Gene: SLC10A2

6555
ASBT|IBAT|ISBT|NTCP2|PBAM
solute carrier family 10 member 2
protein-coding
13q33.1
Ensembl:ENSG00000125255 MIM:601295 Vega:OTTHUMG00000017313 UniprotKB:Q12908
NG_016648.1
PubMed
0   ANCO-SNPs
ND|AD
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
5.428e-1 (AD)  9.985e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
GJA100.743
OR4C160.718
NBPF70.718
C4orf170.676
CST9L0.665
ADAD10.638
PSG20.636
ZNF705G0.633
LIPK0.632
SEMG20.608

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
BOP1-0.259
ANKRD55-0.258
EFR3B-0.254
ARRB1-0.252
NOG-0.246
DBP-0.24
ASAP2-0.239
CLPB-0.237
FBXL18-0.237
MAZ-0.237

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00091CyclosporineSmall Molecule59865-13-3Approved|InvestigationalTransporter
DB00577ValaciclovirSmall Molecule124832-26-4Approved|InvestigationalTransporter
DB00787AciclovirSmall Molecule59277-89-3ApprovedTransporter
DB01586Ursodeoxycholic acidSmall Molecule128-13-2Approved|InvestigationalTransporter
DB02123Glycochenodeoxycholic AcidSmall Molecule640-79-9ExperimentalTransporter
DB02659Cholic AcidSmall Molecule81-25-4ApprovedTransporter
DB03619Deoxycholic AcidSmall Molecule83-44-3ApprovedTransporter
DB04348Taurocholic AcidSmall Molecule81-24-3ExperimentalTransporter
DB13914VolixibatSmall Molecule1025216-57-2Experimental|InvestigationalTarget
ID Drug Name Action PubMed
C0264861,2,5,6-dibenzanthracene"1,2,5,6-dibenzanthracene results in increased expression of SLC10A2 mRNA"26377693
C4668001-(4-(4-(3,3-dibutyl-7-(dimethylamino)-2,3,4,5-tetrahydro-4-hydroxy-1,1-dioxido-1-benzothiepin-5-yl)phenoxy)butyl)-4-aza-1-azoniabicyclo(2.2.2)octane"1-(4-(4-(3,3-dibutyl-7-(dimethylamino)-2,3,4,5-tetrahydro-4-hydroxy-1,1-dioxido-1-benzothiepin-5-yl)phenoxy)butyl)-4-aza-1-azoniabicyclo(2.2.2)octane results in increased expression of SLC10A2 mRNA"15254889
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased expression of SLC10A2 mRNA"28903501
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of SLC10A2 mRNA"19114083
C0142112,3,7,8-tetrachlorodibenzofuran"2,3,7,8-tetrachlorodibenzofuran results in decreased expression of SLC10A2 mRNA"25768209
C5850042-monochloropropanediol2-monochloropropanediol results in decreased expression of SLC10A2 mRNA28522335
D000082AcetaminophenAcetaminophen affects the expression of SLC10A2 mRNA17562736
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of SLC10A2 mRNA19770486
C008088alfacalcidolalfacalcidol results in increased expression of SLC10A2 mRNA19581390
D000517alpha-Chlorohydrinalpha-Chlorohydrin results in decreased expression of SLC10A2 mRNA28522335
D000643Ammonium ChlorideAmmonium Chloride affects the expression of SLC10A2 mRNA16483693
D000069059Atorvastatin CalciumAtorvastatin Calcium results in increased expression of SLC10A2 mRNA15986414
D000069059Atorvastatin CalciumAtorvastatin Calcium results in increased expression of SLC10A2 protein15986414
D001398AztreonamAztreonam results in decreased expression of SLC10A2 mRNA24657338
C006703benzo(b)fluoranthenebenzo(b)fluoranthene results in increased expression of SLC10A2 mRNA26377693
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of SLC10A2 mRNA22316170
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of SLC10A2 mRNA19770486|2196490
C072553benzyloxycarbonylleucyl-leucyl-leucine aldehydebenzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [resveratrol results in decreased expression of SLC10A2 protein]24498857
C072553benzyloxycarbonylleucyl-leucyl-leucine aldehydebenzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of SLC10A2 protein23872411
C023888beta-hexachlorocyclohexanebeta-hexachlorocyclohexane results in decreased expression of SLC10A2 mRNA28392238
D001647Bile Acids and SaltsSLC10A2 protein affects the transport of Bile Acids and Salts12663868
D001647Bile Acids and SaltsBile Acids and Salts inhibits the reaction [SLC10A2 protein results in increased uptake of Taurocholic Acid]19464309
C006780bisphenol Abisphenol A affects the expression of SLC10A2 mRNA21786754
C006780bisphenol Abisphenol A results in decreased expression of SLC10A2 mRNA25181051
D019256Cadmium ChlorideCadmium Chloride results in increased expression of SLC10A2 mRNA23741332
D002635Chenodeoxycholic AcidChenodeoxycholic Acid inhibits the reaction [SLC10A2 protein results in increased transport of Taurocholic Acid]25466967
C023676chloroquine diphosphatechloroquine diphosphate results in increased expression of SLC10A2 protein23872411
D019826Cholic AcidCholic Acid results in decreased expression of SLC10A2 mRNA25582706
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased expression of SLC10A2 mRNA20938992
D002922CiguatoxinsCiguatoxins affects the expression of SLC10A2 mRNA18353800
D002994ClofibrateClofibrate results in decreased expression of SLC10A2 mRNA25270620|2897355
D002994Clofibrate[PPARA gene mutant form results in increased susceptibility to Clofibrate] which results in increased expression of SLC10A2 mRNA29175453
D016572CyclosporineCyclosporine results in decreased expression of SLC10A2 mRNA19770486
D003907Dexamethasone[Dexamethasone co-treated with Ibuprofen] results in increased expression of SLC10A2 mRNA29222744
D003907DexamethasoneDexamethasone results in increased expression of SLC10A2 mRNA29222744
D003907DexamethasoneDexamethasone affects the expression of SLC10A2 mRNA15102944
D003999Dichloroacetic AcidDichloroacetic Acid results in decreased expression of SLC10A2 mRNA28962523
D003633Dichlorodiphenyl DichloroethyleneDichlorodiphenyl Dichloroethylene results in decreased expression of SLC10A2 mRNA28392238
D004008DiclofenacDiclofenac results in increased expression of SLC10A2 mRNA26934552
D004051Diethylhexyl PhthalateDiethylhexyl Phthalate results in decreased expression of SLC10A2 mRNA28085963
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with Phenobarbital] results in increased expression of SLC10A2 mRNA24535843
D002117CalcitriolCalcitriol results in increased expression of SLC10A2 mRNA16002434
C045651epigallocatechin gallateepigallocatechin gallate inhibits the reaction [Ethinyl Estradiol results in decreased expression of SLC10A2 mRNA]23146761
C045651epigallocatechin gallateepigallocatechin gallate results in decreased expression of SLC10A2 mRNA23146761
D000431EthanolEthanol results in decreased expression of SLC10A2 mRNA19167417
D000431EthanolEthanol results in decreased expression of SLC10A2 mRNA15353170
D004997Ethinyl Estradiolepigallocatechin gallate inhibits the reaction [Ethinyl Estradiol results in decreased expression of SLC10A2 mRNA]23146761
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of SLC10A2 mRNA23146761
D005485FlutamideFlutamide results in decreased expression of SLC10A2 mRNA24793618
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased expression of SLC10A2 mRNA20938992
C039281furanfuran results in increased expression of SLC10A2 mRNA24183702
D019833GenisteinGenistein results in decreased expression of SLC10A2 mRNA24967385
D007052Ibuprofen[Dexamethasone co-treated with Ibuprofen] results in increased expression of SLC10A2 mRNA29222744
C099406L 742694L 742694 affects the expression of SLC10A2 mRNA15102944
C067713lactacystinlactacystin inhibits the reaction [resveratrol results in decreased expression of SLC10A2 protein]24498857
C525086LDN 57444LDN 57444 inhibits the reaction [resveratrol results in decreased expression of SLC10A2 protein]24498857
C045463leflunomideleflunomide results in decreased expression of SLC10A2 mRNA24136188
D008095Lithocholic AcidLithocholic Acid results in increased expression of SLC10A2 mRNA17256725|2558270
D008095Lithocholic AcidNR1H3 protein inhibits the reaction [Lithocholic Acid results in increased expression of SLC10A2 mRNA]17256725
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased expression of SLC10A2 mRNA20938992
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of SLC10A2 mRNA26011545
C500085muraglitazarmuraglitazar results in decreased expression of SLC10A2 mRNA21515302
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of SLC10A2 mRNA"25620056
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of SLC10A2 mRNA"25620056
D010098OxycodoneOxycodone results in decreased expression of SLC10A2 mRNA23439660
C471071perfluorohexanesulfonic acidperfluorohexanesulfonic acid results in decreased expression of SLC10A2 mRNA21705711
C076994perfluorooctane sulfonic acidSLC10A2 protein results in increased transport of perfluorooctane sulfonic acid26001962
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in decreased expression of SLC10A2 mRNA21705711
C023036perfluorooctanoic acidperfluorooctanoic acid results in decreased expression of SLC10A2 mRNA28511854
D010634Phenobarbital[Diethylnitrosamine co-treated with Phenobarbital] results in increased expression of SLC10A2 mRNA24535843
D010634PhenobarbitalNR1I3 protein affects the reaction [Phenobarbital results in increased expression of SLC10A2 mRNA]19482888
D010634PhenobarbitalPhenobarbital affects the expression of SLC10A2 mRNA23091169
D010634PhenobarbitalPhenobarbital results in increased expression of SLC10A2 mRNA19482888
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of SLC10A2 mRNA19710929
C006253pirinixic acidpirinixic acid results in decreased expression of SLC10A2 mRNA25270620
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in increased expression of SLC10A2 mRNA28903501
C045950propiconazolepropiconazole results in increased expression of SLC10A2 mRNA21278054
C059514resveratrolbenzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [resveratrol results in decreased expression of SLC10A2 protein]24498857
C059514resveratrollactacystin inhibits the reaction [resveratrol results in decreased expression of SLC10A2 protein]24498857
C059514resveratrolLDN 57444 inhibits the reaction [resveratrol results in decreased expression of SLC10A2 protein]24498857
C059514resveratrolresveratrol results in decreased expression of and results in decreased activity of SLC10A2 protein24498857
C059514resveratrolresveratrol results in decreased expression of SLC10A2 mRNA24498857
C059514resveratrolresveratrol results in decreased expression of and results in decreased activity of SLC10A2 protein24498857
C059514resveratrolresveratrol results in decreased expression of and results in decreased activity of SLC10A2 protein mutant form24498857
C089730rosiglitazonerosiglitazone results in decreased expression of SLC10A2 mRNA21515302
C016104sodium bichromatesodium bichromate results in decreased expression of SLC10A2 mRNA24612858
D013655Taurochenodeoxycholic AcidTaurochenodeoxycholic Acid results in increased expression of SLC10A2 protein11672435
D013656Taurocholic AcidChenodeoxycholic Acid inhibits the reaction [SLC10A2 protein results in increased transport of Taurocholic Acid]25466967
D013656Taurocholic AcidSLC10A2 protein results in increased transport of Taurocholic Acid25466967
D013656Taurocholic AcidSLC10A2 protein results in increased uptake of Taurocholic Acid15209631
D013656Taurocholic AcidBile Acids and Salts inhibits the reaction [SLC10A2 protein results in increased uptake of Taurocholic Acid]19464309
D013656Taurocholic AcidSLC10A2 protein results in increased uptake of Taurocholic Acid19464309
C037351tauromuricholic acidtauromuricholic acid results in increased expression of SLC10A2 protein11672435
C031655tauroursodeoxycholic acidtauroursodeoxycholic acid results in increased expression of SLC10A2 protein11672435
C501413tesaglitazartesaglitazar results in decreased expression of SLC10A2 mRNA21515302
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of SLC10A2 mRNA21570461|2637764
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with TIPARP gene mutant form] results in decreased expression of SLC10A2 mRNA25975270
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of SLC10A2 mRNA19770486
D013752TetracyclineTetracycline results in decreased expression of SLC10A2 mRNA24489787
D013853ThioacetamideThioacetamide results in increased expression of SLC10A2 mRNA26222700
D014050TolueneToluene affects the expression of SLC10A2 mRNA18653662
C032910triadimefontriadimefon results in decreased expression of SLC10A2 mRNA26790661
C057693troglitazonetroglitazone results in increased expression of SLC10A2 mRNA28973697
C057693troglitazonetroglitazone results in decreased expression of SLC10A2 mRNA21515302
D014580Ursodeoxycholic AcidUrsodeoxycholic Acid results in increased expression of SLC10A2 mRNA25582706
D014580Ursodeoxycholic AcidUrsodeoxycholic Acid results in increased expression of SLC10A2 mRNA16764892
D014750VincristineSLC10A2 gene SNP results in increased susceptibility to Vincristine21245421
C029297vinylidene chloridevinylidene chloride results in decreased expression of SLC10A2 mRNA26682919

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005342organic acid transmembrane transporter activity-IBA21873635  
GO:0008508bile acid:sodium symporter activity-IBA21873635  
GO:0008508bile acid:sodium symporter activity-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006814sodium ion transport-IEA-  
GO:0015721bile acid and bile salt transport-IBA21873635  
GO:0015721bile acid and bile salt transport-TAS-  
GO:0055085transmembrane transport-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005886plasma membrane-TAS-  
GO:0005887integral component of plasma membrane-TAS7592981  
GO:0005902microvillus-IEA-  
GO:0016324apical plasma membrane-IEA-  
KEGG ID KEGG Term
hsa04976Bile secretion
Reactome ID Reactome Term Evidence
R-HSA-1430728MetabolismTAS
R-HSA-159418Recycling of bile acids and saltsTAS
R-HSA-194068Bile acid and bile salt metabolismTAS
R-HSA-556833Metabolism of lipidsTAS
R-HSA-8957322Metabolism of steroidsTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
20201924Genome-wide association study of alcohol dependence implicates a region on chromosome 11. (2010 May)Edenberg HJAlcohol Clin Exp Res
27770636Two novel loci, COBL and SLC10A2, for Alzheimer's disease in African Americans. (2017 Feb)Mez JAlzheimers Dement