Gene: SLC14A1

6563
HUT11|HsT1341|JK|RACH1|RACH2|UT-B1|UT1|UTE
solute carrier family 14 member 1 (Kidd blood group)
protein-coding
18q12.3
Ensembl:ENSG00000141469 MIM:613868 Vega:OTTHUMG00000132617 UniprotKB:Q13336
NG_011775.3
PubMed
0   ANCO-SNPs
ND|AD
5   
NA (AD)  NA (ND)   (Frontal_Cortex)
6.758e-1 (AD)  5.531e-2 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
PAPLN0.861
HIF3A0.837
ACACB0.824
PLIN50.796
ITGB40.795
ETNPPL0.788
GJA10.781
SDC40.774
COLCA20.773
METTL7A0.764

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
PNOC-0.513
LBH-0.462
KCNS3-0.452
LGI2-0.446
LAMB3-0.436
TC2N-0.432
TRPC3-0.432
PTGIS-0.426
TMEM52B-0.425
CRHBP-0.42

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB03904UreaSmall Molecule57-13-6Approved|InvestigationalTransporter
ID Drug Name Action PubMed
C5486512-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in increased expression of SLC14A1 mRNA19933214
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of SLC14A1 mRNA"21346803
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in increased expression of SLC14A1 mRNA"23196670
C030686acetamideSLC14A1 protein affects the transport of acetamide17506977
D020106AcrylamideAcrylamide inhibits the reaction [SLC14A1 protein affects the transport of Urea]17506977
D020106AcrylamideSLC14A1 protein affects the transport of Acrylamide17506977
D016604Aflatoxin B1Aflatoxin B1 results in increased methylation of SLC14A1 gene27153756
D000643Ammonium ChlorideAmmonium Chloride affects the expression of SLC14A1 mRNA16483693
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of SLC14A1 mRNA20106945
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide affects the expression of SLC14A1 mRNA"20382639
D004958EstradiolEstradiol results in decreased expression of SLC14A1 mRNA20106945
D004958Estradiol[Progesterone co-treated with Estradiol] results in decreased expression of SLC14A1 mRNA17404688
C006780bisphenol Abisphenol A results in decreased expression of SLC14A1 mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of SLC14A1 gene28505145
C070766carbamic acidSLC14A1 protein affects the transport of carbamic acid17506977
C019289carbohydrazideSLC14A1 protein affects the transport of carbohydrazide17506977
D002251Carbon TetrachlorideCarbon Tetrachloride affects the expression of SLC14A1 mRNA12734012
D002330CarmustineSLC14A1 mRNA affects the susceptibility to Carmustine16365179
D0027314-Chloromercuribenzenesulfonate4-Chloromercuribenzenesulfonate inhibits the reaction [SLC14A1 protein results in increased transport of Urea]9019665
C012843cinnamic aldehydecinnamic aldehyde results in increased expression of SLC14A1 mRNA19524605
D003042CocaineCocaine affects the expression of SLC14A1 mRNA20187946
D003471CuprizoneCuprizone results in increased expression of SLC14A1 mRNA27523638
D016572CyclosporineCyclosporine results in decreased expression of SLC14A1 mRNA20106945
D004237DiuronDiuron results in decreased expression of SLC14A1 mRNA25152437
D004237DiuronDiuron results in increased expression of SLC14A1 mRNA21551480
C031066formamideSLC14A1 protein affects the transport of formamide17506977
C069837fullerene C60fullerene C60 results in decreased expression of SLC14A1 mRNA19167457
C053956glycolamideSLC14A1 protein affects the transport of glycolamide17506977
D006918HydroxyureaSLC14A1 protein results in increased uptake of Hydroxyurea21256917
D006918HydroxyureaSLC14A1 protein affects the transport of Hydroxyurea17506977
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of SLC14A1 mRNA26752646
D008558MelphalanMelphalan results in decreased expression of SLC14A1 mRNA22363485
D017669Mercury CompoundsMercury Compounds inhibits the reaction [SLC14A1 protein results in increased transport of Urea]8982255
C002950methylformamidemethylformamide inhibits the reaction [SLC14A1 protein affects the transport of Urea]17506977
C002950methylformamideSLC14A1 protein affects the transport of methylformamide17506977
C008493methylselenic acidmethylselenic acid results in increased expression of SLC14A1 mRNA18548127
C002352methylureamethylurea inhibits the reaction [SLC14A1 protein affects the transport of Urea]17506977
C002352methylureaSLC14A1 protein affects the transport of methylurea17506977
D008782Methylurea CompoundsMethylurea Compounds analog inhibits the reaction [SLC14A1 protein affects the transport of Urea]17506977
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of SLC14A1 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of SLC14A1 mRNA"25554681
D009532NickelNickel results in decreased expression of SLC14A1 mRNA24768652|2558310
C028007nickel monoxidenickel monoxide results in decreased expression of SLC14A1 mRNA19167457
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in decreased expression of SLC14A1 mRNA25729387
C030110oxaliplatinoxaliplatin results in decreased expression of SLC14A1 mRNA25729387
C046012pentanalpentanal results in increased expression of SLC14A1 mRNA26079696
D010634PhenobarbitalPhenobarbital results in decreased expression of SLC14A1 mRNA19084549
D010693PhloretinPhloretin inhibits the reaction [SLC14A1 protein results in increased transport of Urea]9019665
D010693PhloretinPhloretin inhibits the reaction [SLC14A1 protein results in increased transport of Urea]8982255
D011374Progesterone[Progesterone co-treated with Estradiol] results in decreased expression of SLC14A1 mRNA17404688
D011374ProgesteroneProgesterone results in decreased expression of SLC14A1 mRNA17404688|2179573
D011374ProgesteroneProgesterone results in decreased expression of SLC14A1 mRNA22238285
C005556propionaldehydepropionaldehyde results in increased expression of SLC14A1 mRNA26079696
D011441PropylthiouracilPropylthiouracil results in increased expression of SLC14A1 mRNA24780913
D018038Sodium SeleniteSodium Selenite results in decreased expression of SLC14A1 mRNA18175754
C047246temozolomideSLC14A1 mRNA affects the susceptibility to temozolomide16365179
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of SLC14A1 mRNA11007951|2010694
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of SLC14A1 mRNA21570461
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of SLC14A1 mRNA18691609|1993321
D013890ThioureaThiourea inhibits the reaction [SLC14A1 protein affects the transport of Urea]17506977
C009495titanium dioxidetitanium dioxide results in increased expression of SLC14A1 mRNA23557971
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in decreased expression of SLC14A1 mRNA25729387
D019772TopotecanTopotecan results in decreased expression of SLC14A1 mRNA25729387
D014508Urea4-Chloromercuribenzenesulfonate inhibits the reaction [SLC14A1 protein results in increased transport of Urea]9019665
D014508UreaPhloretin inhibits the reaction [SLC14A1 protein results in increased transport of Urea]9019665
D014508UreaSLC14A1 protein results in increased transport of Urea9019665
D014508UreaAcrylamide inhibits the reaction [SLC14A1 protein affects the transport of Urea]17506977
D014508Ureamethylformamide inhibits the reaction [SLC14A1 protein affects the transport of Urea]17506977
D014508UreaMethylurea Compounds analog inhibits the reaction [SLC14A1 protein affects the transport of Urea]17506977
D014508Ureamethylurea inhibits the reaction [SLC14A1 protein affects the transport of Urea]17506977
D014508UreaSLC14A1 protein affects the transport of Urea17506977
D014508UreaThiourea inhibits the reaction [SLC14A1 protein affects the transport of Urea]17506977
D014508UreaMercury Compounds inhibits the reaction [SLC14A1 protein results in increased transport of Urea]8982255
D014508UreaPhloretin inhibits the reaction [SLC14A1 protein results in increased transport of Urea]8982255
D014508UreaSLC14A1 protein results in increased transport of Urea8982255
C088658zoledronic acidzoledronic acid results in decreased expression of SLC14A1 mRNA24714768

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005372water transmembrane transporter activity-IEA-  
GO:0015204urea transmembrane transporter activity-TAS-  
GO:0015265urea channel activity-IDA19865084  
GO ID GO Term Qualifier Evidence PubMed
GO:0006833water transport-IEA-  
GO:0015840urea transport-TAS7989337  
GO:0055085transmembrane transport-TAS-  
GO:0071918urea transmembrane transport-IDA19865084  
GO ID GO Term Qualifier Evidence PubMed
GO:0005730nucleolus-IDA-  
GO:0005886plasma membrane-TAS-  
GO:0005887integral component of plasma membrane-IDA19865084  
GO:0016323basolateral plasma membrane-IEA-  
GO:0043231intracellular membrane-bounded organelle-IDA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-382551Transport of small moleculesTAS
R-HSA-425366Transport of bile salts and organic acids, metal ions and amine compoundsTAS
R-HSA-425407SLC-mediated transmembrane transportTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
25218484Replicative study of GWAS TP63C/T, TERTC/T, and SLC14A1C/T with susceptibility to bladder cancer in North Indians. (2014 Nov)Singh VUrol Oncol
28696897Polymorphisms of xenobiotic metabolizing enzymes in bladder cancer patients of the Semmelweis University Budapest, Hungary. (2017)Ebbinghaus DJ Toxicol Environ Health A
29028944Identification and replication of the interplay of four genetic high-risk variants for urinary bladder cancer. (2017 Dec 7)Selinski SCarcinogenesis
21824976A genome-wide association study of bladder cancer identifies a new susceptibility locus within SLC14A1, a urea transporter gene on chromosome 18q12.3. (2011 Nov 1)Garcia-Closas MHum Mol Genet
23981442Stress-response pathways are altered in the hippocampus of chronic alcoholics. (2013 Nov)McClintick JNAlcohol