Gene: SLC19A1

6573
CHMD|FOLT|IFC-1|IFC1|REFC|RFC|RFC1
solute carrier family 19 member 1
protein-coding
21q22.3
Ensembl:ENSG00000173638 MIM:600424 Vega:OTTHUMG00000090397 UniprotKB:P41440
NG_028278.2
PubMed
0   ANCO-SNPs
ND
4   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.598e-1 (AD)  9.572e-1 (ND)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg21279603chr21:46963527SLC19A1Promoter7.255e-5Alcohol use disorders26763658
cg03721454chr21:46961395SLC19A1Promoter6.067e-4Alcohol use disorders26763658
cg21279603chr21:46963527SLC19A18.400e-8Smoking27651444

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
COL5A30.736
SLC6A120.709
ADAM330.68
RGS110.672
ISYNA10.663
PLEC0.66
TPCN20.651
SLC6A130.645
AGRN0.644
COL9A10.639

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.43
OR4F29-0.397
GRHL3-0.333
GSC-0.318
IRX2-0.313
APOL4-0.311
MARCH3-0.31
MTHFD2-0.303
CRNDE-0.298
S100A3-0.295

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00563MethotrexateSmall Molecule59-05-2ApprovedTransporter
DB06813PralatrexateSmall Molecule146464-95-1Approved|InvestigationalTransporter
DB11256Levomefolic acidSmall Molecule31690-09-2Approved|InvestigationalTransporter
DB00507NitazoxanideSmall Molecule55981-09-4Approved|InvestigationalCarrier
ID Drug Name Action PubMed
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene inhibits the reaction [SLC19A1 protein results in increased uptake of Methotrexate]"17482559
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in decreased activity of SLC19A1 protein"17482559
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"bisindolylmaleimide inhibits the reaction [1,4-bis(2-(3,5-dichloropyridyloxy))benzene inhibits the reaction [SLC19A1 protein results in increased uptake of Methotrexate]]"17482559
C5321622-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine"[PIK3CA gene mutant form results in increased susceptibility to 2-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine] which results in decreased expression of SLC19A1 mRNA"20453058
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of SLC19A1 mRNA"21346803
C0352074-amino-2,6-dinitrotoluene"4-amino-2,6-dinitrotoluene affects the expression of SLC19A1 mRNA"21346803
C0303715,6,7,8-tetrahydrofolic acid"5,6,7,8-tetrahydrofolic acid inhibits the reaction [SLC19A1 protein affects the transport of Methotrexate]"14612385
C0303715,6,7,8-tetrahydrofolic acid"5,6,7,8-tetrahydrofolic acid results in decreased activity of SLC19A1 protein"14612385
C0059845-methyltetrahydrofolate[5-methyltetrahydrofolate results in decreased activity of SLC19A1 protein] which results in decreased uptake of Folic Acid17034785
C0059845-methyltetrahydrofolate5-methyltetrahydrofolate inhibits the reaction [SLC19A1 protein affects the transport of Methotrexate]14612385
C0059845-methyltetrahydrofolate5-methyltetrahydrofolate results in decreased activity of SLC19A1 protein14612385
D0128564-Acetamido-4'-isothiocyanatostilbene-2,2'-disulfonic Acid"[4-Acetamido-4'-isothiocyanatostilbene-2,2'-disulfonic Acid results in decreased activity of SLC19A1 protein] which results in decreased uptake of Folic Acid"17034785
D000082AcetaminophenAcetaminophen results in decreased expression of SLC19A1 mRNA29067470
D000082AcetaminophenAcetaminophen affects the expression of SLC19A1 mRNA17562736
D012435S-AdenosylhomocysteineSLC19A1 protein affects the abundance of S-Adenosylhomocysteine15705887
D012436S-AdenosylmethionineSLC19A1 protein affects the abundance of S-Adenosylmethionine15705887
D019386AlendronateAlendronate affects the expression of SLC19A1 mRNA16079270
D000535Aluminum[APP protein modified form binds to Aluminum] which results in increased expression of SLC19A1 mRNA21298039
D000643Ammonium ChlorideAmmonium Chloride affects the expression of SLC19A1 mRNA16483693
D018501Antirheumatic AgentsAntirheumatic Agents results in increased expression of SLC19A1 mRNA24449571
D018501Antirheumatic AgentsSLC19A1 gene polymorphism results in increased susceptibility to Antirheumatic Agents18322994
D018501Antirheumatic AgentsSLC19A1 protein affects the susceptibility to Antirheumatic Agents18322994
D001151ArsenicArsenic affects the methylation of SLC19A1 gene25304211
C000606252ARV-825ARV-825 deficiency affects the reaction [ARV-825 results in decreased expression of SLC19A1 protein]26051217
C000606252ARV-825ARV-825 results in decreased expression of SLC19A1 protein26051217
D001262AtenololAtenolol results in decreased expression of SLC19A1 mRNA19616087
D001280AtrazineAtrazine results in decreased expression of SLC19A1 mRNA22378314
D001397AzoxymethaneSLC19A1 gene mutant form results in increased susceptibility to Azoxymethane15705887
D004958EstradiolEstradiol results in increased expression of SLC19A1 mRNA23019147
C504663BGC638BGC638 binds to and results in decreased activity of SLC19A1 protein16357184
C504663BGC638BGC638 binds to and results in decreased activity of SLC19A1 protein16357184
C504662BGC945BGC945 binds to and results in decreased activity of SLC19A1 protein16357184
C504662BGC945BGC945 binds to and results in decreased activity of SLC19A1 protein16357184
C088060bisindolylmaleimide"bisindolylmaleimide inhibits the reaction [1,4-bis(2-(3,5-dichloropyridyloxy))benzene inhibits the reaction [SLC19A1 protein results in increased uptake of Methotrexate]]"17482559
C088060bisindolylmaleimidebisindolylmaleimide inhibits the reaction [Phenobarbital inhibits the reaction [SLC19A1 protein results in increased uptake of Methotrexate]]17482559
C088060bisindolylmaleimidebisindolylmaleimide inhibits the reaction [Tetradecanoylphorbol Acetate inhibits the reaction [SLC19A1 protein results in increased uptake of Methotrexate]]17482559
C006780bisphenol Abisphenol A affects the expression of SLC19A1 mRNA21786754
C006780bisphenol Abisphenol A results in decreased expression of SLC19A1 mRNA29275510
C006780bisphenol Abisphenol A affects the expression of SLC19A1 mRNA25181051
D002034BumetanideBumetanide inhibits the reaction [SLC19A1 protein affects the transport of Methotrexate]14612385
D002034BumetanideBumetanide results in decreased activity of SLC19A1 protein14612385
C584509C646 compoundC646 compound results in decreased expression of SLC19A1 mRNA26191083
D002220CarbamazepineCarbamazepine affects the expression of SLC19A1 mRNA24752500
D002220CarbamazepineCarbamazepine inhibits the reaction [SLC19A1 protein results in increased uptake of Methotrexate]17482559|2173757
D002220CarbamazepineCarbamazepine results in decreased activity of SLC19A1 protein17482559
D002220CarbamazepineCarbamazepine results in decreased expression of SLC19A1 protein21737571
D002220Carbamazepine[Carbamazepine results in decreased expression of SLC19A1 protein] which results in decreased transport of Methotrexate21737571
D002746ChlorpromazineChlorpromazine inhibits the reaction [SLC19A1 protein results in increased uptake of Methotrexate]17482559
D002746ChlorpromazineChlorpromazine results in decreased activity of SLC19A1 protein17482559
D020355CholatesCholates inhibits the reaction [SLC19A1 protein affects the transport of Methotrexate]14612385
D020355CholatesCholates results in decreased activity of SLC19A1 protein14612385
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of SLC19A1 gene20938992
D002922CiguatoxinsCiguatoxins affects the expression of SLC19A1 mRNA18353800
D002994ClofibrateClofibrate results in increased expression of SLC19A1 mRNA23811191
D003022ClotrimazoleClotrimazole inhibits the reaction [SLC19A1 protein results in increased uptake of Methotrexate]17482559
D003022ClotrimazoleClotrimazole results in decreased activity of SLC19A1 protein17482559
C018021cobaltous chloridecobaltous chloride results in decreased expression of SLC19A1 mRNA19320972
D003300Copper[NSC 689534 binds to Copper] which results in decreased expression of SLC19A1 mRNA20971185
D019327Copper SulfateCopper Sulfate results in decreased expression of SLC19A1 mRNA19549813
D016572CyclosporineCyclosporine results in increased expression of SLC19A1 mRNA19770486
C014347decitabinedecitabine results in increased expression of SLC19A1 mRNA11509559
D013759DronabinolDronabinol results in decreased expression of SLC19A1 mRNA19616087
D003976DiazinonDiazinon results in increased methylation of SLC19A1 gene22964155
C041517dibenzo(a,l)pyrene"dibenzo(a,l)pyrene results in decreased expression of SLC19A1 mRNA"25908611
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in increased expression of SLC19A1 mRNA27392435
D004008DiclofenacDiclofenac affects the expression of SLC19A1 mRNA24752500
C036042dicyclohexyl phthalatedicyclohexyl phthalate affects the expression of SLC19A1 mRNA26924002
C010920dihydrofolatedihydrofolate inhibits the reaction [SLC19A1 protein affects the transport of Methotrexate]14612385
C010920dihydrofolatedihydrofolate results in decreased activity of SLC19A1 protein14612385
D0178784,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid"[4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid results in decreased activity of SLC19A1 protein] which results in decreased uptake of Folic Acid"17034785
C024629dimethyl phthalatedimethyl phthalate results in increased expression of SLC19A1 mRNA26924002
D004785Environmental PollutantsEnvironmental Pollutants affects the expression of SLC19A1 mRNA19118595
D000431EthanolEthanol results in decreased expression of SLC19A1 mRNA19616087
D000431EthanolEthanol results in increased expression of SLC19A1 protein17449590
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of SLC19A1 mRNA17942748
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of SLC19A1 mRNA17942748
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of SLC19A1 mRNA16079270
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of SLC19A1 mRNA17108234
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in decreased expression of SLC19A1 mRNA23649840
C082360fipronilfipronil results in decreased expression of SLC19A1 mRNA23962444
D005419FlavonoidsFlavonoids results in increased expression of SLC19A1 mRNA18035473
D005492Folic Acid"[4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid results in decreased activity of SLC19A1 protein] which results in decreased uptake of Folic Acid"17034785
D005492Folic Acid"[4-Acetamido-4'-isothiocyanatostilbene-2,2'-disulfonic Acid results in decreased activity of SLC19A1 protein] which results in decreased uptake of Folic Acid"17034785
D005492Folic Acid[5-methyltetrahydrofolate results in decreased activity of SLC19A1 protein] which results in decreased uptake of Folic Acid17034785
D005492Folic AcidFolic Acid affects the expression of SLC19A1 mRNA17311948
D005492Folic AcidFolic Acid deficiency results in decreased expression of SLC19A1 mRNA18499665|2046599
D005492Folic AcidFolic Acid deficiency results in decreased expression of SLC19A1 protein18499665
D005492Folic AcidFolic Acid deficiency results in increased expression of SLC19A1 mRNA18623116
D005492Folic AcidFolic Acid results in decreased expression of SLC19A1 mRNA17616776
D005492Folic AcidFolic Acid results in decreased expression of SLC19A1 protein17616776
D005492Folic Acid[Indomethacin results in decreased activity of SLC19A1 protein] which results in decreased uptake of Folic Acid17034785
D005492Folic Acid[Methotrexate results in decreased activity of SLC19A1 protein] which results in decreased uptake of Folic Acid17034785
D005492Folic AcidSLC19A1 gene SNP affects the abundance of Folic Acid17325736
D005492Folic AcidSLC19A1 gene SNP affects the uptake of and affects the localization of Folic Acid16750224
D005492Folic AcidSLC19A1 protein results in increased uptake of Folic Acid16900951
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of SLC19A1 gene20938992
D005492Folic AcidSLC19A1 protein affects the uptake of Folic Acid16495369
D005492Folic AcidSLC19A1 protein results in increased transport of Folic Acid17616776
D005557FormaldehydeFormaldehyde results in decreased expression of SLC19A1 mRNA23649840
D002955LeucovorinLeucovorin inhibits the reaction [SLC19A1 protein results in increased transport of Methotrexate]21879757
C039281furanfuran results in increased methylation of SLC19A1 gene22079235
D019833GenisteinGenistein results in increased expression of SLC19A1 mRNA23019147
D006861Hydrogen PeroxideHydrogen Peroxide affects the expression of SLC19A1 mRNA20044591
C492448ICG 001ICG 001 results in decreased expression of SLC19A1 mRNA26191083
D007213Indomethacin[Indomethacin results in decreased activity of SLC19A1 protein] which results in decreased uptake of Folic Acid17034785
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of SLC19A1 mRNA25613284
C051890irinotecanirinotecan analog results in decreased expression of SLC19A1 mRNA18927307
C544151jinfukang[Cisplatin co-treated with jinfukang] results in increased expression of SLC19A1 mRNA27392435
C544151jinfukangjinfukang results in increased expression of SLC19A1 mRNA27392435
C561695(+)-JQ1 compound(+)-JQ1 compound deficiency inhibits the reaction [(+)-JQ1 compound results in decreased expression of SLC19A1 protein]26051217
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of SLC19A1 mRNA21889194|2379244
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of SLC19A1 protein26051217
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of SLC19A1 mRNA25982114
D008070LipopolysaccharidesCholecalciferol inhibits the reaction [Lipopolysaccharides results in decreased expression of SLC19A1 mRNA]25673501
D008070LipopolysaccharidesLipopolysaccharides results in decreased expression of SLC19A1 mRNA25673501
C045894lometrexollometrexol inhibits the reaction [SLC19A1 protein results in increased transport of Methotrexate]21879757
C045894lometrexolSLC19A1 protein results in increased susceptibility to lometrexol21879757
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of SLC19A1 gene20938992
D008727MethotrexateLeucovorin inhibits the reaction [SLC19A1 protein results in increased transport of Methotrexate]21879757
D008727Methotrexatelometrexol inhibits the reaction [SLC19A1 protein results in increased transport of Methotrexate]21879757
D008727MethotrexateMethotrexate affects the expression of SLC19A1 mRNA23838799
D008727Methotrexate[Methotrexate results in decreased activity of SLC19A1 protein] which results in decreased uptake of Folic Acid17034785
D008727MethotrexateMethotrexate results in decreased expression of SLC19A1 mRNA24736981
D008727MethotrexateMethotrexate results in decreased expression of SLC19A1 protein24736981|2507858
D008727Methotrexate[Methotrexate results in decreased expression of SLC19A1 protein] which results in decreased import of and results in decreased susceptibility to Methotrexate25078587
D008727Methotrexate"N-((5-((2-amino-4-oxo-4,7-dihydro-3H-pyrrolo(2,3-d)pyrimidin-6-yl)propyl)thiophen-2-yl)carbonyl)glutamic acid affects the reaction [SLC19A1 protein results in increased transport of Methotrexate]"21879757
D008727MethotrexatePemetrexed inhibits the reaction [SLC19A1 protein results in increased transport of Methotrexate]21879757
D008727Methotrexateraltitrexed inhibits the reaction [SLC19A1 protein results in increased transport of Methotrexate]21879757
D008727MethotrexateSLC19A1 3' UTR polymorphism affects the transport of Methotrexate24927955
D008727MethotrexateSLC19A1 exon mutant form results in decreased susceptibility to Methotrexate16505119
D008727MethotrexateSLC19A1 gene SNP affects the susceptibility to and affects the abundance of Methotrexate17325736
D008727MethotrexateSLC19A1 gene SNP affects the susceptibility to Methotrexate17410198|2285935
D008727MethotrexateSLC19A1 gene SNP results in increased susceptibility to Methotrexate25124723
D008727MethotrexateSLC19A1 mRNA results in increased susceptibility to Methotrexate19426680
D008727MethotrexateSLC19A1 protein affects the susceptibility to Methotrexate14679136
D008727MethotrexateSLC19A1 protein results in increased susceptibility to Methotrexate11509559
D008727MethotrexateSLC19A1 protein results in increased transport of Methotrexate11509559|2187975
D008727MethotrexateSLC19A1 protein results in increased susceptibility to Methotrexate12396629
D008727Methotrexate"1,4-bis(2-(3,5-dichloropyridyloxy))benzene inhibits the reaction [SLC19A1 protein results in increased uptake of Methotrexate]"17482559
D008727Methotrexate"5,6,7,8-tetrahydrofolic acid inhibits the reaction [SLC19A1 protein affects the transport of Methotrexate]"14612385
D008727Methotrexate5-methyltetrahydrofolate inhibits the reaction [SLC19A1 protein affects the transport of Methotrexate]14612385
D008727Methotrexate"bisindolylmaleimide inhibits the reaction [1,4-bis(2-(3,5-dichloropyridyloxy))benzene inhibits the reaction [SLC19A1 protein results in increased uptake of Methotrexate]]"17482559
D008727Methotrexatebisindolylmaleimide inhibits the reaction [Phenobarbital inhibits the reaction [SLC19A1 protein results in increased uptake of Methotrexate]]17482559
D008727Methotrexatebisindolylmaleimide inhibits the reaction [Tetradecanoylphorbol Acetate inhibits the reaction [SLC19A1 protein results in increased uptake of Methotrexate]]17482559
D008727MethotrexateBumetanide inhibits the reaction [SLC19A1 protein affects the transport of Methotrexate]14612385
D008727MethotrexateCarbamazepine inhibits the reaction [SLC19A1 protein results in increased uptake of Methotrexate]17482559|2173757
D008727Methotrexate[Carbamazepine results in decreased expression of SLC19A1 protein] which results in decreased transport of Methotrexate21737571
D008727MethotrexateChlorpromazine inhibits the reaction [SLC19A1 protein results in increased uptake of Methotrexate]17482559
D008727MethotrexateCholates inhibits the reaction [SLC19A1 protein affects the transport of Methotrexate]14612385
D008727MethotrexateClotrimazole inhibits the reaction [SLC19A1 protein results in increased uptake of Methotrexate]17482559
D008727Methotrexatedihydrofolate inhibits the reaction [SLC19A1 protein affects the transport of Methotrexate]14612385
D008727MethotrexateMethotrexate inhibits the reaction [SLC19A1 protein affects the transport of Methotrexate]14612385
D008727MethotrexateMethotrexate results in decreased activity of SLC19A1 protein14612385
D008727MethotrexateOkadaic Acid inhibits the reaction [SLC19A1 protein results in increased uptake of Methotrexate]17482559
D008727MethotrexatePhenobarbital inhibits the reaction [SLC19A1 protein results in increased uptake of Methotrexate]17482559|2173757
D008727Methotrexate[Phenobarbital results in decreased expression of SLC19A1 protein] which results in decreased transport of Methotrexate21737571
D008727MethotrexateSLC19A1 protein affects the transport of Methotrexate14612385
D008727MethotrexateSLC19A1 protein results in increased susceptibility to Methotrexate14612385
D008727MethotrexateSLC19A1 protein results in increased uptake of Methotrexate17482559|2045154
D008727MethotrexateSulfobromophthalein inhibits the reaction [SLC19A1 protein affects the transport of Methotrexate]14612385
D008727MethotrexateTaurocholic Acid inhibits the reaction [SLC19A1 protein affects the transport of Methotrexate]14612385
D008727MethotrexateTetrachlorodibenzodioxin inhibits the reaction [SLC19A1 protein results in increased uptake of Methotrexate]20451541
D008727MethotrexateTetradecanoylphorbol Acetate inhibits the reaction [SLC19A1 protein results in increased uptake of Methotrexate]17482559
C014085methotrexate polyglutamateSLC19A1 gene SNP affects the abundance of methotrexate polyglutamate17325736
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of SLC19A1 mRNA23649840
C008493methylselenic acidmethylselenic acid results in decreased expression of SLC19A1 mRNA18548127
C517284monomethyl phthalatemonomethyl phthalate affects the expression of SLC19A1 mRNA26924002
C583365N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide"N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide results in increased expression of SLC19A1 mRNA"29244179
C568952N-((5-((2-amino-4-oxo-4,7-dihydro-3H-pyrrolo(2,3-d)pyrimidin-6-yl)propyl)thiophen-2-yl)carbonyl)glutamic acid"N-((5-((2-amino-4-oxo-4,7-dihydro-3H-pyrrolo(2,3-d)pyrimidin-6-yl)propyl)thiophen-2-yl)carbonyl)glutamic acid affects the reaction [SLC19A1 protein results in increased transport of Methotrexate]"21879757
C085590N(alpha)-(4-amino-4-deoxypteroyl)-N(delta)-hemiphthaloyl-L-ornithineSLC19A1 exon mutant form results in decreased susceptibility to N(alpha)-(4-amino-4-deoxypteroyl)-N(delta)-hemiphthaloyl-L-ornithine analog16505119
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of SLC19A1 mRNA"25554681|2562005
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of SLC19A1 mRNA"25554681|2562005
D009538NicotineNicotine results in decreased expression of SLC19A1 mRNA19616087
C558013NSC 689534[NSC 689534 binds to Copper] which results in decreased expression of SLC19A1 mRNA20971185
D019319Okadaic AcidOkadaic Acid inhibits the reaction [SLC19A1 protein results in increased uptake of Methotrexate]17482559
D019319Okadaic AcidOkadaic Acid results in decreased activity of SLC19A1 protein17482559
C000605331OTX015OTX015 deficiency inhibits the reaction [OTX015 results in decreased expression of SLC19A1 protein]26051217
C000605331OTX015OTX015 results in decreased expression of SLC19A1 protein26051217
D010100OxygenOxygen deficiency results in decreased expression of SLC19A1 mRNA26516004
D000068437PemetrexedPemetrexed inhibits the reaction [SLC19A1 protein results in increased transport of Methotrexate]21879757
D000068437PemetrexedSLC19A1 exon mutant form results in increased susceptibility to Pemetrexed16505119
C471071perfluorohexanesulfonic acidperfluorohexanesulfonic acid results in decreased expression of SLC19A1 mRNA22790973
D010634Phenobarbitalbisindolylmaleimide inhibits the reaction [Phenobarbital inhibits the reaction [SLC19A1 protein results in increased uptake of Methotrexate]]17482559
D010634PhenobarbitalPhenobarbital inhibits the reaction [SLC19A1 protein results in increased uptake of Methotrexate]17482559|2173757
D010634PhenobarbitalPhenobarbital results in decreased activity of SLC19A1 protein17482559
D010634PhenobarbitalPhenobarbital results in decreased expression of SLC19A1 protein21737571
D010634Phenobarbital[Phenobarbital results in decreased expression of SLC19A1 protein] which results in decreased transport of Methotrexate21737571
D010936Plant ExtractsPlant Extracts results in decreased expression of SLC19A1 mRNA23557933
C027373potassium chromate(VI)potassium chromate(VI) results in increased expression of SLC19A1 mRNA22714537
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in increased expression of SLC19A1 mRNA28903501
D020849Raloxifene HydrochlorideRaloxifene Hydrochloride affects the expression of SLC19A1 mRNA16079270
C068874raltitrexedraltitrexed inhibits the reaction [SLC19A1 protein results in increased transport of Methotrexate]21879757
C068874raltitrexedSLC19A1 exon mutant form results in decreased susceptibility to raltitrexed16505119
C068874raltitrexedSLC19A1 protein results in increased susceptibility to raltitrexed21879757
D012643SeleniumSelenium results in decreased expression of SLC19A1 mRNA19244175
D013448SulfobromophthaleinSulfobromophthalein inhibits the reaction [SLC19A1 protein affects the transport of Methotrexate]14612385
D013448SulfobromophthaleinSulfobromophthalein results in decreased activity of SLC19A1 protein14612385
D013656Taurocholic AcidTaurocholic Acid inhibits the reaction [SLC19A1 protein affects the transport of Methotrexate]14612385
D013656Taurocholic AcidTaurocholic Acid results in decreased activity of SLC19A1 protein14612385
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of SLC19A1 mRNA21570461
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of SLC19A1 mRNA17942748
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of SLC19A1 mRNA19770486
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin inhibits the reaction [SLC19A1 protein results in increased uptake of Methotrexate]20451541
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased activity of SLC19A1 protein20451541
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of SLC19A1 mRNA20451541
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of SLC19A1 protein20451541
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of SLC19A1 mRNA25613284
D013755Tetradecanoylphorbol Acetatebisindolylmaleimide inhibits the reaction [Tetradecanoylphorbol Acetate inhibits the reaction [SLC19A1 protein results in increased uptake of Methotrexate]]17482559
D013755Tetradecanoylphorbol AcetateTetradecanoylphorbol Acetate inhibits the reaction [SLC19A1 protein results in increased uptake of Methotrexate]17482559
D013755Tetradecanoylphorbol AcetateTetradecanoylphorbol Acetate results in decreased activity of SLC19A1 protein17482559
D014212TretinoinTretinoin results in decreased expression of SLC19A1 mRNA23724009
C012589trichostatin Atrichostatin A results in decreased expression of SLC19A1 mRNA28542535
C015559trimellitic anhydridetrimellitic anhydride results in increased expression of SLC19A1 mRNA19042947
D016597TrimetrexateSLC19A1 protein results in decreased susceptibility to Trimetrexate12396629
C057693troglitazonetroglitazone results in increased expression of SLC19A1 mRNA28973697
D014520UrethaneUrethane results in decreased expression of SLC19A1 mRNA28818685
D014635Valproic AcidValproic Acid results in increased methylation of SLC19A1 gene29154799
D002762CholecalciferolCholecalciferol inhibits the reaction [Lipopolysaccharides results in decreased expression of SLC19A1 mRNA]25673501
D014810Vitamin EVitamin E results in decreased expression of SLC19A1 mRNA19244175

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005542folic acid binding-IBA21873635  
GO:0008517folic acid transmembrane transporter activity-IBA21873635  
GO:0008517folic acid transmembrane transporter activity-ISS-  
GO:0008517folic acid transmembrane transporter activity-TAS-  
GO:0008518folate:anion antiporter activity-IBA21873635  
GO:0008518folate:anion antiporter activity-IDA14609557  
GO:0022857transmembrane transporter activity-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0015884folic acid transport-ISS-  
GO:0046655folic acid metabolic process-TAS-  
GO:0055085transmembrane transport-IBA21873635  
GO:0098838folate transmembrane transport-IBA21873635  
GO:0098838folate transmembrane transport-IDA14609557  
GO ID GO Term Qualifier Evidence PubMed
GO:0005886plasma membrane-IBA21873635  
GO:0005886plasma membrane-TAS-  
GO:0005887integral component of plasma membrane-IEA-  
GO:0016323basolateral plasma membrane-IBA21873635  
GO:0016323basolateral plasma membrane-IDA10787414  
GO:0016324apical plasma membrane-IBA21873635  
GO:0016324apical plasma membrane-IDA10787414  
KEGG ID KEGG Term
hsa04977Vitamin digestion and absorption
Reactome ID Reactome Term Evidence
R-HSA-1430728MetabolismTAS
R-HSA-196757Metabolism of folate and pterinesTAS
R-HSA-196849Metabolism of water-soluble vitamins and cofactorsTAS
R-HSA-196854Metabolism of vitamins and cofactorsTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
21254359Folate pathway and nonsyndromic cleft lip and palate. (2011 Jan)Blanton SHBirth Defects Res A Clin Mol Teratol
23552396Genetic and non-genetic predictors of LINE-1 methylation in leukocyte DNA. (2013 Jun)Tajuddin SMEnviron Health Perspect
22103680Folate network genetic variation, plasma homocysteine, and global genomic methylation content: a genetic association study. (2011 Nov 21)Wernimont SMBMC Med Genet
18635682Genetic analysis of 56 polymorphisms in 17 genes involved in methionine metabolism in patients with abdominal aortic aneurysm. (2008 Nov)Giusti BJ Med Genet