Gene: SLC10A1

6554
NTCP
solute carrier family 10 member 1
protein-coding
14q24.1
Ensembl:ENSG00000100652 MIM:182396 Vega:OTTHUMG00000171236 UniprotKB:Q14973
NC_000014.9
PubMed
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
6.929e-3 (AD)  2.863e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ZNF4600.628
ZBTB200.613
NUTM10.561
OR2F20.558
PAPOLB0.523
TAS2R300.517
C17orf780.512
PRR260.508
MTRNR2L50.505
CSAG30.501

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
KLRC3-0.273
SPNS3-0.249
BCHE-0.233
SUSD3-0.231
CENPH-0.223
KCNK18-0.217
CHP2-0.215
SPRR2A-0.212
OLFML3-0.212
RNASE6-0.209

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00091CyclosporineSmall Molecule59865-13-3Approved|InvestigationalTransporter
DB00279LiothyronineSmall Molecule6893-02-3ApprovedTransporter
DB00286Conjugated estrogensSmall Molecule12126-59-9ApprovedTransporter
DB00328IndomethacinSmall Molecule53-86-1Approved|InvestigationalTransporter
DB00396ProgesteroneSmall Molecule57-83-0ApprovedTransporter
DB00624TestosteroneSmall Molecule58-22-0Approved|InvestigationalTransporter
DB00887BumetanideSmall Molecule28395-03-1ApprovedTransporter
DB00977Ethinyl EstradiolSmall Molecule57-63-6ApprovedTransporter
DB01032ProbenecidSmall Molecule57-66-9Approved|InvestigationalTransporter
DB01583LiotrixSmall Molecule8065-29-0ApprovedTransporter
DB01586Ursodeoxycholic acidSmall Molecule128-13-2Approved|InvestigationalTransporter
DB02123Glycochenodeoxycholic AcidSmall Molecule640-79-9ExperimentalTransporter
DB02659Cholic AcidSmall Molecule81-25-4ApprovedTransporter
DB03619Deoxycholic AcidSmall Molecule83-44-3ApprovedTransporter
DB04348Taurocholic AcidSmall Molecule81-24-3ExperimentalTransporter
DB06290SimeprevirSmall Molecule923604-59-5ApprovedTransporter
DB08860PitavastatinSmall Molecule147511-69-1ApprovedTransporter
DB13943Testosterone cypionateSmall Molecule58-20-8ApprovedTransporter
DB13944Testosterone enanthateSmall Molecule315-37-7ApprovedTransporter
DB13946Testosterone undecanoateSmall Molecule5949-44-0Approved|InvestigationalTransporter
ID Drug Name Action PubMed
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased expression of SLC10A1 mRNA"28903501
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"[Lithocholic Acid co-treated with 1,4-bis(2-(3,5-dichloropyridyloxy))benzene] results in increased expression of SLC10A1 mRNA"18032408
C4901661-(4-methoxyphenyl)piperazine1-(4-methoxyphenyl)piperazine results in decreased expression of SLC10A1 mRNA26821219
C0780921-piperonylpiperazine1-piperonylpiperazine results in decreased expression of SLC10A1 mRNA26821219
C021279(1R-(exo,exo))-3-(4-fluorophenyl)-8-methyl-8- azabicyclo(3.2.1)octane-2-carboxylic acid, methyl ester"(1R-(exo,exo))-3-(4-fluorophenyl)-8-methyl-8- azabicyclo(3.2.1)octane-2-carboxylic acid, methyl ester inhibits the reaction [Methamphetamine results in decreased expression of SLC10A1 mRNA]"11756511
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of SLC10A1 mRNA"21346803
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of SLC10A1 mRNA"21346803
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of SLC10A1 mRNA"28973690
C5131183,6-dihydroxy-7-fluorocholanoic acid"3,6-dihydroxy-7-fluorocholanoic acid inhibits the reaction [Ethinyl Estradiol results in decreased expression of SLC10A1 mRNA]"16487557
C0159298-((4-chlorophenyl)thio)cyclic-3',5'-AMP"8-((4-chlorophenyl)thio)cyclic-3',5'-AMP results in increased expression of SLC10A1 mRNA"27160211
D000081AcetamidesAcetamides analog inhibits the reaction [SLC10A1 protein results in increased transport of Taurocholic Acid]22641618
D000082AcetaminophenAcetaminophen results in decreased expression of SLC10A1 mRNA29067470
D000082AcetaminophenAcetaminophen affects the expression of SLC10A1 mRNA17562736
D000082Acetaminophen[Acetaminophen co-treated with Sodium Chloride] results in decreased expression of SLC10A1 mRNA17934960
D000082AcetaminophenAcetaminophen results in decreased expression of SLC10A1 mRNA15496496
D000082Acetaminophen[Clofibrate co-treated with Acetaminophen] affects the expression of SLC10A1 mRNA17585979
D000082AcetaminophenPPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of SLC10A1 mRNA]17585979
D000083AcetanilidesAcetanilides analog promotes the reaction [SLC10A1 protein results in increased transport of Taurocholic Acid]22641618
C016601afimoxifeneafimoxifene results in decreased expression of SLC10A1 mRNA29285606
D016604Aflatoxin B1Aflatoxin B1 affects the expression of SLC10A1 protein20106945
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of SLC10A1 mRNA27153756
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of SLC10A1 mRNA19770486
C031442Agkistrodon venomsAgkistrodon venoms results in increased expression of SLC10A1 mRNA15844712
C031143AICA ribonucleotideAICA ribonucleotide results in decreased expression of SLC10A1 mRNA27090119
D000452AldrinAldrin results in increased expression of SLC10A1 mRNA18579281
C526957alisol B 23-acetatealisol B 23-acetate promotes the reaction [1-Naphthylisothiocyanate results in decreased expression of SLC10A1 mRNA]25655198
C526957alisol B 23-acetate"pregna-4,17-diene-3,16-dione inhibits the reaction [alisol B 23-acetate promotes the reaction [1-Naphthylisothiocyanate results in decreased expression of SLC10A1 mRNA]]"25655198
C006463allyl alcoholallyl alcohol results in decreased expression of SLC10A1 mRNA19371622
C006463allyl alcoholallyl alcohol results in decreased expression of SLC10A1 protein19371622
D000638AmiodaroneAmiodarone results in decreased expression of SLC10A1 mRNA27765674
D000643Ammonium ChlorideAmmonium Chloride affects the expression of SLC10A1 mRNA16483693
D000880AnthraquinonesAnthraquinones analog inhibits the reaction [SLC10A1 protein results in increased transport of Taurocholic Acid]22641618
D000069059Atorvastatin CalciumAtorvastatin Calcium results in increased expression of SLC10A1 mRNA25278499
D001379AzathioprineAzathioprine results in decreased expression of SLC10A1 mRNA27765674
D001398AztreonamAztreonam results in increased expression of SLC10A1 mRNA24657338
D001557BenzenesulfonatesBenzenesulfonates analog inhibits the reaction [SLC10A1 protein results in increased transport of Taurocholic Acid]22641618
D019324beta-Naphthoflavonebeta-Naphthoflavone results in decreased expression of SLC10A1 mRNA22258563
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of SLC10A1 mRNA20106945
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of SLC10A1 mRNA22316170
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of SLC10A1 mRNA19770486
D004958EstradiolEstradiol results in decreased expression of SLC10A1 mRNA20106945
C023888beta-hexachlorocyclohexanebeta-hexachlorocyclohexane results in increased expression of SLC10A1 mRNA28392238
D001647Bile Acids and SaltsBile Acids and Salts inhibits the reaction [SLC10A1 protein results in increased uptake of Taurocholic Acid]19464309
D001647Bile Acids and SaltsSLC10A1 protein affects the transport of Bile Acids and Salts12663868|1558213
D001647Bile Acids and SaltsSLC10A1 protein affects the uptake of Bile Acids and Salts15841457
D001647Bile Acids and SaltsSLC10A1 protein results in increased transport of Bile Acids and Salts24211540
D001647Bile Acids and SaltsTAK-875 inhibits the reaction [SLC10A1 protein results in increased transport of Bile Acids and Salts]28108665
D001647Bile Acids and SaltsBile Acids and Salts inhibits the reaction [SLC10A1 protein results in increased uptake of Taurocholic Acid]19464309
D001647Bile Acids and SaltsSLC10A1 protein results in increased transport of Bile Acids and Salts24211540
C006780bisphenol Abisphenol A inhibits the reaction [[Sodium co-treated with SLC10A1 protein] results in increased uptake of Taurocholic Acid]27989701
C006780bisphenol Abisphenol A results in decreased expression of SLC10A1 mRNA25181051
C000611646bisphenol Fbisphenol F inhibits the reaction [[Sodium co-treated with SLC10A1 protein] results in increased uptake of Taurocholic Acid]27989701
C086232bosentanbosentan results in decreased expression of SLC10A1 mRNA28369585
C086232bosentanbosentan results in decreased expression of SLC10A1 mRNA27765674
C086232bosentanbosentan results in decreased activity of SLC10A1 protein23721565
D002220CarbamazepineCarbamazepine results in increased expression of SLC10A1 mRNA17112801
D002251Carbon TetrachlorideCarbon Tetrachloride results in decreased expression of SLC10A1 mRNA15496496|2733941
D002251Carbon TetrachlorideCarbon Tetrachloride results in decreased expression of SLC10A1 protein16177239
D002251Carbon TetrachlorideCarbon Tetrachloride affects the expression of SLC10A1 mRNA15963342
D002330CarmustineCarmustine results in increased expression of SLC10A1 mRNA15980968
D002512Cephalothin[Cephalothin co-treated with Neomycin] results in increased expression of SLC10A1 mRNA24657338
D002635Chenodeoxycholic AcidChenodeoxycholic Acid results in decreased expression of SLC10A1 mRNA25055961
D002635Chenodeoxycholic AcidSLC10A1 protein affects the transport of Chenodeoxycholic Acid15297262
D002635Chenodeoxycholic AcidChenodeoxycholic Acid inhibits the reaction [Ethinyl Estradiol results in decreased expression of SLC10A1 mRNA]27743861
D002635Chenodeoxycholic AcidChenodeoxycholic Acid results in decreased expression of SLC10A1 mRNA27743861
D002635Chenodeoxycholic AcidN-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Chenodeoxycholic Acid inhibits the reaction [Ethinyl Estradiol results in decreased expression of SLC10A1 mRNA]]27743861
D002706ChlordanChlordan results in decreased expression of SLC10A1 mRNA24464585
D002713ChlorineChlorine results in decreased expression of SLC10A1 mRNA18636392
D002713Chlorine[Ozone co-treated with Chlorine] affects the expression of SLC10A1 mRNA18636392
D002746ChlorpromazineChlorpromazine results in decreased expression of SLC10A1 mRNA27765674|2839135
D020355CholatesSLC10A1 protein affects the transport of Cholates15297262
D002791Cholesterol, Dietary"Cholesterol, Dietary results in increased expression of SLC10A1 mRNA"28549616
D019826Cholic AcidCholic Acid results in decreased expression of SLC10A1 mRNA25055961
D019826Cholic Acid[Cholic Acid binds to and results in increased activity of NR1H4 protein] which results in decreased expression of SLC10A1 mRNA22540009
D019826Cholic AcidCholic Acid results in decreased expression of SLC10A1 mRNA11438506|1600256
D019826Cholic AcidCholic Acid results in decreased expression of SLC10A1 protein11438506
D002793Cholic Acids[Cyclosporine results in decreased activity of SLC10A1 protein] which affects the abundance of Cholic Acids26198044
D002793Cholic Acids[Cholic Acids co-treated with Deoxycholic Acid] results in decreased expression of SLC10A1 mRNA28391356
C027113chrysophanic acidchrysophanic acid results in decreased expression of SLC10A1 mRNA28161596
C027113chrysophanic acidchrysophanic acid results in decreased expression of SLC10A1 protein28161596
C019304ciprofibrateciprofibrate results in decreased expression of SLC10A1 protein12381268
D002994Clofibrate[Clofibrate co-treated with Acetaminophen] affects the expression of SLC10A1 mRNA17585979
D002994ClofibrateClofibrate results in decreased expression of SLC10A1 mRNA17585979
D002994ClofibrateClofibrate results in increased expression of SLC10A1 mRNA28973556
D002994ClofibratePPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of SLC10A1 mRNA]17585979
D002995Clofibric AcidClofibric Acid affects the expression of SLC10A1 mRNA17602206
D060729Coal AshCoal Ash results in decreased expression of SLC10A1 mRNA19000753
D003042CocaineCocaine results in increased expression of SLC10A1 mRNA12629581
D016578Crack CocaineCrack Cocaine results in decreased expression of SLC10A1 mRNA12629581
C057862cyanoginosin LRcyanoginosin LR results in decreased expression of SLC10A1 mRNA17654400
D016572CyclosporineCyclosporine affects the expression of SLC10A1 mRNA24973091
D016572CyclosporineCyclosporine results in decreased activity of SLC10A1 protein26198044
D016572Cyclosporine[Cyclosporine results in decreased activity of SLC10A1 protein] which affects the abundance of Cholic Acids26198044
D016572CyclosporineCyclosporine results in decreased expression of SLC10A1 mRNA20106945|2383089
D016572CyclosporineCyclosporine results in decreased expression of SLC10A1 mRNA19770486|2383089
D016572CyclosporineCyclosporine results in decreased expression of SLC10A1 mRNA27765674|2839135
C089595cylindrospermopsincylindrospermopsin results in decreased expression of SLC10A1 mRNA24921660
C093628cyproconazolecyproconazole results in increased expression of SLC10A1 mRNA22334560
C004742daidzeindaidzein metabolite inhibits the reaction [SLC10A1 protein results in increased transport of estrone sulfate]25319728
C004742daidzeindaidzein metabolite promotes the reaction [SLC10A1 protein results in increased transport of estrone sulfate]25319728
C004742daidzeinestrone sulfate inhibits the reaction [SLC10A1 protein results in increased transport of daidzein metabolite]25319728
C004742daidzeinSLC10A1 protein results in increased transport of daidzein metabolite25319728
C004742daidzeinTaurocholic Acid inhibits the reaction [SLC10A1 protein results in increased transport of daidzein metabolite]25319728
D003634DDTDDT results in decreased expression of SLC10A1 mRNA24464585
C010902decabromobiphenyl etherdecabromobiphenyl ether results in increased expression of SLC10A1 mRNA23914054
D003840Deoxycholic AcidDeoxycholic Acid results in decreased expression of SLC10A1 mRNA25582706
D003840Deoxycholic AcidDeoxycholic Acid results in increased expression of SLC10A1 mRNA21914718
D003840Deoxycholic Acid[Cholic Acids co-treated with Deoxycholic Acid] results in decreased expression of SLC10A1 mRNA28391356
D003907DexamethasoneDexamethasone results in increased expression of SLC10A1 mRNA20832446|2088889
D003907Dexamethasone[Dexamethasone co-treated with Ibuprofen] results in increased expression of SLC10A1 mRNA29222744
D003907DexamethasoneDexamethasone results in increased expression of SLC10A1 mRNA29222744
D003907DexamethasoneDexamethasone inhibits the reaction [Lipopolysaccharides results in decreased expression of SLC10A1 mRNA]15205389
D003907DexamethasoneDexamethasone results in decreased expression of SLC10A1 mRNA11328961
D003907DexamethasoneDexamethasone results in decreased expression of SLC10A1 protein15258109
D003907DexamethasoneDexamethasone results in increased expression of SLC10A1 mRNA20888898
D016264Dextran SulfateDextran Sulfate results in decreased expression of SLC10A1 mRNA27580383
D016264Dextran SulfateDextran Sulfate results in decreased expression of SLC10A1 protein27580383
D004026DieldrinDieldrin results in decreased expression of SLC10A1 mRNA24464585
D004026DieldrinDieldrin results in decreased expression of SLC10A1 mRNA23153324
D004041Dietary FatsOligosaccharides inhibits the reaction [Dietary Fats results in increased expression of SLC10A1 mRNA]28549616
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with Thioacetamide] results in decreased expression of SLC10A1 mRNA28943392
D004052DiethylnitrosamineDiethylnitrosamine results in decreased expression of SLC10A1 mRNA19638242
D004128DimethylnitrosamineDimethylnitrosamine results in decreased expression of SLC10A1 mRNA17072980
C019357dioscindioscin inhibits the reaction [1-Naphthylisothiocyanate results in decreased expression of SLC10A1 mRNA]27317372
D004318DoxycyclineDoxycycline results in decreased expression of SLC10A1 mRNA27765674
D004642EmodinEmodin results in decreased expression of SLC10A1 mRNA28161596
D004642EmodinEmodin results in decreased expression of SLC10A1 protein28161596
D004726EndosulfanEndosulfan results in decreased expression of SLC10A1 mRNA24464585
D004785Environmental PollutantsEnvironmental Pollutants results in decreased expression of SLC10A1 mRNA12655031
C045651epigallocatechin gallateepigallocatechin gallate inhibits the reaction [Ethinyl Estradiol results in decreased expression of SLC10A1 protein]23146761
C045651epigallocatechin gallateepigallocatechin gallate results in decreased expression of SLC10A1 mRNA23146761
C109476epoxiconazoleepoxiconazole results in increased expression of SLC10A1 mRNA22334560
C017296estrone sulfatedaidzein metabolite inhibits the reaction [SLC10A1 protein results in increased transport of estrone sulfate]25319728
C017296estrone sulfatedaidzein metabolite promotes the reaction [SLC10A1 protein results in increased transport of estrone sulfate]25319728
C017296estrone sulfateestrone sulfate inhibits the reaction [SLC10A1 protein results in increased transport of daidzein metabolite]25319728
D000431EthanolEthanol results in increased expression of SLC10A1 mRNA19167417
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of SLC10A1 mRNA27743861
D004997Ethinyl EstradiolESR1 protein promotes the reaction [Ethinyl Estradiol results in decreased expression of SLC10A1 mRNA]16606610
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of SLC10A1 mRNA16606610|2781822
D004997Ethinyl EstradiolSRT1720 inhibits the reaction [Ethinyl Estradiol results in decreased expression of SLC10A1 mRNA]27818225
D004997Ethinyl Estradiol"3,6-dihydroxy-7-fluorocholanoic acid inhibits the reaction [Ethinyl Estradiol results in decreased expression of SLC10A1 mRNA]"16487557
D004997Ethinyl EstradiolChenodeoxycholic Acid inhibits the reaction [Ethinyl Estradiol results in decreased expression of SLC10A1 mRNA]27743861
D004997Ethinyl Estradiolepigallocatechin gallate inhibits the reaction [Ethinyl Estradiol results in decreased expression of SLC10A1 protein]23146761
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of SLC10A1 mRNA12187295|1250776
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of SLC10A1 protein12187295|1250776
D004997Ethinyl EstradiolN-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Chenodeoxycholic Acid inhibits the reaction [Ethinyl Estradiol results in decreased expression of SLC10A1 mRNA]]27743861
D004997Ethinyl EstradiolN-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Ursodeoxycholic Acid inhibits the reaction [Ethinyl Estradiol results in decreased expression of SLC10A1 mRNA]]27743861
D004997Ethinyl EstradiolPRKAA1 protein inhibits the reaction [Ethinyl Estradiol results in decreased expression of SLC10A1 mRNA]27090119
D004997Ethinyl EstradiolUrsodeoxycholic Acid inhibits the reaction [Ethinyl Estradiol results in decreased expression of SLC10A1 mRNA]16487557|2774386
D011345FenofibrateFenofibrate results in decreased expression of SLC10A1 mRNA25572481
D011345FenofibrateFenofibrate results in decreased expression of SLC10A1 mRNA27765674
C082360fipronilfipronil results in increased expression of SLC10A1 mRNA23962444
D005419FlavonoidsFlavonoids results in decreased expression of SLC10A1 mRNA18035473
D005485FlutamideFlutamide results in decreased expression of SLC10A1 mRNA24136188
D015378Imipenem[Vancomycin co-treated with Imipenem] results in increased expression of SLC10A1 mRNA24657338
C056933fumonisin B1fumonisin B1 results in decreased expression of SLC10A1 mRNA16221962
C039281furanfuran results in decreased expression of SLC10A1 mRNA25539665
D005672Fusidic AcidFusidic Acid inhibits the reaction [SLC10A1 protein results in increased transport of Taurocholic Acid]27676153
D019833Genistein[Genistein co-treated with Methoxychlor] results in decreased expression of SLC10A1 mRNA21782745
D019833GenisteinGenistein results in decreased expression of SLC10A1 mRNA21782745
D005897GlafenineGlafenine results in decreased expression of SLC10A1 mRNA24136188
D005905GlyburideGlyburide results in decreased expression of SLC10A1 mRNA27765674|2839135
D005999Glycochenodeoxycholic AcidSLC10A1 protein results in increased uptake of Glycochenodeoxycholic Acid29024779
D005999Glycochenodeoxycholic AcidSLC10A1 protein affects the transport of Glycochenodeoxycholic Acid15297262
D006000Glycocholic AcidSLC10A1 protein affects the transport of Glycocholic Acid15297262
D006002Glycodeoxycholic AcidGlycodeoxycholic Acid results in decreased expression of SLC10A1 mRNA24994853
C024033glycoursodeoxycholic acidSLC10A1 protein affects the transport of glycoursodeoxycholic acid15297262
C412815GW 4064[GW 4064 binds to and results in increased activity of NR1H4 protein] which results in decreased expression of SLC10A1 mRNA22540009
C412815GW 4064GW 4064 promotes the reaction [NR1H4 protein binds to SLC10A1 gene]20091679
C412815GW 4064GW 4064 results in increased expression of SLC10A1 mRNA27609522
C412815GW 4064GW 4064 results in increased expression of SLC10A1 protein27609522
C412815GW 4064GW 4064 results in decreased expression of SLC10A1 mRNA15644430
C412815GW 4064GW 4064 results in increased expression of SLC10A1 mRNA14623915
C010178heliotrineheliotrine results in decreased expression of SLC10A1 mRNA26100227
D006533HeptachlorHeptachlor results in decreased expression of SLC10A1 mRNA24464585
D006533HeptachlorHeptachlor results in decreased expression of SLC10A1 mRNA23153324
D007052Ibuprofen[Dexamethasone co-treated with Ibuprofen] results in increased expression of SLC10A1 mRNA29222744
D007213IndomethacinIndomethacin results in increased expression of SLC10A1 mRNA28201806
C008261lead acetatelead acetate results in decreased expression of SLC10A1 mRNA22609695
C052901lemongrass oillemongrass oil affects the expression of SLC10A1 mRNA25976427
D001556LindaneLindane results in decreased expression of SLC10A1 mRNA24464585
D008070LipopolysaccharidesLipopolysaccharides results in decreased expression of SLC10A1 mRNA15205115
D008070LipopolysaccharidesLipopolysaccharides results in decreased expression of SLC10A1 mRNA15312234|1531319
D008070LipopolysaccharidesDexamethasone inhibits the reaction [Lipopolysaccharides results in decreased expression of SLC10A1 mRNA]15205389
D008070LipopolysaccharidesLipopolysaccharides results in decreased expression of SLC10A1 mRNA15205115|1520538
D008095Lithocholic Acid"[Lithocholic Acid co-treated with 1,4-bis(2-(3,5-dichloropyridyloxy))benzene] results in increased expression of SLC10A1 mRNA"18032408
D008095Lithocholic AcidLithocholic Acid results in decreased expression of SLC10A1 mRNA12637555|1643665
D008095Lithocholic AcidLithocholic Acid results in decreased expression of SLC10A1 protein16436656
D008095Lithocholic AcidNR1H3 protein inhibits the reaction [Lithocholic Acid results in decreased expression of SLC10A1 mRNA]17256725
D008095Lithocholic AcidSMAD3 protein promotes the reaction [Lithocholic Acid results in decreased expression of SLC10A1 mRNA]23034213
C533860macitentanmacitentan results in decreased expression of SLC10A1 mRNA28369585
D008694Methamphetamine"(1R-(exo,exo))-3-(4-fluorophenyl)-8-methyl-8- azabicyclo(3.2.1)octane-2-carboxylic acid, methyl ester inhibits the reaction [Methamphetamine results in decreased expression of SLC10A1 mRNA]"11756511
D008694MethamphetamineMethamphetamine results in decreased expression of SLC10A1 mRNA11756511
D008701MethapyrileneMethapyrilene results in decreased expression of SLC10A1 mRNA15120968|2852906
D008727MethotrexateMethotrexate results in decreased expression of SLC10A1 mRNA15120968
D008731Methoxychlor[Genistein co-treated with Methoxychlor] results in decreased expression of SLC10A1 mRNA21782745
D008731MethoxychlorMethoxychlor results in decreased expression of SLC10A1 mRNA21782745
D008730MethoxsalenMethoxsalen results in decreased expression of SLC10A1 mRNA28552422
D008730MethoxsalenMethoxsalen results in decreased expression of SLC10A1 protein28552422
D008917MirexMirex results in decreased expression of SLC10A1 mRNA23153324
C063509N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamideN-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Chenodeoxycholic Acid inhibits the reaction [Ethinyl Estradiol results in decreased expression of SLC10A1 mRNA]]27743861
C063509N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamideN-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Ursodeoxycholic Acid inhibits the reaction [Ethinyl Estradiol results in decreased expression of SLC10A1 mRNA]]27743861
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of SLC10A1 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of SLC10A1 mRNA"25554681
D0150581-Naphthylisothiocyanate1-Naphthylisothiocyanate results in decreased expression of SLC10A1 mRNA19181614|2565519
D0150581-Naphthylisothiocyanatealisol B 23-acetate promotes the reaction [1-Naphthylisothiocyanate results in decreased expression of SLC10A1 mRNA]25655198
D0150581-NaphthylisothiocyanateNFE2L2 inhibits the reaction [1-Naphthylisothiocyanate results in decreased expression of SLC10A1 mRNA]19181614
D0150581-Naphthylisothiocyanate"pregna-4,17-diene-3,16-dione inhibits the reaction [alisol B 23-acetate promotes the reaction [1-Naphthylisothiocyanate results in decreased expression of SLC10A1 mRNA]]"25655198
D0150581-Naphthylisothiocyanate1-Naphthylisothiocyanate results in decreased expression of SLC10A1 mRNA14623915|2412042
D0150581-Naphthylisothiocyanatedioscin inhibits the reaction [1-Naphthylisothiocyanate results in decreased expression of SLC10A1 mRNA]27317372
C461488N-benzylpiperazineN-benzylpiperazine results in decreased expression of SLC10A1 mRNA26821219
C066471NCS 382NCS 382 results in increased expression of SLC10A1 mRNA28119166
C051752nefazodonenefazodone results in decreased expression of SLC10A1 mRNA24136188
D009355Neomycin[Cephalothin co-treated with Neomycin] results in increased expression of SLC10A1 mRNA24657338
C012655nimesulidenimesulide results in decreased expression of SLC10A1 mRNA24136188
C464660obeticholic acidobeticholic acid results in decreased expression of SLC10A1 mRNA15911693
C464660obeticholic acidobeticholic acid results in decreased expression of SLC10A1 mRNA15644430
D009828Oleanolic AcidOleanolic Acid results in decreased expression of SLC10A1 mRNA23948738
D009828Oleanolic AcidOleanolic Acid results in decreased expression of SLC10A1 protein23948738
D009844OligosaccharidesOligosaccharides inhibits the reaction [Dietary Fats results in increased expression of SLC10A1 mRNA]28549616
C026209oltiprazoltipraz results in decreased expression of SLC10A1 mRNA16837569
C016340o,p'-DDT"o,p'-DDT results in decreased expression of SLC10A1 mRNA"24464585
D010126Ozone[Ozone co-treated with Chlorine] affects the expression of SLC10A1 mRNA18636392
D052638Particulate MatterParticulate Matter results in decreased expression of SLC10A1 mRNA25803276
C539348perfluorobutanesulfonic acidSLC10A1 protein results in increased transport of perfluorobutanesulfonic acid26001962
C539348perfluorobutanesulfonic acidSLC10A1 protein results in increased transport of perfluorobutanesulfonic acid26001962
C036567perfluorodecanoic acidperfluorodecanoic acid results in decreased expression of SLC10A1 mRNA18703564|2734434
C036567perfluorodecanoic acidperfluorodecanoic acid results in decreased expression of SLC10A1 protein18703564
C036567perfluorodecanoic acidPPARA protein affects the reaction [perfluorodecanoic acid results in decreased expression of SLC10A1 mRNA]18703564|2734434
C471071perfluorohexanesulfonic acidSLC10A1 protein results in increased transport of perfluorohexanesulfonic acid26001962
C471071perfluorohexanesulfonic acidperfluorohexanesulfonic acid results in decreased expression of SLC10A1 mRNA21705711
C471071perfluorohexanesulfonic acidSLC10A1 protein results in increased transport of perfluorohexanesulfonic acid26001962
C076994perfluorooctane sulfonic acidSLC10A1 protein results in increased transport of perfluorooctane sulfonic acid26001962
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in decreased expression of SLC10A1 mRNA21705711
C076994perfluorooctane sulfonic acidSLC10A1 protein results in increased transport of perfluorooctane sulfonic acid26001962
C023036perfluorooctanoic acidperfluorooctanoic acid results in decreased expression of SLC10A1 mRNA22414604
D010480PerhexilinePerhexiline results in decreased expression of SLC10A1 mRNA27765674
D010634PhenobarbitalPhenobarbital results in decreased expression of SLC10A1 mRNA16837569|1908454
D010634PhenobarbitalPhenobarbital results in increased expression of SLC10A1 mRNA27160211
D010634PhenobarbitalPhenobarbital results in decreased expression of SLC10A1 mRNA16510358
C008905physcionephyscione results in decreased expression of SLC10A1 mRNA28161596
C008905physcionephyscione results in decreased expression of SLC10A1 protein28161596
D010879PiperazinesPiperazines analog promotes the reaction [SLC10A1 protein results in increased transport of Taurocholic Acid]22641618
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of SLC10A1 mRNA19710929
C006253pirinixic acidpirinixic acid results in decreased expression of SLC10A1 mRNA16221962|1917653
D011192Potassium DichromatePotassium Dichromate results in increased expression of SLC10A1 mRNA23608068
D017035PravastatinPravastatin results in decreased expression of SLC10A1 mRNA27225895
D017035PravastatinPravastatin results in decreased expression of SLC10A1 mRNA27225895
C023617pregna-4,17-diene-3,16-dione"pregna-4,17-diene-3,16-dione inhibits the reaction [alisol B 23-acetate promotes the reaction [1-Naphthylisothiocyanate results in decreased expression of SLC10A1 mRNA]]"25655198
D011374ProgesteroneProgesterone results in increased expression of SLC10A1 mRNA20631399
C045950propiconazolepropiconazole results in increased expression of SLC10A1 mRNA22334560
D011718PyrazinamidePyrazinamide results in increased expression of SLC10A1 mRNA27255380
D011718PyrazinamidePyrazinamide results in increased expression of SLC10A1 protein27255380
D011759PyrrolidinesPyrrolidines analog results in decreased expression of SLC10A1 mRNA26365562
D011763Pyrrolizidine AlkaloidsPyrrolizidine Alkaloids results in decreased expression of SLC10A1 mRNA26100227
D012293RifampinRifampin results in decreased expression of SLC10A1 mRNA16837569
D019438RitonavirRitonavir results in decreased expression of SLC10A126626330
C084904Ro 41-5253Ro 41-5253 inhibits the reaction [[RARA protein co-treated with RXRA protein] results in increased expression of SLC10A1 mRNA]25550158
C084904Ro 41-5253Ro 41-5253 inhibits the reaction [[RARB protein co-treated with RXRA protein] results in increased expression of SLC10A1 mRNA]25550158
C084904Ro 41-5253Ro 41-5253 inhibits the reaction [[RARG protein co-treated with RXRA protein] results in increased expression of SLC10A1 mRNA]25550158
C084904Ro 41-5253Ro 41-5253 results in decreased expression of SLC10A1 mRNA25550158
C084904Ro 41-5253Ro 41-5253 results in decreased expression of SLC10A1 protein25550158
C084904Ro 41-5253SLC10A1 protein results in increased susceptibility to Ro 41-525325550158
C066198SDZ 51641SDZ 51641 results in decreased expression of SLC10A1 mRNA19234235
C110822SDZ CPI 975SDZ CPI 975 results in decreased expression of SLC10A1 mRNA19234235
C094089SDZ FOX 988SDZ FOX 988 results in decreased expression of SLC10A1 mRNA19234235
C009237senecioninesenecionine results in decreased expression of SLC10A1 mRNA24641316
C009238senkirkinesenkirkine results in decreased expression of SLC10A1 mRNA26100227
D017632Asbestos, Serpentine"Asbestos, Serpentine results in increased expression of SLC10A1 mRNA"21148743
D019821SimvastatinSimvastatin results in decreased expression of SLC10A1 mRNA27765674
C106276sitaxsentansitaxsentan results in decreased activity of SLC10A1 protein23721565
D012964Sodiumbisphenol A inhibits the reaction [[Sodium co-treated with SLC10A1 protein] results in increased uptake of Taurocholic Acid]27989701
D012964Sodiumbisphenol F inhibits the reaction [[Sodium co-treated with SLC10A1 protein] results in increased uptake of Taurocholic Acid]27989701
D012964Sodium[Sodium co-treated with SLC10A1 protein] results in increased uptake of Taurocholic Acid27989701
D012964SodiumSodium deficiency inhibits the reaction [SLC10A1 protein results in increased import of Taurocholic Acid]25862123|2745050
D012964Sodiumtetrabromobisphenol A inhibits the reaction [[Sodium co-treated with SLC10A1 protein] results in increased uptake of Taurocholic Acid]27989701
C016104sodium bichromatesodium bichromate results in increased expression of SLC10A1 mRNA12325037
D012965Sodium Chloride[Acetaminophen co-treated with Sodium Chloride] results in decreased expression of SLC10A1 mRNA17934960
C075117squalestatin 1squalestatin 1 results in decreased expression of SLC10A1 mRNA27225895
C075117squalestatin 1squalestatin 1 results in decreased expression of SLC10A1 mRNA27225895
C525422SRT1720SRT1720 inhibits the reaction [Ethinyl Estradiol results in decreased expression of SLC10A1 mRNA]27818225
D013448SulfobromophthaleinSulfobromophthalein inhibits the reaction [SLC10A1 protein results in increased uptake of Taurocholic Acid]25106415
C018154sulfolithocholylglycineSLC10A1 protein results in increased uptake of sulfolithocholylglycine29024779
C557331TAK-875TAK-875 inhibits the reaction [SLC10A1 protein results in increased transport of Bile Acids and Salts]28108665
C557331TAK-875TAK-875 results in decreased activity of SLC10A1 protein28108665
D013629TamoxifenTamoxifen metabolite results in increased expression of SLC10A1 mRNA29285606
D013629TamoxifenTamoxifen results in decreased expression of SLC10A1 mRNA27765674
D013655Taurochenodeoxycholic AcidSLC10A1 protein affects the transport of Taurochenodeoxycholic Acid15297262
D013656Taurocholic AcidAcetamides analog inhibits the reaction [SLC10A1 protein results in increased transport of Taurocholic Acid]22641618
D013656Taurocholic AcidAcetanilides analog promotes the reaction [SLC10A1 protein results in increased transport of Taurocholic Acid]22641618
D013656Taurocholic AcidAnthraquinones analog inhibits the reaction [SLC10A1 protein results in increased transport of Taurocholic Acid]22641618
D013656Taurocholic AcidBenzenesulfonates analog inhibits the reaction [SLC10A1 protein results in increased transport of Taurocholic Acid]22641618
D013656Taurocholic AcidBile Acids and Salts inhibits the reaction [SLC10A1 protein results in increased uptake of Taurocholic Acid]19464309
D013656Taurocholic Acidbisphenol A inhibits the reaction [[Sodium co-treated with SLC10A1 protein] results in increased uptake of Taurocholic Acid]27989701
D013656Taurocholic Acidbisphenol F inhibits the reaction [[Sodium co-treated with SLC10A1 protein] results in increased uptake of Taurocholic Acid]27989701
D013656Taurocholic AcidFusidic Acid inhibits the reaction [SLC10A1 protein results in increased transport of Taurocholic Acid]27676153
D013656Taurocholic AcidPiperazines analog promotes the reaction [SLC10A1 protein results in increased transport of Taurocholic Acid]22641618
D013656Taurocholic AcidSLC10A1 protein results in increased import of Taurocholic Acid25862123|2745050
D013656Taurocholic AcidSLC10A1 protein results in increased transport of Taurocholic Acid22641618|2767615
D013656Taurocholic AcidSLC10A1 protein results in increased uptake of Taurocholic Acid19464309|2385098
D013656Taurocholic Acid[Sodium co-treated with SLC10A1 protein] results in increased uptake of Taurocholic Acid27989701
D013656Taurocholic AcidSodium deficiency inhibits the reaction [SLC10A1 protein results in increased import of Taurocholic Acid]25862123|2745050
D013656Taurocholic AcidSulfobromophthalein inhibits the reaction [SLC10A1 protein results in increased uptake of Taurocholic Acid]25106415
D013656Taurocholic AcidTaurocholic Acid inhibits the reaction [SLC10A1 protein results in increased transport of daidzein metabolite]25319728
D013656Taurocholic Acidtetrabromobisphenol A inhibits the reaction [[Sodium co-treated with SLC10A1 protein] results in increased uptake of Taurocholic Acid]27989701
D013656Taurocholic Acidtetrahydrophthalamic acid analog inhibits the reaction [SLC10A1 protein results in increased transport of Taurocholic Acid]22641618
D013656Taurocholic AcidTobacco Smoke Pollution inhibits the reaction [SLC10A1 protein results in increased import of Taurocholic Acid]27450509
D013656Taurocholic AcidTaurocholic Acid results in increased expression of SLC10A1 mRNA27160211
D013656Taurocholic AcidSLC10A1 protein affects the transport of Taurocholic Acid15297262
D013656Taurocholic AcidBile Acids and Salts inhibits the reaction [SLC10A1 protein results in increased uptake of Taurocholic Acid]19464309
D013656Taurocholic AcidSLC10A1 protein results in increased uptake of Taurocholic Acid19464309
C031655tauroursodeoxycholic acidSLC10A1 protein affects the transport of tauroursodeoxycholic acid15297262
C501413tesaglitazartesaglitazar results in decreased expression of SLC10A1 mRNA21515302
C020806tetrabromobisphenol Atetrabromobisphenol A inhibits the reaction [[Sodium co-treated with SLC10A1 protein] results in increased uptake of Taurocholic Acid]27989701
C020806tetrabromobisphenol Atetrabromobisphenol A results in decreased activity of SLC10A1 protein27989701
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of SLC10A1 mRNA22298810
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of SLC10A1 mRNA16837569|1969266
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of SLC10A1 mRNA21570461
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of SLC10A1 mRNA19770486
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of SLC10A1 mRNA22298810
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of SLC10A1 mRNA16054898|1879615
D013752TetracyclineTetracycline results in decreased expression of SLC10A1 mRNA24489787
D013752TetracyclineTetracycline results in decreased expression of SLC10A1 mRNA27765674
C014844tetrahydrophthalamic acidtetrahydrophthalamic acid analog inhibits the reaction [SLC10A1 protein results in increased transport of Taurocholic Acid]22641618
D013853Thioacetamide[Diethylnitrosamine co-treated with Thioacetamide] results in decreased expression of SLC10A1 mRNA28943392
D013853ThioacetamideThioacetamide results in decreased expression of SLC10A1 mRNA23411599|2622270
D013853ThioacetamideThioacetamide results in decreased expression of SLC10A1 protein26222700
C050504tianeptinetianeptine results in decreased expression of SLC10A1 mRNA27765674
D013988TiclopidineTiclopidine results in decreased expression of SLC10A1 mRNA27765674
D014028Tobacco Smoke PollutionTobacco Smoke Pollution inhibits the reaction [SLC10A1 protein results in increased import of Taurocholic Acid]27450509
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of SLC10A1 mRNA27450509
C116664tolvaptantolvaptan metabolite results in decreased activity of SLC10A1 protein26507107
D014212TretinoinTretinoin results in decreased expression of SLC10A1 mRNA25550158
D014241TrichloroethyleneTrichloroethylene results in decreased expression of SLC10A1 mRNA19448997
D014302Trinitrobenzenesulfonic AcidTrinitrobenzenesulfonic Acid results in decreased expression of SLC10A1 mRNA12044520
D014302Trinitrobenzenesulfonic AcidTrinitrobenzenesulfonic Acid results in decreased expression of SLC10A1 protein12044520
C057693troglitazonetroglitazone results in decreased expression of SLC10A1 mRNA25572481
D014425TurpentineTurpentine results in decreased expression of SLC10A1 mRNA15313196
D014580Ursodeoxycholic AcidUrsodeoxycholic Acid affects the expression of SLC10A1 mRNA25582706
D014580Ursodeoxycholic AcidUrsodeoxycholic Acid results in increased expression of SLC10A1 protein25582706
D014580Ursodeoxycholic AcidSLC10A1 protein affects the transport of Ursodeoxycholic Acid15297262
D014580Ursodeoxycholic AcidN-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Ursodeoxycholic Acid inhibits the reaction [Ethinyl Estradiol results in decreased expression of SLC10A1 mRNA]]27743861
D014580Ursodeoxycholic AcidUrsodeoxycholic Acid inhibits the reaction [Ethinyl Estradiol results in decreased expression of SLC10A1 mRNA]16487557|2774386
D014580Ursodeoxycholic AcidUrsodeoxycholic Acid results in increased expression of SLC10A1 mRNA16764892
D014635Valproic AcidValproic Acid results in decreased expression of SLC10A1 mRNA29154799
D014635Valproic AcidValproic Acid results in increased expression of SLC10A1 mRNA24489787
D014635Valproic AcidValproic Acid results in decreased expression of SLC10A1 mRNA27765674
D014640Vancomycin[Vancomycin co-treated with Imipenem] results in increased expression of SLC10A1 mRNA24657338
D001335Vehicle EmissionsVehicle Emissions results in decreased expression of SLC10A1 mRNA25803276
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of SLC10A1 gene25560391
D015032ZincZinc deficiency results in decreased expression of SLC10A1 mRNA15671213

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0001618virus receptor activity-IEA-  
GO:0005342organic acid transmembrane transporter activity-IBA21873635  
GO:0008508bile acid:sodium symporter activity-IBA21873635  
GO:0008508bile acid:sodium symporter activity-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006814sodium ion transport-IEA-  
GO:0015721bile acid and bile salt transport-IBA21873635  
GO:0015721bile acid and bile salt transport-TAS-  
GO:0046718viral entry into host cell-IEA-  
GO:0055085transmembrane transport-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005886plasma membrane-TAS-  
GO:0005887integral component of plasma membrane-TAS8132774  
GO:0016323basolateral plasma membrane-IEA-  
KEGG ID KEGG Term
hsa04976Bile secretion
Reactome ID Reactome Term Evidence
R-HSA-1430728MetabolismTAS
R-HSA-159418Recycling of bile acids and saltsTAS
R-HSA-194068Bile acid and bile salt metabolismTAS
R-HSA-556833Metabolism of lipidsTAS
R-HSA-8957322Metabolism of steroidsTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
27491457Genetic variants in the regulatory region of SLC10A1 are not associated with the risk of hepatitis B virus infection and clearance. (2016 Oct)Chen XInfect Genet Evol