Gene: SLC22A3

6581
EMT|EMTH|OCT3
solute carrier family 22 member 3
protein-coding
6q25.3
Ensembl:ENSG00000146477 MIM:604842 Vega:OTTHUMG00000015953 UniprotKB:O75751
NC_000006.12
PubMed
0   ANCO-SNPs
ND|AD
3   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.651e-1 (AD)  4.951e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
TBX180.815
EBF10.809
PDE5A0.787
COL14A10.776
PLN0.77
GPX80.763
NR2F2-AS10.763
GJA50.76
PDE3A0.76
COL8A10.759

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
MAGIX-0.427
MYADML2-0.422
SAC3D1-0.414
DOHH-0.403
ASPDH-0.397
HAS1-0.397
MYH7B-0.392
FAM43B-0.389
HYAL3-0.386
MBLAC1-0.385

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00122CholineSmall Molecule62-49-7Approved|NutraceuticalTransporter
DB00182AmphetamineSmall Molecule300-62-9Approved|Illicit|InvestigationalTransporter
DB00184NicotineSmall Molecule54-11-5ApprovedTransporter
DB00331MetforminSmall Molecule657-24-9ApprovedTransporter
DB00368NorepinephrineSmall Molecule51-41-2ApprovedTransporter
DB00396ProgesteroneSmall Molecule57-83-0ApprovedTransporter
DB00457PrazosinSmall Molecule19216-56-9ApprovedTransporter
DB00458ImipramineSmall Molecule50-49-7ApprovedTransporter
DB00501CimetidineSmall Molecule51481-61-9Approved|InvestigationalTransporter
DB00526OxaliplatinSmall Molecule61825-94-3Approved|InvestigationalTransporter
DB00536GuanidineSmall Molecule113-00-8ApprovedTransporter
DB00541VincristineSmall Molecule57-22-7Approved|InvestigationalTransporter
DB00575ClonidineSmall Molecule4205-90-7ApprovedTransporter
DB00624TestosteroneSmall Molecule58-22-0Approved|InvestigationalTransporter
DB00709LamivudineSmall Molecule134678-17-4Approved|InvestigationalTransporter
DB00718Adefovir DipivoxilSmall Molecule142340-99-6Approved|InvestigationalTransporter
DB00762IrinotecanSmall Molecule97682-44-5Approved|InvestigationalTransporter
DB00783EstradiolSmall Molecule50-28-2Approved|InvestigationalTransporter
DB00925PhenoxybenzamineSmall Molecule59-96-1ApprovedTransporter
DB00988DopamineSmall Molecule51-61-6ApprovedTransporter
DB01035ProcainamideSmall Molecule51-06-9ApprovedTransporter
DB01042MelphalanSmall Molecule148-82-3ApprovedTransporter
DB01151DesipramineSmall Molecule50-47-5Approved|InvestigationalTransporter
DB01394ColchicineSmall Molecule64-86-8ApprovedTransporter
DB01577MethamphetamineSmall Molecule537-46-2Approved|IllicitTransporter
DB05381HistamineSmall Molecule51-45-6Approved|InvestigationalTransporter
DB08837TetraethylammoniumSmall Molecule66-40-0Experimental|InvestigationalTransporter
DB08838AgmatineSmall Molecule306-60-5Experimental|InvestigationalTransporter
DB08841TyramineSmall Molecule51-67-2Investigational|NutraceuticalTransporter
DB13943Testosterone cypionateSmall Molecule58-20-8ApprovedTransporter
DB13944Testosterone enanthateSmall Molecule315-37-7ApprovedTransporter
DB13946Testosterone undecanoateSmall Molecule5949-44-0Approved|InvestigationalTransporter
DB13952Estradiol acetateSmall Molecule4245-41-4Approved|InvestigationalTransporter
DB13953Estradiol benzoateSmall Molecule50-50-0Approved|InvestigationalTransporter
DB13954Estradiol cypionateSmall Molecule313-06-4Approved|InvestigationalTransporter
DB13955Estradiol dienanthateSmall Molecule7732-97-0Approved|InvestigationalTransporter
DB13956Estradiol valerateSmall Molecule979-32-8Approved|InvestigationalTransporter
ID Drug Name Action PubMed
C0857554-(1H-imidazol-4-ylmethyl)piperidine4-(1H-imidazol-4-ylmethyl)piperidine inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]12411423
C0857554-(1H-imidazol-4-ylmethyl)piperidine4-(1H-imidazol-4-ylmethyl)piperidine inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]12411423
D000082AcetaminophenAcetaminophen results in decreased expression of SLC22A3 mRNA22230336
D000082AcetaminophenAcetaminophen affects the expression of SLC22A3 mRNA17562736
D016604Aflatoxin B1Aflatoxin B1 affects the expression of SLC22A3 protein20106945
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of SLC22A3 mRNA21632981|2164198
D000393Air PollutantsAir Pollutants analog results in decreased expression of SLC22A3 mRNA21757418
D000447AldehydesAldehydes results in decreased expression of SLC22A3 mRNA25014914
D000643Ammonium ChlorideAmmonium Chloride affects the expression of SLC22A3 mRNA16483693
D000069059Atorvastatin CalciumAtorvastatin Calcium inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]21641380
D001285AtropineAtropine inhibits the reaction [SLC22A3 protein results in increased transport of 1-Methyl-4-phenylpyridinium]16263091
D001285AtropineSLC22A3 protein results in increased uptake of Atropine16263091
C547126AZM551248AZM551248 results in decreased expression of SLC22A3 mRNA22323515
C065857beclomethasone 17-monopropionateSLC22A3 protein results in increased susceptibility to [beclomethasone 17-monopropionate results in decreased transport of Formoterol Fumarate]21914487
C006703benzo(b)fluoranthene[Benzo(a)pyrene co-treated with benzo(b)fluoranthene] affects the expression of SLC22A3 mRNA17690111
D001564Benzo(a)pyrene[Benzo(a)pyrene co-treated with benzo(b)fluoranthene] affects the expression of SLC22A3 mRNA17690111
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of SLC22A3 mRNA16269432|2010694
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of SLC22A3 mRNA21839799
D004958EstradiolEstradiol inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]12110607
D004958EstradiolEstradiol results in decreased activity of SLC22A3 protein12110607
D004958EstradiolEstradiol results in decreased expression of SLC22A3 mRNA20106945
D004958EstradiolEstradiol inhibits the reaction [SLC22A3 protein results in increased transport of Histamine]16928864
D004958EstradiolEstradiol results in decreased activity of SLC22A3 protein12181285
C006780bisphenol Abisphenol A results in decreased expression of SLC22A3 mRNA26063408
C006780bisphenol A[bisphenol A co-treated with Genistein] results in increased methylation of SLC22A3 gene28505145
C006780bisphenol Abisphenol A results in decreased expression of SLC22A3 mRNA25181051
C006780bisphenol Abisphenol A results in increased expression of SLC22A3 mRNA18180321
C006780bisphenol Abisphenol A results in increased methylation of SLC22A3 gene28505145
C105826BU 224BU 224 inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]12411423
C105826BU 224BU 224 inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]12411423
D019819BudesonideBudesonide inhibits the reaction [SLC22A3 protein results in increased uptake of Formoterol Fumarate]17920670
D019819BudesonideSLC22A3 protein results in increased susceptibility to [Budesonide results in decreased transport of Formoterol Fumarate]21914487
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide affects the expression of SLC22A3 mRNA23410634
C018475butyraldehydebutyraldehyde results in decreased expression of SLC22A3 mRNA26079696
C043211carvedilolcarvedilol inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]21641380|2169772
C043211carvedilolcarvedilol inhibits the reaction [SLC22A3 protein results in increased uptake of Metformin]21697722
D002737ChloropreneChloroprene results in decreased expression of SLC22A3 mRNA23125180
D002927CimetidineCimetidine inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]21697722
D002927CimetidineCimetidine inhibits the reaction [SLC22A3 protein results in increased uptake of Ethidium]19357179
D002927CimetidineCimetidine inhibits the reaction [SLC22A3 protein results in increased uptake of Metformin]21697722
D002927CimetidineSLC22A3 protein results in increased transport of Cimetidine18253050
C086108clobenpropitclobenpropit inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]12411423
C086108clobenpropitclobenpropit inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]12411423
D003000ClonidineClonidine inhibits the reaction [SLC22A3 protein results in increased transport of 1-Methyl-4-phenylpyridinium]16263091
C018021cobaltous chloridecobaltous chloride results in decreased expression of SLC22A3 mRNA19376846
D019327Copper SulfateCopper Sulfate results in decreased expression of SLC22A3 mRNA19549813
D003345CorticosteroneCorticosterone inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]12110607|1241142
D003345CorticosteroneCorticosterone inhibits the reaction [SLC22A3 protein results in increased uptake of Formoterol Fumarate]17920670
D003345CorticosteroneCorticosterone results in decreased activity of SLC22A3 protein12110607
D003345CorticosteroneCorticosterone inhibits the reaction [SLC22A3 protein results in increased transport of 1-Methyl-4-phenylpyridinium]16928864
D003345CorticosteroneCorticosterone inhibits the reaction [SLC22A3 protein results in increased transport of Histamine]16928864
D003345CorticosteroneCorticosterone results in decreased activity of SLC22A3 protein12181285
D003345Corticosterone[Corticosterone results in decreased activity of SLC22A3 protein] inhibits the reaction [Epinephrine results in increased abundance of Epinephrine metabolite]19053318
D003345Corticosterone[Corticosterone results in decreased activity of SLC22A3 protein] which results in decreased abundance of Epinephrine19053318
D003345Corticosterone[Corticosterone results in decreased activity of SLC22A3 protein] which results in decreased import of Phenylephrine21140131
D003345Corticosterone[Corticosterone results in decreased activity of SLC22A3 protein] which results in decreased import of Synephrine21140131
D003345CorticosteroneCorticosterone results in decreased activity of SLC22A3 protein19053318|2114013
C016855cyanine 863cyanine 863 results in decreased activity of SLC22A3 protein12181285
D016572CyclosporineCyclosporine results in decreased expression of SLC22A3 mRNA20106945|2556210
D016572CyclosporineCyclosporine results in increased expression of SLC22A3 mRNA27989131
C010902decabromobiphenyl etherdecabromobiphenyl ether results in increased expression of SLC22A3 mRNA23640034
C014347decitabinedecitabine affects the expression of SLC22A3 mRNA23300844
C494355desisobutyrylciclesonideSLC22A3 protein results in increased susceptibility to [desisobutyrylciclesonide results in decreased transport of Formoterol Fumarate]21914487
D002945CisplatinCisplatin affects the expression of SLC22A3 mRNA23300844
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in decreased expression of SLC22A3 mRNA27392435
D002945CisplatinCisplatin results in decreased expression of SLC22A321905038
D002945CisplatinCisplatin results in decreased expression of SLC22A3 mRNA27392435
D002945CisplatinSLC22A3 affects the susceptibility to Cisplatin21905038
D002945CisplatinSLC22A3 results in increased uptake of Cisplatin21905038
D019259LamivudineSLC22A3 protein results in increased uptake of Lamivudine19141712
D004041Dietary FatsDietary Fats results in decreased expression of SLC22A3 mRNA18042831
D004041Dietary FatsDietary Fats results in increased expression of SLC22A3 mRNA27401566
D004041Dietary FatsDietary Fats results in increased expression of SLC22A3 protein27401566
D004077DigoxinDigoxin inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]21641380
D004155DiphenhydramineDiphenhydramine inhibits the reaction [SLC22A3 protein results in increased transport of 1-Methyl-4-phenylpyridinium]16263091
C103851disprocynium 24disprocynium 24 inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]12411423
C103851disprocynium 24disprocynium 24 inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]12411423
D004298DopamineSLC22A3 protein results in increased uptake of Dopamine20858707
D004726EndosulfanEndosulfan inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of SLC22A3 mRNA]26159488
D004837EpinephrineSLC22A3 protein results in increased uptake of Epinephrine20858707
D004837Epinephrine[Corticosterone results in decreased activity of SLC22A3 protein] inhibits the reaction [Epinephrine results in increased abundance of Epinephrine metabolite]19053318
D004837Epinephrine[Corticosterone results in decreased activity of SLC22A3 protein] which results in decreased abundance of Epinephrine19053318
D000431EthanolEthanol results in increased expression of SLC22A3 mRNA19167417
D004996Ethidium1-Methyl-4-phenylpyridinium inhibits the reaction [SLC22A3 protein results in increased uptake of Ethidium]19357179
D004996EthidiumCimetidine inhibits the reaction [SLC22A3 protein results in increased uptake of Ethidium]19357179
D004996EthidiumQuinine inhibits the reaction [SLC22A3 protein results in increased uptake of Ethidium]19357179
D004996EthidiumSLC22A3 protein results in increased uptake of Ethidium19357179
D004996EthidiumTetraethylammonium inhibits the reaction [SLC22A3 protein results in increased uptake of Ethidium]19357179
D005039EtilefrineEtilefrine inhibits the reaction [SLC22A3 protein results in increased transport of 1-Methyl-4-phenylpyridinium]16263091
D005039EtilefrineSLC22A3 protein results in increased uptake of Etilefrine16263091
D015738FamotidineFamotidine inhibits the reaction [SLC22A3 protein affects the transport of 1-Methyl-4-phenylpyridinium]16141367
D015738FamotidineFamotidine inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]16141367
D015738FamotidineFamotidine results in decreased activity of SLC22A3 protein16141367
D005424FlecainideFlecainide inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]21641380
D000068298FluticasoneFluticasone inhibits the reaction [SLC22A3 protein results in increased uptake of Formoterol Fumarate]17920670
D000068298FluticasoneSLC22A3 protein results in increased susceptibility to [Fluticasone results in decreased transport of Formoterol Fumarate]21914487
D004397FonofosFonofos results in increased methylation of SLC22A3 promoter22847954
D005557FormaldehydeFormaldehyde results in increased expression of SLC22A3 mRNA23649840
D000068759Formoterol FumarateBudesonide inhibits the reaction [SLC22A3 protein results in increased uptake of Formoterol Fumarate]17920670
D000068759Formoterol FumarateCorticosterone inhibits the reaction [SLC22A3 protein results in increased uptake of Formoterol Fumarate]17920670
D000068759Formoterol FumarateFluticasone inhibits the reaction [SLC22A3 protein results in increased uptake of Formoterol Fumarate]17920670
D000068759Formoterol FumarateSLC22A3 protein results in increased susceptibility to [beclomethasone 17-monopropionate results in decreased transport of Formoterol Fumarate]21914487
D000068759Formoterol FumarateSLC22A3 protein results in increased susceptibility to [Budesonide results in decreased transport of Formoterol Fumarate]21914487
D000068759Formoterol FumarateSLC22A3 protein results in increased susceptibility to [desisobutyrylciclesonide results in decreased transport of Formoterol Fumarate]21914487
D000068759Formoterol FumarateSLC22A3 protein results in increased susceptibility to [Fluticasone results in decreased transport of Formoterol Fumarate]21914487
D000068759Formoterol FumarateSLC22A3 protein results in increased uptake of Formoterol Fumarate17920670
D019833Genistein[bisphenol A co-treated with Genistein] results in increased methylation of SLC22A3 gene28505145
D006632HistamineHistamine inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]12411423
D006632HistamineSLC22A3 protein polymorphism affects the uptake of Histamine20562519
D006632HistamineSLC22A3 protein results in increased uptake of Histamine20858707
D006632HistamineCorticosterone inhibits the reaction [SLC22A3 protein results in increased transport of Histamine]16928864
D006632HistamineEstradiol inhibits the reaction [SLC22A3 protein results in increased transport of Histamine]16928864
D006632HistamineHistamine inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]12411423
D006632Histaminepseudoisocyanine inhibits the reaction [SLC22A3 protein results in increased transport of Histamine]16928864
D006632HistamineSerotonin inhibits the reaction [SLC22A3 protein results in increased transport of Histamine]16928864
D006632HistamineSLC22A3 protein results in increased transport of Histamine16928864
D012701SerotoninSLC22A3 protein results in increased uptake of Serotonin20858707
D012701SerotoninSerotonin inhibits the reaction [SLC22A3 protein results in increased transport of Histamine]16928864
D006861Hydrogen PeroxideHydrogen Peroxide affects the expression of SLC22A3 mRNA23410634
D007099ImipramineImipramine inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]21697722
D007099ImipramineImipramine inhibits the reaction [SLC22A3 protein results in increased uptake of Metformin]21697722
D007454IodidesIodides deficiency affects the expression of SLC22A3 mRNA21623536
D009241IpratropiumIpratropium inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]21641380
C544151jinfukang[Cisplatin co-treated with jinfukang] results in decreased expression of SLC22A3 mRNA27392435
C008261lead acetate[lead acetate co-treated with zinc protoporphyrin] results in increased expression of SLC22A3 mRNA22839698
D008012LidocaineLidocaine inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]21641380
D015122MercaptopurineMercaptopurine results in decreased expression of SLC22A3 mRNA23358152
D008627Mercuric ChlorideMercuric Chloride results in increased expression of SLC22A3 mRNA28536007
D008687Metformincarvedilol inhibits the reaction [SLC22A3 protein results in increased uptake of Metformin]21697722
D008687MetforminCimetidine inhibits the reaction [SLC22A3 protein results in increased uptake of Metformin]21697722
D008687MetforminImipramine inhibits the reaction [SLC22A3 protein results in increased uptake of Metformin]21697722
D008687MetforminMetformin inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]16141367
D008687MetforminSLC22A3 protein results in increased uptake of Metformin21697722
D008687MetforminVerapamil inhibits the reaction [SLC22A3 protein results in increased uptake of Metformin]21697722
D008687Metformin[1-Methyl-4-phenylpyridinium results in decreased activity of [SLC22A3 protein co-treated with SLC47A1 protein]] which results in decreased transport of Metformin23562376
D008687MetforminSLC22A3 protein results in increased uptake of Metformin23562376
D0156551-Methyl-4-phenylpyridinium1-Methyl-4-phenylpyridinium inhibits the reaction [SLC22A3 protein results in increased uptake of Ethidium]19357179
D0156551-Methyl-4-phenylpyridinium4-(1H-imidazol-4-ylmethyl)piperidine inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]12411423
D0156551-Methyl-4-phenylpyridiniumAtorvastatin Calcium inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]21641380
D0156551-Methyl-4-phenylpyridiniumAtropine inhibits the reaction [SLC22A3 protein results in increased transport of 1-Methyl-4-phenylpyridinium]16263091
D0156551-Methyl-4-phenylpyridiniumBU 224 inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]12411423
D0156551-Methyl-4-phenylpyridiniumcarvedilol inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]21641380|2169772
D0156551-Methyl-4-phenylpyridiniumCimetidine inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]21697722
D0156551-Methyl-4-phenylpyridiniumclobenpropit inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]12411423
D0156551-Methyl-4-phenylpyridiniumClonidine inhibits the reaction [SLC22A3 protein results in increased transport of 1-Methyl-4-phenylpyridinium]16263091
D0156551-Methyl-4-phenylpyridiniumCorticosterone inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]12110607|1241142
D0156551-Methyl-4-phenylpyridiniumDigoxin inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]21641380
D0156551-Methyl-4-phenylpyridiniumDiphenhydramine inhibits the reaction [SLC22A3 protein results in increased transport of 1-Methyl-4-phenylpyridinium]16263091
D0156551-Methyl-4-phenylpyridiniumdisprocynium 24 inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]12411423
D0156551-Methyl-4-phenylpyridiniumEstradiol inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]12110607
D0156551-Methyl-4-phenylpyridiniumEtilefrine inhibits the reaction [SLC22A3 protein results in increased transport of 1-Methyl-4-phenylpyridinium]16263091
D0156551-Methyl-4-phenylpyridiniumFamotidine inhibits the reaction [SLC22A3 protein affects the transport of 1-Methyl-4-phenylpyridinium]16141367
D0156551-Methyl-4-phenylpyridiniumFamotidine inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]16141367
D0156551-Methyl-4-phenylpyridiniumFlecainide inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]21641380
D0156551-Methyl-4-phenylpyridiniumHistamine inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]12411423
D0156551-Methyl-4-phenylpyridiniumImipramine inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]21697722
D0156551-Methyl-4-phenylpyridiniumIpratropium inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]21641380
D0156551-Methyl-4-phenylpyridiniumLidocaine inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]21641380
D0156551-Methyl-4-phenylpyridiniumMetformin inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]16141367
D0156551-Methyl-4-phenylpyridiniummetiprenaline inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]12110607
D0156551-Methyl-4-phenylpyridiniumMolsidomine inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]21641380
D0156551-Methyl-4-phenylpyridiniumNifedipine inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]21641380
D0156551-Methyl-4-phenylpyridiniumPapaverine inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]12411423
D0156551-Methyl-4-phenylpyridiniumPhenoxybenzamine inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]12110607
D0156551-Methyl-4-phenylpyridiniumPhentolamine inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]12411423
D0156551-Methyl-4-phenylpyridiniumPrazosin inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]12110607
D0156551-Methyl-4-phenylpyridiniumProgesterone inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]12110607
D0156551-Methyl-4-phenylpyridiniumPropafenone inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]21641380
D0156551-Methyl-4-phenylpyridiniumPropranolol inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]21641380
D0156551-Methyl-4-phenylpyridiniumpseudoisocyanine inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]12110607|2085870
D0156551-Methyl-4-phenylpyridiniumQuinidine inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]16141367
D0156551-Methyl-4-phenylpyridiniumQuinine inhibits the reaction [SLC22A3 protein results in increased transport of 1-Methyl-4-phenylpyridinium]16263091
D0156551-Methyl-4-phenylpyridiniumRanitidine inhibits the reaction [SLC22A3 protein affects the transport of 1-Methyl-4-phenylpyridinium]16141367
D0156551-Methyl-4-phenylpyridiniumRanitidine inhibits the reaction [SLC22A3 protein results in increased transport of 1-Methyl-4-phenylpyridinium]16263091
D0156551-Methyl-4-phenylpyridiniumRanitidine inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]16141367
D0156551-Methyl-4-phenylpyridiniumSK&F 550 inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]12110607
D0156551-Methyl-4-phenylpyridiniumSLC22A3 protein polymorphism affects the uptake of 1-Methyl-4-phenylpyridinium20562519
D0156551-Methyl-4-phenylpyridiniumSLC22A3 protein results in increased transport of 1-Methyl-4-phenylpyridinium16263091
D0156551-Methyl-4-phenylpyridiniumSLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium12110607|1241142
D0156551-Methyl-4-phenylpyridiniumSpironolactone inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]21641380
D0156551-Methyl-4-phenylpyridiniumTetraethylammonium inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]16141367
D0156551-Methyl-4-phenylpyridiniumthioperamide inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]12411423
D0156551-Methyl-4-phenylpyridiniumtrimazosin inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]12411423
D0156551-Methyl-4-phenylpyridiniumVerapamil inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]21641380|2169772
D0156551-Methyl-4-phenylpyridinium[1-Methyl-4-phenylpyridinium results in decreased activity of [SLC22A3 protein co-treated with SLC47A1 protein]] which results in decreased transport of Metformin23562376
D0156551-Methyl-4-phenylpyridinium4-(1H-imidazol-4-ylmethyl)piperidine inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]12411423
D0156551-Methyl-4-phenylpyridiniumBU 224 inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]12411423
D0156551-Methyl-4-phenylpyridiniumclobenpropit inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]12411423
D0156551-Methyl-4-phenylpyridiniumCorticosterone inhibits the reaction [SLC22A3 protein results in increased transport of 1-Methyl-4-phenylpyridinium]16928864
D0156551-Methyl-4-phenylpyridiniumdisprocynium 24 inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]12411423
D0156551-Methyl-4-phenylpyridiniumHistamine inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]12411423
D0156551-Methyl-4-phenylpyridiniumPapaverine inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]12411423
D0156551-Methyl-4-phenylpyridiniumPhentolamine inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]12411423
D0156551-Methyl-4-phenylpyridiniumpseudoisocyanine inhibits the reaction [SLC22A3 protein results in increased transport of 1-Methyl-4-phenylpyridinium]16928864
D0156551-Methyl-4-phenylpyridiniumSLC22A3 protein results in increased transport of 1-Methyl-4-phenylpyridinium16928864|2254327
D0156551-Methyl-4-phenylpyridiniumSLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium12411423
D0156551-Methyl-4-phenylpyridiniumthioperamide inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]12411423
D0156551-Methyl-4-phenylpyridiniumtrimazosin inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]12411423
C008401metiprenalinemetiprenaline inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]12110607
C008401metiprenalinemetiprenaline results in decreased activity of SLC22A3 protein12110607
D015735MifepristoneMifepristone results in decreased expression of SLC22A3 mRNA17584828
D008981MolsidomineMolsidomine inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]21641380
D009543NifedipineNifedipine inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]21641380
D009638NorepinephrineSLC22A3 protein results in increased uptake of Norepinephrine20858707
D017239PaclitaxelSLC22A3 protein affects the susceptibility to Paclitaxel16217747
D017239PaclitaxelPaclitaxel results in increased expression of SLC22A3 mRNA15585946
D000073878Palm OilPalm Oil results in decreased expression of SLC22A3 mRNA18042831
D010208PapaverinePapaverine inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]12411423
D010208PapaverinePapaverine inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]12411423
D010278ParathionParathion results in increased methylation of SLC22A3 promoter22847954
D052638Particulate MatterParticulate Matter results in decreased expression of SLC22A3 mRNA22178795
C046012pentanalpentanal results in decreased expression of SLC22A3 mRNA26079696
C494474perchlorateperchlorate affects the expression of SLC22A3 mRNA21623536
C027579periodate-oxidized adenosineperiodate-oxidized adenosine affects the expression of SLC22A3 mRNA17097637
D010634PhenobarbitalPhenobarbital affects the expression of SLC22A3 mRNA19159669
D010634PhenobarbitalNR1I3 protein affects the reaction [Phenobarbital results in increased expression of SLC22A3 mRNA]19482888
D010634PhenobarbitalPhenobarbital affects the expression of SLC22A3 mRNA23091169
D010634PhenobarbitalPhenobarbital results in increased expression of SLC22A3 mRNA19482888
D010643PhenoxybenzaminePhenoxybenzamine inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]12110607
D010643PhenoxybenzaminePhenoxybenzamine results in decreased activity of SLC22A3 protein12110607
D010646PhentolaminePhentolamine inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]12411423
D010646PhentolaminePhentolamine inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]12411423
D010656Phenylephrine[Corticosterone results in decreased activity of SLC22A3 protein] which results in decreased import of Phenylephrine21140131
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of SLC22A3 mRNA18489776
C006253pirinixic acidpirinixic acid results in increased expression of SLC22A3 mRNA17426115|2081375
D011224PrazosinPrazosin inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]12110607
D011224PrazosinPrazosin results in decreased activity of SLC22A3 protein12110607
D011374ProgesteroneProgesterone inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]12110607
D011374ProgesteroneProgesterone results in decreased activity of SLC22A3 protein12110607
D011405PropafenonePropafenone inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]21641380
C005556propionaldehydepropionaldehyde results in decreased expression of SLC22A3 mRNA26079696
D011433PropranololPropranolol inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]21641380
C100254pseudoisocyaninepseudoisocyanine inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]12110607|2085870
C100254pseudoisocyanineSLC22A3 protein results in increased uptake of pseudoisocyanine28597291
C100254pseudoisocyaninepseudoisocyanine inhibits the reaction [SLC22A3 protein results in increased transport of 1-Methyl-4-phenylpyridinium]16928864
C100254pseudoisocyaninepseudoisocyanine inhibits the reaction [SLC22A3 protein results in increased transport of Histamine]16928864
D011794QuercetinQuercetin results in decreased expression of SLC22A3 mRNA21632981
D011794QuercetinQuercetin results in increased expression of SLC22A3 mRNA18095365
D011802QuinidineQuinidine inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]16141367
D011803QuinineQuinine inhibits the reaction [SLC22A3 protein results in increased transport of 1-Methyl-4-phenylpyridinium]16263091
D011803QuinineQuinine inhibits the reaction [SLC22A3 protein results in increased uptake of Ethidium]19357179
D015125OxyquinolineOxyquinoline results in decreased expression of SLC22A3 mRNA21632981
D011899RanitidineRanitidine inhibits the reaction [SLC22A3 protein affects the transport of 1-Methyl-4-phenylpyridinium]16141367
D011899RanitidineRanitidine inhibits the reaction [SLC22A3 protein results in increased transport of 1-Methyl-4-phenylpyridinium]16263091
D011899RanitidineRanitidine inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]16141367
D000068299Salmeterol XinafoateSLC22A3 protein results in increased uptake of Salmeterol Xinafoate17920670
C110822SDZ CPI 975SDZ CPI 975 results in decreased expression of SLC22A3 mRNA19234235
C094089SDZ FOX 988SDZ FOX 988 results in decreased expression of SLC22A3 mRNA19234235
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of SLC22A3 mRNA25895662
D012822Silicon DioxideSilicon Dioxide analog results in increased expression of SLC22A3 mRNA23806026
C102994SK&F 550SK&F 550 inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]12110607
C102994SK&F 550SK&F 550 results in decreased activity of SLC22A3 protein12110607
D013148SpironolactoneSpironolactone inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]21641380
D013469SulpirideSLC22A3 protein results in increased uptake of Sulpiride28597291
D013578Synephrine[Corticosterone results in decreased activity of SLC22A3 protein] which results in decreased import of Synephrine21140131
C012568terbufosterbufos results in increased methylation of SLC22A3 promoter22847954
C020806tetrabromobisphenol Atetrabromobisphenol A results in increased expression of SLC22A3 mRNA28300664
D013749TetrachlorodibenzodioxinEndosulfan inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of SLC22A3 mRNA]26159488
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of SLC22A3 mRNA22298810
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of SLC22A3 mRNA20106945|2163298
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of SLC22A3 mRNA26377647
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of SLC22A3 mRNA21215274|2623252
D019789TetraethylammoniumSLC22A3 protein results in increased uptake of Tetraethylammonium21256917
D019789TetraethylammoniumTetraethylammonium inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]16141367
D019789TetraethylammoniumTetraethylammonium inhibits the reaction [SLC22A3 protein results in increased uptake of Ethidium]19357179
C052075thioperamidethioperamide inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]12411423
C052075thioperamidethioperamide inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]12411423
D014212TretinoinTretinoin results in increased expression of SLC22A3 mRNA20488242
C005185trimazosintrimazosin inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]12411423
C005185trimazosintrimazosin inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]12411423
D014295TrimethoprimSLC22A3 protein results in increased transport of Trimethoprim18253050
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of SLC22A3 mRNA"26179874
D014415TunicamycinTunicamycin results in increased expression of SLC22A3 mRNA17127020
D014635Valproic AcidValproic Acid affects the expression of SLC22A3 mRNA25979313
D014635Valproic AcidValproic Acid affects the expression of SLC22A3 mRNA17292431
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of SLC22A3 gene25560391
D014700VerapamilVerapamil inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]21641380|2169772
D014700VerapamilVerapamil inhibits the reaction [SLC22A3 protein results in increased uptake of Metformin]21697722
D014747VinblastineSLC22A3 protein affects the susceptibility to Vinblastine16217747
D024483Vitamin K 3Vitamin K 3 affects the expression of SLC22A3 mRNA23410634
C017803zinc protoporphyrin[lead acetate co-treated with zinc protoporphyrin] results in increased expression of SLC22A3 mRNA22839698

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI17474147  
GO:0015101organic cation transmembrane transporter activity-EXP19141712  
GO:0015101organic cation transmembrane transporter activity-IDA10966924  16024787  
GO:0015101organic cation transmembrane transporter activity-TAS-  
GO:0015651quaternary ammonium group transmembrane transporter activity-IDA10966924  
GO:0019534toxin transmembrane transporter activity-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006855drug transmembrane transport-TAS-  
GO:0015695organic cation transport-IDA10966924  16024787  
GO:0015697quaternary ammonium group transport-IDA10966924  
GO:0015711organic anion transport-IEA-  
GO:0032098regulation of appetite-IEA-  
GO:0051615histamine uptake-IEA-  
GO:1901998toxin transport-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005886plasma membrane-TAS-  
GO:0005887integral component of plasma membrane-TAS9933568  
GO:0016020membrane-TAS9933568  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-1430728MetabolismTAS
R-HSA-2161517Abacavir transmembrane transportTAS
R-HSA-2161522Abacavir transport and metabolismTAS
R-HSA-382551Transport of small moleculesTAS
R-HSA-425366Transport of bile salts and organic acids, metal ions and amine compoundsTAS
R-HSA-425407SLC-mediated transmembrane transportTAS
R-HSA-549127Organic cation transportTAS
R-HSA-549132Organic cation/anion/zwitterion transportTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
19033200Organic cation transporter 3: Keeping the brake on extracellular serotonin in serotonin-transporter-deficient mice. (2008 Dec 2)Baganz NLProc Natl Acad Sci U S A
25143296Organic cation transporter variation and response to smoking cessation therapies. (2014 Dec)Bergen AWNicotine Tob Res
22216278Large scale association analysis identifies three susceptibility loci for coronary artery disease. (2011)Saade SPLoS One