Gene: SLC8A2

6543
NCX2
solute carrier family 8 member A2
protein-coding
19q13.32
Ensembl:ENSG00000118160 MIM:601901 Vega:OTTHUMG00000183529 UniprotKB:Q9UPR5
NC_000019.10
SNP Mapped
2   ANCO-SNPs
OD|AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.019e-1 (AD)  9.177e-2 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs830140chr19:47444725 (GRCh38.p7)A>Galcohol dependenceSNV(Single Nucleotide Variation)
rs698705chr19:47434209 (GRCh38.p7)A>Gopioid dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CACNG30.962
PGBD50.961
LINGO10.959
CLSTN30.955
LRTM20.954
ANKRD34A0.954
NGEF0.954
ATCAY0.953
SYNGR10.953
IQSEC20.953

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
REST-0.603
YES1-0.598
WWTR1-0.592
HEY2-0.572
TFPI2-0.568
RAI14-0.563
MYL3-0.558
RNF135-0.549
SNHG18-0.548
CNN2-0.547

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SLC8A2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SLC8A2 mRNA"27188386
D000082AcetaminophenAcetaminophen results in decreased expression of SLC8A2 mRNA22230336
D000447AldehydesAldehydes results in increased expression of SLC8A2 mRNA25014914
D000643Ammonium ChlorideAmmonium Chloride affects the expression of SLC8A2 mRNA16483693
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of SLC8A2 mRNA24449571
D001280AtrazineAtrazine results in increased expression of SLC8A2 mRNA22378314
C013418bromfenacoumbromfenacoum results in increased expression of SLC8A2 protein28903499
C018475butyraldehydebutyraldehyde results in increased expression of SLC8A2 mRNA26079696
D002118CalciumSLC8A2 protein results in increased uptake of Calcium14660663
D003300CopperCopper deficiency results in increased expression of SLC8A2 mRNA26033743
D003471CuprizoneCuprizone results in decreased expression of SLC8A2 mRNA26577399
C014347decitabinedecitabine affects the expression of SLC8A2 mRNA23300844
D002945CisplatinCisplatin affects the expression of SLC8A2 mRNA23300844
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in decreased expression of SLC8A2 mRNA27392435
D002945CisplatinCisplatin results in decreased expression of SLC8A2 mRNA27392435
D004041Dietary FatsDietary Fats results in increased expression of SLC8A2 mRNA25016146
C118739entinostatentinostat results in increased expression of SLC8A2 mRNA27188386
C544151jinfukang[Cisplatin co-treated with jinfukang] results in decreased expression of SLC8A2 mRNA27392435
C544151jinfukangjinfukang results in decreased expression of SLC8A2 mRNA27392435
D008731MethoxychlorMethoxychlor results in increased methylation of SLC8A2 gene23303685
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of SLC8A2 protein25809596
C046012pentanalpentanal results in increased expression of SLC8A2 mRNA26079696
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SLC8A2 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in decreased expression of SLC8A2 mRNA26272509
C005556propionaldehydepropionaldehyde results in increased expression of SLC8A2 mRNA26079696
D011441PropylthiouracilPropylthiouracil results in decreased expression of SLC8A2 mRNA24780913
D012834SilverSilver results in increased expression of SLC8A2 mRNA27131904
C017947sodium arsenitesodium arsenite affects the methylation of SLC8A2 gene28589171
D012999SomanSoman results in decreased expression of SLC8A2 mRNA19281266
D014635Valproic AcidValproic Acid affects the expression of SLC8A2 mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of SLC8A2 mRNA23179753
D014635Valproic AcidValproic Acid results in increased methylation of SLC8A2 gene29154799
C025643vinclozolinvinclozolin results in increased expression of SLC8A2 mRNA22615374

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005432calcium:sodium antiporter activity-ISS-  
GO:0005432calcium:sodium antiporter activity-TAS-  
GO:0005516calmodulin binding-IEA-  
GO:0046872metal ion binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006811ion transport-TAS-  
GO:0006874cellular calcium ion homeostasis-ISS-  
GO:0007154cell communication-IEA-  
GO:0007612learning-ISS-  
GO:0007613memory-ISS-  
GO:0035725sodium ion transmembrane transport-ISS-  
GO:0048172regulation of short-term neuronal synaptic plasticity-ISS-  
GO:0060291long-term synaptic potentiation-ISS-  
GO:0070588calcium ion transmembrane transport-ISS-  
GO:1903779regulation of cardiac conduction-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005886plasma membrane-TAS-  
GO:0005887integral component of plasma membrane-ISS-  
GO:0016323basolateral plasma membrane-IEA-  
GO:0043197dendritic spine-IEA-  
GO:0043204perikaryon-IEA-  
KEGG ID KEGG Term
hsa04020Calcium signaling pathway
hsa04974Protein digestion and absorption
Reactome ID Reactome Term Evidence
R-HSA-109582HemostasisTAS
R-HSA-382551Transport of small moleculesTAS
R-HSA-397014Muscle contractionTAS
R-HSA-418346Platelet homeostasisTAS
R-HSA-418359Reduction of cytosolic Ca++ levelsTAS
R-HSA-418360Platelet calcium homeostasisTAS
R-HSA-425393Transport of inorganic cations/anions and amino acids/oligopeptidesTAS
R-HSA-425407SLC-mediated transmembrane transportTAS
R-HSA-425561Sodium/Calcium exchangersTAS
R-HSA-5576891Cardiac conductionTAS
R-HSA-5578775Ion homeostasisTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal