Gene: SLCO1A2

6579
OATP|OATP-A|OATP1A2|SLC21A3
solute carrier organic anion transporter family member 1A2
protein-coding
12p12.1
Ensembl:ENSG00000084453 MIM:602883 Vega:OTTHUMG00000156259 UniprotKB:P46721
NC_000012.12
PubMed
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
9.545e-1 (AD)  6.240e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ERMN0.929
CTNNA30.927
MOBP0.92
RASSF20.913
ARHGEF370.904
OPALIN0.899
FAM107B0.887
ZFP570.884
MBP0.879
ASPA0.879

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
PCDH8-0.535
CUX2-0.534
NEUROD1-0.521
SHROOM3-0.52
KCNG1-0.511
HCN4-0.508
ASB2-0.491
CNGB1-0.482
CDH22-0.479
GPR83-0.479

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00091CyclosporineSmall Molecule59865-13-3Approved|InvestigationalTransporter
DB00175PravastatinSmall Molecule81093-37-0ApprovedTransporter
DB00220NelfinavirSmall Molecule159989-64-7ApprovedTransporter
DB00224IndinavirSmall Molecule150378-17-9ApprovedTransporter
DB00227LovastatinSmall Molecule75330-75-5Approved|InvestigationalTransporter
DB00279LiothyronineSmall Molecule6893-02-3ApprovedTransporter
DB00286Conjugated estrogensSmall Molecule12126-59-9ApprovedTransporter
DB00291ChlorambucilSmall Molecule305-03-3ApprovedTransporter
DB00328IndomethacinSmall Molecule53-86-1Approved|InvestigationalTransporter
DB00345Aminohippuric acidSmall Molecule61-78-9Approved|InvestigationalTransporter
DB00390DigoxinSmall Molecule20830-75-5ApprovedTransporter
DB00421SpironolactoneSmall Molecule52-01-7ApprovedTransporter
DB00451LevothyroxineSmall Molecule51-48-9ApprovedTransporter
DB00468QuinineSmall Molecule130-95-0ApprovedTransporter
DB00503RitonavirSmall Molecule155213-67-5Approved|InvestigationalTransporter
DB00563MethotrexateSmall Molecule59-05-2ApprovedTransporter
DB00584EnalaprilSmall Molecule75847-73-3ApprovedTransporter
DB00624TestosteroneSmall Molecule58-22-0Approved|InvestigationalTransporter
DB00635PrednisoneSmall Molecule53-03-2ApprovedTransporter
DB00641SimvastatinSmall Molecule79902-63-9ApprovedTransporter
DB00655EstroneSmall Molecule53-16-7ApprovedTransporter
DB00661VerapamilSmall Molecule52-53-9ApprovedTransporter
DB00669SumatriptanSmall Molecule103628-46-2Approved|InvestigationalTransporter
DB00728RocuroniumSmall Molecule143558-00-3ApprovedTransporter
DB00741HydrocortisoneSmall Molecule50-23-7ApprovedTransporter
DB00783EstradiolSmall Molecule50-28-2Approved|InvestigationalTransporter
DB00788NaproxenSmall Molecule22204-53-1ApprovedTransporter
DB00860PrednisoloneSmall Molecule50-24-8ApprovedTransporter
DB00887BumetanideSmall Molecule28395-03-1ApprovedTransporter
DB00908QuinidineSmall Molecule56-54-2Approved|InvestigationalTransporter
DB00917DinoprostoneSmall Molecule363-24-6ApprovedTransporter
DB00950FexofenadineSmall Molecule83799-24-0Approved|InvestigationalTransporter
DB01009KetoprofenSmall Molecule22071-15-4ApprovedTransporter
DB01016GlyburideSmall Molecule10238-21-8ApprovedTransporter
DB01026KetoconazoleSmall Molecule65277-42-1Approved|InvestigationalTransporter
DB01032ProbenecidSmall Molecule57-66-9Approved|InvestigationalTransporter
DB01045RifampicinSmall Molecule13292-46-1ApprovedTransporter
DB01050IbuprofenSmall Molecule15687-27-1ApprovedTransporter
DB01076AtorvastatinSmall Molecule134523-00-5ApprovedTransporter
DB01092OuabainSmall Molecule630-60-4ApprovedTransporter
DB01098RosuvastatinSmall Molecule287714-41-4ApprovedTransporter
DB01124TolbutamideSmall Molecule64-77-7Approved|InvestigationalTransporter
DB01183NaloxoneSmall Molecule465-65-6ApprovedTransporter
DB01232SaquinavirSmall Molecule127779-20-8Approved|InvestigationalTransporter
DB01234DexamethasoneSmall Molecule50-02-2Approved|InvestigationalTransporter
DB01396DigitoxinSmall Molecule71-63-6Approved|InvestigationalTransporter
DB01583LiotrixSmall Molecule8065-29-0ApprovedTransporter
DB01586Ursodeoxycholic acidSmall Molecule128-13-2Approved|InvestigationalTransporter
DB02123Glycochenodeoxycholic AcidSmall Molecule640-79-9ExperimentalTransporter
DB02659Cholic AcidSmall Molecule81-25-4ApprovedTransporter
DB02691Glycocholic acidSmall Molecule475-31-0Experimental|InvestigationalTransporter
DB03619Deoxycholic AcidSmall Molecule83-44-3ApprovedTransporter
DB04348Taurocholic AcidSmall Molecule81-24-3ExperimentalTransporter
DB04573EstriolSmall Molecule50-27-1Approved|InvestigationalTransporter
DB04630AldosteroneSmall Molecule52-39-1Experimental|InvestigationalTransporter
DB05804Prasterone sulfateSmall Molecule651-48-9InvestigationalTransporter
DB06710MethyltestosteroneSmall Molecule58-18-4ApprovedTransporter
DB08834Tauroursodeoxycholic acidSmall Molecule14605-22-2Approved|InvestigationalTransporter
DB08836TemocaprilSmall Molecule111902-57-9Experimental|InvestigationalTransporter
DB08893MirabegronSmall Molecule223673-61-8ApprovedTransporter
DB11591BilastineSmall Molecule202189-78-4Approved|InvestigationalTransporter
DB11611LifitegrastSmall Molecule1025967-78-5ApprovedTransporter
DB13943Testosterone cypionateSmall Molecule58-20-8ApprovedTransporter
DB13944Testosterone enanthateSmall Molecule315-37-7ApprovedTransporter
DB13946Testosterone undecanoateSmall Molecule5949-44-0Approved|InvestigationalTransporter
DB13952Estradiol acetateSmall Molecule4245-41-4Approved|InvestigationalTransporter
DB13953Estradiol benzoateSmall Molecule50-50-0Approved|InvestigationalTransporter
DB13954Estradiol cypionateSmall Molecule313-06-4Approved|InvestigationalTransporter
DB13955Estradiol dienanthateSmall Molecule7732-97-0Approved|InvestigationalTransporter
DB13956Estradiol valerateSmall Molecule979-32-8Approved|InvestigationalTransporter
DB01045RifampicinSmall Molecule13292-46-1ApprovedTarget
ID Drug Name Action PubMed
C0780921-piperonylpiperazine1-piperonylpiperazine results in decreased expression of SLCO1A2 mRNA26821219
C0297902,2',3',4,4',5-hexachlorobiphenyl"[2,5,2',5'-tetrachlorobiphenyl co-treated with 2,2',3,5',6-pentachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,3,3',4',6-pentachlorobiphenyl co-treated with 2,3',4,4',5-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl] results in increased expression of SLCO1A2 mRNA"29142165
C0329042,2',3,5',6-pentachlorobiphenyl"[2,5,2',5'-tetrachlorobiphenyl co-treated with 2,2',3,5',6-pentachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,3,3',4',6-pentachlorobiphenyl co-treated with 2,3',4,4',5-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl] results in increased expression of SLCO1A2 mRNA"29142165
C0600802,2-bis(bromomethyl)-1,3-propanediol"2,2-bis(bromomethyl)-1,3-propanediol results in decreased expression of SLCO1A2 mRNA"24273086
C0329032,3,3',4',6-pentachlorobiphenyl"[2,5,2',5'-tetrachlorobiphenyl co-treated with 2,2',3,5',6-pentachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,3,3',4',6-pentachlorobiphenyl co-treated with 2,3',4,4',5-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl] results in increased expression of SLCO1A2 mRNA"29142165
C0700552,3',4,4',5-pentachlorobiphenyl"[2,5,2',5'-tetrachlorobiphenyl co-treated with 2,2',3,5',6-pentachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,3,3',4',6-pentachlorobiphenyl co-treated with 2,3',4,4',5-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl] results in increased expression of SLCO1A2 mRNA"29142165
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[2,5,2',5'-tetrachlorobiphenyl co-treated with 2,2',3,5',6-pentachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,3,3',4',6-pentachlorobiphenyl co-treated with 2,3',4,4',5-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl] results in increased expression of SLCO1A2 mRNA"29142165
C0098282,4,5,2',5'-pentachlorobiphenyl"[2,5,2',5'-tetrachlorobiphenyl co-treated with 2,2',3,5',6-pentachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,3,3',4',6-pentachlorobiphenyl co-treated with 2,3',4,4',5-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl] results in increased expression of SLCO1A2 mRNA"29142165
C0094072,5,2',5'-tetrachlorobiphenyl"[2,5,2',5'-tetrachlorobiphenyl co-treated with 2,2',3,5',6-pentachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,3,3',4',6-pentachlorobiphenyl co-treated with 2,3',4,4',5-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl] results in increased expression of SLCO1A2 mRNA"29142165
C4879483-iodothyronamineSLCO1A2 mRNA affects the uptake of 3-iodothyronamine19074582
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SLCO1A2 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SLCO1A2 mRNA"27188386
C5688624-(6-bromo-1,3-benzodioxol-5-yl)-3a,4,5,9b-3H-cyclopenta(c)quinoline"4-(6-bromo-1,3-benzodioxol-5-yl)-3a,4,5,9b-3H-cyclopenta(c)quinoline inhibits the reaction [Ethinyl Estradiol results in decreased expression of SLCO1A2 protein]"27090119
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SLCO1A2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SLCO1A2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine inhibits the reaction [1-Naphthylisothiocyanate results in decreased expression of SLCO1A2 mRNA]"27702592
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine inhibits the reaction [Ethinyl Estradiol results in decreased expression of SLCO1A2 mRNA]"27090119
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine inhibits the reaction [Ethinyl Estradiol results in decreased expression of SLCO1A2 protein]"27090119
C0118647-hydroxymethotrexate7-hydroxymethotrexate inhibits the reaction [SLCO1A2 mRNA results in increased import of estrone sulfate]16702441
D020106AcrylamideAcrylamide results in decreased expression of SLCO1A2 mRNA28959563
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of SLCO1A2 gene27153756
C031143AICA ribonucleotideAICA ribonucleotide results in decreased expression of SLCO1A2 mRNA27090119
D000535Aluminum[APP protein modified form binds to Aluminum] which results in decreased expression of SLCO1A2 mRNA21298039
D001647Bile Acids and SaltsBile Acids and Salts inhibits the reaction [SLCO1A2 protein results in increased uptake of estradiol-17 beta-glucuronide]19464309
D001647Bile Acids and SaltsBile Acids and Salts inhibits the reaction [SLCO1A2 protein results in increased uptake of Taurocholic Acid]19464309
C543008bis(4-hydroxyphenyl)sulfonebis(4-hydroxyphenyl)sulfone results in increased expression of SLCO1A2 mRNA25470364
C543008bis(4-hydroxyphenyl)sulfonebis(4-hydroxyphenyl)sulfone results in increased expression of SLCO1A2 mRNA26894911
C006780bisphenol Abisphenol A results in decreased expression of SLCO1A2 mRNA25181051
C086232bosentanbosentan results in decreased activity of SLCO1A2 protein23721565
D002065BuspironeBuspirone results in increased expression of SLCO1A2 mRNA24136188
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of SLCO1A2 mRNA25993096
D002220CarbamazepineCarbamazepine results in increased expression of SLCO1A2 mRNA17112801
D002330CarmustineCarmustine results in decreased expression of SLCO1A2 mRNA15980968
D002635Chenodeoxycholic AcidChenodeoxycholic Acid inhibits the reaction [Ethinyl Estradiol results in decreased expression of SLCO1A2 mRNA]27743861
D002635Chenodeoxycholic AcidChenodeoxycholic Acid results in decreased expression of SLCO1A2 mRNA27743861
C018021cobaltous chloridecobaltous chloride results in decreased expression of SLCO1A2 mRNA24386269
D003474CurcuminCurcumin results in increased expression of SLCO1A2 mRNA18421014
D002117CalcitriolCalcitriol results in increased expression of SLCO1A2 mRNA16002434|2710755
C019357dioscindioscin results in increased expression of SLCO1A2 mRNA27317372
C039602diosmetindiosmetin inhibits the reaction [SLCO1A2 protein results in increased uptake of Rosuvastatin Calcium]28867436
C025483estradiol-17 beta-glucuronideBile Acids and Salts inhibits the reaction [SLCO1A2 protein results in increased uptake of estradiol-17 beta-glucuronide]19464309
C025483estradiol-17 beta-glucuronideSLCO1A2 protein results in increased uptake of estradiol-17 beta-glucuronide19464309
C017296estrone sulfate7-hydroxymethotrexate inhibits the reaction [SLCO1A2 mRNA results in increased import of estrone sulfate]16702441
C017296estrone sulfateMethotrexate inhibits the reaction [SLCO1A2 mRNA results in increased import of estrone sulfate]16702441
C017296estrone sulfatenaringin inhibits the reaction [SLCO1A2 protein alternative form results in increased uptake of estrone sulfate]25466967
C017296estrone sulfatenaringin inhibits the reaction [SLCO1A2 protein results in increased transport of estrone sulfate]25466967
C017296estrone sulfateperfluorodecanoic acid inhibits the reaction [SLCO1A2 protein results in increased import of estrone sulfate]20639259
C017296estrone sulfateSLCO1A2 mRNA results in increased import of estrone sulfate16702441
C017296estrone sulfateSLCO1A2 protein alternative form results in increased uptake of estrone sulfate25466967
C017296estrone sulfateSLCO1A2 protein results in increased import of estrone sulfate20639259
C017296estrone sulfateSLCO1A2 protein results in increased transport of estrone sulfate25466967
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of SLCO1A2 mRNA27743861
D004997Ethinyl Estradiol"4-(6-bromo-1,3-benzodioxol-5-yl)-3a,4,5,9b-3H-cyclopenta(c)quinoline inhibits the reaction [Ethinyl Estradiol results in decreased expression of SLCO1A2 protein]"27090119
D004997Ethinyl Estradiol"(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine inhibits the reaction [Ethinyl Estradiol results in decreased expression of SLCO1A2 mRNA]"27090119
D004997Ethinyl Estradiol"(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine inhibits the reaction [Ethinyl Estradiol results in decreased expression of SLCO1A2 protein]"27090119
D004997Ethinyl EstradiolChenodeoxycholic Acid inhibits the reaction [Ethinyl Estradiol results in decreased expression of SLCO1A2 mRNA]27743861
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of SLCO1A2 mRNA27090119|2774386
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of SLCO1A2 protein27090119
D004997Ethinyl Estradiolfulvestrant inhibits the reaction [Ethinyl Estradiol results in decreased expression of SLCO1A2 protein]27090119
D004997Ethinyl EstradiolGW 4064 inhibits the reaction [Ethinyl Estradiol results in decreased expression of SLCO1A2 mRNA]27090119
D004997Ethinyl EstradiolNR1H4 protein inhibits the reaction [Ethinyl Estradiol results in decreased expression of SLCO1A2 mRNA]27090119
D004997Ethinyl EstradiolPRKAA1 protein inhibits the reaction [Ethinyl Estradiol results in decreased expression of SLCO1A2 mRNA]27090119
D004997Ethinyl EstradiolUrsodeoxycholic Acid inhibits the reaction [Ethinyl Estradiol results in decreased expression of SLCO1A2 mRNA]27743861
D018120FinasterideFinasteride results in increased expression of SLCO1A2 mRNA24136188
C070081fulvestrantfulvestrant inhibits the reaction [Ethinyl Estradiol results in decreased expression of SLCO1A2 protein]27090119
C039281furanfuran results in decreased expression of SLCO1A2 mRNA25539665
D005897GlafenineGlafenine results in decreased expression of SLCO1A2 mRNA24136188
C412815GW 4064GW 4064 inhibits the reaction [Ethinyl Estradiol results in decreased expression of SLCO1A2 mRNA]27090119
D006918HydroxyureaSLCO1A2 protein results in increased uptake of Hydroxyurea21256917
C052901lemongrass oillemongrass oil results in increased expression of SLCO1A2 mRNA25458622
C482199lipopolysaccharide, E coli O55-B5"[Sulindac co-treated with lipopolysaccharide, E coli O55-B5] affects the expression of SLCO1A2 mRNA"20371263
C502354lithocholic acid acetatelithocholic acid acetate results in increased expression of SLCO1A2 mRNA22474172
D008627Mercuric ChlorideMercuric Chloride results in decreased expression of SLCO1A2 mRNA28536007
D008687MetforminMetformin results in decreased expression of SLCO1A2 mRNA19022234
D008727MethotrexateMethotrexate inhibits the reaction [SLCO1A2 mRNA results in increased import of estrone sulfate]16702441
D008727MethotrexateSLCO1A2 gene polymorphism affects the susceptibility to Methotrexate16702441
D008727MethotrexateSLCO1A2 mRNA results in increased import of Methotrexate16702441
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of SLCO1A2 mRNA28001369
D0150581-Naphthylisothiocyanate1-Naphthylisothiocyanate results in decreased expression of SLCO1A2 mRNA24120425|2770259
D0150581-Naphthylisothiocyanate"(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine inhibits the reaction [1-Naphthylisothiocyanate results in decreased expression of SLCO1A2 mRNA]"27702592
C005274naringinnaringin inhibits the reaction [SLCO1A2 protein alternative form results in increased uptake of estrone sulfate]25466967
C005274naringinnaringin inhibits the reaction [SLCO1A2 protein results in increased transport of estrone sulfate]25466967
C005274naringinnaringin inhibits the reaction [SLCO1A2 protein results in increased uptake of Quercetin]24947867
C461488N-benzylpiperazineN-benzylpiperazine results in decreased expression of SLCO1A2 mRNA26821219
C051752nefazodonenefazodone results in increased expression of SLCO1A2 mRNA24136188
C025589ochratoxin ASLCO1A2 protein results in increased uptake of ochratoxin A28532671
C025589ochratoxin Aochratoxin A results in decreased expression of SLCO1A2 mRNA29126803
C025589ochratoxin ASLCO1A2 protein results in increased uptake of ochratoxin A9928634
D009853OmeprazoleOmeprazole results in increased expression of SLCO1A2 mRNA19118567
C036567perfluorodecanoic acidperfluorodecanoic acid inhibits the reaction [SLCO1A2 protein results in increased import of estrone sulfate]20639259
C101814perfluoro-n-undecanoic acidperfluoro-n-undecanoic acid results in decreased expression of SLCO1A2 mRNA23602845
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in increased expression of SLCO1A2 mRNA21046362
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SLCO1A2 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in decreased expression of SLCO1A2 mRNA26272509
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in increased expression of SLCO1A2 mRNA19118567
D011794Quercetinnaringin inhibits the reaction [SLCO1A2 protein results in increased uptake of Quercetin]24947867
D011794QuercetinSLCO1A2 protein results in increased uptake of Quercetin24947867
D011794QuercetinSulfobromophthalein inhibits the reaction [SLCO1A2 protein results in increased uptake of Quercetin]24947867
D011794QuercetinVerapamil inhibits the reaction [SLCO1A2 protein results in increased uptake of Quercetin]24947867
D000068718Rosuvastatin Calciumdiosmetin inhibits the reaction [SLCO1A2 protein results in increased uptake of Rosuvastatin Calcium]28867436
D000068718Rosuvastatin CalciumSLCO1A2 protein results in increased uptake of Rosuvastatin Calcium28867436
D019258SaquinavirSLCO1A2 protein affects the uptake of Saquinavir15832500
C009237senecioninesenecionine results in decreased expression of SLCO1A2 mRNA24641316
C106276sitaxsentansitaxsentan results in decreased activity of SLCO1A2 protein23721565
C017947sodium arsenitesodium arsenite affects the methylation of SLCO1A2 gene28589171
D013448SulfobromophthaleinSulfobromophthalein inhibits the reaction [SLCO1A2 protein results in increased uptake of Quercetin]24947867
D013467Sulindac"[Sulindac co-treated with lipopolysaccharide, E coli O55-B5] affects the expression of SLCO1A2 mRNA"20371263
D013656Taurocholic AcidBile Acids and Salts inhibits the reaction [SLCO1A2 protein results in increased uptake of Taurocholic Acid]19464309
D013656Taurocholic AcidSLCO1A2 protein results in increased uptake of Taurocholic Acid19464309
C004648testosterone enanthatetestosterone enanthate affects the expression of SLCO1A2 mRNA17440010
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of SLCO1A2 mRNA21724226
C582340tetradecabromodiphenoxybenzenetetradecabromodiphenoxybenzene analog results in decreased expression of SLCO1A2 mRNA25222814
D014050TolueneToluene results in increased expression of SLCO1A2 mRNA22967744
D014212Tretinoin[Cholecalciferol co-treated with Tretinoin] promotes the reaction [[VDR protein binds to RXRA protein] which binds to SLCO1A2 promoter]22474172
C005445triphenyl phosphatetriphenyl phosphate metabolite results in decreased expression of SLCO1A2 mRNA25350880
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of SLCO1A2 mRNA"24273086|2524241
D014317Tritolyl PhosphatesTritolyl Phosphates results in increased expression of SLCO1A2 mRNA24273086
C003330trospium chlorideSLCO1A2 protein results in increased metabolism of trospium chloride25466967
C003330trospium chloridetrospium chloride results in decreased activity of SLCO1A2 protein25466967
C003330trospium chloridetrospium chloride results in decreased activity of SLCO1A2 protein alternative form25466967
C080163trovafloxacintrovafloxacin results in increased expression of SLCO1A2 mRNA24136188
D014580Ursodeoxycholic AcidUrsodeoxycholic Acid inhibits the reaction [Ethinyl Estradiol results in decreased expression of SLCO1A2 mRNA]27743861
C406224valdecoxibvaldecoxib results in increased expression of SLCO1A2 mRNA24136188
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SLCO1A2 mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of SLCO1A2 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of SLCO1A2 mRNA24935251|2800136
D014635Valproic AcidValproic Acid results in increased expression of SLCO1A2 mRNA26272509
D014700VerapamilVerapamil inhibits the reaction [SLCO1A2 protein results in increased uptake of Quercetin]24947867
D002762Cholecalciferol[Cholecalciferol binds to VDR protein] which results in increased expression of SLCO1A2 mRNA22474172
D002762Cholecalciferol[Cholecalciferol co-treated with Tretinoin] promotes the reaction [[VDR protein binds to RXRA protein] which binds to SLCO1A2 promoter]22474172
D002762CholecalciferolCholecalciferol promotes the reaction [VDR protein binds to SLCO1A2 promoter]22474172
D002762CholecalciferolCholecalciferol promotes the reaction [[VDR protein binds to SLCO1A2 promoter] which results in increased expression of SLCO1A2 mRNA]22474172|2247417
D002762CholecalciferolCholecalciferol results in increased expression of SLCO1A2 mRNA22474172
D002762CholecalciferolCholecalciferol results in increased expression of SLCO1A2 protein22474172
D002762CholecalciferolVDR protein affects the reaction [Cholecalciferol results in increased expression of SLCO1A2 mRNA]22474172
C111237vorinostatvorinostat results in increased expression of SLCO1A2 mRNA27188386

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0008514organic anion transmembrane transporter activity-TAS9007731  
GO:0015125bile acid transmembrane transporter activity-IBA21873635  
GO:0015125bile acid transmembrane transporter activity-TAS-  
GO:0015347sodium-independent organic anion transmembrane transporter activity-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0015711organic anion transport-TAS9007731  
GO:0015721bile acid and bile salt transport-IBA21873635  
GO:0015721bile acid and bile salt transport-TAS-  
GO:0043252sodium-independent organic anion transport-IBA21873635  
GO:0043252sodium-independent organic anion transport-TAS-  
GO:0055085transmembrane transport-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005886plasma membrane-IDA-  
GO:0005886plasma membrane-TAS-  
GO:0005887integral component of plasma membrane-IBA21873635  
KEGG ID KEGG Term
hsa04976Bile secretion
Reactome ID Reactome Term Evidence
R-HSA-1430728MetabolismTAS
R-HSA-159418Recycling of bile acids and saltsTAS
R-HSA-194068Bile acid and bile salt metabolismTAS
R-HSA-382551Transport of small moleculesTAS
R-HSA-425397Transport of vitamins, nucleosides, and related moleculesTAS
R-HSA-425407SLC-mediated transmembrane transportTAS
R-HSA-556833Metabolism of lipidsTAS
R-HSA-879518Transport of organic anionsTAS
R-HSA-8957322Metabolism of steroidsTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
27799384Severe asthma exists despite suppressed tissue inflammation: findings of the U-BIOPRED study. (2016 Nov)Wilson SJEur Respir J