Gene: SLC18A3

6572
CMS21|VACHT
solute carrier family 18 member A3
protein-coding
10q11.23
Ensembl:ENSG00000187714 MIM:600336 Vega:OTTHUMG00000018196 UniprotKB:Q16572
NG_053144.1
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
6.645e-1 (AD)  5.545e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
DGKK0.969
SLC35D30.953
GPR1010.947
LHX80.944
AMBN0.941
SAG0.929
ENTHD10.922
DRD30.92
PRLR0.916
CHAT0.915

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SLC17A7-0.508
SYTL2-0.438
NEUROD2-0.425
SOHLH1-0.392
TNNT2-0.389
TESPA1-0.379
GALNT9-0.378
NXPH3-0.376
TBR1-0.374
EMX1-0.344

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0352074-amino-2,6-dinitrotoluene"4-amino-2,6-dinitrotoluene affects the expression of SLC18A3 mRNA"21346803
D000643Ammonium ChlorideAmmonium Chloride affects the expression of SLC18A3 mRNA16483693
D001280AtrazineAtrazine results in decreased expression of SLC18A3 mRNA25929836
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of SLC18A3 mRNA21839799
C006780bisphenol Abisphenol A results in decreased expression of SLC18A3 mRNA25181051
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of SLC18A3 mRNA16644059
C010063carbonyl sulfidecarbonyl sulfide results in decreased expression of SLC18A3 mRNA19395590
D004390ChlorpyrifosChlorpyrifos results in increased expression of SLC18A3 mRNA18812211
D003976DiazinonDiazinon results in increased expression of SLC18A3 mRNA18812211
D003994BucladesineBucladesine results in increased expression of SLC18A3 protein20361958
D003994BucladesineNicotine promotes the reaction [Bucladesine results in increased expression of SLC18A3 protein]20361958
C036042dicyclohexyl phthalatedicyclohexyl phthalate affects the expression of SLC18A3 mRNA26924002
D004026DieldrinDieldrin affects the expression of SLC18A3 mRNA18812211
D005419FlavonoidsFlavonoids results in increased expression of SLC18A3 mRNA18035473
D019833GenisteinGenistein results in increased expression of SLC18A3 mRNA15901920
C049863ginsenoside Rdginsenoside Rd results in increased expression of SLC18A3 mRNA24599032
C049864ginsenoside Reginsenoside Re results in increased expression of SLC18A3 mRNA24599032
C008261lead acetatelead acetate results in decreased expression of SLC18A3 protein27492863
D009151Mustard GasMustard Gas results in increased expression of SLC18A3 mRNA15674843
D009532NickelNickel results in decreased expression of SLC18A3 mRNA18812211
D009538NicotineNicotine inhibits the reaction [Vanadium results in decreased expression of SLC18A3 protein]22119111
D009538NicotineNicotine promotes the reaction [Bucladesine results in increased expression of SLC18A3 protein]20361958
D010100OxygenOxygen deficiency results in increased expression of SLC18A3 mRNA25937560
D010100OxygenTrimetazidine promotes the reaction [Oxygen deficiency results in increased expression of SLC18A3 mRNA]25937560
D010830PhysostigminePhysostigmine results in increased expression of SLC18A3 protein22640809
D011441PropylthiouracilPropylthiouracil results in decreased expression of SLC18A3 mRNA24780913
D020849Raloxifene Hydrochloride[Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of SLC18A3 mRNA19059307
D012524SarinSarin results in decreased expression of SLC18A3 protein22640809
C061133tamibarotenetamibarotene results in increased expression of SLC18A3 mRNA20138974
D013629Tamoxifen[Tamoxifen co-treated with ESR2 protein] results in decreased expression of SLC18A3 mRNA19059307
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of SLC18A3 mRNA21570461
D014292TrimetazidineTrimetazidine promotes the reaction [Oxygen deficiency results in increased expression of SLC18A3 mRNA]25937560
C005460uranyl acetateuranyl acetate results in decreased expression of SLC18A3 mRNA19409444
D014635Valproic AcidValproic Acid affects the expression of SLC18A3 mRNA25979313
D014639VanadiumNicotine inhibits the reaction [Vanadium results in decreased expression of SLC18A3 protein]22119111
D014639VanadiumVanadium results in decreased expression of SLC18A3 protein22119111

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005277acetylcholine transmembrane transporter activity-IBA21873635  
GO:0005277acetylcholine transmembrane transporter activity-TAS-  
GO:0022857transmembrane transporter activity-IBA21873635  
GO:0042166acetylcholine binding-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0006855drug transmembrane transport-IEA-  
GO:0007268chemical synaptic transmission-IBA21873635  
GO:0007269neurotransmitter secretion-TAS-  
GO:0015695organic cation transport-IEA-  
GO:0061024membrane organization-TAS-  
GO:0072488ammonium transmembrane transport-IEA-  
GO:1901374acetate ester transport-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005886plasma membrane-TAS-  
GO:0016021integral component of membrane-IEA-  
GO:0030121AP-1 adaptor complex-IBA21873635  
GO:0030122AP-2 adaptor complex-IBA21873635  
GO:0030665clathrin-coated vesicle membrane-TAS-  
GO:0043195terminal bouton-IBA21873635  
GO:0060201clathrin-sculpted acetylcholine transport vesicle membrane-TAS-  
GO:0098793presynapse-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-112310Neurotransmitter release cycleTAS
R-HSA-112315Transmission across Chemical SynapsesTAS
R-HSA-112316Neuronal SystemTAS
R-HSA-199991Membrane TraffickingTAS
R-HSA-264642Acetylcholine Neurotransmitter Release CycleTAS
R-HSA-5653656Vesicle-mediated transportTAS
R-HSA-8856825Cargo recognition for clathrin-mediated endocytosisTAS
R-HSA-8856828Clathrin-mediated endocytosisTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
23222296Inhibition of cholinergic signaling causes apoptosis in human bronchioalveolar carcinoma. (2013 Feb 15)Lau JKCancer Res