Gene: SLC11A1

6556
LSH|NRAMP|NRAMP1
solute carrier family 11 member 1
protein-coding
2q35
Ensembl:ENSG00000018280 MIM:600266 Vega:OTTHUMG00000086747 UniprotKB:P49279
NG_012128.1
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
3.178e-1 (AD)  3.788e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
TLR20.929
FPR10.919
FCGR2A0.91
SERPINA10.904
SIGLEC90.904
HCLS10.902
TYMP0.892
ABI30.891
RUNX10.891
LAIR10.89

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
WNT7A-0.557
KCNIP3-0.528
MARCH4-0.52
CPLX3-0.517
NEUROD6-0.511
KIT-0.511
ATP2C2-0.49
ABCC12-0.48
SLC7A4-0.479
C1QTNF2-0.478

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C5850042-monochloropropanediol2-monochloropropanediol results in decreased expression of SLC11A1 mRNA28522335
D000082AcetaminophenAcetaminophen affects the expression of SLC11A1 mRNA17562736
D000082Acetaminophen[Clofibrate co-treated with Acetaminophen] affects the expression of SLC11A1 mRNA17585979
D000082AcetaminophenPPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of SLC11A1 mRNA]17585979
D000643Ammonium ChlorideAmmonium Chloride affects the expression of SLC11A1 mRNA16483693
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of SLC11A1 mRNA24449571
C006632arsenic trioxidearsenic trioxide results in increased expression of SLC11A1 mRNA20458559
D001564Benzo(a)pyreneBenzo(a)pyrene affects the expression of SLC11A1 mRNA22342234
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of SLC11A1 mRNA22228805
D004958EstradiolEstradiol affects the expression of SLC11A1 mRNA16684588
C006780bisphenol Abisphenol A results in decreased expression of SLC11A1 mRNA25181051
D019256Cadmium ChlorideCadmium Chloride results in increased expression of SLC11A1 mRNA27647474
D002251Carbon TetrachlorideCarbon Tetrachloride affects the expression of SLC11A1 mRNA17484886
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of SLC11A1 mRNA27339419
D002994Clofibrate[Clofibrate co-treated with Acetaminophen] affects the expression of SLC11A1 mRNA17585979
D002994ClofibratePPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of SLC11A1 mRNA]17585979
D003300Copper[manganese chloride results in increased expression of SLC11A1 mRNA] which results in increased uptake of Copper22465424
D003300CopperSLC11A1 protein affects the reaction [manganese chloride results in increased uptake of Copper]22465424
D016572CyclosporineCyclosporine results in increased methylation of SLC11A1 promoter27989131
D004041Dietary FatsDietary Fats results in decreased expression of SLC11A1 mRNA18042831
D004041Dietary FatsDietary Fats results in increased expression of SLC11A1 mRNA22609946
D052244Endocrine DisruptorsEndocrine Disruptors results in increased expression of SLC11A1 mRNA25198161
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of SLC11A1 mRNA12072388
C013531ferric ammonium citrateferric ammonium citrate results in increased expression of SLC11A1 mRNA11054110
C000499ferric oxideferric oxide analog results in increased expression of SLC11A1 mRNA25086211
C004312glycidolglycidol results in increased expression of SLC11A1 mRNA24915197
D007501Iron[CP gene mutant form results in increased abundance of Iron] which results in increased expression of SLC11A1 mRNA16988052
D007538IsoniazidIsoniazid affects the expression of SLC11A1 mRNA20623750
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of SLC11A1 mRNA23086925
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of SLC11A1 mRNA27339419
D058185Magnetite Nanoparticles[Succimer binds to Magnetite Nanoparticles] which results in increased expression of SLC11A1 mRNA21641980
D058185Magnetite Nanoparticles[Succimer co-treated with Magnetite Nanoparticles] results in increased expression of SLC11A1 mRNA26378955
C025340manganese chloridemanganese chloride results in increased expression of SLC11A1 mRNA22465424
C025340manganese chloride[manganese chloride results in increased expression of SLC11A1 mRNA] which results in increased uptake of Copper22465424
C025340manganese chlorideSLC11A1 protein affects the reaction [manganese chloride results in increased uptake of Copper]22465424
D008628MercuryMercury results in increased expression of SLC11A1 mRNA19937285
D008727MethotrexateMethotrexate results in decreased expression of SLC11A1 mRNA17400583
D037742Nanotubes, Carbon"Nanotubes, Carbon affects the expression of SLC11A1 mRNA"23845593
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of SLC11A1 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of SLC11A1 mRNA"25554681
C028007nickel monoxidenickel monoxide results in increased expression of SLC11A1 mRNA19167457
D000073878Palm OilPalm Oil results in decreased expression of SLC11A1 mRNA18042831
D010269ParaquatParaquat results in increased expression of SLC11A1 mRNA21371552
D010396PenicillaminePenicillamine results in increased expression of SLC11A1 mRNA19575532
D012834SilverSilver analog results in increased expression of SLC11A1 mRNA22727896
D053260SootSoot results in increased expression of SLC11A1 mRNA22461453
D004113Succimer[Succimer binds to Magnetite Nanoparticles] which results in increased expression of SLC11A1 mRNA21641980
D004113Succimer[Succimer co-treated with Magnetite Nanoparticles] results in increased expression of SLC11A1 mRNA26378955
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of SLC11A1 mRNA21570461|2892240
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin promotes the reaction [AHR protein binds to SLC11A1 gene]28213091
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of SLC11A1 mRNA28213091
D013853ThioacetamideThioacetamide results in decreased expression of SLC11A1 mRNA23411599
D014028Tobacco Smoke PollutionTobacco Smoke Pollution affects the expression of SLC11A1 mRNA20133372
C013320tris(2-butoxyethyl) phosphatetris(2-butoxyethyl) phosphate affects the expression of SLC11A1 mRNA29024780
C025643vinclozolinvinclozolin results in increased expression of SLC11A1 mRNA23034163
C029297vinylidene chloridevinylidene chloride results in increased expression of SLC11A1 mRNA26682919
D014874Water Pollutants, Chemical"Water Pollutants, Chemical results in increased expression of SLC11A1 mRNA"25198161

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005384manganese ion transmembrane transporter activity-ISS-  
GO:0042803protein homodimerization activity-IDA8537108  
GO:0046915transition metal ion transmembrane transporter activity-IGI17932044  
GO:0051139metal ion:proton antiporter activity-IGI17932044  
GO:0051139metal ion:proton antiporter activity-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0001818negative regulation of cytokine production-ISS-  
GO:0001819positive regulation of cytokine production-ISS-  
GO:0002309T cell proliferation involved in immune response-ISS-  
GO:0002369T cell cytokine production-ISS-  
GO:0002606positive regulation of dendritic cell antigen processing and presentation-ISS-  
GO:0002827positive regulation of T-helper 1 type immune response-ISS-  
GO:0006826iron ion transport-IMP16510578  
GO:0006828manganese ion transport-ISS-  
GO:0006876cellular cadmium ion homeostasis-IGI17932044  
GO:0006879cellular iron ion homeostasis-IMP16510578  
GO:0006909phagocytosis-ISS-  
GO:0006954inflammatory response-ISS-  
GO:0007035vacuolar acidification-ISS-  
GO:0009617response to bacterium-IDA7717395  
GO:0010628positive regulation of gene expression-ISS-  
GO:0015707nitrite transport-ISS-  
GO:0019730antimicrobial humoral response-TAS-  
GO:0032147activation of protein kinase activity-ISS-  
GO:0032496response to lipopolysaccharide-ISS-  
GO:0032623interleukin-2 production-ISS-  
GO:0032632interleukin-3 production-ISS-  
GO:0032729positive regulation of interferon-gamma production-ISS-  
GO:0034341response to interferon-gamma-ISS-  
GO:0042060wound healing-ISS-  
GO:0042116macrophage activation-ISS-  
GO:0042742defense response to bacterium-ISS-  
GO:0042832defense response to protozoan-ISS-  
GO:0043312neutrophil degranulation-TAS-  
GO:0045342MHC class II biosynthetic process-ISS-  
GO:0045454cell redox homeostasis-TAS-  
GO:0045730respiratory burst-ISS-  
GO:0045944positive regulation of transcription by RNA polymerase II-ISS-  
GO:0048002antigen processing and presentation of peptide antigen-ISS-  
GO:0048255mRNA stabilization-ISS-  
GO:0050766positive regulation of phagocytosis-ISS-  
GO:0050829defense response to Gram-negative bacterium-ISS-  
GO:0055072iron ion homeostasis-ISS-  
GO:0060586multicellular organismal iron ion homeostasis-ISS-  
GO:0070574cadmium ion transmembrane transport-IGI17932044  
GO:0070839divalent metal ion export-ISS17932044  
GO:0071421manganese ion transmembrane transport-IEA-  
GO:1902023L-arginine transport-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005764lysosome-ISS-  
GO:0005770late endosome-ISS-  
GO:0005886plasma membrane-IMP17932044  
GO:0005886plasma membrane-TAS-  
GO:0005887integral component of plasma membrane-NAS8537108  
GO:0030670phagocytic vesicle membrane-IDA12070036  
GO:0031902late endosome membrane-TAS-  
GO:0070821tertiary granule membrane-IDA12070036  
GO:0070821tertiary granule membrane-TAS-  
GO:0101003ficolin-1-rich granule membrane-TAS-  
KEGG ID KEGG Term
hsa04142Lysosome
Reactome ID Reactome Term Evidence
R-HSA-1222556ROS, RNS production in phagocytesTAS
R-HSA-168249Innate Immune SystemTAS
R-HSA-168256Immune SystemTAS
R-HSA-382551Transport of small moleculesTAS
R-HSA-425366Transport of bile salts and organic acids, metal ions and amine compoundsTAS
R-HSA-425407SLC-mediated transmembrane transportTAS
R-HSA-425410Metal ion SLC transportersTAS
R-HSA-6798695Neutrophil degranulationTAS
R-HSA-6803157Antimicrobial peptidesTAS
R-HSA-6803544Ion influx/efflux at host-pathogen interfaceTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
17223386Genetic polymorphisms in alveolar macrophage response-related genes, and risk of silicosis and pulmonary tuberculosis in Chinese iron miners. (2007 Dec)Qu YInt J Hyg Environ Health