Gene: BMP7

655
OP-1
bone morphogenetic protein 7
protein-coding
20q13.31
Ensembl:ENSG00000101144 MIM:112267 Vega:OTTHUMG00000032812 UniprotKB:P18075
NG_032771.1
PubMed
ND
4   
NA (AD)  NA (ND)   (Frontal_Cortex)
9.386e-1 (AD)  4.218e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
GPR37L10.929
MLC10.924
FGFR30.913
LRP40.904
ACSS10.9
GRIN2C0.899
SOX210.897
CLDN100.894
ACSBG10.894
EZR0.886

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CCDC68-0.431
CD163L1-0.422
OSBPL10-0.412
EMB-0.402
OR4F5-0.402
TPH2-0.398
SYNPO2-0.396
CACNA1F-0.389
LRMP-0.389
NRG1-0.388

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0979491,25-dihydroxyvitamin D"1,25-dihydroxyvitamin D inhibits the reaction [Puromycin Aminonucleoside results in decreased expression of BMP7 mRNA]"19594554
C0979491,25-dihydroxyvitamin D"1,25-dihydroxyvitamin D inhibits the reaction [Puromycin Aminonucleoside results in decreased expression of BMP7 protein]"19594554
C0294972,3-bis(3'-hydroxybenzyl)butyrolactone"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in decreased expression of BMP7 mRNA"19167446
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of BMP7 mRNA"21346803
C4086042-(4-nitrophenyl)-4-(4-fluorophenyl)-5-(4-pyridinyl)-1H-imidazole2-(4-nitrophenyl)-4-(4-fluorophenyl)-5-(4-pyridinyl)-1H-imidazole inhibits the reaction [(4-(7-chloroquinolin-4-yl)piperazino)(1-phenyl-5-(trifluoromethyl)-1H-pyrazol-4-yl)methanone promotes the reaction [BMP2 protein results in increased expression of BMP7 mRNA]]25789987
C4727913-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid results in increased expression of BMP7 mRNA16788091
C0909424-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [(4-(7-chloroquinolin-4-yl)piperazino)(1-phenyl-5-(trifluoromethyl)-1H-pyrazol-4-yl)methanone promotes the reaction [BMP2 protein results in increased expression of BMP7 mRNA]]25789987
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of BMP7 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of BMP7 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of BMP7 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of BMP7 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of BMP7 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of BMP7 mRNA"27188386
C000603489(4-(7-chloroquinolin-4-yl)piperazino)(1-phenyl-5-(trifluoromethyl)-1H-pyrazol-4-yl)methanone2-(4-nitrophenyl)-4-(4-fluorophenyl)-5-(4-pyridinyl)-1H-imidazole inhibits the reaction [(4-(7-chloroquinolin-4-yl)piperazino)(1-phenyl-5-(trifluoromethyl)-1H-pyrazol-4-yl)methanone promotes the reaction [BMP2 protein results in increased expression of BMP7 mRNA]]25789987
C000603489(4-(7-chloroquinolin-4-yl)piperazino)(1-phenyl-5-(trifluoromethyl)-1H-pyrazol-4-yl)methanone4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [(4-(7-chloroquinolin-4-yl)piperazino)(1-phenyl-5-(trifluoromethyl)-1H-pyrazol-4-yl)methanone promotes the reaction [BMP2 protein results in increased expression of BMP7 mRNA]]25789987
C000603489(4-(7-chloroquinolin-4-yl)piperazino)(1-phenyl-5-(trifluoromethyl)-1H-pyrazol-4-yl)methanone(4-(7-chloroquinolin-4-yl)piperazino)(1-phenyl-5-(trifluoromethyl)-1H-pyrazol-4-yl)methanone promotes the reaction [BMP2 protein results in increased expression of BMP7 mRNA]25789987
C000603489(4-(7-chloroquinolin-4-yl)piperazino)(1-phenyl-5-(trifluoromethyl)-1H-pyrazol-4-yl)methanoneSB 203580 inhibits the reaction [(4-(7-chloroquinolin-4-yl)piperazino)(1-phenyl-5-(trifluoromethyl)-1H-pyrazol-4-yl)methanone promotes the reaction [BMP2 protein results in increased expression of BMP7 mRNA]]25789987
C0357635,5'-bis(8-(phenylamino)-1-naphthalenesulfonate)"5,5'-bis(8-(phenylamino)-1-naphthalenesulfonate) promotes the reaction [BMP7 protein binds to BMPR2 protein]"17363346
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of BMP7 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of BMP7 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of BMP7 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of BMP7 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of BMP7 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of BMP7 mRNA"27188386
D000082AcetaminophenAcetaminophen affects the expression of BMP7 mRNA17562736
D000111Acetylcysteine[Ethanol co-treated with Dietary Fats co-treated with Acetylcysteine] results in increased expression of BMP7 mRNA21051528
C016601afimoxifeneafimoxifene inhibits the reaction [Estrogens results in decreased expression of BMP7 mRNA]21233418
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of BMP7 mRNA19770486
D000447AldehydesAldehydes results in increased expression of BMP7 mRNA25014914
D000643Ammonium ChlorideAmmonium Chloride affects the expression of BMP7 mRNA16483693
D018501Antirheumatic AgentsAntirheumatic Agents results in increased expression of BMP7 mRNA24449571
C000228aristolochic acid Iaristolochic acid I results in decreased expression of and results in decreased activity of BMP7 protein22525892
C000228aristolochic acid Iaristolochic acid I results in decreased expression of BMP7 mRNA22525892
C000228aristolochic acid IBMP7 protein results in decreased susceptibility to aristolochic acid I22525892
C000228aristolochic acid IGREM1 mutant form inhibits the reaction [aristolochic acid I results in decreased activity of BMP7 protein]22525892
C000228aristolochic acid IGREM1 protein inhibits the reaction [BMP7 protein results in decreased susceptibility to aristolochic acid I]22525892
D034341Aristolochic AcidsBMP7 protein inhibits the reaction [Aristolochic Acids results in decreased expression of CDH1 protein]20696222
D034341Aristolochic AcidsBMP7 protein inhibits the reaction [Aristolochic Acids results in increased activity of CASP3 protein]20696222
D034341Aristolochic AcidsBMP7 protein inhibits the reaction [Aristolochic Acids results in increased expression of ACTA2 protein]20696222
D034341Aristolochic AcidsBMP7 protein inhibits the reaction [Aristolochic Acids results in increased secretion of TGFB1 protein]20696222
D034341Aristolochic AcidsBMP7 protein results in decreased susceptibility to Aristolochic Acids20696222
D001205Ascorbic Acid[Ascorbic Acid co-treated with beta-glycerophosphoric acid] results in increased expression of BMP7 mRNA15994055
C030935benz(a)anthracenebenz(a)anthracene results in decreased expression of BMP7 mRNA26377693
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of BMP7 mRNA22316170
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of BMP7 mRNA19770486
D004958EstradiolBMP7 protein inhibits the reaction [[Estradiol co-treated with Progesterone] results in increased expression of IGFBP1 mRNA]20085912
D004958EstradiolBMP7 protein inhibits the reaction [[Estradiol co-treated with Progesterone] results in increased secretion of IGFBP1 protein]20085912
D004958EstradiolEGF protein inhibits the reaction [Estradiol results in decreased expression of BMP7 mRNA]24758408
D004958Estradiol[Estradiol co-treated with Progesterone] results in decreased expression of BMP7 mRNA20085912
D004958Estradiol[Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of BMP7 mRNA19619570
D004958EstradiolEstradiol results in decreased expression of BMP7 mRNA14994273|1916744
D004958EstradiolEstradiol results in increased expression of BMP7 mRNA19619570
D004958EstradiolEstradiol results in decreased expression of BMP7 mRNA14994273
D004958EstradiolEstradiol results in increased expression of BMP7 mRNA19484750
D004958EstradiolEstradiol results in decreased expression of BMP7 mRNA17823450|1870914
D004958Estradiol[bisphenol A co-treated with Estradiol] results in decreased expression of BMP7 mRNA26496021
D004958EstradiolBMP7 protein inhibits the reaction [IGF1 protein promotes the reaction [FSHB protein results in increased abundance of Estradiol]]22067323
D004958Estradiol[BMP7 protein results in increased expression of CYP19A1 mRNA] promotes the reaction [FSHB protein results in increased abundance of Estradiol]22067323
D004958EstradiolEstradiol results in decreased expression of BMP7 mRNA15680359
C031463beta-glycerophosphoric acid[Ascorbic Acid co-treated with beta-glycerophosphoric acid] results in increased expression of BMP7 mRNA15994055
C006780bisphenol Abisphenol A results in decreased expression of BMP7 mRNA14994273
C006780bisphenol Abisphenol A results in decreased methylation of BMP7 promoter27312807
C006780bisphenol Afulvestrant inhibits the reaction [bisphenol A results in decreased expression of BMP7 mRNA]14994273
C006780bisphenol A[bisphenol A co-treated with Estradiol] results in decreased expression of BMP7 mRNA26496021
C006780bisphenol Abisphenol A results in decreased expression of BMP7 mRNA25181051
D001895BoronBoron results in increased expression of BMP7 mRNA21625915
C546611brevetoxin 2brevetoxin 2 results in increased expression of BMP7 mRNA20498034
C018475butyraldehydebutyraldehyde results in increased expression of BMP7 mRNA26079696
D002251Carbon TetrachlorideCarbon Tetrachloride results in decreased expression of BMP7 mRNA25270620
D002330CarmustineCarmustine results in decreased expression of BMP7 mRNA15980968
D003375Coumestrol"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in decreased expression of BMP7 mRNA"19167446
D003375Coumestrol[Coumestrol co-treated with resveratrol] results in decreased expression of BMP7 mRNA19167446
D003375CoumestrolCoumestrol results in decreased expression of BMP7 mRNA19167446
D003484CyanamideCyanamide inhibits the reaction [CGA protein results in increased expression of BMP7 mRNA]22285649
D016572CyclosporineCyclosporine results in decreased expression of BMP7 mRNA21354196
C014347decitabinedecitabine results in decreased methylation of BMP7 promoter19283074
C014347decitabinedecitabine results in increased expression of BMP7 mRNA16367923|1928307
C014347decitabinedecitabine results in increased expression of BMP7 mRNA27915011
D003687DehydroepiandrosteroneDehydroepiandrosterone results in decreased expression of BMP7 mRNA17823450|1870914
D003907Dexamethasone[licarin A affects the susceptibility to [INS protein co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone]] which results in increased expression of BMP7 mRNA29288687
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of BMP7 mRNA19464577
D002945CisplatinBMP7 protein affects the susceptibility to Cisplatin16217747
C027118didecyldimethylammoniumdidecyldimethylammonium results in decreased expression of BMP7 mRNA23537712
D004041Dietary Fats[Ethanol co-treated with Dietary Fats co-treated with Acetylcysteine] results in increased expression of BMP7 mRNA21051528
D004052DiethylnitrosamineDiethylnitrosamine results in increased expression of BMP7 mRNA24535843
D004054DiethylstilbestrolDiethylstilbestrol results in decreased expression of BMP7 mRNA17823450
D002117CalcitriolCalcitriol results in decreased expression of BMP7 protein15728789
D004147DioxinsDioxins affects the expression of BMP7 mRNA20463971
D004221DisulfiramDisulfiram inhibits the reaction [[FSHB protein co-treated with LHB protein co-treated with Testosterone] results in increased expression of BMP7 mRNA]22285649
C070609EMD 53998EMD 53998 analog results in increased expression of BMP7 mRNA24977338
C118739entinostatentinostat results in increased expression of BMP7 mRNA26272509|2718838
C118739entinostat"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of BMP7 mRNA"27188386
D004967Estrogensafimoxifene inhibits the reaction [Estrogens results in decreased expression of BMP7 mRNA]21233418
D004967EstrogensEstrogens results in decreased expression of BMP7 mRNA21233418
D000431Ethanol[Ethanol co-treated with Dietary Fats co-treated with Acetylcysteine] results in increased expression of BMP7 mRNA21051528
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of BMP7 mRNA17606305
D018120FinasterideFinasteride results in increased expression of BMP7 mRNA24136188
C070081fulvestrantfulvestrant inhibits the reaction [bisphenol A results in decreased expression of BMP7 mRNA]14994273
D005944GlucosamineGlucosamine inhibits the reaction [IL1B results in increased expression of BMP7 mRNA]17109745
D005944GlucosamineGlucosamine results in increased expression of BMP7 mRNA17109745
D017313FenretinideFenretinide results in increased expression of BMP7 mRNA28973697
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of BMP7 mRNA25613284
D0150561-Methyl-3-isobutylxanthine[licarin A affects the susceptibility to [INS protein co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone]] which results in increased expression of BMP7 mRNA29288687
D007657Ketone BodiesKetone Bodies results in decreased expression of BMP7 mRNA16807920
D007854LeadLead affects the expression of BMP7 mRNA28903495
C533894LG 100815LG 100815 results in decreased expression of BMP7 mRNA16951191
C432503licarin A[licarin A affects the susceptibility to [INS protein co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone]] which results in increased expression of BMP7 mRNA29288687
C042720mercuric bromidemercuric bromide results in increased expression of BMP7 mRNA26272509
C042720mercuric bromide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of BMP7 mRNA"27188386
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of BMP7 mRNA28001369
D008942MitoxantroneBMP7 protein affects the susceptibility to Mitoxantrone16217747
C406082monomethylarsonous acidmonomethylarsonous acid results in increased expression of BMP7 mRNA22108045
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of BMP7 mRNA"25554681|2562005
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of BMP7 mRNA"25554681|2562005
D009532NickelNickel results in decreased expression of BMP7 mRNA24768652
C062198octa-2,4,6-trienoic acid"octa-2,4,6-trienoic acid results in decreased expression of BMP7 mRNA"16951191
D015282OctreotideOctreotide promotes the reaction [BMP7 protein results in increased expression of ID1 mRNA]23137853
D010126OzoneOzone results in decreased expression of BMP7 mRNA28623178
D017239PaclitaxelBMP7 mRNA results in increased susceptibility to Paclitaxel16322897
C496932panobinostat"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of BMP7 mRNA"27188386
C496932panobinostatpanobinostat results in increased expression of BMP7 mRNA26272509
C517782pasireotidepasireotide promotes the reaction [BMP7 protein results in increased expression of ID1 mRNA]23137853
C046012pentanalpentanal results in increased expression of BMP7 mRNA26079696
C101816perfluoro-n-nonanoic acidperfluoro-n-nonanoic acid results in decreased expression of BMP7 mRNA21984479
C023036perfluorooctanoic acidperfluorooctanoic acid results in decreased expression of BMP7 mRNA17560707
C023036perfluorooctanoic acidperfluorooctanoic acid results in decreased expression of BMP7 mRNA18709148|2198447
D010656PhenylephrinePhenylephrine results in decreased expression of BMP7 mRNA18158353
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of BMP7 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in increased expression of BMP7 mRNA26272509
D010936Plant ExtractsPlant Extracts results in decreased expression of BMP7 mRNA23557933
D011374ProgesteroneBMP7 protein inhibits the reaction [[Estradiol co-treated with Progesterone] results in increased expression of IGFBP1 mRNA]20085912
D011374ProgesteroneBMP7 protein inhibits the reaction [[Estradiol co-treated with Progesterone] results in increased secretion of IGFBP1 protein]20085912
D011374Progesterone[Estradiol co-treated with Progesterone] results in decreased expression of BMP7 mRNA20085912
D011374ProgesteroneProgesterone results in decreased expression of BMP7 mRNA20085912
D011374Progesterone[BMP7 protein results in decreased expression of STAR mRNA] inhibits the reaction [FSHB protein results in increased abundance of Progesterone]22067323
D011374ProgesteroneGH1 protein inhibits the reaction [BMP7 protein inhibits the reaction [FSHB protein results in increased abundance of Progesterone]]22067323
D011374ProgesteroneIGF1 protein inhibits the reaction [BMP7 protein inhibits the reaction [FSHB protein results in increased abundance of Progesterone]]22067323
D011374ProgesteroneProgesterone results in increased expression of BMP7 mRNA20726854
C005556propionaldehydepropionaldehyde results in increased expression of BMP7 mRNA26079696
D011441PropylthiouracilPropylthiouracil results in increased expression of BMP7 mRNA24780913
D011509ProteoglycansBMP7 protein results in increased abundance of Proteoglycans19011540
D011509ProteoglycansBMP7 protein results in increased chemical synthesis of Proteoglycans22252971
D011509Proteoglycansresveratrol promotes the reaction [BMP7 protein results in increased chemical synthesis of Proteoglycans]22252971
D011692Puromycin Aminonucleoside"1,25-dihydroxyvitamin D inhibits the reaction [Puromycin Aminonucleoside results in decreased expression of BMP7 mRNA]"19594554
D011692Puromycin Aminonucleoside"1,25-dihydroxyvitamin D inhibits the reaction [Puromycin Aminonucleoside results in decreased expression of BMP7 protein]"19594554
D011692Puromycin AminonucleosidePuromycin Aminonucleoside results in decreased expression of BMP7 mRNA19594554
D011692Puromycin AminonucleosidePuromycin Aminonucleoside results in decreased expression of BMP7 protein19594554
C513428pyrachlostrobinpyrachlostrobin results in increased expression of BMP7 mRNA27029645
D020849Raloxifene HydrochlorideRaloxifene Hydrochloride affects the expression of BMP7 mRNA14699072
D017257RamiprilRamipril inhibits the reaction [Tacrolimus results in decreased expression of BMP7 protein]17703430
C059514resveratrol[Coumestrol co-treated with resveratrol] results in decreased expression of BMP7 mRNA19167446
C059514resveratrolresveratrol promotes the reaction [BMP7 protein results in increased chemical synthesis of Proteoglycans]22252971
C009166retinol acetateretinol acetate results in increased expression of BMP7 mRNA16772331
C009172rhodiolosiderhodioloside results in increased expression of BMP7 mRNA24055767
C513635S-2-pentyl-4-pentynoic hydroxamic acidS-2-pentyl-4-pentynoic hydroxamic acid results in increased expression of BMP7 mRNA21427059
C093642SB 203580SB 203580 inhibits the reaction [(4-(7-chloroquinolin-4-yl)piperazino)(1-phenyl-5-(trifluoromethyl)-1H-pyrazol-4-yl)methanone promotes the reaction [BMP2 protein results in increased expression of BMP7 mRNA]]25789987
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of BMP7 mRNA25895662
C017947sodium arsenitesodium arsenite affects the methylation of BMP7 gene28589171
C017947sodium arsenitesodium arsenite results in decreased expression of BMP7 mRNA23137061
D013311StreptozocinStreptozocin affects the expression of BMP7 mRNA17437042
D013311StreptozocinStreptozocin results in increased expression of BMP7 protein17437042
C105686SU 5402SU 5402 results in decreased expression of BMP7 mRNA12421715
D014284TriiodothyronineTriiodothyronine results in increased expression of BMP7 mRNA17403546
D016559TacrolimusRamipril inhibits the reaction [Tacrolimus results in decreased expression of BMP7 protein]17703430
D016559TacrolimusTacrolimus results in decreased expression of BMP7 protein17703430
D016559TacrolimusValsartan inhibits the reaction [Tacrolimus results in decreased expression of BMP7 protein]17703430
D013629TamoxifenTamoxifen affects the expression of BMP7 mRNA14699072
D013629TamoxifenTamoxifen results in increased expression of BMP7 mRNA25123088
D013739TestosteroneDisulfiram inhibits the reaction [[FSHB protein co-treated with LHB protein co-treated with Testosterone] results in increased expression of BMP7 mRNA]22285649
D013739Testosterone[FSHB protein co-treated with LHB protein co-treated with Testosterone] results in increased expression of BMP7 mRNA22285649
D013739TestosteroneTestosterone results in increased expression of BMP7 mRNA22138414
D013739TestosteroneTretinoin inhibits the reaction [[FSHB protein co-treated with LHB protein co-treated with Testosterone] results in increased expression of BMP7 mRNA]22285649
D013749Tetrachlorodibenzodioxin[Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of BMP7 mRNA19619570
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of BMP7 mRNA19619570
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of BMP7 mRNA21570461
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of BMP7 mRNA19770486
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of BMP7 mRNA25613284
D013974ThyroxineThyroxine results in decreased expression of BMP7 mRNA17403546
D013974ThyroxineThyroxine results in increased expression of BMP7 mRNA17403546
C009495titanium dioxidetitanium dioxide results in decreased expression of BMP7 mRNA23557971
D014212TretinoinTretinoin results in decreased expression of BMP7 mRNA23724009|2383079
D014212TretinoinTretinoin results in increased expression of BMP7 mRNA17196394
D014212TretinoinSHH protein promotes the reaction [Tretinoin results in increased expression of BMP7 mRNA]15996115
D014212TretinoinTretinoin inhibits the reaction [[FSHB protein co-treated with LHB protein co-treated with Testosterone] results in increased expression of BMP7 mRNA]22285649
D014212TretinoinTretinoin results in increased expression of BMP7 mRNA15996115
C012589trichostatin A"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of BMP7 mRNA"27188386
C012589trichostatin Atrichostatin A results in increased expression of BMP7 mRNA24935251|2627250
C015559trimellitic anhydridetrimellitic anhydride results in decreased expression of BMP7 mRNA19042947
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of BMP7 mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of BMP7 mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of BMP7 mRNA23179753|2438349
D014635Valproic AcidValproic Acid results in increased expression of BMP7 mRNA19136453|2142705
D000068756ValsartanValsartan inhibits the reaction [Tacrolimus results in decreased expression of BMP7 protein]17703430
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of BMP7 gene25560391
C111237vorinostatvorinostat results in increased expression of BMP7 mRNA27188386

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005125cytokine activity-IBA21873635  
GO:0005160transforming growth factor beta receptor binding-IBA21873635  
GO:0005515protein binding-IPI9872992  18184661  18339631  
GO:0008083growth factor activity-IEA-  
GO:0008201heparin binding-IEA-  
GO:0070700BMP receptor binding-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0001501skeletal system development-TAS2357959  
GO:0001503ossification-IEA-  
GO:0001656metanephros development-IEP18437684  
GO:0001657ureteric bud development-ISS-  
GO:0001707mesoderm formation-IEA-  
GO:0001823mesonephros development-IEP18437684  
GO:0001837epithelial to mesenchymal transition-TAS14679171  
GO:0003272endocardial cushion formation-ISS-  
GO:0003344pericardium morphogenesis-ISS-  
GO:0007411axon guidance-IEA-  
GO:0009880embryonic pattern specification-IEA-  
GO:0010469regulation of signaling receptor activity-IEA-  
GO:0010628positive regulation of gene expression-IDA28124060  
GO:0010664negative regulation of striated muscle cell apoptotic process-ISS-  
GO:0010718positive regulation of epithelial to mesenchymal transition-IEA-  
GO:0010800positive regulation of peptidyl-threonine phosphorylation-IDA19736306  
GO:0010862positive regulation of pathway-restricted SMAD protein phosphorylation-IBA21873635  
GO:0010862positive regulation of pathway-restricted SMAD protein phosphorylation-IDA9311995  16049014  17244894  19736306  
GO:0010862positive regulation of pathway-restricted SMAD protein phosphorylation-TAS11580864  
GO:0016358dendrite development-TAS11580864  
GO:0021502neural fold elevation formation-ISS-  
GO:0030326embryonic limb morphogenesis-IEA-  
GO:0030501positive regulation of bone mineralization-IDA18436533  
GO:0030509BMP signaling pathway-IBA21873635  
GO:0030509BMP signaling pathway-IDA16049014  18436533  
GO:0030509BMP signaling pathway-IMP18326817  
GO:0030855epithelial cell differentiation-IEA-  
GO:0030902hindbrain development-ISS-  
GO:0032088negative regulation of NF-kappaB transcription factor activity-ISS-  
GO:0032355response to estradiol-IEA-  
GO:0033280response to vitamin D-IEA-  
GO:0034116positive regulation of heterotypic cell-cell adhesion-IDA15100360  
GO:0034504protein localization to nucleus-IDA17244894  
GO:0042326negative regulation of phosphorylation-IDA17244894  
GO:0042475odontogenesis of dentin-containing tooth-IEA-  
GO:0042981regulation of apoptotic process-IBA21873635  
GO:0043065positive regulation of apoptotic process-IEA-  
GO:0043401steroid hormone mediated signaling pathway-IMP17244894  
GO:0043407negative regulation of MAP kinase activity-IDA17244894  
GO:0043408regulation of MAPK cascade-IBA21873635  
GO:0043434response to peptide hormone-IEA-  
GO:0045665negative regulation of neuron differentiation-IDA16325379  
GO:0045669positive regulation of osteoblast differentiation-IDA18436533  
GO:0045746negative regulation of Notch signaling pathway-IEA-  
GO:0045786negative regulation of cell cycle-IDA11502704  
GO:0045839negative regulation of mitotic nuclear division-IDA17244894  
GO:0045892negative regulation of transcription, DNA-templated-IDA15100360  17244894  
GO:0045893positive regulation of transcription, DNA-templated-IDA14517293  15100360  16049014  
GO:0045944positive regulation of transcription by RNA polymerase II-IEA-  
GO:0048468cell development-IBA21873635  
GO:0048596embryonic camera-type eye morphogenesis-IEA-  
GO:0048738cardiac muscle tissue development-ISS-  
GO:0048754branching morphogenesis of an epithelial tube-IEA-  
GO:0048762mesenchymal cell differentiation-IDA9693150  
GO:0048812neuron projection morphogenesis-IDA16325379  
GO:0051216cartilage development-IEA-  
GO:0060037pharyngeal system development-ISS-  
GO:0060272embryonic skeletal joint morphogenesis-IEA-  
GO:0060393regulation of pathway-restricted SMAD protein phosphorylation-IDA16049014  
GO:0060395SMAD protein signal transduction-IBA21873635  
GO:0060395SMAD protein signal transduction-IDA17244894  
GO:0060411cardiac septum morphogenesis-ISS-  
GO:0060445branching involved in salivary gland morphogenesis-IEA-  
GO:0060485mesenchyme development-ISS-  
GO:0060548negative regulation of cell death-IDA12631064  
GO:0060686negative regulation of prostatic bud formation-IEA-  
GO:0060687regulation of branching involved in prostate gland morphogenesis-IEA-  
GO:0060710chorio-allantoic fusion-ISS-  
GO:0061384heart trabecula morphogenesis-ISS-  
GO:0070487monocyte aggregation-IDA15100360  
GO:0071456cellular response to hypoxia-ISS-  
GO:0071773cellular response to BMP stimulus-IMP18326817  
GO:0072040negative regulation of mesenchymal cell apoptotic process involved in nephron morphogenesis-IEA-  
GO:0072125negative regulation of glomerular mesangial cell proliferation-IDA17244894  
GO:0072133metanephric mesenchyme morphogenesis-IEA-  
GO:0072134nephrogenic mesenchyme morphogenesis-IEA-  
GO:0072136metanephric mesenchymal cell proliferation involved in metanephros development-IEA-  
GO:1900006positive regulation of dendrite development-IDA11580864  
GO:1900106positive regulation of hyaluranon cable assembly-IDA15100360  
GO:1901223negative regulation of NIK/NF-kappaB signaling-ISS-  
GO:1905069allantois development-ISS-  
GO:1905312positive regulation of cardiac neural crest cell migration involved in outflow tract morphogenesis-IEA-  
GO:2000121regulation of removal of superoxide radicals-ISS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005576extracellular region-TAS-  
GO:0005615extracellular space-IBA21873635  
GO:0005615extracellular space-IDA17977014  
GO:0031012extracellular matrix-IEA-  
GO:0031982vesicle-IEA-  
KEGG ID KEGG Term
hsa04060Cytokine-cytokine receptor interaction
hsa04340Hedgehog signaling pathway
hsa04350TGF-beta signaling pathway
Reactome ID Reactome Term Evidence
R-HSA-1474244Extracellular matrix organizationTAS
R-HSA-1566948Elastic fibre formationTAS
R-HSA-2129379Molecules associated with elastic fibresTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
29616282A large lung gene expression study identifying IL1B as a novel player in airway inflammation in COPD airway epithelial cells. (2018 Jun)Yi GInflamm Res
19345526[Origin of the mediacalcosis in kidney failure]. (2009 May)Torres PAJ Mal Vasc
12958694Semiquantitative mRNA measurements of osteoinductive growth factors in human iliac-crest bone: expression of LMP splice variants in human bone. (2003 Nov)Bunger MHCalcif Tissue Int
21609526[Genetic variations of bone morphogenetic protein 7 gene are associated with hypertriglyceridemia of Uygur Chinese in Xinjiang]. (2011 Mar)Yan ZTZhonghua Xin Xue Guan Bing Za Zhi