Gene: LRTM2

654429
-
leucine rich repeats and transmembrane domains 2
protein-coding
12p13.33
Ensembl:ENSG00000166159 Vega:OTTHUMG00000168088 UniprotKB:Q8N967
NC_000012.12
SNP Mapped
1   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
5.096e-1 (AD)  6.663e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs2887631chr12:1825415 (GRCh38.p7)G>Aalcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg23331653chr12:1929348LRTM2Promoter3.620e-5Alcohol use disorders26763658

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CDK5R20.956
ABCG40.954
NGEF0.954
SLC8A20.954
TMEM38A0.951
CHRNB20.95
CLSTN30.95
CACNG30.948
SLC12A50.948
FAM131A0.947

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
WWTR1-0.667
YES1-0.665
REST-0.655
CNN2-0.632
CLEC2B-0.623
TFPI2-0.62
RAI14-0.617
MYL3-0.617
HEY2-0.613
RAB13-0.611

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0291412,2,5,7,8-pentamethyl-1-hydroxychroman"2,2,5,7,8-pentamethyl-1-hydroxychroman results in decreased expression of LRTM2 mRNA"21920950
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of LRTM2 mRNA23630614
C030935benz(a)anthracenebenz(a)anthracene results in increased expression of LRTM2 mRNA26377693
C030935benz(a)anthracene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of LRTM2 mRNA27858113
C006703benzo(b)fluoranthene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of LRTM2 mRNA27858113
D001564Benzo(a)pyrene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of LRTM2 mRNA27858113
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of LRTM2 mRNA22610609
C006780bisphenol Abisphenol A results in decreased expression of LRTM2 mRNA25181051
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of LRTM2 mRNA25993096
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of LRTM2 gene20938992
C031180chrysene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of LRTM2 mRNA27858113
D004041Dietary FatsDietary Fats results in decreased expression of LRTM2 mRNA18042831|2501614
C014476diethyl maleatediethyl maleate results in decreased expression of LRTM2 mRNA21161181
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of LRTM2 gene20938992
C039281furanfuran results in decreased expression of LRTM2 mRNA27387713
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of LRTM2 gene20938992
D037742Nanotubes, Carbon"Nanotubes, Carbon affects the expression of LRTM2 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon analog affects the expression of LRTM2 mRNA"25554681
D000073878Palm OilPalm Oil results in decreased expression of LRTM2 mRNA18042831
C016104sodium bichromatesodium bichromate results in decreased expression of LRTM2 mRNA25993096
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of LRTM2 mRNA21570461
D013853ThioacetamideThioacetamide results in decreased expression of LRTM2 mRNA23411599
D014028Tobacco Smoke PollutionTobacco Smoke Pollution affects the expression of LRTM2 mRNA20133372
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of LRTM2 mRNA"26179874
D014635Valproic AcidValproic Acid results in increased methylation of LRTM2 gene29154799
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of LRTM2 gene25560391
D015034Zinc OxideZinc Oxide analog results in decreased expression of LRTM2 mRNA27215404

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO ID GO Term Qualifier Evidence PubMed
GO:0051965positive regulation of synapse assembly-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0016021integral component of membrane-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal