Gene info: ID 6578

Gene: SLCO2A1

GENE ID: 6578

Synonyms: MATR1|OATP2A1|PGT|PHOAR2|SLC21A2

Description: solute carrier organic anion transporter family member 2A1

Gene type: protein-coding

Location: 3q22.1-q22.2

dbXrefs: Ensembl:ENSG00000174640 MIM:601460 Vega:OTTHUMG00000159745 UniprotKB:Q92959

RefSeq: NG_031964.2

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: ND

# Publications: 1

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 3.909e-1 (AD) 7.730e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
SNED1	0.702
DGKA	0.677
TSPAN14	0.651
MYO5C	0.644
LAMB1	0.64
SLC7A6	0.636
MEF2A	0.632
PRKCD	0.63
ATP7B	0.629
IL27RA	0.626

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
SOX3	-0.344
DIAPH3	-0.328
PDE11A	-0.326
BCAS1	-0.314
RFTN2	-0.303
MOBP	-0.299
KLRC2	-0.295
C5orf64	-0.289
SLC27A6	-0.284
LPAR1	-0.283

ID	Drug Name	Drug Type	CAS Num	Status	Role
DB00119	Pyruvic acid	Small Molecule	127-17-3	Approved\|Investigational\|Nutraceutical	Transporter
DB00695	Furosemide	Small Molecule	54-31-9	Approved	Transporter
DB00770	Alprostadil	Small Molecule	745-65-3	Approved\|Investigational	Transporter
DB00917	Dinoprostone	Small Molecule	363-24-6	Approved	Transporter
DB01088	Iloprost	Small Molecule	78919-13-8	Approved\|Investigational	Transporter
DB01160	Dinoprost Tromethamine	Small Molecule	38562-01-5	Approved	Transporter
DB01174	Phenobarbital	Small Molecule	50-06-6	Approved\|Investigational	Transporter
DB01819	Phosphoenolpyruvate	Small Molecule	138-08-9	Experimental	Transporter
DB02056	Prostaglandin D2	Small Molecule	41598-07-6	Investigational	Transporter
DB02263	Glyceraldehyde-3-Phosphate	Small Molecule	142-10-9	Experimental	Transporter
DB03581	Glucose-6-Phosphate	Small Molecule	56-73-5	Experimental	Transporter
DB04398	Lactic Acid	Small Molecule	50-21-5	Approved	Transporter
DB04551	beta-D-fructofuranose 1,6-bisphosphate	Small Molecule		Experimental	Transporter
DB04557	Arachidonic Acid	Small Molecule	506-32-1	Experimental	Transporter

ID	Drug Name	Action	PubMed
C511295	2,2',4,4'-tetrabromodiphenyl ether	"2,2',4,4'-tetrabromodiphenyl ether results in increased expression of SLCO2A1 mRNA"	25614096
C511295	2,2',4,4'-tetrabromodiphenyl ether	"2,2',4,4'-tetrabromodiphenyl ether affects the expression of SLCO2A1 mRNA"	23962555
C029141	2,2,5,7,8-pentamethyl-1-hydroxychroman	"2,2,5,7,8-pentamethyl-1-hydroxychroman results in decreased expression of SLCO2A1 mRNA"	21920950
C111118	2',3,3',4',5-pentachloro-4-hydroxybiphenyl	"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of SLCO2A1 mRNA"	19114083
C016403	2,4-dinitrotoluene	"2,4-dinitrotoluene affects the expression of SLCO2A1 mRNA"	21346803
C023035	3,4,5,3',4'-pentachlorobiphenyl	"3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of SLCO2A1 mRNA"	20959002
D000082	Acetaminophen	Acetaminophen affects the expression of SLCO2A1 mRNA	17562736
D016604	Aflatoxin B1	Aflatoxin B1 results in increased methylation of SLCO2A1 gene	27153756
D016604	Aflatoxin B1	Aflatoxin B1 results in decreased expression of SLCO2A1 mRNA	19770486
D018501	Antirheumatic Agents	Antirheumatic Agents results in decreased expression of SLCO2A1 mRNA	24449571
D001151	Arsenic	Arsenic results in decreased expression of SLCO2A1 mRNA	19654921
D001152	Arsenicals	Arsenicals results in decreased expression of SLCO2A1 mRNA	28625800
C030935	benz(a)anthracene	benz(a)anthracene results in increased expression of SLCO2A1 mRNA	23656968
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of SLCO2A1 mRNA	20106945
D001564	Benzo(a)pyrene	Benzo(a)pyrene affects the expression of SLCO2A1 mRNA	22342234
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of SLCO2A1 mRNA	19770486
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of SLCO2A1 mRNA	22228805
D004958	Estradiol	[Estradiol binds to ESR2 protein] which results in increased expression of SLCO2A1 mRNA	20404318
D004958	Estradiol	[Estradiol co-treated with Progesterone] results in decreased expression of SLCO2A1 mRNA	20660070
D004958	Estradiol	Estradiol results in increased expression of SLCO2A1 mRNA	23019147
C006780	bisphenol A	bisphenol A results in increased expression of SLCO2A1 mRNA	19371625\|2301914
C006780	bisphenol A	bisphenol A results in increased methylation of SLCO2A1 promoter	27312807
C006780	bisphenol A	bisphenol A affects the expression of SLCO2A1 mRNA	25181051
D002251	Carbon Tetrachloride	Carbon Tetrachloride affects the expression of SLCO2A1 mRNA	17484886
D002737	Chloroprene	Chloroprene results in increased expression of SLCO2A1 mRNA	23125180
C074702	chromium hexavalent ion	chromium hexavalent ion affects the expression of SLCO2A1 mRNA	28472532
C019304	ciprofibrate	ciprofibrate results in decreased expression of SLCO2A1 mRNA	15919853
D002994	Clofibrate	Clofibrate results in decreased expression of SLCO2A1 mRNA	15919853
D016572	Cyclosporine	Cyclosporine results in decreased expression of SLCO2A1 mRNA	24907557
C014347	decitabine	decitabine results in increased expression of SLCO2A1 mRNA	23137910
C014347	decitabine	Rifampin inhibits the reaction [decitabine results in increased expression of SLCO2A1 mRNA]	23137910
D003907	Dexamethasone	Dexamethasone results in decreased expression of SLCO2A1 mRNA	15919853
D003976	Diazinon	Diazinon results in increased methylation of SLCO2A1 gene	22964155
D003993	Dibutyl Phthalate	Dibutyl Phthalate results in increased expression of SLCO2A1 mRNA	21266533
D003999	Dichloroacetic Acid	Dichloroacetic Acid results in decreased expression of SLCO2A1 mRNA	28962523
D004008	Diclofenac	Diclofenac inhibits the reaction [SLCO2A1 protein results in increased transport of Dinoprostone]	19843975
C036042	dicyclohexyl phthalate	dicyclohexyl phthalate affects the expression of SLCO2A1 mRNA	26924002
D004041	Dietary Fats	Dietary Fats results in decreased expression of SLCO2A1 mRNA	22609946
D004051	Diethylhexyl Phthalate	Diethylhexyl Phthalate results in decreased expression of SLCO2A1 mRNA	15919853
C014476	diethyl maleate	diethyl maleate results in decreased expression of SLCO2A1 mRNA	21161181
D004052	Diethylnitrosamine	[Diethylnitrosamine co-treated with Phenobarbital] results in decreased expression of SLCO2A1 mRNA	24535843
D004052	Diethylnitrosamine	Diethylnitrosamine results in increased expression of SLCO2A1 mRNA	20360939
C024629	dimethyl phthalate	dimethyl phthalate results in increased expression of SLCO2A1 mRNA	26924002
D005038	Ethylnitrosourea	Ethylnitrosourea results in increased mutagenesis of SLCO2A1 mRNA	27776689
D005472	Fluorouracil	Fluorouracil affects the expression of SLCO2A1 mRNA	16584549
D005485	Flutamide	Flutamide results in decreased expression of SLCO2A1 mRNA	24136188
C069837	fullerene C60	fullerene C60 results in increased expression of SLCO2A1 mRNA	19167457
C039281	furan	furan results in decreased expression of SLCO2A1 mRNA	25539665
D019833	Genistein	Genistein results in increased expression of SLCO2A1 mRNA	19371625\|2301914
D017313	Fenretinide	Fenretinide results in increased expression of SLCO2A1 mRNA	28973697
D006861	Hydrogen Peroxide	Hydrogen Peroxide results in increased expression of SLCO2A1 mRNA	26846883
D007213	Indomethacin	Indomethacin promotes the reaction [SLCO2A1 protein results in increased transport of Dinoprostone]	19843975
D015759	Ionomycin	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of SLCO2A1 mRNA	25613284
C561695	(+)-JQ1 compound	(+)-JQ1 compound results in decreased expression of SLCO2A1 mRNA	24796395
D007660	Ketoprofen	Ketoprofen promotes the reaction [SLCO2A1 protein results in increased transport of Dinoprostone]	19843975
C072042	latanoprost	SLCO2A1 protein results in increased transport of latanoprost metabolite	20019365
C008261	lead acetate	lead acetate results in increased expression of SLCO2A1 mRNA	22641619
C473384	lumiracoxib	lumiracoxib inhibits the reaction [SLCO2A1 protein results in increased transport of Dinoprostone]	19843975
D008727	Methotrexate	Methotrexate results in decreased expression of SLCO2A1 mRNA	17400583
C005219	methyl cellosolve	methyl cellosolve results in increased expression of SLCO2A1 mRNA	21061450
D015735	Mifepristone	Mifepristone promotes the reaction [Progesterone affects the expression of SLCO2A1 mRNA]	22414680
D009288	Naproxen	Naproxen promotes the reaction [SLCO2A1 protein results in increased transport of Dinoprostone]	19843975
C051752	nefazodone	nefazodone results in decreased expression of SLCO2A1 mRNA	24136188
D009538	Nicotine	Nicotine results in increased expression of SLCO2A1 mRNA	23825647
C012655	nimesulide	nimesulide results in decreased expression of SLCO2A1 mRNA	24136188
C016340	o,p'-DDT	"o,p'-DDT results in increased expression of SLCO2A1 mRNA"	19371625
D010126	Ozone	Ozone results in decreased expression of SLCO2A1 mRNA	16716893
D015232	Dinoprostone	Diclofenac inhibits the reaction [SLCO2A1 protein results in increased transport of Dinoprostone]	19843975
D015232	Dinoprostone	Indomethacin promotes the reaction [SLCO2A1 protein results in increased transport of Dinoprostone]	19843975
D015232	Dinoprostone	Ketoprofen promotes the reaction [SLCO2A1 protein results in increased transport of Dinoprostone]	19843975
D015232	Dinoprostone	lumiracoxib inhibits the reaction [SLCO2A1 protein results in increased transport of Dinoprostone]	19843975
D015232	Dinoprostone	Naproxen promotes the reaction [SLCO2A1 protein results in increased transport of Dinoprostone]	19843975
D015232	Dinoprostone	SLCO2A1 protein results in increased transport of Dinoprostone	19843975
D010634	Phenobarbital	Phenobarbital results in increased expression of SLCO2A1 mRNA	19084549
D010634	Phenobarbital	[Diethylnitrosamine co-treated with Phenobarbital] results in decreased expression of SLCO2A1 mRNA	24535843
D010634	Phenobarbital	NR1I3 protein affects the reaction [Phenobarbital results in decreased expression of SLCO2A1 mRNA]	19482888
D010634	Phenobarbital	Phenobarbital results in decreased expression of SLCO2A1 mRNA	19482888
D010795	Phthalic Acids	Phthalic Acids results in increased expression of SLCO2A1 mRNA	21061450
C006253	pirinixic acid	pirinixic acid results in decreased expression of SLCO2A1 mRNA	17426115\|2381119
C006253	pirinixic acid	pirinixic acid results in increased expression of SLCO2A1 mRNA	19162173
D011285	Pregnenolone Carbonitrile	Pregnenolone Carbonitrile results in decreased expression of SLCO2A1 mRNA	15919853
D011374	Progesterone	[Estradiol co-treated with Progesterone] results in decreased expression of SLCO2A1 mRNA	20660070
D011374	Progesterone	Mifepristone promotes the reaction [Progesterone affects the expression of SLCO2A1 mRNA]	22414680
D011374	Progesterone	Progesterone results in decreased expression of SLCO2A1 mRNA	22238285
D011794	Quercetin	SLCO2A1 protein results in increased uptake of Quercetin	24947867
C059514	resveratrol	resveratrol results in increased expression of SLCO2A1 mRNA	19371625
C059514	resveratrol	resveratrol results in increased expression of SLCO2A1 mRNA	23419489
D012293	Rifampin	Rifampin inhibits the reaction [decitabine results in increased expression of SLCO2A1 mRNA]	23137910
C089730	rosiglitazone	rosiglitazone results in increased expression of SLCO2A1 mRNA	25572481
D012969	Sodium Fluoride	Sodium Fluoride results in increased expression of SLCO2A1 mRNA	27862939
D013148	Spironolactone	Spironolactone results in decreased expression of SLCO2A1 mRNA	15919853
D013629	Tamoxifen	Tamoxifen results in decreased expression of SLCO2A1 mRNA	25123088
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of SLCO2A1 mRNA	20106945
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of SLCO2A1 mRNA	21570461
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of SLCO2A1 mRNA	19770486
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of SLCO2A1 mRNA	20959002\|2121527
D013755	Tetradecanoylphorbol Acetate	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of SLCO2A1 mRNA	25613284
D013853	Thioacetamide	Thioacetamide results in decreased expression of SLCO2A1 mRNA	23411599
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution results in decreased expression of SLCO2A1 mRNA	28065790
C024746	tobacco tar	tobacco tar results in decreased expression of SLCO2A1 mRNA	19559774
D014212	Tretinoin	Tretinoin results in increased expression of SLCO2A1 mRNA	21934132
D014241	Trichloroethylene	Trichloroethylene results in decreased expression of SLCO2A1 mRNA	25549359
D017973	Tungsten Compounds	Tungsten Compounds results in decreased expression of SLCO2A1 mRNA	28666766
C406224	valdecoxib	valdecoxib results in decreased expression of SLCO2A1 mRNA	24136188
D001335	Vehicle Emissions	Vehicle Emissions results in decreased methylation of SLCO2A1 gene	25560391
C025643	vinclozolin	vinclozolin affects the expression of SLCO2A1 mRNA	19015723
D015215	Zidovudine	Zidovudine results in decreased expression of SLCO2A1 mRNA	24292225
C088658	zoledronic acid	zoledronic acid results in increased expression of SLCO2A1 mRNA	24714768

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005319	lipid transporter activity	-	TAS	8787677
GO:0015132	prostaglandin transmembrane transporter activity	-	IBA	21873635
GO:0015132	prostaglandin transmembrane transporter activity	-	TAS	-
GO:0015347	sodium-independent organic anion transmembrane transporter activity	-	IBA	21873635

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0006869	lipid transport	-	TAS	8787677
GO:0015732	prostaglandin transport	-	IBA	21873635
GO:0015732	prostaglandin transport	-	IEA	-
GO:0043252	sodium-independent organic anion transport	-	IBA	21873635
GO:0043252	sodium-independent organic anion transport	-	TAS	-
GO:0055085	transmembrane transport	-	IEA	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005886	plasma membrane	-	TAS	-
GO:0005887	integral component of plasma membrane	-	IBA	21873635
GO:0005887	integral component of plasma membrane	-	TAS	8787677
GO:0016020	membrane	-	TAS	8787677

KEGG ID	KEGG Term

Reactome ID	Reactome Term	Evidence
R-HSA-1643685	Disease	TAS
R-HSA-382551	Transport of small molecules	TAS
R-HSA-425397	Transport of vitamins, nucleosides, and related molecules	TAS
R-HSA-425407	SLC-mediated transmembrane transport	TAS
R-HSA-5619095	Defective SLCO2A1 causes primary, autosomal recessive hypertrophic osteoarthropathy 2 (PHOAR2)	TAS
R-HSA-5619102	SLC transporter disorders	TAS
R-HSA-5619115	Disorders of transmembrane transporters	TAS
R-HSA-879518	Transport of organic anions	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
24694755	Genetic variability in key genes in prostaglandin E2 pathway (COX-2, HPGD, ABCC4 and SLCO2A1) and their involvement in colorectal cancer development. (2014)	Pereira C	PLoS One