6 protein results in decreased phosphorylation of MAPK1 protein]23566955
C017947sodium arsenitesodium arsenite inhibits the reaction [BMP6 protein results in decreased phosphorylation of MAPK3 protein]23566955
C017947sodium arsenitesodium arsenite inhibits the reaction [BMP6 protein results in increased activity of NOTCH1 protein]23566955
C017947sodium arsenitesodium arsenite inhibits the reaction [BMP6 protein results in increased expression of DUSP12 mRNA]28713220
C017947sodium arsenitesodium arsenite inhibits the reaction [BMP6 protein results in increased expression of DUSP14 mRNA]23566955
C017947sodium arsenitesodium arsenite inhibits the reaction [BMP6 protein results in increased expression of DUSP2 mRNA]23566955|2871322
C017947sodium arsenitesodium arsenite inhibits the reaction [BMP6 protein results in increased expression of FOXN1 mRNA]23566955
C017947sodium arsenitesodium arsenite inhibits the reaction [BMP6 protein results in increased expression of KRT10 mRNA]23566955
C017947sodium arsenitesodium arsenite inhibits the reaction [BMP6 protein results in increased expression of KRT1 mRNA]23566955
C017947sodium arsenitesodium arsenite inhibits the reaction [BMP6 protein results in increased phosphorylation of SMAD1 protein]23566955
C017947sodium arsenitesodium arsenite inhibits the reaction [BMP6 protein results in increased phosphorylation of SMAD5 protein]23566955
D053260SootSoot results in decreased expression of BMP6 mRNA26551751
D013311Streptozocinesculetin inhibits the reaction [Streptozocin results in decreased expression of BMP6 mRNA]21450970
D013311StreptozocinStreptozocin results in decreased expression of BMP6 mRNA21450970
D014284Triiodothyronine"4-OH-2',3,3',4',5'-pentachlorobiphenyl inhibits the reaction [Triiodothyronine results in decreased expression of BMP6 mRNA]"14761676
D014284TriiodothyroninePolychlorinated Biphenyls inhibits the reaction [Triiodothyronine results in decreased expression of BMP6 mRNA]14761676
D014284TriiodothyronineTetrachlorodibenzodioxin promotes the reaction [Triiodothyronine results in decreased expression of BMP6 mRNA]14761676
D014284TriiodothyronineTriiodothyronine results in decreased expression of BMP6 mRNA14761676
D013739TestosteroneTestosterone results in increased expression of BMP6 mRNA19693291
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin promotes the reaction [Triiodothyronine results in decreased expression of BMP6 mRNA]14761676
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin promotes the reaction [AHR protein binds to BMP6 gene]28213091
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of BMP6 mRNA19770486|1993321
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of BMP6 mRNA28213091
D013750TetrachloroethyleneTetrachloroethylene results in increased expression of BMP6 mRNA28973375
D013755Tetradecanoylphorbol Acetatefulvic acid inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Calcimycin] results in increased expression of BMP6 mRNA]21331654
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Calcimycin] results in increased expression of BMP6 mRNA21331654
C402769tipifarnibtipifarnib results in increased expression of BMP6 mRNA16403772
C009495titanium dioxidetitanium dioxide results in decreased expression of BMP6 mRNA23557971
D014028Tobacco Smoke PollutionTobacco Smoke Pollution affects the expression of BMP6 mRNA20133372
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in increased expression of BMP6 mRNA25729387
D019772TopotecanTopotecan results in increased expression of BMP6 mRNA25729387
D014118Toxins, Biological"Toxins, Biological affects the expression of BMP6 mRNA"19682533
D014212TretinoinTretinoin promotes the reaction [BMP6 protein results in increased expression of SOST mRNA]15268896
D014212TretinoinTretinoin results in increased expression of BMP6 mRNA17196394
C012589trichostatin Atrichostatin A affects the expression of BMP6 mRNA28542535
D014260TriclosanTriclosan promotes the reaction [Lipopolysaccharides results in increased expression of BMP6 mRNA]20507366
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of BMP6 mRNA"26179874
C013320tris(2-butoxyethyl) phosphatetris(2-butoxyethyl) phosphate affects the expression of BMP6 mRNA29024780
D014520UrethaneUrethane results in increased expression of BMP6 mRNA28818685
D014635Valproic AcidValproic Acid results in increased expression of BMP6 mRNA23179753|2718838
D014635Valproic AcidValproic Acid results in increased methylation of BMP6 gene29154799
D014635Valproic AcidValproic Acid affects the expression of BMP6 mRNA17963808
D014635Valproic AcidValproic Acid results in increased expression of BMP6 mRNA19136453|2142705
C025643vinclozolinvinclozolin results in increased expression of BMP6 mRNA23034163

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005125cytokine activity-IBA21873635  
GO:0005160transforming growth factor beta receptor binding-IBA21873635  
GO:0008083growth factor activity-IEA-  
GO:0046982protein heterodimerization activity-IDA7811286  
GO:0070700BMP receptor binding-IBA21873635  
GO:0070700BMP receptor binding-IDA7811286  
GO ID GO Term Qualifier Evidence PubMed
GO:0000122negative regulation of transcription by RNA polymerase II-ISS-  
GO:0001501skeletal system development-TAS8089189  
GO:0001649osteoblast differentiation-IEA-  
GO:0001654eye development-IEA-  
GO:0001822kidney development-IEA-  
GO:0001938positive regulation of endothelial cell proliferation-IEA-  
GO:0001958endochondral ossification-IEA-  
GO:0003323type B pancreatic cell development-IDA11865031  
GO:0006879cellular iron ion homeostasis-ISS-  
GO:0006954inflammatory response-IEA-  
GO:0006955immune response-IMP16886151  
GO:0008284positive regulation of cell proliferation-NAS15516325  
GO:0010469regulation of signaling receptor activity-IEA-  
GO:0010862positive regulation of pathway-restricted SMAD protein phosphorylation-IBA21873635  
GO:0010862positive regulation of pathway-restricted SMAD protein phosphorylation-IDA17244894  19366699  
GO:0010862positive regulation of pathway-restricted SMAD protein phosphorylation-ISS-  
GO:0014823response to activity-IEA-  
GO:0030501positive regulation of bone mineralization-IDA18436533  
GO:0030509BMP signaling pathway-IBA21873635  
GO:0030509BMP signaling pathway-IDA18436533  
GO:0030509BMP signaling pathway-IMP18326817  
GO:0030509BMP signaling pathway-ISS-  
GO:0030539male genitalia development-IEA-  
GO:0031666positive regulation of lipopolysaccharide-mediated signaling pathway-ISS-  
GO:0032026response to magnesium ion-IEA-  
GO:0032332positive regulation of chondrocyte differentiation-IEA-  
GO:0032349positive regulation of aldosterone biosynthetic process-IDA16527843  
GO:0032526response to retinoic acid-IEA-  
GO:0042981regulation of apoptotic process-IBA21873635  
GO:0043408regulation of MAPK cascade-IBA21873635  
GO:0045603positive regulation of endothelial cell differentiation-IEA-  
GO:0045666positive regulation of neuron differentiation-IEA-  
GO:0045669positive regulation of osteoblast differentiation-IDA18436533  
GO:0045944positive regulation of transcription by RNA polymerase II-IDA16527843  
GO:0045944positive regulation of transcription by RNA polymerase II-IGI18326817  
GO:0045944positive regulation of transcription by RNA polymerase II-ISS-  
GO:0045944positive regulation of transcription by RNA polymerase II-NAS15516325  
GO:0048468cell development-IBA21873635  
GO:0050679positive regulation of epithelial cell proliferation-IDA11865031  
GO:0050714positive regulation of protein secretion-NAS15516325  
GO:0051216cartilage development-IEA-  
GO:0051384response to glucocorticoid-IEA-  
GO:0060391positive regulation of SMAD protein signal transduction-ISS-  
GO:0060395SMAD protein signal transduction-IBA21873635  
GO:0060395SMAD protein signal transduction-IDA17244894  
GO:0060395SMAD protein signal transduction-ISS-  
GO:0060586multicellular organismal iron ion homeostasis-ISS-  
GO:0071260cellular response to mechanical stimulus-IEA-  
GO:0071281cellular response to iron ion-ISS-  
GO:0071773cellular response to BMP stimulus-IMP18326817  
GO:2000860positive regulation of aldosterone secretion-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005615extracellular space-IBA21873635  
GO:0005737cytoplasm-IEA-  
GO:0031982vesicle-IEA-  
KEGG ID KEGG Term
hsa04340Hedgehog signaling pathway
hsa04350TGF-beta signaling pathway
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
25121767Bone morphogenetic protein 6 polymorphisms are associated with radiographic progression in ankylosing spondylitis. (2014)Joo YBPLoS One
28441666A MicroRNA-124 Polymorphism is Associated with Fracture Healing via Modulating BMP6 Expression. (2017)Zou LCell Physiol Biochem