Gene: SLC8A1

6546
NCX1
solute carrier family 8 member A1
protein-coding
2p22.1
Ensembl:ENSG00000183023 MIM:182305 Vega:OTTHUMG00000102183 UniprotKB:P32418
NC_000002.12
PubMed|SNP Mapped
4   ANCO-SNPs
ND|AD
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
3.551e-1 (AD)  7.854e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs6755144chr2:40409100 (GRCh38.p7)A>Galcohol dependenceSNV(Single Nucleotide Variation)
rs9789765chr2:40407694 (GRCh38.p7)A>Talcohol dependenceSNV(Single Nucleotide Variation)
rs10490045chr2:40404215 (GRCh38.p7)T>Calcohol dependenceSNV(Single Nucleotide Variation)
rs10490046chr2:40403538 (GRCh38.p7)A>Calcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
PCLO0.956
DGKI0.952
SYNJ10.951
SCN2A0.948
GPR1580.948
WDR70.947
AAK10.947
GABRG20.946
NEGR10.944
CLVS20.944

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CSAG1-0.555
COPZ2-0.553
RAB13-0.551
HEY2-0.544
ASB4-0.528
MYL3-0.525
RHOD-0.524
YES1-0.52
CHST14-0.519
SYDE1-0.517

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB09498Strontium chloride Sr-89Small Molecule38270-90-5Approved|InvestigationalTransporter
DB11093Calcium CitrateSmall Molecule813-94-5ApprovedTransporter
DB11348Calcium PhosphateSmall Molecule10103-46-5ApprovedTransporter
DB00132Alpha-Linolenic AcidSmall Molecule463-40-1Approved|NutraceuticalTarget
DB00159IcosapentSmall Molecule10417-94-4Approved|NutraceuticalTarget
DB06231CaldaretSmall Molecule133804-44-1InvestigationalTarget
ID Drug Name Action PubMed
C0493251,2-dithiol-3-thione"1,2-dithiol-3-thione results in decreased expression of SLC8A1 mRNA"19162173
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased expression of SLC8A1 mRNA"22698814
C0297902,2',3',4,4',5-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of SLC8A1 mRNA"25510870
C1016702-(2-(4-(4-nitrobenzyloxy)phenyl)ethyl)isothiourea methanesulfonate2-(2-(4-(4-nitrobenzyloxy)phenyl)ethyl)isothiourea methanesulfonate inhibits the reaction [SLC8A1 protein results in increased transport of Calcium]15375168
C1016702-(2-(4-(4-nitrobenzyloxy)phenyl)ethyl)isothiourea methanesulfonate2-(2-(4-(4-nitrobenzyloxy)phenyl)ethyl)isothiourea methanesulfonate inhibits the reaction [SLC8A1 protein results in increased uptake of Calcium]14660663
C1016702-(2-(4-(4-nitrobenzyloxy)phenyl)ethyl)isothiourea methanesulfonate2-(2-(4-(4-nitrobenzyloxy)phenyl)ethyl)isothiourea methanesulfonate inhibits the reaction [SLC8A1 protein results in increased susceptibility to Chlorodiphenyl (54% Chlorine)]16009740
C1016702-(2-(4-(4-nitrobenzyloxy)phenyl)ethyl)isothiourea methanesulfonate2-(2-(4-(4-nitrobenzyloxy)phenyl)ethyl)isothiourea methanesulfonate inhibits the reaction [SLC8A1 protein results in increased transport of Calcium]18822394
C1016702-(2-(4-(4-nitrobenzyloxy)phenyl)ethyl)isothiourea methanesulfonate2-(2-(4-(4-nitrobenzyloxy)phenyl)ethyl)isothiourea methanesulfonate results in decreased activity of SLC8A1 protein17541957
C1016702-(2-(4-(4-nitrobenzyloxy)phenyl)ethyl)isothiourea methanesulfonate2-(2-(4-(4-nitrobenzyloxy)phenyl)ethyl)isothiourea methanesulfonate results in decreased activity of SLC8A1 protein12215493
C0817662,4,4'-trichlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of SLC8A1 mRNA"25510870
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of SLC8A1 mRNA"25510870
C0098282,4,5,2',5'-pentachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of SLC8A1 mRNA"25510870
C0094072,5,2',5'-tetrachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of SLC8A1 mRNA"25510870
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SLC8A1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SLC8A1 mRNA"27188386
D000082AcetaminophenAcetaminophen affects the expression of SLC8A1 mRNA25458485
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of SLC8A1 gene27153756
D000395Air Pollutants, Occupational"Air Pollutants, Occupational results in decreased expression of SLC8A1 mRNA"23195993
D000493AllopurinolAllopurinol affects the expression of SLC8A1 mRNA17071724
D000493AllopurinolAllopurinol affects the expression of SLC8A1 protein17071724
D000638AmiodaroneAmiodarone results in decreased activity of SLC8A1 protein15288574
D000638AmiodaroneAmiodarone results in increased expression of SLC8A1 protein12479229|7573397
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of SLC8A1 mRNA24449571
D001151ArsenicArsenic affects the methylation of SLC8A1 gene25304211
D001280AtrazineAtrazine results in decreased expression of SLC8A1 mRNA25929836
D001464BariumSLC8A1 protein affects the transport of Barium17560225
C030935benz(a)anthracene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of SLC8A1 mRNA27858113
C006703benzo(b)fluoranthene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of SLC8A1 mRNA27858113
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of SLC8A1 mRNA20064835
D001564Benzo(a)pyrene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of SLC8A1 mRNA27858113
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of SLC8A1 mRNA"20382639
D015764BepridilBepridil inhibits the reaction [SLC8A1 protein results in increased susceptibility to Chlorodiphenyl (54% Chlorine)]16009740
D004958EstradiolEstradiol results in increased expression of SLC8A1 mRNA21795739
D004958EstradiolProgesterone inhibits the reaction [Estradiol results in increased expression of SLC8A1 mRNA]21795739
C070515bisindolylmaleimide Ibisindolylmaleimide I inhibits the reaction [Phenylephrine results in decreased expression of SLC8A1 mRNA]17257893
C006780bisphenol Abisphenol A affects the expression of SLC8A1 mRNA20170705
C006780bisphenol Abisphenol A results in decreased expression of SLC8A1 mRNA27685785
C006780bisphenol Abisphenol A results in increased expression of SLC8A1 protein23418087
C006780bisphenol Abisphenol A affects the expression of SLC8A1 mRNA25181051
C006780bisphenol Abisphenol A results in increased expression of SLC8A1 mRNA29097150
C018475butyraldehydebutyraldehyde results in increased expression of SLC8A1 mRNA26079696
D019256Cadmium ChlorideCadmium Chloride results in decreased methylation of SLC8A1 promoter22457795
D002118Calcium2-(2-(4-(4-nitrobenzyloxy)phenyl)ethyl)isothiourea methanesulfonate inhibits the reaction [SLC8A1 protein results in increased transport of Calcium]15375168
D002118Calcium2-(2-(4-(4-nitrobenzyloxy)phenyl)ethyl)isothiourea methanesulfonate inhibits the reaction [SLC8A1 protein results in increased uptake of Calcium]14660663
D002118CalciumSEA 0400 inhibits the reaction [SLC8A1 protein results in increased uptake of Calcium]14660663
D002118CalciumSLC8A1 protein results in increased transport of Calcium15375168
D002118CalciumSLC8A1 protein results in increased uptake of Calcium14660663
D002118CalciumCalcium inhibits the reaction [SLC8A1 protein results in increased uptake of Nickel]10329968
D002118CalciumPPP3R1 gene mutant form inhibits the reaction [SLC8A1 protein affects the transport of Calcium]19700627
D002118Calcium2-(2-(4-(4-nitrobenzyloxy)phenyl)ethyl)isothiourea methanesulfonate inhibits the reaction [SLC8A1 protein results in increased transport of Calcium]18822394
D002118CalciumSLC8A1 protein results in increased transport of Calcium18822394
D002509CephaloridineCephaloridine results in decreased expression of SLC8A1 mRNA18500788
D020111Chlorodiphenyl (54% Chlorine)2-(2-(4-(4-nitrobenzyloxy)phenyl)ethyl)isothiourea methanesulfonate inhibits the reaction [SLC8A1 protein results in increased susceptibility to Chlorodiphenyl (54% Chlorine)]16009740
D020111Chlorodiphenyl (54% Chlorine)Bepridil inhibits the reaction [SLC8A1 protein results in increased susceptibility to Chlorodiphenyl (54% Chlorine)]16009740
D020111Chlorodiphenyl (54% Chlorine)SLC8A1 protein results in increased susceptibility to Chlorodiphenyl (54% Chlorine)16009740
C031180chrysene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of SLC8A1 mRNA27858113
C012843cinnamic aldehydecinnamic aldehyde results in increased expression of SLC8A1 mRNA19524605
D003035CobaltCobalt results in decreased expression of SLC8A1 protein15340849
C018021cobaltous chloridecobaltous chloride results in increased expression of SLC8A1 mRNA21293012
C018021cobaltous chloridecobaltous chloride results in increased expression of SLC8A1 protein21293012
D003300Copper[NSC 689534 binds to Copper] which results in decreased expression of SLC8A1 mRNA20971185
D003300CopperCopper deficiency results in increased expression of SLC8A1 mRNA26033743
D003471CuprizoneCuprizone results in decreased expression of SLC8A1 mRNA26577399
D003634DDT"[o,p'-DDT co-treated with DDT] results in increased expression of SLC8A1 mRNA"27325568
C010902decabromobiphenyl etherdecabromobiphenyl ether results in decreased expression of SLC8A1 mRNA23640034
D003999Dichloroacetic AcidDichloroacetic Acid results in decreased expression of SLC8A1 mRNA28962523
D004041Dietary FatsDietary Fats results in decreased expression of SLC8A1 mRNA25016146
D004041Dietary Fats[Fructose co-treated with Dietary Fats] results in decreased expression of SLC8A1 mRNA28916335
D004041Dietary Fatstroxerutin inhibits the reaction [[Fructose co-treated with Dietary Fats] results in decreased expression of SLC8A1 mRNA]28916335
D019422Dietary SucroseDietary Sucrose results in increased expression of SLC8A1 mRNA26033743
D002117CalcitriolCalcitriol results in increased expression of SLC8A1 mRNA16857747
D004317DoxorubicinDoxorubicin results in decreased expression of SLC8A1 mRNA28940058
D004656Enalapril[Ranolazine co-treated with Enalapril] affects the expression of SLC8A1 protein18820026
C074283estradiol 3-benzoateestradiol 3-benzoate results in increased methylation of SLC8A1 promoter27415467
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of SLC8A1 mRNA20170705|2686566
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of SLC8A1 mRNA29097150
D005485FlutamideFlutamide inhibits the reaction [CD38 gene mutant form results in increased expression of SLC8A1 mRNA]21840325
D005632Fructose[Fructose co-treated with Dietary Fats] results in decreased expression of SLC8A1 mRNA28916335
D005632Fructosetroxerutin inhibits the reaction [[Fructose co-treated with Dietary Fats] results in decreased expression of SLC8A1 mRNA]28916335
C069837fullerene C60fullerene C60 results in decreased expression of SLC8A1 mRNA19167457
C001277geldanamycingeldanamycin results in increased expression of SLC8A1 mRNA26705709
D019833GenisteinGenistein results in decreased expression of SLC8A1 mRNA26865667
D005947Glucose[[Glucose deficiency co-treated with Oxygen deficiency] results in increased expression of HIF1A protein] which results in increased expression of SLC8A1 mRNA21293012
D005947Glucose[Glucose deficiency co-treated with Oxygen deficiency] results in increased expression of SLC8A1 mRNA21293012
D005947Glucose[Glucose deficiency co-treated with Oxygen deficiency] results in increased expression of SLC8A1 protein21293012
C004312glycidolglycidol results in decreased expression of SLC8A1 mRNA24915197
D007545IsoproterenolEGR1 protein affects the reaction [[Isoproterenol co-treated with Phenylephrine] results in increased expression of SLC8A1 mRNA]15621046
D007545IsoproterenolEGR1 protein affects the reaction [[Isoproterenol co-treated with Phenylephrine] results in increased expression of SLC8A1 protein]15621046
D007545IsoproterenolPropranolol inhibits the reaction [[Isoproterenol co-treated with Phenylephrine] results in increased expression of SLC8A1 protein]15621046
D007545IsoproterenolIsoproterenol results in increased expression of SLC8A1 mRNA11179087
D058185Magnetite Nanoparticles[Succimer co-treated with Magnetite Nanoparticles] results in increased expression of SLC8A1 mRNA26378955
D008344Maneb[Paraquat co-treated with Maneb] affects the expression of SLC8A1 mRNA22563483
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of SLC8A1 protein25809596
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in decreased expression of SLC8A1 mRNA"26251327
D008790Metoprolol[Ranolazine co-treated with Metoprolol] affects the expression of SLC8A1 protein18820026
C583365N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide"N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide results in increased expression of SLC8A1 mRNA"29244179
D009532NickelCalcium inhibits the reaction [SLC8A1 protein results in increased uptake of Nickel]10329968
D009532NickelNickel results in decreased expression of SLC8A1 mRNA23195993
D009532NickelSLC8A1 protein results in increased uptake of Nickel10329968
D009532NickelSodium promotes the reaction [SLC8A1 protein results in increased uptake of Nickel]10329968
D009638NorepinephrineNorepinephrine results in increased expression of SLC8A1 mRNA11179087
D009638NorepinephrineNorepinephrine results in increased expression of SLC8A1 protein11179087
C111654NPS R-467NPS R-467 results in decreased expression of SLC8A1 mRNA16164647
C558013NSC 689534[NSC 689534 binds to Copper] which results in decreased expression of SLC8A1 mRNA20971185
C016340o,p'-DDT"[o,p'-DDT co-treated with DDT] results in increased expression of SLC8A1 mRNA"27325568
D010100Oxygen[[Glucose deficiency co-treated with Oxygen deficiency] results in increased expression of HIF1A protein] which results in increased expression of SLC8A1 mRNA21293012
D010100Oxygen[Glucose deficiency co-treated with Oxygen deficiency] results in increased expression of SLC8A1 mRNA21293012
D010100Oxygen[Glucose deficiency co-treated with Oxygen deficiency] results in increased expression of SLC8A1 protein21293012
D010100OxygenHIF1A protein promotes the reaction [Oxygen deficiency results in increased expression of SLC8A1 protein]21293012
D010100OxygenOxygen deficiency results in decreased expression of SLC8A1 mRNA25937560
D010100OxygenOxygen deficiency results in increased expression of SLC8A1 mRNA17394575
D010100OxygenOxygen deficiency results in increased expression of SLC8A1 protein17394575|2129301
D010100OxygenTrimetazidine inhibits the reaction [Oxygen deficiency results in decreased expression of SLC8A1 mRNA]25937560
D010269ParaquatIGF1 gene mutant form inhibits the reaction [Paraquat results in decreased expression of SLC8A1 protein]17979500
D010269Paraquat[Paraquat co-treated with Maneb] affects the expression of SLC8A1 mRNA22563483
D010269ParaquatParaquat results in decreased expression of SLC8A1 protein17979500
C410127PCB 180"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of SLC8A1 mRNA"25510870
C046012pentanalpentanal results in increased expression of SLC8A1 mRNA26079696
C101814perfluoro-n-undecanoic acidperfluoro-n-undecanoic acid results in decreased expression of SLC8A1 mRNA23602845
D010656PhenylephrineEGR1 protein affects the reaction [[Isoproterenol co-treated with Phenylephrine] results in increased expression of SLC8A1 mRNA]15621046
D010656PhenylephrineEGR1 protein affects the reaction [[Isoproterenol co-treated with Phenylephrine] results in increased expression of SLC8A1 protein]15621046
D010656PhenylephrinePropranolol inhibits the reaction [[Isoproterenol co-treated with Phenylephrine] results in increased expression of SLC8A1 protein]15621046
D010656Phenylephrinebisindolylmaleimide I inhibits the reaction [Phenylephrine results in decreased expression of SLC8A1 mRNA]17257893
D010656PhenylephrinePhenylephrine results in decreased expression of SLC8A1 mRNA17257893
D010656PhenylephrinePrazosin inhibits the reaction [Phenylephrine results in decreased expression of SLC8A1 mRNA]17257893
D010656PhenylephrinePhenylephrine results in decreased expression of SLC8A1 protein19244478
D010656PhenylephrinePhenylephrine results in increased expression of SLC8A1 mRNA11179087
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of SLC8A1 mRNA22714537
D011224PrazosinPrazosin inhibits the reaction [Phenylephrine results in decreased expression of SLC8A1 mRNA]17257893
D011374ProgesteroneProgesterone inhibits the reaction [Estradiol results in increased expression of SLC8A1 mRNA]21795739
D011433PropranololPropranolol inhibits the reaction [[Isoproterenol co-treated with Phenylephrine] results in increased expression of SLC8A1 protein]15621046
C428725pyridabenpyridaben results in increased expression of SLC8A1 mRNA22563483
D000069458RanolazineRanolazine affects the expression of SLC8A1 protein18820026
D000069458Ranolazine[Ranolazine co-treated with Enalapril] affects the expression of SLC8A1 protein18820026
D000069458Ranolazine[Ranolazine co-treated with Metoprolol] affects the expression of SLC8A1 protein18820026
C059514resveratrolresveratrol results in decreased expression of SLC8A1 mRNA22610192
C059514resveratrolresveratrol results in decreased expression of SLC8A1 protein25425099
C430918SEA 0400SEA 0400 inhibits the reaction [SLC8A1 protein results in increased uptake of Calcium]14660663
C430918SEA 0400SEA 0400 binds to and results in decreased activity of SLC8A1 protein17917422
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of SLC8A1 mRNA23806026
D012822Silicon DioxideSilicon Dioxide results in decreased expression of SLC8A1 mRNA23623845
D012964SodiumSodium promotes the reaction [SLC8A1 protein results in increased uptake of Nickel]10329968
D053260SootSoot results in decreased expression of SLC8A1 mRNA26551751
D010042OuabainSLC8A1 affects the susceptibility to Ouabain16166162
D010042OuabainOuabain results in increased expression of SLC8A1 protein19897708
D010042OuabainSLC8A1 mRNA mutant form inhibits the reaction [Ouabain results in increased expression of SLC8A1 protein]19897708|1989770
D010042OuabainSLC8A1 mRNA mutant form inhibits the reaction [Ouabain results in increased expression of TRPC6 protein]19897708
D010042OuabainTRPC6 mRNA mutant form inhibits the reaction [Ouabain results in increased expression of SLC8A1 protein]19897708
C041711St. Thomas' Hospital cardioplegic solutionSt. Thomas' Hospital cardioplegic solution results in increased expression of SLC8A1 mRNA16214533
D004113Succimer[Succimer co-treated with Magnetite Nanoparticles] results in increased expression of SLC8A1 mRNA26378955
D013739TestosteroneTestosterone results in decreased expression of SLC8A1 mRNA20090667
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of SLC8A1 mRNA21570461
D013755Tetradecanoylphorbol AcetateTetradecanoylphorbol Acetate inhibits the reaction [Thapsigargin results in increased expression of SLC8A1 mRNA]19244478
D013792ThalidomideThalidomide results in decreased expression of SLC8A1 mRNA26006729|2621778
D019284ThapsigarginTetradecanoylphorbol Acetate inhibits the reaction [Thapsigargin results in increased expression of SLC8A1 mRNA]19244478
D019284ThapsigarginThapsigargin results in increased expression of SLC8A1 mRNA19244478
D019284ThapsigarginThapsigargin results in increased expression of SLC8A1 protein19244478
D013849ThimerosalThimerosal results in increased expression of SLC8A1 mRNA27188386
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of SLC8A1 mRNA28065790
D014241TrichloroethyleneTrichloroethylene results in increased methylation of SLC8A1 gene27618143
C012589trichostatin Atrichostatin A results in increased expression of SLC8A1 mRNA24935251
D014292TrimetazidineTrimetazidine inhibits the reaction [Oxygen deficiency results in decreased expression of SLC8A1 mRNA]25937560
C005865troxerutintroxerutin inhibits the reaction [[Fructose co-treated with Dietary Fats] results in decreased expression of SLC8A1 mRNA]28916335
D014415TunicamycinTunicamycin results in increased expression of SLC8A1 mRNA17127020
D014501UraniumUranium results in decreased expression of SLC8A1 mRNA17118558
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SLC8A1 mRNA"27188386
D014635Valproic AcidValproic Acid results in decreased expression of SLC8A1 mRNA23179753
D014635Valproic AcidValproic Acid results in increased expression of SLC8A1 mRNA19101580|2438349
D014638VanadatesVanadates results in increased expression of SLC8A1 mRNA22714537
D014640VancomycinVancomycin results in increased expression of SLC8A1 mRNA18930951
D001335Vehicle EmissionsVehicle Emissions affects the methylation of SLC8A1 gene25560391
C025643vinclozolinvinclozolin results in increased expression of SLC8A1 mRNA23034163
C029297vinylidene chloridevinylidene chloride results in decreased expression of SLC8A1 mRNA26682919

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005432calcium:sodium antiporter activity-IDA1374913  
GO:0005432calcium:sodium antiporter activity-IMP25589784  
GO:0005432calcium:sodium antiporter activity-TAS-  
GO:0005509calcium ion binding-ISS-  
GO:0005515protein binding-IPI16292983  25589784  
GO:0005516calmodulin binding-IEA-  
GO:0008092cytoskeletal protein binding-IDA16292983  
GO:0030506ankyrin binding-IPI17178715  
GO:0030506ankyrin binding-ISS-  
GO:0044325ion channel binding-ISS-  
GO:0099580ion antiporter activity involved in regulation of postsynaptic membrane potential-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0002026regulation of the force of heart contraction-IC19481548  
GO:0002026regulation of the force of heart contraction-ISS-  
GO:0002027regulation of heart rate-ISS-  
GO:0002028regulation of sodium ion transport-IEA-  
GO:0006811ion transport-TAS-  
GO:0006883cellular sodium ion homeostasis-IDA1374913  
GO:0006936muscle contraction-TAS1374913  
GO:0009749response to glucose-IEA-  
GO:0010649regulation of cell communication by electrical coupling-TAS17614935  
GO:0010763positive regulation of fibroblast migration-IEA-  
GO:0010881regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion-ISS-  
GO:0010881regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion-TAS23608603  
GO:0010882regulation of cardiac muscle contraction by calcium ion signaling-TAS23224879  
GO:0014829vascular smooth muscle contraction-ISS-  
GO:0021537telencephalon development-IEA-  
GO:0030501positive regulation of bone mineralization-IMP25589784  
GO:0033198response to ATP-IEA-  
GO:0035725sodium ion transmembrane transport-IGI25589784  
GO:0035725sodium ion transmembrane transport-IMP25589784  
GO:0035902response to immobilization stress-IEA-  
GO:0035994response to muscle stretch-IMP15105296  
GO:0036376sodium ion export across plasma membrane-IEA-  
GO:0042542response to hydrogen peroxide-IEA-  
GO:0044557relaxation of smooth muscle-ISS-  
GO:0051481negative regulation of cytosolic calcium ion concentration-ISS-  
GO:0055013cardiac muscle cell development-ISS-  
GO:0055074calcium ion homeostasis-ISS-  
GO:0055119relaxation of cardiac muscle-IC19481548  
GO:0055119relaxation of cardiac muscle-TAS23224879  
GO:0060048cardiac muscle contraction-TAS23224879  
GO:0060078regulation of postsynaptic membrane potential-IEA-  
GO:0060401cytosolic calcium ion transport-TAS19095005  
GO:0060402calcium ion transport into cytosol-ISS-  
GO:0070509calcium ion import-IDA1374913  
GO:0070588calcium ion transmembrane transport-IGI25589784  
GO:0071313cellular response to caffeine-ISS-  
GO:0071320cellular response to cAMP-IEA-  
GO:0071456cellular response to hypoxia-IEA-  
GO:0086012membrane depolarization during cardiac muscle cell action potential-TAS23608603  
GO:0086064cell communication by electrical coupling involved in cardiac conduction-ISS-  
GO:0098719sodium ion import across plasma membrane-IDA1374913  
GO:0098735positive regulation of the force of heart contraction-IMP15105296  
GO:1903779regulation of cardiac conduction-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005654nucleoplasm-IDA-  
GO:0005739mitochondrion-IEA-  
GO:0005874microtubule-IEA-  
GO:0005886plasma membrane-IDA-  
GO:0005886plasma membrane-TAS19095005  
GO:0005887integral component of plasma membrane-IDA1374913  
GO:0014704intercalated disc-ISS-  
GO:0014704intercalated disc-TAS17614935  
GO:0030018Z disc-ISS-  
GO:0030315T-tubule-ISS-  
GO:0030315T-tubule-TAS17614935  
GO:0042383sarcolemma-ISS-  
GO:0043197dendritic spine-IEA-  
GO:0043198dendritic shaft-IEA-  
GO:0045211postsynaptic membrane-IEA-  
KEGG ID KEGG Term
hsa04020Calcium signaling pathway
hsa04260Cardiac muscle contraction
hsa04974Protein digestion and absorption
hsa05410Hypertrophic cardiomyopathy (HCM)
hsa05412Arrhythmogenic right ventricular cardiomyopathy (ARVC)
hsa05414Dilated cardiomyopathy
Reactome ID Reactome Term Evidence
R-HSA-109582HemostasisTAS
R-HSA-382551Transport of small moleculesTAS
R-HSA-397014Muscle contractionTAS
R-HSA-418346Platelet homeostasisTAS
R-HSA-418359Reduction of cytosolic Ca++ levelsTAS
R-HSA-418360Platelet calcium homeostasisTAS
R-HSA-425393Transport of inorganic cations/anions and amino acids/oligopeptidesTAS
R-HSA-425407SLC-mediated transmembrane transportTAS
R-HSA-425561Sodium/Calcium exchangersTAS
R-HSA-5576891Cardiac conductionTAS
R-HSA-5578775Ion homeostasisTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
19562039Targeting 160 candidate genes for blood pressure regulation with a genome-wide genotyping array. (2009 Jun 29)Sober SPLoS One