Gene: SLC22A1

6580
HOCT1|OCT1|oct1_cds
solute carrier family 22 member 1
protein-coding
6q25.3
Ensembl:ENSG00000175003 MIM:602607 Vega:OTTHUMG00000015947 UniprotKB:O15245
NC_000006.12
PubMed
CD|ND
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
6.507e-1 (AD)  4.908e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CCDC840.445
FBXL120.419
TNFAIP20.412
CFP0.411
RNPEP0.409
C19orf660.402
DCAF150.401
LIN370.399
RNF1660.399
TMEM39B0.398

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
BTBD8-0.223
OR51G2-0.22
DYNAP-0.209
BTNL2-0.195
OR4F5-0.193
GOLGA6C-0.193
PCDHA4-0.189
TBX10-0.187
OR2T10-0.185
SHCBP1L-0.175

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00122CholineSmall Molecule62-49-7Approved|NutraceuticalTransporter
DB00127SpermineSmall Molecule71-44-3Approved|NutraceuticalTransporter
DB00152ThiamineSmall Molecule70-16-6Approved|Investigational|NutraceuticalTransporter
DB00184NicotineSmall Molecule54-11-5ApprovedTransporter
DB00206ReserpineSmall Molecule50-55-5Approved|InvestigationalTransporter
DB00220NelfinavirSmall Molecule159989-64-7ApprovedTransporter
DB00224IndinavirSmall Molecule150378-17-9ApprovedTransporter
DB00242CladribineSmall Molecule4291-63-8Approved|InvestigationalTransporter
DB00280DisopyramideSmall Molecule3737-09-5ApprovedTransporter
DB00318CodeineSmall Molecule76-57-3Approved|IllicitTransporter
DB00331MetforminSmall Molecule657-24-9ApprovedTransporter
DB00345Aminohippuric acidSmall Molecule61-78-9Approved|InvestigationalTransporter
DB00368NorepinephrineSmall Molecule51-41-2ApprovedTransporter
DB00396ProgesteroneSmall Molecule57-83-0ApprovedTransporter
DB00406Gentian VioletSmall Molecule7438-46-2ApprovedTransporter
DB00413PramipexoleSmall Molecule104632-26-0Approved|InvestigationalTransporter
DB00457PrazosinSmall Molecule19216-56-9ApprovedTransporter
DB00458ImipramineSmall Molecule50-49-7ApprovedTransporter
DB00468QuinineSmall Molecule130-95-0ApprovedTransporter
DB00477ChlorpromazineSmall Molecule50-53-3Approved|InvestigationalTransporter
DB00501CimetidineSmall Molecule51481-61-9Approved|InvestigationalTransporter
DB00520CaspofunginSmall Molecule162808-62-0ApprovedTransporter
DB00526OxaliplatinSmall Molecule61825-94-3Approved|InvestigationalTransporter
DB00536GuanidineSmall Molecule113-00-8ApprovedTransporter
DB00575ClonidineSmall Molecule4205-90-7ApprovedTransporter
DB00594AmilorideSmall Molecule2609-46-3ApprovedTransporter
DB00619ImatinibSmall Molecule152459-95-5ApprovedTransporter
DB00624TestosteroneSmall Molecule58-22-0Approved|InvestigationalTransporter
DB00654LatanoprostSmall Molecule130209-82-4Approved|InvestigationalTransporter
DB00661VerapamilSmall Molecule52-53-9ApprovedTransporter
DB00668EpinephrineSmall Molecule51-43-4ApprovedTransporter
DB00683MidazolamSmall Molecule59467-70-8Approved|IllicitTransporter
DB00709LamivudineSmall Molecule134678-17-4Approved|InvestigationalTransporter
DB00728RocuroniumSmall Molecule143558-00-3ApprovedTransporter
DB00783EstradiolSmall Molecule50-28-2Approved|InvestigationalTransporter
DB00787AciclovirSmall Molecule59277-89-3ApprovedTransporter
DB00863RanitidineSmall Molecule66357-35-5ApprovedTransporter
DB00908QuinidineSmall Molecule56-54-2Approved|InvestigationalTransporter
DB00914PhenforminSmall Molecule114-86-3Approved|Investigational|WithdrawnTransporter
DB00915AmantadineSmall Molecule768-94-5ApprovedTransporter
DB00917DinoprostoneSmall Molecule363-24-6ApprovedTransporter
DB00925PhenoxybenzamineSmall Molecule59-96-1ApprovedTransporter
DB00987CytarabineSmall Molecule147-94-4Approved|InvestigationalTransporter
DB00988DopamineSmall Molecule51-61-6ApprovedTransporter
DB01004GanciclovirSmall Molecule82410-32-0Approved|InvestigationalTransporter
DB01032ProbenecidSmall Molecule57-66-9Approved|InvestigationalTransporter
DB01035ProcainamideSmall Molecule51-06-9ApprovedTransporter
DB01075DiphenhydramineSmall Molecule58-73-1Approved|InvestigationalTransporter
DB01114ChlorphenamineSmall Molecule132-22-9ApprovedTransporter
DB01151DesipramineSmall Molecule50-47-5Approved|InvestigationalTransporter
DB01193AcebutololSmall Molecule37517-30-9Approved|InvestigationalTransporter
DB01199TubocurarineSmall Molecule57-95-4ApprovedTransporter
DB01232SaquinavirSmall Molecule127779-20-8Approved|InvestigationalTransporter
DB01337PancuroniumSmall Molecule-ApprovedTransporter
DB01339VecuroniumSmall Molecule86029-43-8ApprovedTransporter
DB01614AcepromazineSmall Molecule61-00-7ApprovedTransporter
DB01621PipotiazineSmall Molecule39860-99-6Approved|InvestigationalTransporter
DB01622ThioproperazineSmall Molecule316-81-4ApprovedTransporter
DB01623ThiothixeneSmall Molecule3313-26-6ApprovedTransporter
DB03128AcetylcholineSmall Molecule51-84-3ApprovedTransporter
DB03566SpermidineSmall Molecule124-20-9ExperimentalTransporter
DB04348Taurocholic AcidSmall Molecule81-24-3ExperimentalTransporter
DB04485DeoxythymidineSmall Molecule50-89-5Experimental|InvestigationalTransporter
DB04574Estrone sulfateSmall Molecule481-97-0ApprovedTransporter
DB04830BuforminSmall Molecule692-13-7Investigational|WithdrawnTransporter
DB05381HistamineSmall Molecule51-45-6Approved|InvestigationalTransporter
DB08837TetraethylammoniumSmall Molecule66-40-0Experimental|InvestigationalTransporter
DB08838AgmatineSmall Molecule306-60-5Experimental|InvestigationalTransporter
DB11591BilastineSmall Molecule202189-78-4Approved|InvestigationalTransporter
DB11642PitolisantSmall Molecule362665-56-3Approved|InvestigationalTransporter
DB11660Latanoprostene BunodSmall Molecule860005-21-6Approved|InvestigationalTransporter
DB11817BaricitinibSmall Molecule1187594-09-7Approved|InvestigationalTransporter
DB12267BrigatinibSmall Molecule1197953-54-0Approved|InvestigationalTransporter
DB12332RucaparibSmall Molecule283173-50-2Approved|InvestigationalTransporter
DB12598NafamostatSmall Molecule81525-10-2Approved|InvestigationalTransporter
DB13943Testosterone cypionateSmall Molecule58-20-8ApprovedTransporter
DB13944Testosterone enanthateSmall Molecule315-37-7ApprovedTransporter
DB13946Testosterone undecanoateSmall Molecule5949-44-0Approved|InvestigationalTransporter
DB13952Estradiol acetateSmall Molecule4245-41-4Approved|InvestigationalTransporter
DB13953Estradiol benzoateSmall Molecule50-50-0Approved|InvestigationalTransporter
DB13954Estradiol cypionateSmall Molecule313-06-4Approved|InvestigationalTransporter
DB13955Estradiol dienanthateSmall Molecule7732-97-0Approved|InvestigationalTransporter
DB13956Estradiol valerateSmall Molecule979-32-8Approved|InvestigationalTransporter
DB09555Dexchlorpheniramine maleateSmall MoleculeApprovedCarrier
ID Drug Name Action PubMed
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased expression of SLC22A1 mRNA"27413110
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of SLC22A1 mRNA"19114083
C0495842-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine"2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of SLC22A1 mRNA"15059925
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in decreased expression of SLC22A1 mRNA"18648102
C0323154-(4-dimethylaminostyryl)-1-methylpyridinium4-(4-dimethylaminostyryl)-1-methylpyridinium inhibits the reaction [SLC22A1 protein results in increased uptake of retrorsine]24799337
C0323154-(4-dimethylaminostyryl)-1-methylpyridiniumSLC22A1 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium24799337
C0323154-(4-dimethylaminostyryl)-1-methylpyridiniumTetraethylammonium inhibits the reaction [SLC22A1 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium]24799337
C0067574-biphenylamine4-biphenylamine inhibits the reaction [SLC22A1 protein results in increased import of Tetraethylammonium]27450509
C106538abacavir[Quinine results in decreased activity of SLC22A1] which results in decreased uptake of abacavir25844889
D000082AcetaminophenAcetaminophen results in decreased expression of SLC22A1 mRNA29067470
D000082AcetaminophenAcetaminophen affects the expression of SLC22A1 mRNA17562736
D020106AcrylamideAcrylamide results in decreased expression of SLC22A1 mRNA28959563
D016604Aflatoxin B1Aflatoxin B1 affects the expression of SLC22A1 protein20106945
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of SLC22A1 mRNA27153756
D000493AllopurinolAllopurinol inhibits the reaction [potassium oxonate results in decreased expression of SLC22A1 mRNA]21909718
D000493AllopurinolAllopurinol inhibits the reaction [potassium oxonate results in decreased expression of SLC22A1 protein]21909718|2286564
D000493AllopurinolAllopurinol inhibits the reaction [Fructose results in decreased expression of SLC22A1 mRNA]19605544
D000493AllopurinolAllopurinol inhibits the reaction [Fructose results in decreased expression of SLC22A1 protein]19605544
D000517alpha-Chlorohydrinalpha-Chlorohydrin results in increased expression of SLC22A1 mRNA28522335
D000638AmiodaroneAmiodarone inhibits the reaction [SLC22A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]21641380
D000638AmiodaroneAmiodarone affects the expression of SLC22A1 mRNA19483382
D000643Ammonium ChlorideAmmonium Chloride affects the expression of SLC22A1 mRNA16483693
C011659angelicinangelicin results in decreased expression of SLC22A1 mRNA22173200
C011659angelicinangelicin results in increased expression of SLC22A1 protein22173200
D034341Aristolochic AcidsAristolochic Acids results in decreased expression of SLC22A1 mRNA21167265
D001262AtenololAtenolol inhibits the reaction [SLC22A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]21641380
D000069059Atorvastatin CalciumAtorvastatin Calcium inhibits the reaction [SLC22A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]21641380
D000069059Atorvastatin CalciumAtorvastatin Calcium results in increased expression of SLC22A1 mRNA25278499
D001285AtropineAtropine inhibits the reaction [SLC22A1 protein results in increased transport of 1-Methyl-4-phenylpyridinium]16263091
D001285AtropineAtropine inhibits the reaction [SLC22A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]21641380
C547126AZM551248AZM551248 results in decreased expression of SLC22A1 mRNA22323515
D001414BacitracinBacitracin results in decreased expression of SLC22A1 mRNA18289764
D001553BenzbromaroneBenzbromarone affects the expression of SLC22A1 mRNA19483382
D019324beta-Naphthoflavonebeta-Naphthoflavone results in decreased expression of SLC22A1 mRNA22258563
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of SLC22A1 mRNA20106945
D001564Benzo(a)pyreneBenzo(a)pyrene promotes the reaction [AHR protein binds to SLC22A1 promoter]19654925
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of SLC22A1 mRNA22228805
D004958EstradiolEstradiol results in decreased expression of SLC22A1 protein17684116
D004958EstradiolEstradiol inhibits the reaction [SLC22A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]12110607
D004958EstradiolEstradiol results in decreased activity of SLC22A1 protein12110607
D004958EstradiolEstradiol results in decreased expression of SLC22A1 mRNA20106945
C543008bis(4-hydroxyphenyl)sulfonebis(4-hydroxyphenyl)sulfone promotes the reaction [SLC22A1 protein results in increased uptake of Tetraethylammonium]27989701
D017298BisoprololBisoprolol inhibits the reaction [SLC22A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]21641380
C006780bisphenol Abisphenol A inhibits the reaction [SLC22A1 protein results in increased uptake of Tetraethylammonium]27989701
C006780bisphenol Abisphenol A results in decreased activity of SLC22A1 protein27989701
C006780bisphenol Abisphenol A results in decreased expression of SLC22A1 mRNA25181051
C000611646bisphenol Fbisphenol F inhibits the reaction [SLC22A1 protein results in increased uptake of Tetraethylammonium]27989701
D002104CadmiumCadmium inhibits the reaction [SLC22A1 protein results in increased uptake of Tetraethylammonium]21513783
D002104CadmiumSLC22A1 protein results in increased uptake of Cadmium21513783
D002104CadmiumTetraethylammonium inhibits the reaction [SLC22A1 protein results in increased uptake of Cadmium]21513783
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of SLC22A1 mRNA25588984
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of SLC22A1 protein25588984
D002251Carbon TetrachlorideCarbon Tetrachloride results in decreased expression of SLC22A1 protein17544377
C043211carvedilolcarvedilol inhibits the reaction [SLC22A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]21641380
D002635Chenodeoxycholic AcidChenodeoxycholic Acid results in decreased expression of SLC22A1 mRNA27174168
D002706ChlordanChlordan results in decreased activity of SLC22A1 protein24464585
D002713Chlorine[Ozone co-treated with Chlorine] results in increased expression of SLC22A1 mRNA18636392
D002744ChlorpheniramineChlorpheniramine affects the reaction [SLC22A1 protein results in increased uptake of Tetraethylammonium]12440152
D002927CimetidineCimetidine inhibits the reaction [SLC22A1 protein results in increased uptake of Ethidium]19357179
D002927CimetidineSLC22A1 protein results in increased uptake of Cimetidine16006492
D002994ClofibrateClofibrate affects the expression of SLC22A1 mRNA19483382
D003000ClonidineClonidine inhibits the reaction [SLC22A1 protein results in increased transport of 1-Methyl-4-phenylpyridinium]16263091
C018021cobaltous chloridecobaltous chloride results in decreased expression of SLC22A1 mRNA24386269
D016572CyclosporineCyclosporine results in decreased expression of SLC22A1 mRNA20106945
D003840Deoxycholic AcidDeoxycholic Acid results in decreased expression of SLC22A1 mRNA21914718
D003907DexamethasoneDexamethasone results in increased expression of SLC22A1 mRNA24399729
D003907DexamethasoneDexamethasone results in increased expression of SLC22A1 protein24399729
D003907DexamethasoneDexamethasone inhibits the reaction [Lipopolysaccharides results in decreased expression of SLC22A1 mRNA]15205389
D004008DiclofenacDiclofenac results in decreased activity of SLC22A1 protein12388633
D019259LamivudineSLC22A1 protein results in increased uptake of Lamivudine19141712
D004026DieldrinDieldrin results in decreased activity of SLC22A1 protein24464585
D004054DiethylstilbestrolDiethylstilbestrol results in decreased expression of SLC22A1 protein17684116
D004054DiethylstilbestrolDiethylstilbestrol results in increased expression of SLC22A1 mRNA21658437
D004077DigoxinDigoxin inhibits the reaction [SLC22A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]21641380
D004110DiltiazemDiltiazem inhibits the reaction [SLC22A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]21641380
C039602diosmetindiosmetin inhibits the reaction [SLC22A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]28867436
D004155DiphenhydramineDiphenhydramine inhibits the reaction [SLC22A1 protein results in increased transport of 1-Methyl-4-phenylpyridinium]16263091
D004206DisopyramideDisopyramide affects the reaction [SLC22A1 protein results in increased uptake of Tetraethylammonium]12440152
D004298DopamineDopamine affects the reaction [SLC22A1 protein results in increased uptake of Tetraethylammonium]12440152
D004317DoxorubicinDoxorubicin results in decreased expression of SLC22A1 mRNA19915844
D004365Drugs, Chinese Herbal"Drugs, Chinese Herbal inhibits the reaction [potassium oxonate results in decreased expression of SLC22A1 mRNA]"22967667
D004365Drugs, Chinese Herbal"Drugs, Chinese Herbal inhibits the reaction [potassium oxonate results in decreased expression of SLC22A1 protein]"22967667
D004726EndosulfanEndosulfan results in decreased activity of SLC22A1 protein24464585
D004726EndosulfanEndosulfan results in decreased expression of SLC22A1 mRNA24464585
D004996Ethidium1-Methyl-4-phenylpyridinium inhibits the reaction [SLC22A1 protein results in increased uptake of Ethidium]19357179
D004996EthidiumCimetidine inhibits the reaction [SLC22A1 protein results in increased uptake of Ethidium]19357179
D004996EthidiumQuinine inhibits the reaction [SLC22A1 protein results in increased uptake of Ethidium]19357179
D004996EthidiumSLC22A1 protein results in increased uptake of Ethidium19357179
D004996EthidiumTetraethylammonium inhibits the reaction [SLC22A1 protein results in increased uptake of Ethidium]19357179
D004996EthidiumSLC22A1 protein affects the uptake of Ethidium19357179
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in decreased expression of SLC22A1 mRNA17942748
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of SLC22A1 mRNA17108234|1900256
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of SLC22A1 protein19002567
D005001EthionineEthionine affects the expression of SLC22A1 mRNA19483382
D005039EtilefrineEtilefrine inhibits the reaction [SLC22A1 protein results in increased transport of 1-Methyl-4-phenylpyridinium]16263091
D015738FamotidineFamotidine inhibits the reaction [SLC22A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]16141367
D015738FamotidineSLC22A1 protein affects the transport of Famotidine16141367
D015738FamotidineSLC22A1 protein results in increased uptake of Famotidine16006492
D005363FicusinFicusin results in decreased expression of SLC22A1 mRNA22173200
D005363FicusinFicusin results in increased expression of SLC22A1 protein22173200
D018120FinasterideFinasteride results in increased expression of SLC22A1 mRNA24136188
D005424FlecainideFlecainide inhibits the reaction [SLC22A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]21641380
D005485FlutamideFlutamide results in increased expression of SLC22A1 mRNA24136188
D005492Folic AcidFolic Acid deficiency results in decreased expression of SLC22A1 mRNA20465997
D004397FonofosFonofos results in increased methylation of SLC22A1 promoter22847954
D005632FructoseAllopurinol inhibits the reaction [Fructose results in decreased expression of SLC22A1 mRNA]19605544
D005632FructoseAllopurinol inhibits the reaction [Fructose results in decreased expression of SLC22A1 protein]19605544
D005632FructoseFructose results in decreased expression of SLC22A1 mRNA19605544
D005632FructoseFructose results in decreased expression of SLC22A1 protein19605544
D005632FructoseQuercetin inhibits the reaction [Fructose results in decreased expression of SLC22A1 mRNA]19605544
D005632FructoseQuercetin inhibits the reaction [Fructose results in decreased expression of SLC22A1 protein]19605544
D005632FructoseRutin inhibits the reaction [Fructose results in decreased expression of SLC22A1 mRNA]19605544
D005632FructoseRutin inhibits the reaction [Fructose results in decreased expression of SLC22A1 protein]19605544
C056933fumonisin B1fumonisin B1 results in decreased expression of SLC22A1 mRNA16221962
D005839GentamicinsGentamicins results in decreased expression of SLC22A1 mRNA18289764
D005897GlafenineGlafenine results in decreased expression of SLC22A1 mRNA24136188
D006533HeptachlorHeptachlor results in decreased activity of SLC22A1 protein24464585
D017313FenretinideFenretinide results in increased expression of SLC22A1 mRNA28973697
C001654hyperforinhyperforin promotes the reaction [NR1I2 protein results in decreased expression of SLC22A1 mRNA]26920453
C001654hyperforinhyperforin results in decreased expression of SLC22A1 protein26920453
C001654hyperforin[NR1I2 protein co-treated with hyperforin] results in decreased expression of SLC22A1 mRNA26920453
C001654hyperforin[NR1I2 protein results in increased susceptibility to hyperforin] which results in decreased expression of SLC22A1 mRNA26920453
D007052IbuprofenIbuprofen results in decreased activity of SLC22A1 protein12388633
D007099ImipramineImipramine inhibits the reaction [SLC22A1 protein results in increased uptake of Metformin]25106415
D007099ImipramineImipramine inhibits the reaction [SLC22A1 protein results in increased uptake of Quercetin]24947867
D007099ImipramineImipramine inhibits the reaction [SLC22A1 protein results in increased uptake of Tetraethylammonium]25106415
C031534imperatorinimperatorin results in increased expression of SLC22A1 mRNA22173200
C031534imperatorinimperatorin results in increased expression of SLC22A1 protein22173200
D007213IndomethacinIndomethacin results in decreased activity of SLC22A1 protein12388633
C055542isoimperatorinisoimperatorin results in increased expression of SLC22A1 protein22173200
D009241IpratropiumIpratropium inhibits the reaction [SLC22A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]21641380
D007660KetoprofenKetoprofen results in decreased activity of SLC22A1 protein12388633
D008012LidocaineLidocaine inhibits the reaction [SLC22A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]21641380
D001556LindaneLindane results in decreased activity of SLC22A1 protein24464585
D008070LipopolysaccharidesDexamethasone inhibits the reaction [Lipopolysaccharides results in decreased expression of SLC22A1 mRNA]15205389
D008070LipopolysaccharidesLipopolysaccharides results in decreased expression of SLC22A1 mRNA15205389
C013592mangiferinmangiferin results in increased expression of SLC22A1 mRNA21348301
D008528Mefenamic AcidMefenamic Acid results in decreased activity of SLC22A1 protein12388633
D008628MercuryMercury results in increased expression of SLC22A1 mRNA12730625
D008687MetforminSLC22A1 protein results in increased transport of Metformin17600084
D008687MetforminImipramine inhibits the reaction [SLC22A1 protein results in increased uptake of Metformin]25106415
D008687MetforminMetformin inhibits the reaction [SLC22A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]16141367
D008687MetforminSLC22A1 protein results in increased susceptibility to Metformin20956498
D008687MetforminSLC22A1 protein results in increased uptake of Metformin25106415
D008730MethoxsalenMethoxsalen results in increased expression of SLC22A1 protein22173200
D0156551-Methyl-4-phenylpyridinium1-Methyl-4-phenylpyridinium inhibits the reaction [SLC22A1 protein results in increased uptake of Ethidium]19357179
D0156551-Methyl-4-phenylpyridiniumAmiodarone inhibits the reaction [SLC22A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]21641380
D0156551-Methyl-4-phenylpyridiniumAtenolol inhibits the reaction [SLC22A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]21641380
D0156551-Methyl-4-phenylpyridiniumAtorvastatin Calcium inhibits the reaction [SLC22A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]21641380
D0156551-Methyl-4-phenylpyridiniumAtropine inhibits the reaction [SLC22A1 protein results in increased transport of 1-Methyl-4-phenylpyridinium]16263091
D0156551-Methyl-4-phenylpyridiniumAtropine inhibits the reaction [SLC22A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]21641380
D0156551-Methyl-4-phenylpyridiniumBisoprolol inhibits the reaction [SLC22A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]21641380
D0156551-Methyl-4-phenylpyridiniumcarvedilol inhibits the reaction [SLC22A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]21641380
D0156551-Methyl-4-phenylpyridiniumClonidine inhibits the reaction [SLC22A1 protein results in increased transport of 1-Methyl-4-phenylpyridinium]16263091
D0156551-Methyl-4-phenylpyridiniumDigoxin inhibits the reaction [SLC22A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]21641380
D0156551-Methyl-4-phenylpyridiniumDiltiazem inhibits the reaction [SLC22A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]21641380
D0156551-Methyl-4-phenylpyridiniumdiosmetin inhibits the reaction [SLC22A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]28867436
D0156551-Methyl-4-phenylpyridiniumDiphenhydramine inhibits the reaction [SLC22A1 protein results in increased transport of 1-Methyl-4-phenylpyridinium]16263091
D0156551-Methyl-4-phenylpyridiniumEstradiol inhibits the reaction [SLC22A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]12110607
D0156551-Methyl-4-phenylpyridiniumEtilefrine inhibits the reaction [SLC22A1 protein results in increased transport of 1-Methyl-4-phenylpyridinium]16263091
D0156551-Methyl-4-phenylpyridiniumFamotidine inhibits the reaction [SLC22A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]16141367
D0156551-Methyl-4-phenylpyridiniumFlecainide inhibits the reaction [SLC22A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]21641380
D0156551-Methyl-4-phenylpyridiniumIpratropium inhibits the reaction [SLC22A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]21641380
D0156551-Methyl-4-phenylpyridiniumLidocaine inhibits the reaction [SLC22A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]21641380
D0156551-Methyl-4-phenylpyridiniumMetformin inhibits the reaction [SLC22A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]16141367
D0156551-Methyl-4-phenylpyridiniumMetoprolol inhibits the reaction [SLC22A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]21641380
D0156551-Methyl-4-phenylpyridiniumMolsidomine inhibits the reaction [SLC22A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]21641380
D0156551-Methyl-4-phenylpyridiniumMonocrotaline inhibits the reaction [SLC22A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]23831208
D0156551-Methyl-4-phenylpyridinium[MYC protein results in increased expression of SLC22A1 protein] which results in increased import of 1-Methyl-4-phenylpyridinium19239227
D0156551-Methyl-4-phenylpyridiniumNadolol inhibits the reaction [SLC22A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]21641380
D0156551-Methyl-4-phenylpyridiniumNifedipine inhibits the reaction [SLC22A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]21641380
D0156551-Methyl-4-phenylpyridiniumPhenoxybenzamine inhibits the reaction [SLC22A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]12110607
D0156551-Methyl-4-phenylpyridiniumPrazosin inhibits the reaction [SLC22A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]12110607
D0156551-Methyl-4-phenylpyridiniumProgesterone inhibits the reaction [SLC22A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]12110607
D0156551-Methyl-4-phenylpyridiniumPropafenone inhibits the reaction [SLC22A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]21641380
D0156551-Methyl-4-phenylpyridiniumPropranolol inhibits the reaction [SLC22A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]21641380
D0156551-Methyl-4-phenylpyridiniumpseudoisocyanine inhibits the reaction [SLC22A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]12110607
D0156551-Methyl-4-phenylpyridiniumQuinidine inhibits the reaction [SLC22A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]16141367
D0156551-Methyl-4-phenylpyridiniumQuinine inhibits the reaction [SLC22A1 protein results in increased transport of 1-Methyl-4-phenylpyridinium]16263091
D0156551-Methyl-4-phenylpyridiniumRanitidine inhibits the reaction [SLC22A1 protein results in increased transport of 1-Methyl-4-phenylpyridinium]16263091
D0156551-Methyl-4-phenylpyridiniumRanitidine inhibits the reaction [SLC22A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]16141367
D0156551-Methyl-4-phenylpyridiniumSLC22A1 protein results in increased import of 1-Methyl-4-phenylpyridinium22394605
D0156551-Methyl-4-phenylpyridiniumSLC22A1 protein results in increased transport of 1-Methyl-4-phenylpyridinium16263091|2546696
D0156551-Methyl-4-phenylpyridiniumSLC22A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium12110607|1614136
D0156551-Methyl-4-phenylpyridiniumSLC22A1 results in increased import of 1-Methyl-4-phenylpyridinium9260930
D0156551-Methyl-4-phenylpyridiniumSpironolactone inhibits the reaction [SLC22A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]21641380
D0156551-Methyl-4-phenylpyridiniumtalinolol inhibits the reaction [SLC22A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]21641380
D0156551-Methyl-4-phenylpyridiniumTetraethylammonium inhibits the reaction [SLC22A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]16141367
D0156551-Methyl-4-phenylpyridiniumVerapamil inhibits the reaction [SLC22A1 protein results in increased transport of 1-Methyl-4-phenylpyridinium]25466967
D0156551-Methyl-4-phenylpyridiniumVerapamil inhibits the reaction [SLC22A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]21641380
D0156551-Methyl-4-phenylpyridinium1-Methyl-4-phenylpyridinium affects the reaction [SLC22A1 protein results in increased uptake of Tetraethylammonium]12440152
D0156551-Methyl-4-phenylpyridiniumQuinine inhibits the reaction [SLC22A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]16142924
D0156551-Methyl-4-phenylpyridiniumSLC22A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium16142924
D0156551-Methyl-4-phenylpyridiniumtetrabutylammonium inhibits the reaction [SLC22A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]16142924
D0156551-Methyl-4-phenylpyridiniumTetraethylammonium inhibits the reaction [SLC22A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]16142924
D0156551-Methyl-4-phenylpyridiniumtetrapentylammonium inhibits the reaction [SLC22A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]16142924
D0156321-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine"SLC22A1 protein results in increased susceptibility to 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine"25248837
D008790MetoprololMetoprolol inhibits the reaction [SLC22A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]21641380
D008981MolsidomineMolsidomine inhibits the reaction [SLC22A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]21641380
D016686MonocrotalineMonocrotaline inhibits the reaction [SLC22A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]23831208
D016686MonocrotalineQuinidine inhibits the reaction [SLC22A1 protein results in increased uptake of Monocrotaline]23831208
D016686MonocrotalineSLC22A1 protein results in increased uptake of Monocrotaline23831208
D016686Monocrotalinetetrahydropalmatine inhibits the reaction [SLC22A1 protein results in increased uptake of Monocrotaline]23831208
C420606mulberroside Amulberroside A inhibits the reaction [potassium oxonate results in decreased expression of SLC22A1 protein]22865646
C024058N(1)-methylnicotinamideSLC22A1 results in increased import of N(1)-methylnicotinamide9260930
D009248NadololNadolol inhibits the reaction [SLC22A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]21641380
D0150581-Naphthylisothiocyanate1-Naphthylisothiocyanate results in decreased expression of SLC22A1 mRNA15913567
C051752nefazodonenefazodone results in increased expression of SLC22A1 mRNA24136188
D009538NicotineNicotine inhibits the reaction [SLC22A1 protein results in increased import of Tetraethylammonium]27450509
D009543NifedipineNifedipine inhibits the reaction [SLC22A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]21641380
C012655nimesulidenimesulide results in increased expression of SLC22A1 mRNA24136188
C025589ochratoxin Aochratoxin A results in decreased expression of SLC22A1 mRNA16251485|1748331
D009853OmeprazoleOmeprazole affects the expression of SLC22A1 mRNA19483382
C016340o,p'-DDT"o,p'-DDT results in decreased expression of SLC22A1 mRNA"24464585
D009942Organometallic CompoundsOrganometallic Compounds affects the localization of SLC22A1 protein25588984
D010126Ozone[Ozone co-treated with Chlorine] results in increased expression of SLC22A1 mRNA18636392
D010278ParathionParathion results in increased methylation of SLC22A1 promoter22847954
D052638Particulate MatterParticulate Matter results in decreased expression of SLC22A1 mRNA25803276
D010634PhenobarbitalNR1I3 protein affects the reaction [Phenobarbital results in increased expression of SLC22A1 mRNA]19482888
D010634PhenobarbitalPhenobarbital results in increased expression of SLC22A1 mRNA19482888
D010634PhenobarbitalPhenobarbital results in increased expression of SLC22A1 mRNA16510358|1916217
D010643PhenoxybenzaminePhenoxybenzamine inhibits the reaction [SLC22A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]12110607
D010643PhenoxybenzaminePhenoxybenzamine results in decreased activity of SLC22A1 protein12110607
D010656Phenylephrine[Quinidine analog results in decreased activity of SLC22A1 protein] which results in decreased import of Phenylephrine21140131
D010795Phthalic AcidsPhthalic Acids results in increased expression of SLC22A1 mRNA21061450
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of SLC22A1 mRNA19710929
C006253pirinixic acidpirinixic acid affects the expression of SLC22A1 mRNA19483382
C006253pirinixic acidpirinixic acid results in decreased expression of SLC22A1 mRNA16940010|1916217
D010936Plant ExtractsPlant Extracts inhibits the reaction [potassium oxonate results in decreased expression of SLC22A1 mRNA]22967667
D010936Plant ExtractsPlant Extracts inhibits the reaction [potassium oxonate results in decreased expression of SLC22A1 protein]22967667
C058229polydatinpolydatin inhibits the reaction [potassium oxonate results in decreased expression of SLC22A1 protein]22865646
D059808PolyphenolsPolyphenols results in decreased expression of SLC22A1 mRNA16293270
D011192Potassium DichromatePotassium Dichromate results in increased expression of SLC22A1 mRNA23608068
C489337potassium oxonateAllopurinol inhibits the reaction [potassium oxonate results in decreased expression of SLC22A1 mRNA]21909718
C489337potassium oxonateAllopurinol inhibits the reaction [potassium oxonate results in decreased expression of SLC22A1 protein]21909718|2286564
C489337potassium oxonate"Drugs, Chinese Herbal inhibits the reaction [potassium oxonate results in decreased expression of SLC22A1 mRNA]"22967667
C489337potassium oxonate"Drugs, Chinese Herbal inhibits the reaction [potassium oxonate results in decreased expression of SLC22A1 protein]"22967667
C489337potassium oxonatemulberroside A inhibits the reaction [potassium oxonate results in decreased expression of SLC22A1 protein]22865646
C489337potassium oxonatePlant Extracts inhibits the reaction [potassium oxonate results in decreased expression of SLC22A1 mRNA]22967667
C489337potassium oxonatePlant Extracts inhibits the reaction [potassium oxonate results in decreased expression of SLC22A1 protein]22967667
C489337potassium oxonatepolydatin inhibits the reaction [potassium oxonate results in decreased expression of SLC22A1 protein]22865646
C489337potassium oxonatepotassium oxonate results in decreased expression of SLC22A1 mRNA21909718|2296766
C489337potassium oxonatepotassium oxonate results in decreased expression of SLC22A1 protein21909718|2286564
C489337potassium oxonateProbenecid inhibits the reaction [potassium oxonate results in decreased expression of SLC22A1 mRNA]22967667
C489337potassium oxonateProbenecid inhibits the reaction [potassium oxonate results in decreased expression of SLC22A1 protein]22865646|2296766
C489337potassium oxonateQuercetin inhibits the reaction [potassium oxonate results in decreased expression of SLC22A1 mRNA]21909718
C489337potassium oxonateQuercetin inhibits the reaction [potassium oxonate results in decreased expression of SLC22A1 protein]21909718
C489337potassium oxonateresveratrol inhibits the reaction [potassium oxonate results in decreased expression of SLC22A1 protein]22865646
D011224PrazosinPrazosin inhibits the reaction [SLC22A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]12110607
D011224PrazosinPrazosin results in decreased activity of SLC22A1 protein12110607
D011339ProbenecidProbenecid inhibits the reaction [potassium oxonate results in decreased expression of SLC22A1 mRNA]22967667
D011339ProbenecidProbenecid inhibits the reaction [potassium oxonate results in decreased expression of SLC22A1 protein]22865646|2296766
C045362prochlorazprochloraz results in increased expression of SLC22A1 mRNA27028005
D011374ProgesteroneProgesterone inhibits the reaction [SLC22A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]12110607
D011374ProgesteroneProgesterone results in decreased activity of SLC22A1 protein12110607
D011405PropafenonePropafenone inhibits the reaction [SLC22A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]21641380
D011433PropranololPropranolol inhibits the reaction [SLC22A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]21641380
D011441PropylthiouracilPropylthiouracil affects the expression of SLC22A1 mRNA19483382
C100254pseudoisocyaninepseudoisocyanine inhibits the reaction [SLC22A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]12110607
C100254pseudoisocyaninepseudoisocyanine results in decreased activity of SLC22A1 protein12110607
D011794QuercetinImipramine inhibits the reaction [SLC22A1 protein results in increased uptake of Quercetin]24947867
D011794QuercetinQuinidine inhibits the reaction [SLC22A1 protein results in increased uptake of Quercetin]24947867
D011794QuercetinSLC22A1 protein results in increased uptake of Quercetin24947867
D011794QuercetinTrimethoprim inhibits the reaction [SLC22A1 protein results in increased uptake of Quercetin]24947867
D011794QuercetinQuercetin inhibits the reaction [potassium oxonate results in decreased expression of SLC22A1 mRNA]21909718
D011794QuercetinQuercetin inhibits the reaction [potassium oxonate results in decreased expression of SLC22A1 protein]21909718
D011794QuercetinQuercetin inhibits the reaction [Fructose results in decreased expression of SLC22A1 mRNA]19605544
D011794QuercetinQuercetin inhibits the reaction [Fructose results in decreased expression of SLC22A1 protein]19605544
D011802QuinidineQuinidine inhibits the reaction [SLC22A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]16141367
D011802QuinidineQuinidine inhibits the reaction [SLC22A1 protein results in increased uptake of Monocrotaline]23831208
D011802QuinidineQuinidine inhibits the reaction [SLC22A1 protein results in increased uptake of Quercetin]24947867
D011802QuinidineQuinidine inhibits the reaction [SLC22A1 protein results in increased uptake of retrorsine]24799337
D011802Quinidine[Quinidine analog results in decreased activity of SLC22A1 protein] which results in decreased import of Phenylephrine21140131
D011802Quinidine[Quinidine analog results in decreased activity of SLC22A1 protein] which results in decreased import of Synephrine21140131
D011802QuinidineQuinidine analog results in decreased activity of SLC22A1 protein21140131
D011803QuinineQuinine inhibits the reaction [SLC22A1 protein results in increased transport of 1-Methyl-4-phenylpyridinium]16263091
D011803QuinineQuinine inhibits the reaction [SLC22A1 protein results in increased uptake of Ethidium]19357179
D011803QuinineQuinine results in decreased activity of SLC22A125844889
D011803Quinine[Quinine results in decreased activity of SLC22A1] which results in decreased uptake of abacavir25844889
D011803QuinineQuinine inhibits the reaction [SLC22A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]16142924
D011899RanitidineRanitidine inhibits the reaction [SLC22A1 protein results in increased transport of 1-Methyl-4-phenylpyridinium]16263091
D011899RanitidineRanitidine inhibits the reaction [SLC22A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]16141367
D011899RanitidineSLC22A1 protein affects the transport of Ranitidine16141367
D011899RanitidineSLC22A1 protein results in increased uptake of Ranitidine16006492
C059514resveratrolresveratrol inhibits the reaction [potassium oxonate results in decreased expression of SLC22A1 protein]22865646
C003300retrorsine4-(4-dimethylaminostyryl)-1-methylpyridinium inhibits the reaction [SLC22A1 protein results in increased uptake of retrorsine]24799337
C003300retrorsineQuinidine inhibits the reaction [SLC22A1 protein results in increased uptake of retrorsine]24799337
C003300retrorsineSLC22A1 protein promotes the reaction [CYP3A4 protein results in increased susceptibility to retrorsine]24799337
C003300retrorsineSLC22A1 protein results in increased uptake of retrorsine24799337
C003300retrorsineTetraethylammonium inhibits the reaction [SLC22A1 protein results in increased uptake of retrorsine]24799337
C003300retrorsinetetrahydropalmatine inhibits the reaction [SLC22A1 protein results in increased uptake of retrorsine]24799337
D012293RifampinNCOA1 protein inhibits the reaction [[NR1I2 protein co-treated with Rifampin] results in decreased expression of SLC22A1 mRNA]26920453
D012293RifampinNCOA1 protein inhibits the reaction [[NR1I2 protein results in increased susceptibility to Rifampin] which results in decreased expression of SLC22A1 mRNA]26920453
D012293Rifampin[NR1I2 protein co-treated with Rifampin] results in decreased expression of SLC22A1 mRNA26920453
D012293Rifampin[NR1I2 protein results in increased susceptibility to Rifampin] which results in decreased expression of SLC22A1 mRNA26920453
D012293RifampinRifampin inhibits the reaction [NCOA1 protein binds to SLC22A1 promoter]26920453
D012293RifampinRifampin promotes the reaction [NR1I2 protein results in decreased expression of SLC22A1 mRNA]26920453
D012293RifampinRifampin results in decreased expression of SLC22A1 mRNA26920453|2719975
D012293RifampinRifampin results in decreased expression of SLC22A1 protein26920453
C089730rosiglitazonerosiglitazone results in decreased expression of SLC22A1 mRNA25572481
D012431RutinRutin inhibits the reaction [Fructose results in decreased expression of SLC22A1 mRNA]19605544
D012431RutinRutin inhibits the reaction [Fructose results in decreased expression of SLC22A1 protein]19605544
D012822Silicon DioxideSilicon Dioxide analog results in increased expression of SLC22A1 mRNA23806026
C016104sodium bichromatesodium bichromate results in increased expression of SLC22A1 mRNA12325037
D013024Soybean OilSoybean Oil affects the expression of SLC22A1 mRNA15770074
D013148SpironolactoneSpironolactone inhibits the reaction [SLC22A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]21641380
D013311StreptozocinStreptozocin results in decreased expression of SLC22A1 protein19605544
D013467SulindacSulindac results in decreased activity of SLC22A1 protein12388633
D013578Synephrine[Quinidine analog results in decreased activity of SLC22A1 protein] which results in decreased import of Synephrine21140131
C011550talinololtalinolol inhibits the reaction [SLC22A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]21641380
C012568terbufosterbufos results in increased methylation of SLC22A1 promoter22847954
C020806tetrabromobisphenol Atetrabromobisphenol A inhibits the reaction [SLC22A1 protein results in increased uptake of Tetraethylammonium]27989701
C020806tetrabromobisphenol Atetrabromobisphenol A results in decreased activity of SLC22A1 protein27989701
C009405tetrabutylammoniumtetrabutylammonium inhibits the reaction [SLC22A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]16142924
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of SLC22A1 mRNA20106945|2580327
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of SLC22A1 mRNA21570461
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in decreased expression of SLC22A1 mRNA17942748
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of SLC22A1 mRNA22298810
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of SLC22A1 mRNA16054898|2121527
D019789Tetraethylammonium4-biphenylamine inhibits the reaction [SLC22A1 protein results in increased import of Tetraethylammonium]27450509
D019789Tetraethylammoniumbis(4-hydroxyphenyl)sulfone promotes the reaction [SLC22A1 protein results in increased uptake of Tetraethylammonium]27989701
D019789Tetraethylammoniumbisphenol A inhibits the reaction [SLC22A1 protein results in increased uptake of Tetraethylammonium]27989701
D019789Tetraethylammoniumbisphenol F inhibits the reaction [SLC22A1 protein results in increased uptake of Tetraethylammonium]27989701
D019789TetraethylammoniumImipramine inhibits the reaction [SLC22A1 protein results in increased uptake of Tetraethylammonium]25106415
D019789TetraethylammoniumNicotine inhibits the reaction [SLC22A1 protein results in increased import of Tetraethylammonium]27450509
D019789TetraethylammoniumSLC22A1 protein affects the transport of Tetraethylammonium16141367
D019789TetraethylammoniumSLC22A1 protein results in increased import of Tetraethylammonium25862123|2745050
D019789TetraethylammoniumSLC22A1 protein results in increased uptake of Tetraethylammonium21256917|2385098
D019789TetraethylammoniumSLC22A1 results in increased import of Tetraethylammonium9260930
D019789Tetraethylammoniumtetrabromobisphenol A inhibits the reaction [SLC22A1 protein results in increased uptake of Tetraethylammonium]27989701
D019789TetraethylammoniumTetraethylammonium inhibits the reaction [SLC22A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]16141367
D019789TetraethylammoniumTetraethylammonium inhibits the reaction [SLC22A1 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium]24799337
D019789TetraethylammoniumTetraethylammonium inhibits the reaction [SLC22A1 protein results in increased uptake of Ethidium]19357179
D019789TetraethylammoniumTetraethylammonium inhibits the reaction [SLC22A1 protein results in increased uptake of retrorsine]24799337
D019789TetraethylammoniumTobacco Smoke Pollution inhibits the reaction [SLC22A1 protein results in increased import of Tetraethylammonium]27450509
D019789TetraethylammoniumVerapamil inhibits the reaction [SLC22A1 protein results in increased import of Tetraethylammonium]25862123|2745050
D019789TetraethylammoniumVerapamil inhibits the reaction [SLC22A1 protein results in increased uptake of Tetraethylammonium]27989701
D019789TetraethylammoniumCadmium inhibits the reaction [SLC22A1 protein results in increased uptake of Tetraethylammonium]21513783
D019789TetraethylammoniumSLC22A1 protein results in increased uptake of Tetraethylammonium21513783
D019789TetraethylammoniumTetraethylammonium inhibits the reaction [SLC22A1 protein results in increased uptake of Cadmium]21513783
D019789Tetraethylammonium1-Methyl-4-phenylpyridinium affects the reaction [SLC22A1 protein results in increased uptake of Tetraethylammonium]12440152
D019789TetraethylammoniumChlorpheniramine affects the reaction [SLC22A1 protein results in increased uptake of Tetraethylammonium]12440152
D019789TetraethylammoniumDisopyramide affects the reaction [SLC22A1 protein results in increased uptake of Tetraethylammonium]12440152
D019789TetraethylammoniumDopamine affects the reaction [SLC22A1 protein results in increased uptake of Tetraethylammonium]12440152
D019789TetraethylammoniumSLC22A1 protein results in increased uptake of Tetraethylammonium12440152|1600649
D019789TetraethylammoniumTetraethylammonium inhibits the reaction [SLC22A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]16142924
C014215tetrahydropalmatinetetrahydropalmatine inhibits the reaction [SLC22A1 protein results in increased uptake of Monocrotaline]23831208
C014215tetrahydropalmatinetetrahydropalmatine inhibits the reaction [SLC22A1 protein results in increased uptake of retrorsine]24799337
C027435tetrapentylammoniumtetrapentylammonium inhibits the reaction [SLC22A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]16142924
D013853ThioacetamideThioacetamide affects the expression of SLC22A1 mRNA19483382
D013853ThioacetamideThioacetamide results in increased expression of SLC22A1 mRNA23411599|2622270
C009495titanium dioxidetitanium dioxide results in decreased expression of SLC22A1 mRNA23557971
D014028Tobacco Smoke PollutionAHR protein promotes the reaction [Tobacco Smoke Pollution results in decreased expression of SLC22A1 mRNA]27450509
D014028Tobacco Smoke PollutionTobacco Smoke Pollution inhibits the reaction [SLC22A1 protein results in increased import of Tetraethylammonium]27450509
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of SLC22A1 mRNA27450509
D014241TrichloroethyleneTrichloroethylene results in increased methylation of SLC22A1 gene27618143
D014295TrimethoprimTrimethoprim inhibits the reaction [SLC22A1 protein results in increased uptake of Quercetin]24947867
C057693troglitazonetroglitazone results in decreased expression of SLC22A1 mRNA25572481
C003330trospium chlorideSLC22A1 protein results in increased metabolism of trospium chloride25466967
C003330trospium chloridetrospium chloride results in decreased activity of SLC22A1 protein25466967
C080163trovafloxacintrovafloxacin results in decreased expression of SLC22A1 mRNA24136188
D014520UrethaneUrethane results in increased expression of SLC22A1 mRNA28818685
D014635Valproic AcidValproic Acid results in decreased expression of SLC22A1 mRNA29154799
D014635Valproic AcidValproic Acid affects the expression of SLC22A1 mRNA17292431
D001335Vehicle EmissionsVehicle Emissions results in decreased expression of SLC22A1 mRNA25803276
D014700VerapamilVerapamil inhibits the reaction [SLC22A1 protein results in increased import of Tetraethylammonium]25862123|2745050
D014700VerapamilVerapamil inhibits the reaction [SLC22A1 protein results in increased transport of 1-Methyl-4-phenylpyridinium]25466967
D014700VerapamilVerapamil inhibits the reaction [SLC22A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]21641380
D014700VerapamilVerapamil inhibits the reaction [SLC22A1 protein results in increased uptake of Tetraethylammonium]27989701
C025643vinclozolinvinclozolin results in decreased expression of SLC22A1 mRNA23034163
C029297vinylidene chloridevinylidene chloride results in decreased expression of SLC22A1 mRNA26682919

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI11543633  21988832  
GO:0015101organic cation transmembrane transporter activity-EXP19141712  
GO:0015101organic cation transmembrane transporter activity-TAS9187257  
GO:0042803protein homodimerization activity-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006855drug transmembrane transport-TAS-  
GO:0010248establishment or maintenance of transmembrane electrochemical gradient-IEA-  
GO:0015695organic cation transport-TAS9187257  
GO:0015697quaternary ammonium group transport-IEA-  
GO:0015711organic anion transport-IEA-  
GO:0048241epinephrine transport-IEA-  
GO:0051260protein homooligomerization-IEA-  
GO:0072488ammonium transmembrane transport-IEA-  
GO:1901374acetate ester transport-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005886plasma membrane-TAS-  
GO:0005887integral component of plasma membrane-TAS9187257  
GO:0016020membrane-TAS9187257  
GO:0016323basolateral plasma membrane-IEA-  
KEGG ID KEGG Term
hsa04976Bile secretion
Reactome ID Reactome Term Evidence
R-HSA-112310Neurotransmitter release cycleTAS
R-HSA-112311Neurotransmitter clearanceTAS
R-HSA-112315Transmission across Chemical SynapsesTAS
R-HSA-112316Neuronal SystemTAS
R-HSA-1430728MetabolismTAS
R-HSA-181430Norepinephrine Neurotransmitter Release CycleTAS
R-HSA-2161517Abacavir transmembrane transportTAS
R-HSA-2161522Abacavir transport and metabolismTAS
R-HSA-382551Transport of small moleculesTAS
R-HSA-425366Transport of bile salts and organic acids, metal ions and amine compoundsTAS
R-HSA-425407SLC-mediated transmembrane transportTAS
R-HSA-442660Na+/Cl- dependent neurotransmitter transportersTAS
R-HSA-549127Organic cation transportTAS
R-HSA-549132Organic cation/anion/zwitterion transportTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
25143296Organic cation transporter variation and response to smoking cessation therapies. (2014 Dec)Bergen AWNicotine Tob Res
27096250Pharmacokinetics of lamotrigine and its metabolite N-2-glucuronide: Influence of polymorphism of UDP-glucuronosyltransferases and drug transporters. (2016 Aug)Milosheska DBr J Clin Pharmacol