Gene: SLC18A1

6570
CGAT|VAT1|VMAT1
solute carrier family 18 member A1
protein-coding
8p21.3
Ensembl:ENSG00000036565 MIM:193002 Vega:OTTHUMG00000097017 UniprotKB:P54219
NC_000008.11
PubMed
0   ANCO-SNPs
AD
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
5.143e-1 (AD)  5.699e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
DPPA40.753
GADL10.738
MROH50.726
GSDMA0.712
RNF170.701
SUCNR10.701
FER1L60.695
ALX30.685
COL15A10.676
C2orf830.671

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
TM7SF2-0.436
C1orf53-0.433
ASPDH-0.421
PLA2G6-0.419
CYP46A1-0.414
HDAC11-0.413
FUT9-0.41
NDP-0.403
HHATL-0.403
ABCB9-0.401

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00206ReserpineSmall Molecule50-55-5Approved|InvestigationalTarget
DB00368NorepinephrineSmall Molecule51-41-2ApprovedTarget
DB01363EphedraSmall Molecule-Approved|Nutraceutical|WithdrawnTarget
DB01442MMDASmall Molecule13674-05-0Experimental|IllicitTarget
DB01577MethamphetamineSmall Molecule537-46-2Approved|IllicitTarget
ID Drug Name Action PubMed
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in decreased expression of SLC18A1 mRNA"18648102
D000643Ammonium ChlorideAmmonium Chloride affects the expression of SLC18A1 mRNA16483693
D004958Estradiol[bisphenol A co-treated with Estradiol] results in increased expression of SLC18A1 mRNA26496021
C044887beta-methylcholinebeta-methylcholine affects the expression of SLC18A1 mRNA21179406
C006780bisphenol A[bisphenol A co-treated with Estradiol] results in increased expression of SLC18A1 mRNA26496021
C006780bisphenol Abisphenol A results in decreased expression of SLC18A1 mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of SLC18A1 gene28505145
D002713Chlorine[Ozone co-treated with Chlorine] results in increased expression of SLC18A1 mRNA18636392
D004390ChlorpyrifosChlorpyrifos affects the expression of SLC18A1 mRNA18812211|1883540
D003300CopperCopper deficiency results in increased expression of SLC18A1 mRNA26033743
D003976DiazinonDiazinon results in decreased expression of SLC18A1 mRNA18812211|1883540
D003999Dichloroacetic AcidDichloroacetic Acid results in increased expression of SLC18A1 mRNA28962523
D004026DieldrinDieldrin results in decreased expression of SLC18A1 mRNA18812211|1883540
D019422Dietary SucroseDietary Sucrose results in increased expression of SLC18A1 mRNA26033743
D004298DopamineDopamine inhibits the reaction [SLC18A1 protein results in increased uptake of Serotonin]8245983
C039281furanfuran results in increased expression of SLC18A1 mRNA27387713
D005839GentamicinsGentamicins results in decreased expression of SLC18A1 mRNA22061828
C412815GW 4064GW 4064 results in increased expression of SLC18A1 mRNA26655953
D006632HistamineHistamine inhibits the reaction [SLC18A1 protein results in increased uptake of Serotonin]8245983
D012701Serotonin1-Methyl-4-phenylpyridinium inhibits the reaction [SLC18A1 protein results in increased uptake of Serotonin]8245983
D012701SerotoninDopamine inhibits the reaction [SLC18A1 protein results in increased uptake of Serotonin]8245983
D012701SerotoninHistamine inhibits the reaction [SLC18A1 protein results in increased uptake of Serotonin]8245983
D012701SerotoninNorepinephrine inhibits the reaction [SLC18A1 protein results in increased uptake of Serotonin]8245983
D012701Serotoninphenethylamine inhibits the reaction [SLC18A1 protein results in increased uptake of Serotonin]8245983
D012701SerotoninReserpine inhibits the reaction [SLC18A1 protein results in increased uptake of Serotonin]8245983
D012701SerotoninSLC18A1 protein results in increased uptake of Serotonin8245983
D012701SerotoninTetrabenazine inhibits the reaction [SLC18A1 protein results in increased uptake of Serotonin]8245983
D007476IonophoresIonophores results in decreased activity of SLC18A1 protein21712771
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of SLC18A1 mRNA23430699
C008261lead acetatelead acetate results in decreased expression of SLC18A1 mRNA22641619
D0156551-Methyl-4-phenylpyridinium1-Methyl-4-phenylpyridinium inhibits the reaction [SLC18A1 protein results in increased uptake of Serotonin]8245983
D0156551-Methyl-4-phenylpyridiniumU 0126 affects the reaction [1-Methyl-4-phenylpyridinium affects the expression of SLC18A1 mRNA]12710931
C495860naphthol AS-E phosphatenaphthol AS-E phosphate results in decreased expression of SLC18A1 mRNA25150140
D009532NickelNickel results in increased expression of SLC18A1 mRNA18812211|1883540
D009638NorepinephrineNorepinephrine inhibits the reaction [SLC18A1 protein results in increased uptake of Serotonin]8245983
D010126Ozone[Ozone co-treated with Chlorine] results in increased expression of SLC18A1 mRNA18636392
C029261phenethylaminephenethylamine inhibits the reaction [SLC18A1 protein results in increased uptake of Serotonin]8245983
C006253pirinixic acidpirinixic acid results in increased expression of SLC18A1 mRNA23811191
D010936Plant ExtractsPlant Extracts results in decreased expression of SLC18A1 mRNA23557933
C005556propionaldehydepropionaldehyde results in decreased expression of SLC18A1 mRNA26079696
D011441PropylthiouracilPropylthiouracil results in decreased expression of SLC18A1 mRNA24780913
D012110ReserpineReserpine inhibits the reaction [SLC18A1 protein results in increased uptake of Serotonin]8245983
D012110ReserpineReserpine results in decreased activity of SLC18A1 protein21712771
D012110ReserpineReserpine results in decreased activity of SLC18A1 protein10332097|1724488
D012964SodiumSodium results in increased expression of SLC18A1 mRNA17244889
D012964SodiumSodium results in increased expression of SLC18A1 protein17244889
D013747TetrabenazineTetrabenazine inhibits the reaction [SLC18A1 protein results in increased uptake of Serotonin]8245983
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of SLC18A1 mRNA21570461|2637764
C012589trichostatin Atrichostatin A results in decreased expression of SLC18A1 mRNA15901671
C113580U 0126U 0126 affects the reaction [1-Methyl-4-phenylpyridinium affects the expression of SLC18A1 mRNA]12710931
D014635Valproic AcidValproic Acid results in decreased expression of SLC18A1 mRNA15901671
D014640VancomycinVancomycin results in increased expression of SLC18A1 mRNA18930951
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of SLC18A1 gene25560391
C029297vinylidene chloridevinylidene chloride results in decreased expression of SLC18A1 mRNA26682919
D015034Zinc OxideZinc Oxide analog results in decreased expression of SLC18A1 mRNA27215404
D019287Zinc SulfateZinc Sulfate results in decreased expression of SLC18A1 mRNA27215404

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0008504monoamine transmembrane transporter activity-IBA21873635  
GO:0008504monoamine transmembrane transporter activity-TAS8643547  
GO:0015222serotonin transmembrane transporter activity-IBA21873635  
GO:0015238drug transmembrane transporter activity-IEA-  
GO:0022857transmembrane transporter activity-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0006836neurotransmitter transport-IBA21873635  
GO:0006837serotonin transport-IEA-  
GO:0006855drug transmembrane transport-IEA-  
GO:0015842aminergic neurotransmitter loading into synaptic vesicle-IBA21873635  
GO:0015844monoamine transport-TAS8643547  
GO ID GO Term Qualifier Evidence PubMed
GO:0005789endoplasmic reticulum membrane-IEA-  
GO:0030054cell junction-IEA-  
GO:0030672synaptic vesicle membrane-IBA21873635  
GO:0030672synaptic vesicle membrane-IEA-  
GO:0043195terminal bouton-IBA21873635  
GO:0070083clathrin-sculpted monoamine transport vesicle membrane-TAS-  
KEGG ID KEGG Term
hsa05012Parkinson's disease
Reactome ID Reactome Term Evidence
R-HSA-382551Transport of small moleculesTAS
R-HSA-425366Transport of bile salts and organic acids, metal ions and amine compoundsTAS
R-HSA-425407SLC-mediated transmembrane transportTAS
R-HSA-442660Na+/Cl- dependent neurotransmitter transportersTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
26368063Resting-state functional connectivity and presynaptic monoamine signaling in Alcohol Dependence. (2015 Dec)Zhu XHum Brain Mapp
26876819Genetic Variation in the Vesicular Monoamine Transporter 1 (VMAT1/SLC18A1) Gene and Alcohol Withdrawal Severity. (2016 Mar)Dutta NAlcohol Clin Exp Res