Gene info: ID 6583

Gene: SLC22A4

GENE ID: 6583

Synonyms: DFNB60|OCTN1

Description: solute carrier family 22 member 4

Gene type: protein-coding

Location: 5q31.1

dbXrefs: Ensembl:ENSG00000197208 MIM:604190 Vega:OTTHUMG00000059648 UniprotKB:Q9H015

RefSeq: NG_012129.1

Retrived from: PubMed|SNP Mapped

SNPs: 1 ANCO-SNPs

Phenotype: CD|ND|AD

# Publications: 3

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 5.316e-1 (AD) 9.933e-2 (ND)

ANCO-SNPs

SNP ID	Position	Alleles	Trait	Variation Type
rs11739484	chr5:132321067 (GRCh38.p7)	A>G	alcohol dependence	SNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
IL1RAP	0.725
SERPINB8	0.722
NAMPT	0.692
INHBA	0.688
ARFGAP3	0.687
PLK3	0.684
CITED1	0.683
SPOCD1	0.679
MAPK1IP1L	0.668
SOD2	0.662

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
OR4F5	-0.328
OR4F29	-0.283
GAGE10	-0.195
TBX10	-0.192
SPRR2A	-0.188
TEX29	-0.185
LCN1	-0.18
RNASE8	-0.176
LY6D	-0.175
CLDN9	-0.173

ID	Drug Name	Drug Type	CAS Num	Status	Role
DB00122	Choline	Small Molecule	62-49-7	Approved\|Nutraceutical	Transporter
DB00123	L-Lysine	Small Molecule	56-87-1	Approved\|Nutraceutical	Transporter
DB00125	L-Arginine	Small Molecule	74-79-3	Approved\|Nutraceutical	Transporter
DB00127	Spermine	Small Molecule	71-44-3	Approved\|Nutraceutical	Transporter
DB00184	Nicotine	Small Molecule	54-11-5	Approved	Transporter
DB00332	Ipratropium bromide	Small Molecule	22254-24-6	Approved	Transporter
DB00345	Aminohippuric acid	Small Molecule	61-78-9	Approved\|Investigational	Transporter
DB00458	Imipramine	Small Molecule	50-49-7	Approved	Transporter
DB00468	Quinine	Small Molecule	130-95-0	Approved	Transporter
DB00501	Cimetidine	Small Molecule	51481-61-9	Approved\|Investigational	Transporter
DB00536	Guanidine	Small Molecule	113-00-8	Approved	Transporter
DB00575	Clonidine	Small Molecule	4205-90-7	Approved	Transporter
DB00583	L-Carnitine	Small Molecule	541-15-1	Approved\|Investigational	Transporter
DB00594	Amiloride	Small Molecule	2609-46-3	Approved	Transporter
DB00624	Testosterone	Small Molecule	58-22-0	Approved\|Investigational	Transporter
DB00661	Verapamil	Small Molecule	52-53-9	Approved	Transporter
DB00908	Quinidine	Small Molecule	56-54-2	Approved\|Investigational	Transporter
DB01035	Procainamide	Small Molecule	51-06-9	Approved	Transporter
DB01053	Benzylpenicillin	Small Molecule	61-33-6	Approved	Transporter
DB01137	Levofloxacin	Small Molecule	100986-85-4	Approved\|Investigational	Transporter
DB01151	Desipramine	Small Molecule	50-47-5	Approved\|Investigational	Transporter
DB01165	Ofloxacin	Small Molecule	82419-36-1	Approved	Transporter
DB01409	Tiotropium	Small Molecule	186691-13-4	Approved	Transporter
DB01917	Putrescine	Small Molecule	110-60-1	Experimental	Transporter
DB03566	Spermidine	Small Molecule	124-20-9	Experimental	Transporter
DB06691	Mepyramine	Small Molecule	91-84-9	Approved	Transporter
DB08837	Tetraethylammonium	Small Molecule	66-40-0	Experimental\|Investigational	Transporter
DB13943	Testosterone cypionate	Small Molecule	58-20-8	Approved	Transporter
DB13944	Testosterone enanthate	Small Molecule	315-37-7	Approved	Transporter
DB13946	Testosterone undecanoate	Small Molecule	5949-44-0	Approved\|Investigational	Transporter
DB00583	L-Carnitine	Small Molecule	541-15-1	Approved\|Investigational	Target

ID	Drug Name	Action	PubMed
C548651	2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester	2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in increased expression of SLC22A4 mRNA	19933214
C023514	2,6-dinitrotoluene	"2,6-dinitrotoluene results in increased expression of SLC22A4 mRNA"	20406850
C511621	2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide	2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of SLC22A4 mRNA]	23625689
C511621	2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide	2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide results in decreased expression of SLC22A4 mRNA	23625689
D000082	Acetaminophen	Acetaminophen results in decreased expression of SLC22A4 mRNA	26690555
D000082	Acetaminophen	Acetaminophen results in increased expression of SLC22A4 mRNA	29067470
D000082	Acetaminophen	Acetaminophen affects the expression of SLC22A4 mRNA	17562736
D000111	Acetylcysteine	Acetylcysteine inhibits the reaction [Mercury results in decreased activity of SLC22A4 protein]	25490951
D000111	Acetylcysteine	Acetylcysteine inhibits the reaction [methylmercuric chloride results in decreased activity of SLC22A4 protein]	25490951
D020106	Acrylamide	Acrylamide results in increased expression of SLC22A4 mRNA	28959563
D016604	Aflatoxin B1	Aflatoxin B1 affects the expression of SLC22A4 protein	20106945
D016604	Aflatoxin B1	Aflatoxin B1 results in increased expression of SLC22A4 mRNA	22100608
D000493	Allopurinol	Allopurinol inhibits the reaction [potassium oxonate results in decreased expression of SLC22A4 mRNA]	21909718
D000493	Allopurinol	Allopurinol inhibits the reaction [potassium oxonate results in decreased expression of SLC22A4 protein]	21909718\|2286564
D000643	Ammonium Chloride	Ammonium Chloride affects the expression of SLC22A4 mRNA	16483693
C011659	angelicin	angelicin results in decreased expression of SLC22A4 mRNA	22173200
D018501	Antirheumatic Agents	Antirheumatic Agents results in decreased expression of SLC22A4 mRNA	24449571
D034341	Aristolochic Acids	Aristolochic Acids results in decreased expression of SLC22A4 mRNA	21167265
D034341	Aristolochic Acids	Aristolochic Acids results in decreased expression of SLC22A4 protein	21167265
D001285	Atropine	Atropine inhibits the reaction [SLC22A4 protein results in increased uptake of Tetraethylammonium]	21641380
C547126	AZM551248	AZM551248 results in decreased expression of SLC22A4 mRNA	22323515
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of SLC22A4 mRNA	20106945\|2163298
D004958	Estradiol	[Estradiol co-treated with Tetrachlorodibenzodioxin] results in increased expression of SLC22A4 mRNA	19619570
D004958	Estradiol	Estradiol results in increased expression of SLC22A4 mRNA	19619570
D004958	Estradiol	Estradiol results in increased expression of SLC22A4 mRNA	19484750
C006780	bisphenol A	bisphenol A affects the expression of SLC22A4 mRNA	25181051
C006780	bisphenol A	bisphenol A results in increased methylation of SLC22A4 gene	28505145
D002104	Cadmium	Cadmium results in decreased activity of SLC22A4 protein	25490951
D002104	Cadmium	Dithioerythritol inhibits the reaction [Cadmium results in decreased activity of SLC22A4 protein]	25490951
D002251	Carbon Tetrachloride	Carbon Tetrachloride affects the expression of SLC22A4 mRNA	17484886
D002331	Carnitine	SLC22A4 protein results in increased uptake of Carnitine	21256917
C043211	carvedilol	carvedilol inhibits the reaction [SLC22A4 protein results in increased uptake of Tetraethylammonium]	21641380
C074702	chromium hexavalent ion	chromium hexavalent ion affects the expression of SLC22A4 mRNA	28472532
D002922	Ciguatoxins	Ciguatoxins affects the expression of SLC22A4 mRNA	18353800
C018021	cobaltous chloride	cobaltous chloride results in increased expression of SLC22A4 mRNA	24386269
D003471	Cuprizone	Cuprizone results in increased expression of SLC22A4 mRNA	26577399
D003513	Cycloheximide	Cycloheximide results in increased expression of SLC22A4 mRNA	19684285
D003513	Cycloheximide	[Tetrachlorodibenzodioxin co-treated with Cycloheximide] results in increased expression of SLC22A4 mRNA	19684285
D016572	Cyclosporine	Cyclosporine results in increased expression of SLC22A4 mRNA	20106945
D003545	Cysteine	Cysteine inhibits the reaction [Mercury results in decreased activity of SLC22A4 protein]	25490951
D003545	Cysteine	Cysteine inhibits the reaction [methylmercuric chloride results in decreased activity of SLC22A4 protein]	25490951
C014347	decitabine	decitabine results in increased expression of SLC22A4 mRNA	28597291
D003907	Dexamethasone	Dexamethasone results in increased expression of SLC22A4 mRNA	20032058
D003907	Dexamethasone	Testosterone inhibits the reaction [Dexamethasone results in increased expression of SLC22A4 mRNA]	20032058
D002945	Cisplatin	[Cisplatin co-treated with RELB mutant form co-treated with TNF protein] results in decreased expression of SLC22A4 mRNA	23625948
D004041	Dietary Fats	Dietary Fats results in decreased expression of SLC22A4 mRNA	18042831
D004052	Diethylnitrosamine	Diethylnitrosamine results in decreased expression of SLC22A4 mRNA	17942915
D004052	Diethylnitrosamine	MET protein inhibits the reaction [Diethylnitrosamine results in decreased expression of SLC22A4 mRNA]	17942915
D004110	Diltiazem	Diltiazem inhibits the reaction [SLC22A4 protein results in increased uptake of Tetraethylammonium]	21641380
D004226	Dithioerythritol	Dithioerythritol inhibits the reaction [Cadmium results in decreased activity of SLC22A4 protein]	25490951
D004226	Dithioerythritol	Dithioerythritol inhibits the reaction [Mercury results in decreased activity of SLC22A4 protein]	25490951
D004226	Dithioerythritol	Dithioerythritol inhibits the reaction [methylmercuric chloride results in decreased activity of SLC22A4 protein]	25490951
D004365	Drugs, Chinese Herbal	"Drugs, Chinese Herbal inhibits the reaction [potassium oxonate results in decreased expression of SLC22A4 mRNA]"	22967667
D004365	Drugs, Chinese Herbal	"Drugs, Chinese Herbal inhibits the reaction [potassium oxonate results in decreased expression of SLC22A4 protein]"	22967667
D005363	Ficusin	Ficusin results in decreased expression of SLC22A4 mRNA	22173200
D005424	Flecainide	Flecainide inhibits the reaction [SLC22A4 protein results in increased uptake of Tetraethylammonium]	21641380
D005557	Formaldehyde	Formaldehyde results in increased expression of SLC22A4 mRNA	23649840
C069837	fullerene C60	fullerene C60 results in decreased expression of SLC22A4 mRNA	19167457
D006918	Hydroxyurea	SLC22A4 protein results in increased uptake of Hydroxyurea	21256917
C031534	imperatorin	imperatorin results in decreased expression of SLC22A4 mRNA	22173200
D009241	Ipratropium	Ipratropium inhibits the reaction [SLC22A4 protein results in increased uptake of Tetraethylammonium]	21641380
C045463	leflunomide	leflunomide results in decreased expression of SLC22A4 mRNA	28988120
C045463	leflunomide	leflunomide results in increased expression of SLC22A4 mRNA	24136188
D008012	Lidocaine	Lidocaine inhibits the reaction [SLC22A4 protein results in increased uptake of Tetraethylammonium]	21641380
D058185	Magnetite Nanoparticles	[Succimer binds to Magnetite Nanoparticles] which results in increased expression of SLC22A4 mRNA	21641980
C013592	mangiferin	mangiferin results in increased expression of SLC22A4 mRNA	21348301
D008628	Mercury	Acetylcysteine inhibits the reaction [Mercury results in decreased activity of SLC22A4 protein]	25490951
D008628	Mercury	Cysteine inhibits the reaction [Mercury results in decreased activity of SLC22A4 protein]	25490951
D008628	Mercury	Dithioerythritol inhibits the reaction [Mercury results in decreased activity of SLC22A4 protein]	25490951
D008628	Mercury	Mercury binds to and results in decreased activity of SLC22A4 protein	25490951
C093171	methanethiosulfonate ethylammonium	methanethiosulfonate ethylammonium results in decreased activity of SLC22A4 protein	25490951
C004925	methylmercuric chloride	Acetylcysteine inhibits the reaction [methylmercuric chloride results in decreased activity of SLC22A4 protein]	25490951
C004925	methylmercuric chloride	Cysteine inhibits the reaction [methylmercuric chloride results in decreased activity of SLC22A4 protein]	25490951
C004925	methylmercuric chloride	Dithioerythritol inhibits the reaction [methylmercuric chloride results in decreased activity of SLC22A4 protein]	25490951
C004925	methylmercuric chloride	methylmercuric chloride binds to and results in decreased activity of SLC22A4 protein	25490951
D020366	Methylmethacrylate	Methylmethacrylate results in increased expression of SLC22A4 mRNA	16916219
C420606	mulberroside A	mulberroside A inhibits the reaction [potassium oxonate results in decreased expression of SLC22A4 protein]	22865646
C583365	N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide	"N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide results in increased expression of SLC22A4 mRNA"	29244179
D037742	Nanotubes, Carbon	"Nanotubes, Carbon analog results in decreased expression of SLC22A4 mRNA"	25620056
D037742	Nanotubes, Carbon	"Nanotubes, Carbon results in decreased expression of SLC22A4 mRNA"	25620056
C028007	nickel monoxide	nickel monoxide affects the expression of SLC22A4 mRNA	19167457
D009543	Nifedipine	Nifedipine inhibits the reaction [SLC22A4 protein results in increased uptake of Tetraethylammonium]	21641380
C030110	oxaliplatin	[oxaliplatin co-treated with Topotecan] results in decreased expression of SLC22A4 mRNA	25729387
C030110	oxaliplatin	oxaliplatin results in decreased expression of SLC22A4 mRNA	25729387
D000073878	Palm Oil	Palm Oil results in decreased expression of SLC22A4 mRNA	18042831
D010629	Phenformin	SLC22A4 protein affects the uptake of Phenformin	23221006
D010629	Phenformin	SLC22A4 protein results in increased susceptibility to Phenformin	23221006
C006253	pirinixic acid	[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of SLC22A4 mRNA	19710929
D010936	Plant Extracts	Plant Extracts inhibits the reaction [potassium oxonate results in decreased expression of SLC22A4 mRNA]	22967667
D010936	Plant Extracts	Plant Extracts inhibits the reaction [potassium oxonate results in decreased expression of SLC22A4 protein]	22967667
C058229	polydatin	polydatin inhibits the reaction [potassium oxonate results in decreased expression of SLC22A4 protein]	22865646
C489337	potassium oxonate	Allopurinol inhibits the reaction [potassium oxonate results in decreased expression of SLC22A4 mRNA]	21909718
C489337	potassium oxonate	Allopurinol inhibits the reaction [potassium oxonate results in decreased expression of SLC22A4 protein]	21909718\|2286564
C489337	potassium oxonate	"Drugs, Chinese Herbal inhibits the reaction [potassium oxonate results in decreased expression of SLC22A4 mRNA]"	22967667
C489337	potassium oxonate	"Drugs, Chinese Herbal inhibits the reaction [potassium oxonate results in decreased expression of SLC22A4 protein]"	22967667
C489337	potassium oxonate	mulberroside A inhibits the reaction [potassium oxonate results in decreased expression of SLC22A4 protein]	22865646
C489337	potassium oxonate	Plant Extracts inhibits the reaction [potassium oxonate results in decreased expression of SLC22A4 mRNA]	22967667
C489337	potassium oxonate	Plant Extracts inhibits the reaction [potassium oxonate results in decreased expression of SLC22A4 protein]	22967667
C489337	potassium oxonate	polydatin inhibits the reaction [potassium oxonate results in decreased expression of SLC22A4 protein]	22865646
C489337	potassium oxonate	potassium oxonate results in decreased expression of SLC22A4 mRNA	21909718\|2296766
C489337	potassium oxonate	potassium oxonate results in decreased expression of SLC22A4 protein	21909718\|2286564
C489337	potassium oxonate	Probenecid inhibits the reaction [potassium oxonate results in decreased expression of SLC22A4 mRNA]	22967667
C489337	potassium oxonate	Probenecid inhibits the reaction [potassium oxonate results in decreased expression of SLC22A4 protein]	22865646\|2296766
C489337	potassium oxonate	Quercetin inhibits the reaction [potassium oxonate results in decreased expression of SLC22A4 mRNA]	21909718
C489337	potassium oxonate	Quercetin inhibits the reaction [potassium oxonate results in decreased expression of SLC22A4 protein]	21909718
D011339	Probenecid	Probenecid inhibits the reaction [potassium oxonate results in decreased expression of SLC22A4 mRNA]	22967667
D011339	Probenecid	Probenecid inhibits the reaction [potassium oxonate results in decreased expression of SLC22A4 protein]	22865646\|2296766
D011405	Propafenone	Propafenone inhibits the reaction [SLC22A4 protein results in increased uptake of Tetraethylammonium]	21641380
D011433	Propranolol	Propranolol inhibits the reaction [SLC22A4 protein results in increased uptake of Tetraethylammonium]	21641380
D011441	Propylthiouracil	Propylthiouracil affects the expression of SLC22A4 mRNA	24780913
D011794	Quercetin	Quercetin inhibits the reaction [potassium oxonate results in decreased expression of SLC22A4 mRNA]	21909718
D011794	Quercetin	Quercetin inhibits the reaction [potassium oxonate results in decreased expression of SLC22A4 protein]	21909718
D017632	Asbestos, Serpentine	"Asbestos, Serpentine results in increased expression of SLC22A4 mRNA"	24160326
D012822	Silicon Dioxide	Silicon Dioxide analog results in increased expression of SLC22A4 mRNA	25895662
D012834	Silver	Silver results in increased expression of SLC22A4 mRNA	27131904
D012906	Smoke	Smoke results in increased expression of SLC22A4 mRNA	21095227
C016104	sodium bichromate	sodium bichromate results in decreased expression of SLC22A4 mRNA	24612858
D012999	Soman	Soman results in increased expression of SLC22A4 mRNA	19281266
D053260	Soot	Soot results in increased expression of SLC22A4 mRNA	26551751
D013148	Spironolactone	Spironolactone inhibits the reaction [SLC22A4 protein results in increased uptake of Tetraethylammonium]	21641380
D004113	Succimer	[Succimer binds to Magnetite Nanoparticles] which results in increased expression of SLC22A4 mRNA	21641980
D013739	Testosterone	Testosterone inhibits the reaction [Dexamethasone results in increased expression of SLC22A4 mRNA]	20032058
D013749	Tetrachlorodibenzodioxin	2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of SLC22A4 mRNA]	23625689
D013749	Tetrachlorodibenzodioxin	[Estradiol co-treated with Tetrachlorodibenzodioxin] results in increased expression of SLC22A4 mRNA	19619570
D013749	Tetrachlorodibenzodioxin	[Tetrachlorodibenzodioxin co-treated with Cycloheximide] results in increased expression of SLC22A4 mRNA	19684285
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of SLC22A4 mRNA	19619570\|1968428
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of SLC22A4 mRNA	19933214\|2629044
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of SLC22A4 mRNA	16267337
D019789	Tetraethylammonium	Atropine inhibits the reaction [SLC22A4 protein results in increased uptake of Tetraethylammonium]	21641380
D019789	Tetraethylammonium	carvedilol inhibits the reaction [SLC22A4 protein results in increased uptake of Tetraethylammonium]	21641380
D019789	Tetraethylammonium	Diltiazem inhibits the reaction [SLC22A4 protein results in increased uptake of Tetraethylammonium]	21641380
D019789	Tetraethylammonium	Flecainide inhibits the reaction [SLC22A4 protein results in increased uptake of Tetraethylammonium]	21641380
D019789	Tetraethylammonium	Ipratropium inhibits the reaction [SLC22A4 protein results in increased uptake of Tetraethylammonium]	21641380
D019789	Tetraethylammonium	Lidocaine inhibits the reaction [SLC22A4 protein results in increased uptake of Tetraethylammonium]	21641380
D019789	Tetraethylammonium	Nifedipine inhibits the reaction [SLC22A4 protein results in increased uptake of Tetraethylammonium]	21641380
D019789	Tetraethylammonium	Propafenone inhibits the reaction [SLC22A4 protein results in increased uptake of Tetraethylammonium]	21641380
D019789	Tetraethylammonium	Propranolol inhibits the reaction [SLC22A4 protein results in increased uptake of Tetraethylammonium]	21641380
D019789	Tetraethylammonium	SLC22A4 protein results in increased transport of Tetraethylammonium	25490951
D019789	Tetraethylammonium	Spironolactone inhibits the reaction [SLC22A4 protein results in increased uptake of Tetraethylammonium]	21641380
D019789	Tetraethylammonium	Verapamil inhibits the reaction [SLC22A4 protein results in increased uptake of Tetraethylammonium]	21641380
D013849	Thimerosal	Thimerosal results in decreased activity of SLC22A4 protein	25490951
D013853	Thioacetamide	Thioacetamide results in decreased expression of SLC22A4 mRNA	23411599
C009495	titanium dioxide	titanium dioxide results in decreased expression of SLC22A4 mRNA	23557971
D019772	Topotecan	[oxaliplatin co-treated with Topotecan] results in decreased expression of SLC22A4 mRNA	25729387
D019772	Topotecan	Topotecan results in decreased expression of SLC22A4 mRNA	25729387
C496197	trans-10,cis-12-conjugated linoleic acid	"trans-10,cis-12-conjugated linoleic acid results in increased expression of SLC22A4 mRNA"	17951470
D014212	Tretinoin	Tretinoin results in increased expression of SLC22A4 mRNA	23830798
C015559	trimellitic anhydride	trimellitic anhydride results in decreased expression of SLC22A4 mRNA	19042947
C016805	tris(1,3-dichloro-2-propyl)phosphate	"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of SLC22A4 mRNA"	26179874
C057693	troglitazone	troglitazone results in increased expression of SLC22A4 mRNA	19140230
D014635	Valproic Acid	Valproic Acid results in increased expression of SLC22A4 mRNA	23179753\|2915479
D014640	Vancomycin	Vancomycin results in increased expression of SLC22A4 mRNA	18930951
D014700	Verapamil	Verapamil inhibits the reaction [SLC22A4 protein results in increased uptake of Tetraethylammonium]	21641380
C029297	vinylidene chloride	vinylidene chloride results in decreased expression of SLC22A4 mRNA	26682919
D015215	Zidovudine	Zidovudine results in increased expression of SLC22A4 mRNA	24292225
C088658	zoledronic acid	zoledronic acid results in increased expression of SLC22A4 mRNA	24714768

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0000166	nucleotide binding	-	TAS	9426230
GO:0005515	protein binding	-	IPI	15523054
GO:0005524	ATP binding	-	IEA	-
GO:0008513	secondary active organic cation transmembrane transporter activity	-	TAS	-
GO:0015226	carnitine transmembrane transporter activity	-	IDA	16729965
GO:0015293	symporter activity	-	IEA	-
GO:0015491	cation:cation antiporter activity	-	IDA	9426230
GO:0015651	quaternary ammonium group transmembrane transporter activity	-	IDA	9426230
GO:0030165	PDZ domain binding	-	IPI	15523054

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0006641	triglyceride metabolic process	-	IEA	-
GO:0006814	sodium ion transport	-	IEA	-
GO:0007589	body fluid secretion	-	TAS	9426230
GO:0015695	organic cation transport	-	TAS	9426230
GO:0015697	quaternary ammonium group transport	-	IDA	9426230
GO:0015711	organic anion transport	-	IEA	-
GO:0015879	carnitine transport	-	IDA	16729965
GO:1902603	carnitine transmembrane transport	-	IEA	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005739	mitochondrion	-	IDA	16729965
GO:0005886	plasma membrane	-	IC	9426230
GO:0005886	plasma membrane	-	TAS	-
GO:0005887	integral component of plasma membrane	-	TAS	9426230
GO:0016324	apical plasma membrane	-	IDA	18641280

KEGG ID	KEGG Term

Reactome ID	Reactome Term	Evidence
R-HSA-382551	Transport of small molecules	TAS
R-HSA-425366	Transport of bile salts and organic acids, metal ions and amine compounds	TAS
R-HSA-425407	SLC-mediated transmembrane transport	TAS
R-HSA-549127	Organic cation transport	TAS
R-HSA-549132	Organic cation/anion/zwitterion transport	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
25505599	Gene expression analysis of membrane transporters and drug-metabolizing enzymes in the lung of healthy and COPD subjects. (2014 Aug)	Berg T	Pharmacol Res Perspect
26171154	Association of TOMM40 and SLC22A4 polymorphisms with ischemic stroke. (2015 Jul)	Yamase Y	Biomed Rep
15838240	Understanding the genetic contribution to rheumatoid arthritis. (2005 May)	van der Helm-van Mil AH	Curr Opin Rheumatol