Gene: SLC18A2

6571
SVAT|SVMT|VAT2|VMAT2
solute carrier family 18 member A2
protein-coding
10q25.3
Ensembl:ENSG00000165646 MIM:193001 Vega:OTTHUMG00000019121 UniprotKB:Q05940
NC_000010.11
PubMed
0   ANCO-SNPs
CD|ND|AD
8   
2.302e-1 (AD)  7.114e-1 (ND)   (Frontal_Cortex)
9.140e-1 (AD)  5.387e-2 (ND)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg15806304chr10:119000083SLC18A22.200e-8Smoking27651444

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SPAST0.805
CBX30.796
HBS1L0.79
ECHDC10.787
VPS26A0.785
UBE2G10.785
BNIP3L0.784
ARMC10.782
PSMC60.781
RNF140.779

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F29-0.487
OR4F5-0.473
EYA2-0.319
ADAMTSL5-0.307
WDR38-0.283
FOXJ1-0.279
SIX5-0.279
NXNL1-0.272
EVC2-0.269
NKAIN3-0.267

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00182AmphetamineSmall Molecule300-62-9Approved|Illicit|InvestigationalTarget
DB00206ReserpineSmall Molecule50-55-5Approved|InvestigationalTarget
DB00368NorepinephrineSmall Molecule51-41-2ApprovedTarget
DB00502HaloperidolSmall Molecule52-86-8ApprovedTarget
DB00579MazindolSmall Molecule22232-71-9Approved|InvestigationalTarget
DB00865BenzphetamineSmall Molecule156-08-1Approved|IllicitTarget
DB00988DopamineSmall Molecule51-61-6ApprovedTarget
DB01089DeserpidineSmall Molecule131-01-1ApprovedTarget
DB01363EphedraSmall Molecule-Approved|Nutraceutical|WithdrawnTarget
DB01364EphedrineSmall Molecule299-42-3ApprovedTarget
DB01442MMDASmall Molecule13674-05-0Experimental|IllicitTarget
DB01454MidomafetamineSmall Molecule42542-10-9Experimental|Illicit|InvestigationalTarget
DB014724-MethoxyamphetamineSmall Molecule64-13-1Experimental|IllicitTarget
DB01576DextroamphetamineSmall Molecule51-64-9Approved|IllicitTarget
DB01577MethamphetamineSmall Molecule537-46-2Approved|IllicitTarget
DB04821NomifensineSmall Molecule24526-64-5WithdrawnTarget
DB04844TetrabenazineSmall Molecule58-46-8Approved|InvestigationalTarget
DB05381HistamineSmall Molecule51-45-6Approved|InvestigationalTarget
DB06706IsomethepteneSmall Molecule503-01-5ApprovedTarget
DB06714PropylhexedrineSmall Molecule101-40-6ApprovedTarget
DB08839SerotoninSmall Molecule50-67-9Investigational|NutraceuticalTarget
DB09363Rauwolfia serpentina rootSmall Molecule8063-17-0InvestigationalTarget
DB12161DeutetrabenazineSmall Molecule1392826-25-3Approved|InvestigationalTarget
ID Drug Name Action PubMed
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in decreased expression of SLC18A2 mRNA"28903501
C0297902,2',3',4,4',5-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of SLC18A2 mRNA"25510870
C0329042,2',3,5',6-pentachlorobiphenyl"2,2',3,5',6-pentachlorobiphenyl results in increased expression of SLC18A2 mRNA"29233657
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in increased expression of SLC18A2 mRNA"27291303
C0817662,4,4'-trichlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of SLC18A2 mRNA"25510870
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of SLC18A2 mRNA"25510870
C0098282,4,5,2',5'-pentachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of SLC18A2 mRNA"25510870
C0094072,5,2',5'-tetrachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of SLC18A2 mRNA"25510870
C5555592,5-di-(2-phenethyl)pyrrolidine"2,5-di-(2-phenethyl)pyrrolidine results in decreased activity of SLC18A2 protein"20805303
C0087454,4'-bisphenol F"4,4'-bisphenol F results in increased expression of SLC18A2 mRNA"26186136
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SLC18A2 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SLC18A2 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SLC18A2 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SLC18A2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SLC18A2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SLC18A2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SLC18A2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SLC18A2 mRNA"27188386
D000082AcetaminophenAcetaminophen results in increased expression of SLC18A2 mRNA26690555
D020106AcrylamideAcrylamide results in decreased expression of SLC18A225943760
D000393Air PollutantsAir Pollutants results in decreased expression of SLC18A2 mRNA25056781
D000395Air Pollutants, Occupational"Air Pollutants, Occupational results in decreased expression of SLC18A2 mRNA"20224926
D019386AlendronateAlendronate affects the expression of SLC18A2 mRNA16079270
C006486amfonelic acidSLC18A2 protein affects the susceptibility to amfonelic acid12716422
D000643Ammonium ChlorideAmmonium Chloride affects the expression of SLC18A2 mRNA16483693
D003913DextroamphetamineDextroamphetamine binds to SLC18A2 protein7912402
D003913DextroamphetamineSLC18A2 protein affects the susceptibility to Dextroamphetamine12716422
D000661AmphetamineAmphetamine results in decreased expression of SLC18A2 protein11731100
D000661AmphetamineSOD1 protein inhibits the reaction [Amphetamine results in decreased expression of SLC18A2 protein]11731100
D001104ArbutinArbutin results in decreased expression of SLC18A2 mRNA17103032
C026987aroclor 1260aroclor 1260 results in decreased expression of SLC18A2 protein15019086
D001280AtrazineAtrazine results in decreased expression of SLC18A2 mRNA24552878|2486396
D001280AtrazineAtrazine results in decreased expression of SLC18A2 protein24863964|2834157
D001280AtrazineAtrazine results in increased expression of SLC18A2 mRNA23123945
D0123692H-Benzo(a)quinolizin-2-ol, 2-Ethyl-1,3,4,6,7,11b-hexahydro-3-isobutyl-9,10-dimethoxy-"2H-Benzo(a)quinolizin-2-ol, 2-Ethyl-1,3,4,6,7,11b-hexahydro-3-isobutyl-9,10-dimethoxy- results in decreased activity of SLC18A2 protein"25370842
D004958Estradiol"Estradiol inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased activity of SLC18A2 protein]"16011487
D004958Estradiol"Estradiol inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of SLC18A2 protein]"16011487
C006780bisphenol Abisphenol A results in decreased expression of SLC18A2 mRNA25181051
C006780bisphenol Abisphenol A results in increased expression of SLC18A2 mRNA26186136
D002220CarbamazepineCarbamazepine affects the expression of SLC18A2 mRNA25979313
D002259Carbonyl Cyanide p-TrifluoromethoxyphenylhydrazoneCarbonyl Cyanide p-Trifluoromethoxyphenylhydrazone inhibits the reaction [SLC18A2 protein results in increased uptake of Serotonin]1438304
D002392Catechin[Catechin co-treated with Grape Seed Proanthocyanidins] results in decreased expression of SLC18A2 mRNA24763279
D000068579CelecoxibCelecoxib results in decreased expression of SLC18A2 mRNA28201806
D004390ChlorpyrifosChlorpyrifos affects the expression of SLC18A2 mRNA18812211|1883540
D004390ChlorpyrifosChlorpyrifos results in increased expression of SLC18A2 mRNA17452286
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of SLC18A2 gene20938992
D003024ClozapineClozapine results in increased expression of SLC18A2 mRNA12007678
D003024ClozapineClozapine results in increased expression of SLC18A2 protein12007678
D003042CocaineCocaine results in decreased expression of SLC18A2 protein12505801
D003042CocaineSLC18A2 protein affects the susceptibility to Cocaine12716422
D003042CocaineCocaine results in increased expression of SLC18A2 protein25100957
C037304cyhalothrincyhalothrin results in decreased expression of SLC18A2 protein28495607
C017160cypermethrincypermethrin results in decreased expression of SLC18A2 mRNA20815782
D003634DDTDDT inhibits the reaction [SLC18A2 protein results in increased uptake of Dopamine]18533268
C010902decabromobiphenyl etherdecabromobiphenyl ether results in increased expression of SLC18A2 mRNA23640034
D003907DexamethasoneDexamethasone results in increased expression of SLC18A2 mRNA12782123
D003976DiazinonDiazinon affects the expression of SLC18A2 mRNA17452286
D003976DiazinonDiazinon results in decreased expression of SLC18A2 mRNA18812211|1883540
D003632DichlorodiphenyldichloroethaneDichlorodiphenyldichloroethane inhibits the reaction [SLC18A2 protein results in increased uptake of Dopamine]18533268
D004026DieldrinDieldrin results in increased expression of SLC18A2 mRNA16809432
D004026DieldrinDieldrin results in increased expression of SLC18A2 protein16809432
D004041Dietary FatsDietary Fats results in decreased expression of SLC18A2 mRNA25016146
D004077DigoxinABCB1 gene mutant form affects the reaction [Digoxin affects the expression of SLC18A2 mRNA]25419811
C032811dihydrotetrabenazineSLC18A2 protein binds to dihydrotetrabenazine18287335
D002117CalcitriolCalcitriol inhibits the reaction [VDR protein results in increased expression of SLC18A2 mRNA]27450565
D004298DopamineSLC18A2 protein alternative form affects the transport of Dopamine15849736
D004298DopamineDopamine binds to SLC18A2 protein7912402
D004298DopamineDopamine results in decreased activity of SLC18A2 protein15475732
D004298DopamineHeptachlor Epoxide inhibits the reaction [SLC18A2 protein results in increased uptake of Dopamine]10499361
D004298DopamineDDT inhibits the reaction [SLC18A2 protein results in increased uptake of Dopamine]18533268
D004298DopamineDichlorodiphenyldichloroethane inhibits the reaction [SLC18A2 protein results in increased uptake of Dopamine]18533268
D004298DopamineSLC18A2 protein affects the transport of and affects the abundance of Dopamine27287315
D004298DopamineSLC18A2 protein results in increased uptake of Dopamine18533268
D004298DopamineDopamine inhibits the reaction [SLC18A2 protein results in increased uptake of Serotonin]1438304
D004298DopamineSLC18A2 results in decreased abundance of Dopamine19409267
C084101doramectinABCB1 gene mutant form affects the reaction [doramectin affects the expression of SLC18A2 mRNA]25419811
C118739entinostatentinostat results in increased expression of SLC18A2 mRNA26272509|2718838
C118739entinostat"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SLC18A2 mRNA"27188386
D004970Estrone"Estrone inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of SLC18A2 protein]"16011487
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of SLC18A2 mRNA16079270
D005231Fatty Acids, Unsaturated"Fatty Acids, Unsaturated deficiency results in decreased expression of SLC18A2 mRNA"11916751
D005492Folic AcidFolic Acid results in decreased expression of SLC18A2 mRNA25006883
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of SLC18A2 gene20938992
D005557FormaldehydeFormaldehyde results in decreased expression of SLC18A2 mRNA12679049
C511402Grape Seed Proanthocyanidins[Catechin co-treated with Grape Seed Proanthocyanidins] results in decreased expression of SLC18A2 mRNA24763279
D006220HaloperidolHaloperidol binds to SLC18A2 protein7912402
D006533HeptachlorHeptachlor results in decreased activity of SLC18A2 protein alternative form15849736
D006533HeptachlorHeptachlor results in increased expression of SLC18A2 mRNA18577399
D006533HeptachlorHeptachlor results in increased expression of SLC18A2 protein10499361|1611232
D006534Heptachlor EpoxideHeptachlor Epoxide inhibits the reaction [SLC18A2 protein results in increased uptake of Dopamine]10499361
D006540HerbicidesHerbicides results in decreased expression of SLC18A2 mRNA23123945
C089796hexabromocyclododecanehexabromocyclododecane results in decreased expression of SLC18A2 protein26073293|2821474
D006632HistamineSLC18A2 protein alternative form affects the transport of Histamine15849736
D006632HistamineHistamine binds to SLC18A2 protein7912402
D006632HistamineRabeprazole promotes the reaction [SLC18A2 protein results in increased secretion of Histamine]14642791
D006632HistamineSLC18A2 protein results in increased secretion of Histamine14642791
D012701SerotoninSLC18A2 protein alternative form affects the transport of Serotonin15849736
D012701SerotoninSerotonin binds to SLC18A2 protein7912402
D012701SerotoninSLC18A2 gene SNP affects the uptake of Serotonin15475732
D012701SerotoninCarbonyl Cyanide p-Trifluoromethoxyphenylhydrazone inhibits the reaction [SLC18A2 protein results in increased uptake of Serotonin]1438304
D012701SerotoninDopamine inhibits the reaction [SLC18A2 protein results in increased uptake of Serotonin]1438304
D012701SerotoninNorepinephrine inhibits the reaction [SLC18A2 protein results in increased uptake of Serotonin]1438304
D012701SerotoninReserpine inhibits the reaction [SLC18A2 protein results in increased uptake of Serotonin]1438304|18287335
D012701SerotoninSerotonin inhibits the reaction [SLC18A2 protein binds to Reserpine]9038139
D012701SerotoninSerotonin inhibits the reaction [SLC18A2 protein results in increased uptake of Serotonin]1438304
D012701SerotoninSLC18A2 protein binds to Serotonin9038139
D012701SerotoninSLC18A2 protein results in increased transport of Serotonin9038139
D012701SerotoninSLC18A2 protein results in increased uptake of Serotonin1438304|18287335
D012701SerotoninTetrabenazine inhibits the reaction [SLC18A2 protein results in increased uptake of Serotonin]1438304
D012701Serotonintributyltin inhibits the reaction [SLC18A2 protein results in increased uptake of Serotonin]1438304
D012701SerotoninValinomycin promotes the reaction [SLC18A2 protein results in increased uptake of Serotonin]18287335
D007213IndomethacinIndomethacin results in decreased expression of SLC18A2 mRNA28201806
D007559IvermectinABCB1 gene mutant form affects the reaction [Ivermectin affects the expression of SLC18A2 mRNA]25419811
C544151jinfukangjinfukang results in decreased expression of SLC18A2 mRNA27392435
D007654KetoconazoleKetoconazole inhibits the reaction [Maneb results in decreased expression of SLC18A2 protein]22334051
D007654KetoconazoleKetoconazole inhibits the reaction [Paraquat results in decreased expression of SLC18A2 protein]22334051
D007840LatexLatex analog results in decreased expression of SLC18A2 mRNA24768652
C008261lead acetatelead acetate results in decreased expression of SLC18A2 mRNA22613225
C045463leflunomideleflunomide results in decreased expression of SLC18A2 mRNA28988120
D008344ManebKetoconazole inhibits the reaction [Maneb results in decreased expression of SLC18A2 protein]22334051
D008344ManebManeb results in decreased expression of SLC18A2 protein22334051
D008344ManebMelatonin inhibits the reaction [[Paraquat co-treated with Maneb] results in decreased expression of SLC18A2 mRNA]20964710
D008344Maneb[Paraquat co-treated with Maneb] results in decreased expression of SLC18A2 mRNA18386188|2096471
D008344ManebSilymarin inhibits the reaction [[Paraquat co-treated with Maneb] results in decreased expression of SLC18A2 mRNA]20964710
D008345ManganeseManganese results in decreased expression of SLC18A2 mRNA20224926
D008454MazindolMazindol binds to SLC18A2 protein7912402
D008550MelatoninMelatonin inhibits the reaction [[Paraquat co-treated with Maneb] results in decreased expression of SLC18A2 mRNA]20964710
C042720mercuric bromidemercuric bromide results in decreased expression of SLC18A2 mRNA26272509
C042720mercuric bromide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SLC18A2 mRNA"27188386
D008628MercuryMercury analog results in decreased expression of SLC18A2 mRNA25056781
D008694MethamphetamineMethamphetamine results in decreased expression of SLC18A2 protein10958525
D008694MethamphetamineMethamphetamine results in decreased expression of SLC18A2 protein16518646|1662271
D008694MethamphetamineMethamphetamine results in decreased expression of SLC18A2 protein22512859
D008694MethamphetaminePRKCD protein affects the reaction [Methamphetamine results in decreased expression of SLC18A2 protein]22512859
D008694Methamphetamine[rottlerin results in decreased activity of PRKCD protein] inhibits the reaction [Methamphetamine results in decreased expression of SLC18A2 protein]22512859
D008694MethamphetamineSLC18A2 protein affects the susceptibility to Methamphetamine12050851
D008694MethamphetamineSLC18A2 protein results in decreased susceptibility to Methamphetamine18643795
D008694MethamphetamineMethamphetamine affects the localization of SLC18A2 protein17683483
D008694MethamphetamineMethamphetamine results in decreased activity of SLC18A2 protein17683483|1932656
D008694MethamphetamineMethamphetamine results in decreased expression of SLC18A2 protein17683483|1768604
D008694MethamphetamineMethamphetamine results in increased nitrosation of SLC18A2 protein17683483
D008694MethamphetamineS-methylthiocitrulline inhibits the reaction [Methamphetamine results in decreased activity of SLC18A2 protein]17683483
D008694MethamphetamineS-methylthiocitrulline inhibits the reaction [Methamphetamine results in decreased expression of SLC18A2 protein]17683483
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of SLC18A2 gene20938992
D008731MethoxychlorMethoxychlor results in decreased expression of SLC18A2 protein19459224
D008767Methylmercury CompoundsMethylmercury Compounds results in increased expression of SLC18A2 mRNA26558463
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of SLC18A2 mRNA"20188158
D008774MethylphenidateMethylphenidate results in decreased expression of SLC18A2 mRNA22470460
D0156551-Methyl-4-phenylpyridinium1-Methyl-4-phenylpyridinium results in increased expression of SLC18A2 mRNA26558463
D0156551-Methyl-4-phenylpyridiniumSLC18A2 protein results in decreased susceptibility to 1-Methyl-4-phenylpyridinium18287335
D0156321-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine"[1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine co-treated with Probenecid] results in decreased expression of SLC18A2 protein"19653878
D0156321-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine"1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased activity of SLC18A2 protein"16011487
D0156321-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine"1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of SLC18A2 mRNA"16011487
D0156321-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine"1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of SLC18A2 protein"23747572|2837711
D0156321-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine"Estradiol inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased activity of SLC18A2 protein]"16011487
D0156321-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine"Estradiol inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of SLC18A2 protein]"16011487
D0156321-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine"Estrone inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of SLC18A2 protein]"16011487
D0156321-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine"SLC18A2 protein affects the susceptibility to 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine"27287315
D0156321-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine"telmisartan inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of SLC18A2 protein]"23747572
C027837milbemycinABCB1 gene mutant form affects the reaction [milbemycin affects the expression of SLC18A2 mRNA]25419811
D005677G(M1) GangliosideG(M1) Ganglioside results in increased expression of SLC18A2 mRNA14552908
D009627NomifensineNomifensine binds to SLC18A2 protein7912402
D009638NorepinephrineNorepinephrine binds to SLC18A2 protein7912402
D009638NorepinephrineNorepinephrine results in decreased activity of SLC18A2 protein15475732
D009638NorepinephrineNorepinephrine inhibits the reaction [SLC18A2 protein results in increased uptake of Serotonin]1438304
D009655OctopamineSLC18A2 protein alternative form affects the transport of Octopamine15849736
D016627OxidopamineOxidopamine results in decreased expression of SLC18A2 mRNA17803225
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in increased expression of SLC18A2 mRNA25729387
D010269ParaquatKetoconazole inhibits the reaction [Paraquat results in decreased expression of SLC18A2 protein]22334051
D010269ParaquatMelatonin inhibits the reaction [[Paraquat co-treated with Maneb] results in decreased expression of SLC18A2 mRNA]20964710
D010269Paraquat[Paraquat co-treated with Maneb] results in decreased expression of SLC18A2 mRNA18386188|2096471
D010269ParaquatParaquat results in decreased expression of SLC18A2 protein22334051
D010269ParaquatSilymarin inhibits the reaction [[Paraquat co-treated with Maneb] results in decreased expression of SLC18A2 mRNA]20964710
D010269ParaquatParaquat promotes the reaction [Zinc Sulfate results in decreased expression of SLC18A2 mRNA]20553223
D010269ParaquatParaquat promotes the reaction [Zinc Sulfate results in decreased expression of SLC18A2 protein]20553223
D010269ParaquatParaquat results in decreased expression of SLC18A2 mRNA20553223
D010269ParaquatParaquat results in decreased expression of SLC18A2 protein20553223
D010269ParaquatZinc Sulfate promotes the reaction [Paraquat results in decreased expression of SLC18A2 mRNA]20553223
D010269ParaquatZinc Sulfate promotes the reaction [Paraquat results in decreased expression of SLC18A2 protein]20553223
C410127PCB 180"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of SLC18A2 mRNA"25510870
C086401pentabromodiphenyl etherpentabromodiphenyl ether results in decreased expression of SLC18A2 protein23916505
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SLC18A2 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in decreased expression of SLC18A2 mRNA26272509
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of SLC18A2 mRNA19710929
D011078Polychlorinated BiphenylsPolychlorinated Biphenyls analog results in decreased activity of SLC18A2 protein alternative form15849736
D011189Potassium ChloridePotassium Chloride results in increased expression of SLC18A2 mRNA7902299
D045542PQQ CofactorPQQ Cofactor inhibits the reaction [Rotenone results in decreased expression of SLC18A2 protein]26276080
D011339Probenecid"[1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine co-treated with Probenecid] results in decreased expression of SLC18A2 protein"19653878
D011441PropylthiouracilPropylthiouracil affects the expression of SLC18A2 mRNA24780913
C432165pyrazolanthronepyrazolanthrone inhibits the reaction [Rotenone results in decreased activity of SLC18A2 protein]25496994
D019257QuinpiroleSLC18A2 protein affects the susceptibility to Quinpirole12716422
D064750RabeprazoleRabeprazole promotes the reaction [SLC18A2 protein results in increased secretion of Histamine]14642791
D020849Raloxifene HydrochlorideRaloxifene Hydrochloride affects the expression of SLC18A2 mRNA16079270
D012110ReserpineReserpine binds to SLC18A2 protein1357668
D012110ReserpineReserpine results in decreased activity of SLC18A2 protein alternative form15849736
D012110ReserpineReserpine binds to SLC18A2 protein7912402
D012110ReserpineReserpine results in decreased activity of SLC18A2 protein15475732
D012110ReserpineSLC18A2 gene SNP results in decreased susceptibility to Reserpine15475732
D012110ReserpineSLC18A2 affects the susceptibility to Reserpine17664021
D012110ReserpineReserpine inhibits the reaction [SLC18A2 protein results in increased uptake of Serotonin]1438304|18287335
D012110ReserpineReserpine results in increased expression of SLC18A2 mRNA8189248
D012110ReserpineSerotonin inhibits the reaction [SLC18A2 protein binds to Reserpine]9038139
D012110ReserpineSLC18A2 protein binds to Reserpine9038139
D012110ReserpineReserpine results in decreased activity of SLC18A2 protein10332097|1656736
D012402Rotenonepyrazolanthrone inhibits the reaction [Rotenone results in decreased activity of SLC18A2 protein]25496994
D012402RotenoneRotenone results in decreased activity of SLC18A2 protein25496994
D012402RotenonePQQ Cofactor inhibits the reaction [Rotenone results in decreased expression of SLC18A2 protein]26276080
D012402RotenoneRotenone results in decreased expression of SLC18A2 protein18579341|2627608
D012402RotenoneSLC18A2 protein affects the susceptibility to Rotenone21383081
C085746rottlerin[rottlerin results in decreased activity of PRKCD protein] inhibits the reaction [Methamphetamine results in decreased expression of SLC18A2 protein]22512859
C541923sandostatinLARsandostatinLAR results in decreased expression of SLC18A2 mRNA17210224
D012834SilverSilver results in decreased expression of SLC18A2 mRNA27131904
D012838SilymarinSilymarin inhibits the reaction [[Paraquat co-treated with Maneb] results in decreased expression of SLC18A2 mRNA]20964710
C086717S-methylthiocitrullineS-methylthiocitrulline inhibits the reaction [Methamphetamine results in decreased activity of SLC18A2 protein]17683483
C086717S-methylthiocitrullineS-methylthiocitrulline inhibits the reaction [Methamphetamine results in decreased expression of SLC18A2 protein]17683483
D012906SmokeSmoke affects the expression of SLC18A2 mRNA23693141
C017947sodium arsenite[sodium arsenite affects the localization of NR4A2 protein] inhibits the reaction [NR4A2 protein results in increased expression of SLC18A2 mRNA]23283970
C017947sodium arsenitesodium arsenite results in decreased expression of SLC18A2 mRNA23283970
C084178telmisartan"telmisartan inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of SLC18A2 protein]"23747572
D013747TetrabenazineTetrabenazine binds to SLC18A2 protein7912402
D013747TetrabenazineTetrabenazine results in decreased activity of SLC18A2 protein15475732
D013747TetrabenazineTetrabenazine results in decreased activity of SLC18A2 protein19616025
D013747TetrabenazineTetrabenazine inhibits the reaction [SLC18A2 protein results in increased uptake of Serotonin]1438304
D013747TetrabenazineTetrabenazine results in decreased activity of SLC18A2 protein10332097|1724488
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of SLC18A2 mRNA26377647
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with TIPARP gene mutant form] results in increased expression of SLC18A2 mRNA25975270
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of SLC18A2 mRNA21889950|2597527
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in increased expression of SLC18A2 mRNA25729387
D019772TopotecanTopotecan results in increased expression of SLC18A2 mRNA25729387
C011559tributyltintributyltin inhibits the reaction [SLC18A2 protein results in increased uptake of Serotonin]1438304
C012589trichostatin Atrichostatin A results in increased expression of SLC18A2 mRNA24935251
D014439TyramineSLC18A2 protein alternative form affects the transport of Tyramine15849736
D014634ValinomycinValinomycin promotes the reaction [SLC18A2 protein results in increased uptake of Serotonin]18287335
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SLC18A2 mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of SLC18A2 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased methylation of SLC18A2 gene29154799
D014635Valproic AcidValproic Acid results in increased expression of SLC18A2 mRNA24383497|2493525
C043425vanoxerinevanoxerine binds to SLC18A2 protein7912402
D001335Vehicle EmissionsVehicle Emissions affects the methylation of SLC18A2 gene25560391
D015034Zinc OxideZinc Oxide analog results in decreased expression of SLC18A2 mRNA27215404
D019287Zinc SulfateZinc Sulfate results in decreased expression of SLC18A2 mRNA27215404
D019287Zinc SulfateParaquat promotes the reaction [Zinc Sulfate results in decreased expression of SLC18A2 mRNA]20553223
D019287Zinc SulfateParaquat promotes the reaction [Zinc Sulfate results in decreased expression of SLC18A2 protein]20553223
D019287Zinc SulfateZinc Sulfate promotes the reaction [Paraquat results in decreased expression of SLC18A2 mRNA]20553223
D019287Zinc SulfateZinc Sulfate promotes the reaction [Paraquat results in decreased expression of SLC18A2 protein]20553223
D019287Zinc SulfateZinc Sulfate results in decreased expression of SLC18A2 mRNA20553223
D019287Zinc SulfateZinc Sulfate results in decreased expression of SLC18A2 protein20553223

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0008504monoamine transmembrane transporter activity-IBA21873635  
GO:0008504monoamine transmembrane transporter activity-TAS-  
GO:0015222serotonin transmembrane transporter activity-IBA21873635  
GO:0022857transmembrane transporter activity-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0001975response to amphetamine-IEA-  
GO:0006836neurotransmitter transport-IBA21873635  
GO:0006837serotonin transport-IEA-  
GO:0007268chemical synaptic transmission-TAS15217342  
GO:0007269neurotransmitter secretion-TAS-  
GO:0007626locomotory behavior-IEA-  
GO:0009791post-embryonic development-IEA-  
GO:0015842aminergic neurotransmitter loading into synaptic vesicle-IBA21873635  
GO:0015844monoamine transport-TAS8095030  
GO:0015872dopamine transport-TAS21563316  
GO:0042137sequestering of neurotransmitter-NAS24252804  
GO:0055085transmembrane transport-IEA-  
GO:0098700neurotransmitter loading into synaptic vesicle-TAS21563316  
GO:1903427negative regulation of reactive oxygen species biosynthetic process-NAS24252804  
GO ID GO Term Qualifier Evidence PubMed
GO:0005886plasma membrane-TAS-  
GO:0005887integral component of plasma membrane-TAS8095030  
GO:0008021synaptic vesicle-TAS21563316  
GO:0016020membrane-TAS8095030  
GO:0030672synaptic vesicle membrane-IBA21873635  
GO:0043195terminal bouton-IBA21873635  
GO:0070083clathrin-sculpted monoamine transport vesicle membrane-TAS-  
KEGG ID KEGG Term
hsa05012Parkinson's disease
Reactome ID Reactome Term Evidence
R-HSA-112310Neurotransmitter release cycleTAS
R-HSA-112315Transmission across Chemical SynapsesTAS
R-HSA-112316Neuronal SystemTAS
R-HSA-181429Serotonin Neurotransmitter Release CycleTAS
R-HSA-181430Norepinephrine Neurotransmitter Release CycleTAS
R-HSA-212676Dopamine Neurotransmitter Release CycleTAS
R-HSA-382551Transport of small moleculesTAS
R-HSA-425366Transport of bile salts and organic acids, metal ions and amine compoundsTAS
R-HSA-425407SLC-mediated transmembrane transportTAS
R-HSA-442660Na+/Cl- dependent neurotransmitter transportersTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
15988470Association of DNA polymorphisms in the synaptic vesicular amine transporter gene (SLC18A2) with alcohol and nicotine dependence. (2005 Dec)Schwab SGNeuropsychopharmacology
26227246Susceptibility loci for heroin and cocaine addiction in the serotonergic and adrenergic pathways in populations of different ancestry. (2015)Levran OPharmacogenomics
26447226Influence of Dopaminergic System Genetic Variation and Lifestyle Factors on Excessive Alcohol Consumption. (2016 May)Celorrio DAlcohol Alcohol
16340454Autosomal linkage analysis for the level of response to alcohol. (2005 Nov)Schuckit MAAlcohol Clin Exp Res
21083670Limited associations of dopamine system genes with alcohol dependence and related traits in the Irish Affected Sib Pair Study of Alcohol Dependence (IASPSAD). (2011 Feb)Hack LMAlcohol Clin Exp Res
20181938High regulatability favors genetic selection in SLC18A2, a vesicular monoamine transporter essential for life. (2010 Jul)Lin ZFASEB J
15048644Candidate genes for nicotine dependence via linkage, epistasis, and bioinformatics. (2004 Apr 1)Sullivan PFAm J Med Genet B Neuropsychiatr Genet
15829504SLC18A2 promoter haplotypes and identification of a novel protective factor against alcoholism. (2005 May 15)Lin ZHum Mol Genet