Gene info: ID 6584

Gene: SLC22A5

GENE ID: 6584

Synonyms: CDSP|OCTN2

Description: solute carrier family 22 member 5

Gene type: protein-coding

Location: 5q31.1

dbXrefs: Ensembl:ENSG00000197375 MIM:603377 Vega:OTTHUMG00000059634 UniprotKB:O76082

RefSeq: NG_008982.1

Retrived from: SNP Mapped

SNPs: 2 ANCO-SNPs

Phenotype: ND|AD

# Publications: 0

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 5.833e-1 (AD) 1.143e-1 (ND)

ANCO-SNPs

SNP ID	Position	Alleles	Trait	Variation Type
rs274551	chr5:132391988 (GRCh38.p7)	T>C	nicotine dependence	SNV(Single Nucleotide Variation)
rs17689550	chr5:132387373 (GRCh38.p7)	C>T	alcohol dependence	SNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
ECHDC2	0.789
SEMA4B	0.779
TPP1	0.77
ACO1	0.767
MCCC2	0.764
ACOX1	0.761
RYR3	0.754
NEK9	0.753
SLC44A2	0.75
SMARCD2	0.747

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
OR4F5	-0.467
OR4F29	-0.462
SULT2B1	-0.287
IBSP	-0.276
SCARA5	-0.275
FER1L6	-0.251
KRT72	-0.25
CYP1A1	-0.249
FCRL4	-0.247
EXOC3L4	-0.242

ID	Drug Name	Drug Type	CAS Num	Status	Role
DB00122	Choline	Small Molecule	62-49-7	Approved\|Nutraceutical	Transporter
DB00125	L-Arginine	Small Molecule	74-79-3	Approved\|Nutraceutical	Transporter
DB00148	Creatine	Small Molecule	57-00-1	Approved\|Investigational\|Nutraceutical	Transporter
DB00152	Thiamine	Small Molecule	70-16-6	Approved\|Investigational\|Nutraceutical	Transporter
DB00182	Amphetamine	Small Molecule	300-62-9	Approved\|Illicit\|Investigational	Transporter
DB00184	Nicotine	Small Molecule	54-11-5	Approved	Transporter
DB00281	Lidocaine	Small Molecule	137-58-6	Approved	Transporter
DB00313	Valproic Acid	Small Molecule	99-66-1	Approved\|Investigational	Transporter
DB00332	Ipratropium bromide	Small Molecule	22254-24-6	Approved	Transporter
DB00345	Aminohippuric acid	Small Molecule	61-78-9	Approved\|Investigational	Transporter
DB00365	Grepafloxacin	Small Molecule	119914-60-2	Approved\|Investigational\|Withdrawn	Transporter
DB00368	Norepinephrine	Small Molecule	51-41-2	Approved	Transporter
DB00415	Ampicillin	Small Molecule	69-53-4	Approved	Transporter
DB00438	Ceftazidime	Small Molecule	72558-82-8	Approved	Transporter
DB00456	Cefalotin	Small Molecule	153-61-7	Approved\|Investigational	Transporter
DB00468	Quinine	Small Molecule	130-95-0	Approved	Transporter
DB00501	Cimetidine	Small Molecule	51481-61-9	Approved\|Investigational	Transporter
DB00535	Cefdinir	Small Molecule	91832-40-5	Approved	Transporter
DB00536	Guanidine	Small Molecule	113-00-8	Approved	Transporter
DB00567	Cephalexin	Small Molecule	15686-71-2	Approved\|Investigational	Transporter
DB00575	Clonidine	Small Molecule	4205-90-7	Approved	Transporter
DB00583	L-Carnitine	Small Molecule	541-15-1	Approved\|Investigational	Transporter
DB00627	Niacin	Small Molecule	59-67-6	Approved\|Investigational\|Nutraceutical	Transporter
DB00661	Verapamil	Small Molecule	52-53-9	Approved	Transporter
DB00668	Epinephrine	Small Molecule	51-43-4	Approved	Transporter
DB00671	Cefixime	Small Molecule	79350-37-1	Approved\|Investigational	Transporter
DB00689	Cephaloglycin	Small Molecule	3577-01-3	Approved	Transporter
DB00695	Furosemide	Small Molecule	54-31-9	Approved	Transporter
DB00908	Quinidine	Small Molecule	56-54-2	Approved\|Investigational	Transporter
DB00970	Dactinomycin	Small Molecule	50-76-0	Approved\|Investigational	Transporter
DB00978	Lomefloxacin	Small Molecule	98079-51-7	Approved\|Investigational	Transporter
DB00988	Dopamine	Small Molecule	51-61-6	Approved	Transporter
DB01000	Cyclacillin	Small Molecule	3485-14-1	Approved	Transporter
DB01032	Probenecid	Small Molecule	57-66-9	Approved\|Investigational	Transporter
DB01035	Procainamide	Small Molecule	51-06-9	Approved	Transporter
DB01053	Benzylpenicillin	Small Molecule	61-33-6	Approved	Transporter
DB01059	Norfloxacin	Small Molecule	70458-96-7	Approved	Transporter
DB01075	Diphenhydramine	Small Molecule	58-73-1	Approved\|Investigational	Transporter
DB01140	Cefadroxil	Small Molecule	50370-12-2	Approved\|Withdrawn	Transporter
DB01151	Desipramine	Small Molecule	50-47-5	Approved\|Investigational	Transporter
DB01165	Ofloxacin	Small Molecule	82419-36-1	Approved	Transporter
DB01208	Sparfloxacin	Small Molecule	110871-86-8	Approved\|Investigational	Transporter
DB01333	Cefradine	Small Molecule	38821-53-3	Approved	Transporter
DB01409	Tiotropium	Small Molecule	186691-13-4	Approved	Transporter
DB01413	Cefepime	Small Molecule	88040-23-7	Approved\|Investigational	Transporter
DB01577	Methamphetamine	Small Molecule	537-46-2	Approved\|Illicit	Transporter
DB03128	Acetylcholine	Small Molecule	51-84-3	Approved	Transporter
DB04133	Degraded Cephaloridine	Small Molecule	-	Experimental	Transporter
DB04630	Aldosterone	Small Molecule	52-39-1	Experimental\|Investigational	Transporter
DB05381	Histamine	Small Molecule	51-45-6	Approved\|Investigational	Transporter
DB06691	Mepyramine	Small Molecule	91-84-9	Approved	Transporter
DB08795	Azidocillin	Small Molecule	17243-38-8	Approved	Transporter
DB08837	Tetraethylammonium	Small Molecule	66-40-0	Experimental\|Investigational	Transporter
DB08842	Acetylcarnitine	Small Molecule	3040-38-8	Approved\|Investigational	Transporter
DB00583	L-Carnitine	Small Molecule	541-15-1	Approved\|Investigational	Target

ID	Drug Name	Action	PubMed
C049325	1,2-dithiol-3-thione	"1,2-dithiol-3-thione results in decreased expression of SLC22A5 mRNA"	19162173
C525485	2-(2'-hydroxy-3',5'-di-tert-butylphenyl)benzotriazole	"2-(2'-hydroxy-3',5'-di-tert-butylphenyl)benzotriazole affects the expression of SLC22A5 mRNA"	27665778
C016403	2,4-dinitrotoluene	"2,4-dinitrotoluene affects the expression of SLC22A5 mRNA"	21346803
C050147	3-(2,2,2-trimethylhydrazine)propionate	"SLC22A5 protein results in increased uptake of 3-(2,2,2-trimethylhydrazine)propionate"	18981167
C050147	3-(2,2,2-trimethylhydrazine)propionate	"SLC22A5 protein results in increased uptake of 3-(2,2,2-trimethylhydrazine)propionate"	18981167
C050147	3-(2,2,2-trimethylhydrazine)propionate	"SLC22A5 protein results in increased uptake of 3-(2,2,2-trimethylhydrazine)propionate"	18981167
C028451	3,4,3',4'-tetrachlorobiphenyl	"3,4,3',4'-tetrachlorobiphenyl inhibits the reaction [Dietary Fats results in increased expression of SLC22A5 mRNA]"	19467301
D000082	Acetaminophen	Acetaminophen affects the expression of SLC22A5 mRNA	17562736
D000108	Acetylcarnitine	SLC22A5 protein results in increased uptake of Acetylcarnitine	16826461
D000111	Acetylcysteine	Acetylcysteine affects the reaction [Methylmercury Compounds results in decreased transport of SLC22A5 protein]	22900493
D000111	Acetylcysteine	Acetylcysteine inhibits the reaction [Mercuric Chloride results in decreased transport of SLC22A5 protein]	22900493
D020106	Acrylamide	Acrylamide results in decreased expression of SLC22A5 mRNA	28959563
C016601	afimoxifene	afimoxifene inhibits the reaction [Estrogens results in increased expression of SLC22A5 mRNA]	21233418
D016604	Aflatoxin B1	Aflatoxin B1 results in increased expression of SLC22A5 mRNA	19770486
D000493	Allopurinol	Allopurinol inhibits the reaction [potassium oxonate results in decreased expression of SLC22A5 mRNA]	21909718
D000493	Allopurinol	Allopurinol inhibits the reaction [potassium oxonate results in decreased expression of SLC22A5 protein]	21909718\|2286564
D000493	Allopurinol	Allopurinol inhibits the reaction [Fructose results in decreased expression of SLC22A5 protein]	22426011
D000535	Aluminum	[APP protein modified form binds to Aluminum] which results in increased expression of SLC22A5 mRNA	21298039
D000638	Amiodarone	Amiodarone inhibits the reaction [SLC22A5 protein results in increased uptake of Carnitine]	21641380
C011659	angelicin	angelicin results in increased expression of SLC22A5 protein	22173200
D018501	Antirheumatic Agents	Antirheumatic Agents results in increased expression of SLC22A5 mRNA	24449571
D034341	Aristolochic Acids	Aristolochic Acids results in decreased expression of SLC22A5 mRNA	21167265
D034341	Aristolochic Acids	Aristolochic Acids results in decreased expression of SLC22A5 protein	21167265
C006632	arsenic trioxide	SLC22A5 protein results in decreased susceptibility to arsenic trioxide	20707922
D000069059	Atorvastatin Calcium	Atorvastatin Calcium inhibits the reaction [SLC22A5 protein results in increased uptake of Carnitine]	21641380
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of SLC22A5 mRNA	19770486
D004958	Estradiol	Estradiol results in increased expression of SLC22A5 mRNA	15223131\|2301914
D001622	Betaine	Betaine inhibits the reaction [SLC22A5 protein results in increased uptake of Carnitine]	16928358
C006780	bisphenol A	bisphenol A results in decreased expression of SLC22A5 mRNA	21932408
C006780	bisphenol A	bisphenol A results in decreased expression of SLC22A5 mRNA	25181051
D002220	Carbamazepine	Carbamazepine results in decreased expression of SLC22A5 mRNA	17112801
C058251	carebastine	carebastine inhibits the reaction [SLC22A5 gene mutant form affects the transport of and affects the abundance of Pyrilamine]	19821448
D002330	Carmustine	SLC22A5 mRNA affects the susceptibility to Carmustine	16365179
D002331	Carnitine	SLC22A5 protein results in increased uptake of Carnitine	18981167
D002331	Carnitine	Amiodarone inhibits the reaction [SLC22A5 protein results in increased uptake of Carnitine]	21641380
D002331	Carnitine	Atorvastatin Calcium inhibits the reaction [SLC22A5 protein results in increased uptake of Carnitine]	21641380
D002331	Carnitine	Betaine inhibits the reaction [SLC22A5 protein results in increased uptake of Carnitine]	16928358
D002331	Carnitine	Carnitine binds to SLC22A5 protein	19539806
D002331	Carnitine	Carnitine inhibits the reaction [SLC22A5 protein results in increased transport of pivaloylcarnitine]	19539806
D002331	Carnitine	Choline inhibits the reaction [SLC22A5 protein results in increased uptake of Carnitine]	16928358
D002331	Carnitine	[Doxorubicin co-treated with Carnitine] results in increased expression of SLC22A5 mRNA	16283381
D002331	Carnitine	grepafloxacin affects the reaction [SLC22A5 protein results in increased uptake of Carnitine]	16928358
D002331	Carnitine	Ipratropium inhibits the reaction [SLC22A5 protein results in increased uptake of Carnitine]	21641380
D002331	Carnitine	Lidocaine inhibits the reaction [SLC22A5 protein results in increased uptake of Carnitine]	21641380
D002331	Carnitine	Nifedipine inhibits the reaction [SLC22A5 protein results in increased uptake of Carnitine]	21641380
D002331	Carnitine	Ofloxacin inhibits the reaction [SLC22A5 protein results in increased uptake of Carnitine]	16928358
D002331	Carnitine	pivaloylcarnitine inhibits the reaction [SLC22A5 protein results in increased transport of Carnitine]	19539806
D002331	Carnitine	Propranolol inhibits the reaction [SLC22A5 protein results in increased uptake of Carnitine]	21641380
D002331	Carnitine	SLC22A5 protein affects the uptake of Carnitine	15486076
D002331	Carnitine	SLC22A5 protein results in increased transport of Carnitine	19539806
D002331	Carnitine	SLC22A5 protein results in increased uptake of Carnitine	16928358\|1876271
D002331	Carnitine	Spironolactone inhibits the reaction [SLC22A5 protein results in increased uptake of Carnitine]	21641380
D002331	Carnitine	talinolol inhibits the reaction [SLC22A5 protein results in increased uptake of Carnitine]	21641380
D002331	Carnitine	1-Methyl-4-phenylpyridinium inhibits the reaction [SLC22A5 protein results in increased uptake of Carnitine]	12644265
D002331	Carnitine	Carnitine deficiency results in increased expression of SLC22A5 mRNA	20303936
D002331	Carnitine	Carnitine inhibits the reaction [Cyclophosphamide results in decreased expression of SLC22A5 mRNA]	22701146
D002331	Carnitine	Carnitine inhibits the reaction [Cyclophosphamide results in decreased expression of SLC22A5 protein]	22701146
D002331	Carnitine	Carnitine inhibits the reaction [Doxorubicin results in decreased expression of SLC22A5 mRNA]	20470772
D002331	Carnitine	Carnitine inhibits the reaction [SLC22A5 protein results in increased uptake of Tetraethylammonium]	12644265
D002331	Carnitine	Dithioerythritol inhibits the reaction [Omeprazole inhibits the reaction [SLC22A5 protein results in increased transport of Carnitine]]	19041296
D002331	Carnitine	Ofloxacin inhibits the reaction [SLC22A5 protein results in increased uptake of Carnitine]	16928358
D002331	Carnitine	Omeprazole inhibits the reaction [SLC22A5 protein results in increased transport of Carnitine]	19041296
D002331	Carnitine	SLC22A5 protein results in increased transport of Carnitine	19041296
D002331	Carnitine	SLC22A5 protein results in increased uptake of Carnitine	12644265\|1876271
D002331	Carnitine	Tetraethylammonium inhibits the reaction [SLC22A5 protein results in increased uptake of Carnitine]	12644265
D002331	Carnitine	SLC22A5 protein results in increased uptake of Carnitine	16826461
D002392	Catechin	[Catechin co-treated with Grape Seed Proanthocyanidins] results in increased expression of SLC22A5 mRNA	24763279
D002509	Cephaloridine	Cephaloridine results in decreased expression of SLC22A5 mRNA	18500788
D002794	Choline	Choline inhibits the reaction [SLC22A5 protein results in increased uptake of Carnitine]	16928358
D002922	Ciguatoxins	Ciguatoxins affects the expression of SLC22A5 mRNA	18353800
D002994	Clofibrate	Clofibrate results in increased expression of SLC22A5 mRNA	23811191
D002994	Clofibrate	Clofibrate results in increased expression of SLC22A5 mRNA	27665778
D002995	Clofibric Acid	[Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of SLC22A5 mRNA	17602206
D003471	Cuprizone	Cuprizone results in increased expression of SLC22A5 mRNA	26577399
D003520	Cyclophosphamide	Carnitine inhibits the reaction [Cyclophosphamide results in decreased expression of SLC22A5 mRNA]	22701146
D003520	Cyclophosphamide	Carnitine inhibits the reaction [Cyclophosphamide results in decreased expression of SLC22A5 protein]	22701146
D003520	Cyclophosphamide	Cyclophosphamide results in decreased expression of SLC22A5 mRNA	22701146
D003520	Cyclophosphamide	Cyclophosphamide results in decreased expression of SLC22A5 protein	22701146
D016572	Cyclosporine	Cyclosporine results in increased expression of SLC22A5 mRNA	20106945
D003533	Cyproheptadine	Cyproheptadine affects the reaction [SLC22A5 gene mutant form affects the transport of and affects the abundance of Pyrilamine]	19821448
D003545	Cysteine	Cysteine inhibits the reaction [Mercuric Chloride results in decreased transport of SLC22A5 protein]	22900493
D003545	Cysteine	Cysteine inhibits the reaction [Methylmercury Compounds results in decreased transport of SLC22A5 protein]	22900493
C010902	decabromobiphenyl ether	decabromobiphenyl ether results in increased expression of SLC22A5 mRNA	23640034
C014347	decitabine	decitabine results in increased expression of SLC22A5 mRNA	28597291
D003999	Dichloroacetic Acid	Dichloroacetic Acid results in increased expression of SLC22A5 mRNA	28962523
D002945	Cisplatin	[Cisplatin co-treated with jinfukang] results in decreased expression of SLC22A5 mRNA	27392435
D002945	Cisplatin	Cisplatin results in decreased expression of SLC22A5 mRNA	19736245\|2739243
D002945	Cisplatin	Cisplatin results in decreased expression of SLC22A5 protein	19736245
D004041	Dietary Fats	"3,4,3',4'-tetrachlorobiphenyl inhibits the reaction [Dietary Fats results in increased expression of SLC22A5 mRNA]"	19467301
D004041	Dietary Fats	Dietary Fats results in increased expression of SLC22A5 mRNA	19467301
D004052	Diethylnitrosamine	[Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of SLC22A5 mRNA	17602206
D004155	Diphenhydramine	Diphenhydramine affects the reaction [SLC22A5 gene mutant form affects the transport of and affects the abundance of Pyrilamine]	19821448
D004155	Diphenhydramine	Diphenhydramine inhibits the reaction [SLC22A5 gene mutant form affects the transport of and affects the abundance of Pyrilamine]	19821448
D004226	Dithioerythritol	Dithioerythritol inhibits the reaction [Mercuric Chloride results in decreased transport of SLC22A5 protein]	22900493
D004226	Dithioerythritol	Dithioerythritol inhibits the reaction [Methylmercury Compounds results in decreased transport of SLC22A5 protein]	22900493
D004226	Dithioerythritol	Dithioerythritol inhibits the reaction [Omeprazole inhibits the reaction [SLC22A5 protein results in increased transport of Carnitine]]	19041296
D004281	Docosahexaenoic Acids	PPARA protein promotes the reaction [Docosahexaenoic Acids results in increased expression of SLC22A5 mRNA]	18489776
D004317	Doxorubicin	[Doxorubicin co-treated with Carnitine] results in increased expression of SLC22A5 mRNA	16283381
D004317	Doxorubicin	Carnitine inhibits the reaction [Doxorubicin results in decreased expression of SLC22A5 mRNA]	20470772
D004317	Doxorubicin	Doxorubicin results in decreased expression of SLC22A5 mRNA	20470772
C118667	dronedarone	SLC22A5 protein affects the susceptibility to dronedarone	24881592
D004365	Drugs, Chinese Herbal	"Drugs, Chinese Herbal inhibits the reaction [potassium oxonate results in decreased expression of SLC22A5 mRNA]"	22967667
D004365	Drugs, Chinese Herbal	"Drugs, Chinese Herbal inhibits the reaction [potassium oxonate results in decreased expression of SLC22A5 protein]"	22967667
C058249	ebastine	ebastine inhibits the reaction [SLC22A5 gene mutant form affects the transport of and affects the abundance of Pyrilamine]	19821448
D015118	Eicosapentaenoic Acid	PPARA protein promotes the reaction [Eicosapentaenoic Acid results in increased expression of SLC22A5 mRNA]	18489776
D004967	Estrogens	afimoxifene inhibits the reaction [Estrogens results in increased expression of SLC22A5 mRNA]	21233418
D004967	Estrogens	Estrogens results in increased expression of SLC22A5 mRNA	21233418
D004997	Ethinyl Estradiol	Ethinyl Estradiol affects the expression of SLC22A5 mRNA	17555576
D005020	Ethyl Methanesulfonate	Ethyl Methanesulfonate results in increased expression of SLC22A5 mRNA	23649840
D011345	Fenofibrate	Fenofibrate results in increased expression of SLC22A5 mRNA	27665778
D005363	Ficusin	Ficusin results in increased expression of SLC22A5 protein	22173200
D005419	Flavonoids	Flavonoids results in increased expression of SLC22A5 mRNA	18035473
D005485	Flutamide	Flutamide results in decreased expression of SLC22A5 mRNA	24136188
D005632	Fructose	Allopurinol inhibits the reaction [Fructose results in decreased expression of SLC22A5 protein]	22426011
D005632	Fructose	Fructose results in decreased expression of SLC22A5 protein	22426011
D005632	Fructose	Quercetin inhibits the reaction [Fructose results in decreased expression of SLC22A5 protein]	22426011
D015248	Gemfibrozil	Gemfibrozil results in increased expression of SLC22A5 mRNA	27665778
D019833	Genistein	Genistein results in increased expression of SLC22A5 mRNA	23019147
D005897	Glafenine	Glafenine results in decreased expression of SLC22A5 mRNA	24136188
C511402	Grape Seed Proanthocyanidins	[Catechin co-treated with Grape Seed Proanthocyanidins] results in increased expression of SLC22A5 mRNA	24763279
C075375	grepafloxacin	grepafloxacin affects the reaction [SLC22A5 protein results in increased uptake of Carnitine]	16928358
D006918	Hydroxyurea	SLC22A5 protein results in increased uptake of Hydroxyurea	21256917
D007069	Ifosfamide	Ifosfamide results in decreased expression of SLC22A5 mRNA	22701146
D007069	Ifosfamide	Ifosfamide results in decreased expression of SLC22A5 protein	22701146
C031534	imperatorin	imperatorin results in increased expression of SLC22A5 protein	22173200
D015759	Ionomycin	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of SLC22A5 mRNA	25613284
C055542	isoimperatorin	isoimperatorin results in increased expression of SLC22A5 protein	22173200
D009241	Ipratropium	Ipratropium inhibits the reaction [SLC22A5 protein results in increased uptake of Carnitine]	21641380
C544151	jinfukang	[Cisplatin co-treated with jinfukang] results in decreased expression of SLC22A5 mRNA	27392435
C045463	leflunomide	leflunomide results in increased expression of SLC22A5 mRNA	24136188
D008012	Lidocaine	Lidocaine inhibits the reaction [SLC22A5 protein results in increased uptake of Carnitine]	21641380
C018091	maduramicin	maduramicin results in increased expression of SLC22A5 mRNA	29128925
C013592	mangiferin	mangiferin results in increased expression of SLC22A5 mRNA	21348301
D008627	Mercuric Chloride	Acetylcysteine inhibits the reaction [Mercuric Chloride results in decreased transport of SLC22A5 protein]	22900493
D008627	Mercuric Chloride	Cysteine inhibits the reaction [Mercuric Chloride results in decreased transport of SLC22A5 protein]	22900493
D008627	Mercuric Chloride	Dithioerythritol inhibits the reaction [Mercuric Chloride results in decreased transport of SLC22A5 protein]	22900493
D008627	Mercuric Chloride	Mercuric Chloride results in decreased expression of SLC22A5 mRNA	16507785
D008627	Mercuric Chloride	Mercuric Chloride results in decreased transport of SLC22A5 protein	22900493
D008730	Methoxsalen	Methoxsalen results in increased expression of SLC22A5 protein	22173200
D008767	Methylmercury Compounds	Acetylcysteine affects the reaction [Methylmercury Compounds results in decreased transport of SLC22A5 protein]	22900493
D008767	Methylmercury Compounds	Cysteine inhibits the reaction [Methylmercury Compounds results in decreased transport of SLC22A5 protein]	22900493
D008767	Methylmercury Compounds	Dithioerythritol inhibits the reaction [Methylmercury Compounds results in decreased transport of SLC22A5 protein]	22900493
D008767	Methylmercury Compounds	Methylmercury Compounds results in decreased transport of SLC22A5 protein	22900493
D015655	1-Methyl-4-phenylpyridinium	1-Methyl-4-phenylpyridinium inhibits the reaction [SLC22A5 protein results in increased uptake of Carnitine]	12644265
D015655	1-Methyl-4-phenylpyridinium	1-Methyl-4-phenylpyridinium inhibits the reaction [SLC22A5 protein results in increased uptake of Tetraethylammonium]	12644265
C420606	mulberroside A	mulberroside A inhibits the reaction [potassium oxonate results in decreased expression of SLC22A5 protein]	22865646
C500085	muraglitazar	muraglitazar results in increased expression of SLC22A5 mRNA	21515302
D009151	Mustard Gas	Mustard Gas results in increased expression of SLC22A5 mRNA	15674844
C583365	N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide	"N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide results in increased expression of SLC22A5 mRNA"	29244179
D037742	Nanotubes, Carbon	"Nanotubes, Carbon analog results in increased expression of SLC22A5 mRNA"	25620056
D037742	Nanotubes, Carbon	"Nanotubes, Carbon results in increased expression of SLC22A5 mRNA"	25620056
C051752	nefazodone	nefazodone results in increased expression of SLC22A5 mRNA	24136188
D009543	Nifedipine	Nifedipine inhibits the reaction [SLC22A5 protein results in increased uptake of Carnitine]	21641380
D015242	Ofloxacin	Ofloxacin inhibits the reaction [SLC22A5 protein results in increased uptake of Carnitine]	16928358
D015242	Ofloxacin	Ofloxacin inhibits the reaction [SLC22A5 protein results in increased uptake of Carnitine]	16928358
D009853	Omeprazole	Dithioerythritol inhibits the reaction [Omeprazole inhibits the reaction [SLC22A5 protein results in increased transport of Carnitine]]	19041296
D009853	Omeprazole	Omeprazole inhibits the reaction [SLC22A5 protein results in increased transport of Carnitine]	19041296
D010098	Oxycodone	Oxycodone results in increased expression of SLC22A5 mRNA	23439660
C016030	pantogab	pantogab results in increased expression of SLC22A5 mRNA	17379144
D010416	Pentachlorophenol	Pentachlorophenol results in increased expression of SLC22A5 mRNA	23892564
D010426	Pentosan Sulfuric Polyester	Pentosan Sulfuric Polyester results in decreased expression of SLC22A5 mRNA	28973697
C471071	perfluorohexanesulfonic acid	perfluorohexanesulfonic acid results in increased expression of SLC22A5 mRNA	28558994
C584865	perfluorononanoic acid	perfluorononanoic acid results in increased expression of SLC22A5 mRNA	28558994
C076994	perfluorooctane sulfonic acid	perfluorooctane sulfonic acid results in increased expression of SLC22A5 mRNA	28558994
C023036	perfluorooctanoic acid	perfluorooctanoic acid results in increased expression of SLC22A5 mRNA	28558994
C023036	perfluorooctanoic acid	perfluorooctanoic acid results in increased expression of SLC22A5 mRNA	16221955\|1916217
D010634	Phenobarbital	Phenobarbital results in increased expression of SLC22A5 mRNA	19270015
C006253	pirinixic acid	[pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of SLC22A5 mRNA	18489776
C006253	pirinixic acid	[pirinixic acid co-treated with PPARA] results in increased expression of SLC22A5 mRNA	20813756
C006253	pirinixic acid	pirinixic acid results in increased expression of SLC22A5 mRNA	17426115\|1830175
C006253	pirinixic acid	PPARA protein promotes the reaction [pirinixic acid results in increased expression of SLC22A5 mRNA]	20059764
C006253	pirinixic acid	[pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of SLC22A5 mRNA	19735737
C006253	pirinixic acid	pirinixic acid results in increased expression of SLC22A5 mRNA	19162173\|2248451
C054040	pivaloylcarnitine	Carnitine inhibits the reaction [SLC22A5 protein results in increased transport of pivaloylcarnitine]	19539806
C054040	pivaloylcarnitine	pivaloylcarnitine binds to SLC22A5 protein	19539806
C054040	pivaloylcarnitine	pivaloylcarnitine inhibits the reaction [SLC22A5 protein results in increased transport of Carnitine]	19539806
C054040	pivaloylcarnitine	SLC22A5 protein results in increased transport of pivaloylcarnitine	19539806
C054040	pivaloylcarnitine	SLC22A5 protein results in increased uptake of pivaloylcarnitine	18762717
C054040	pivaloylcarnitine	SLC22A5 protein results in increased uptake of pivaloylcarnitine	18762717
C054040	pivaloylcarnitine	pivaloylcarnitine results in decreased activity of SLC22A5 protein	16826461
D010936	Plant Extracts	Plant Extracts inhibits the reaction [potassium oxonate results in decreased expression of SLC22A5 mRNA]	22967667
D010936	Plant Extracts	Plant Extracts inhibits the reaction [potassium oxonate results in decreased expression of SLC22A5 protein]	22967667
C058229	polydatin	polydatin inhibits the reaction [potassium oxonate results in decreased expression of SLC22A5 protein]	22865646
C489337	potassium oxonate	Allopurinol inhibits the reaction [potassium oxonate results in decreased expression of SLC22A5 mRNA]	21909718
C489337	potassium oxonate	Allopurinol inhibits the reaction [potassium oxonate results in decreased expression of SLC22A5 protein]	21909718\|2286564
C489337	potassium oxonate	"Drugs, Chinese Herbal inhibits the reaction [potassium oxonate results in decreased expression of SLC22A5 mRNA]"	22967667
C489337	potassium oxonate	"Drugs, Chinese Herbal inhibits the reaction [potassium oxonate results in decreased expression of SLC22A5 protein]"	22967667
C489337	potassium oxonate	mulberroside A inhibits the reaction [potassium oxonate results in decreased expression of SLC22A5 protein]	22865646
C489337	potassium oxonate	Plant Extracts inhibits the reaction [potassium oxonate results in decreased expression of SLC22A5 mRNA]	22967667
C489337	potassium oxonate	Plant Extracts inhibits the reaction [potassium oxonate results in decreased expression of SLC22A5 protein]	22967667
C489337	potassium oxonate	polydatin inhibits the reaction [potassium oxonate results in decreased expression of SLC22A5 protein]	22865646
C489337	potassium oxonate	potassium oxonate results in decreased expression of SLC22A5 mRNA	21909718\|2296766
C489337	potassium oxonate	potassium oxonate results in decreased expression of SLC22A5 protein	21909718\|2286564
C489337	potassium oxonate	Probenecid inhibits the reaction [potassium oxonate results in decreased expression of SLC22A5 mRNA]	22967667
C489337	potassium oxonate	Probenecid inhibits the reaction [potassium oxonate results in decreased expression of SLC22A5 protein]	22865646\|2296766
C489337	potassium oxonate	Quercetin inhibits the reaction [potassium oxonate results in decreased expression of SLC22A5 mRNA]	21909718
C489337	potassium oxonate	Quercetin inhibits the reaction [potassium oxonate results in decreased expression of SLC22A5 protein]	21909718
D017035	Pravastatin	Pravastatin results in decreased expression of SLC22A5 mRNA	27225895
D017035	Pravastatin	Pravastatin affects the expression of SLC22A5 mRNA	27225895
D011339	Probenecid	Probenecid inhibits the reaction [potassium oxonate results in decreased expression of SLC22A5 mRNA]	22967667
D011339	Probenecid	Probenecid inhibits the reaction [potassium oxonate results in decreased expression of SLC22A5 protein]	22865646\|2296766
D011374	Progesterone	Progesterone results in increased expression of SLC22A5 mRNA	21540246
D011398	Promethazine	Promethazine affects the reaction [SLC22A5 gene mutant form affects the transport of and affects the abundance of Pyrilamine]	19821448
D011398	Promethazine	Promethazine inhibits the reaction [SLC22A5 gene mutant form affects the transport of and affects the abundance of Pyrilamine]	19821448
C045950	propiconazole	propiconazole results in increased expression of SLC22A5 mRNA	21278054
D011433	Propranolol	Propranolol inhibits the reaction [SLC22A5 protein results in increased uptake of Carnitine]	21641380
D011738	Pyrilamine	carebastine inhibits the reaction [SLC22A5 gene mutant form affects the transport of and affects the abundance of Pyrilamine]	19821448
D011738	Pyrilamine	Cyproheptadine affects the reaction [SLC22A5 gene mutant form affects the transport of and affects the abundance of Pyrilamine]	19821448
D011738	Pyrilamine	Diphenhydramine affects the reaction [SLC22A5 gene mutant form affects the transport of and affects the abundance of Pyrilamine]	19821448
D011738	Pyrilamine	Diphenhydramine inhibits the reaction [SLC22A5 gene mutant form affects the transport of and affects the abundance of Pyrilamine]	19821448
D011738	Pyrilamine	ebastine inhibits the reaction [SLC22A5 gene mutant form affects the transport of and affects the abundance of Pyrilamine]	19821448
D011738	Pyrilamine	Promethazine affects the reaction [SLC22A5 gene mutant form affects the transport of and affects the abundance of Pyrilamine]	19821448
D011738	Pyrilamine	Promethazine inhibits the reaction [SLC22A5 gene mutant form affects the transport of and affects the abundance of Pyrilamine]	19821448
D011738	Pyrilamine	SLC22A5 gene mutant form affects the transport of and affects the abundance of Pyrilamine	19821448
D011738	Pyrilamine	SLC22A5 protein affects the transport of and affects the abundance of Pyrilamine	19821448
D011794	Quercetin	Quercetin results in decreased expression of SLC22A5 mRNA	21632981
D011794	Quercetin	Quercetin inhibits the reaction [potassium oxonate results in decreased expression of SLC22A5 mRNA]	21909718
D011794	Quercetin	Quercetin inhibits the reaction [potassium oxonate results in decreased expression of SLC22A5 protein]	21909718
D011794	Quercetin	Quercetin inhibits the reaction [Fructose results in decreased expression of SLC22A5 protein]	22426011
D020849	Raloxifene Hydrochloride	Raloxifene Hydrochloride affects the expression of SLC22A5 mRNA	14699072
C089730	rosiglitazone	rosiglitazone results in increased expression of SLC22A5 mRNA	25572481
C089730	rosiglitazone	rosiglitazone results in increased expression of SLC22A5 mRNA	21515302
C064116	S-(1,1,2,2-tetrafluoroethyl)cysteine	"S-(1,1,2,2-tetrafluoroethyl)cysteine results in increased expression of SLC22A5 mRNA"	16678137
D013148	Spironolactone	Spironolactone inhibits the reaction [SLC22A5 protein results in increased uptake of Carnitine]	21641380
C075117	squalestatin 1	squalestatin 1 results in increased expression of SLC22A5 mRNA	27225895
C075117	squalestatin 1	squalestatin 1 results in increased expression of SLC22A5 mRNA	27225895
C011550	talinolol	talinolol inhibits the reaction [SLC22A5 protein results in increased uptake of Carnitine]	21641380
D013629	Tamoxifen	Tamoxifen affects the expression of SLC22A5 mRNA	17555576
C047246	temozolomide	SLC22A5 mRNA affects the susceptibility to temozolomide	16365179
C501413	tesaglitazar	tesaglitazar results in increased expression of SLC22A5 mRNA	21515302
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of SLC22A5 mRNA	22574217
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of SLC22A5 mRNA	21570461
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of SLC22A5 mRNA	16120747
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of SLC22A5 mRNA	21215274
D013750	Tetrachloroethylene	Tetrachloroethylene results in increased expression of SLC22A5 mRNA	28973375
D013755	Tetradecanoylphorbol Acetate	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of SLC22A5 mRNA	25613284
D019789	Tetraethylammonium	1-Methyl-4-phenylpyridinium inhibits the reaction [SLC22A5 protein results in increased uptake of Tetraethylammonium]	12644265
D019789	Tetraethylammonium	Carnitine inhibits the reaction [SLC22A5 protein results in increased uptake of Tetraethylammonium]	12644265
D019789	Tetraethylammonium	SLC22A5 protein results in increased uptake of Tetraethylammonium	12644265
D019789	Tetraethylammonium	Tetraethylammonium inhibits the reaction [SLC22A5 protein results in increased uptake of Carnitine]	12644265
C009495	titanium dioxide	titanium dioxide affects the expression of SLC22A5 mRNA	17656681
D014050	Toluene	Toluene affects the expression of SLC22A5 mRNA	18653662
D014212	Tretinoin	Tretinoin results in increased expression of SLC22A5 mRNA	21934132
D014241	Trichloroethylene	Trichloroethylene affects the expression of SLC22A5 mRNA	21135412
D014241	Trichloroethylene	Trichloroethylene results in increased expression of SLC22A5 mRNA	25549359
C012589	trichostatin A	trichostatin A results in increased expression of SLC22A5 mRNA	15901671
C057693	troglitazone	troglitazone results in increased expression of SLC22A5 mRNA	28973697
C057693	troglitazone	troglitazone results in increased expression of SLC22A5 mRNA	21515302
D014520	Urethane	Urethane results in decreased expression of SLC22A5 mRNA	28818685
C406224	valdecoxib	valdecoxib results in increased expression of SLC22A5 mRNA	24136188
D014635	Valproic Acid	Valproic Acid results in decreased methylation of SLC22A5 gene	29154799
D014635	Valproic Acid	Valproic Acid affects the expression of SLC22A5 mRNA	17292431
D014635	Valproic Acid	Valproic Acid results in increased expression of SLC22A5 mRNA	15901671
C044923	valproylcarnitine	SLC22A5 protein results in increased uptake of valproylcarnitine	18762717
C044923	valproylcarnitine	SLC22A5 protein results in increased uptake of valproylcarnitine	18762717
C044923	valproylcarnitine	valproylcarnitine results in decreased activity of SLC22A5 protein	16826461
D014640	Vancomycin	Vancomycin results in increased expression of SLC22A5 mRNA	18930951
D001335	Vehicle Emissions	Vehicle Emissions results in increased methylation of SLC22A5 gene	25560391
D014700	Verapamil	Verapamil results in decreased activity of SLC22A5 protein	15486076
C029297	vinylidene chloride	vinylidene chloride results in decreased expression of SLC22A5 mRNA	26682919
C111237	vorinostat	vorinostat results in decreased expression of SLC22A5 mRNA	27188386
D015215	Zidovudine	Zidovudine results in increased expression of SLC22A5 mRNA	24292225

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005515	protein binding	-	IPI	15523054
GO:0005524	ATP binding	-	IEA	-
GO:0015226	carnitine transmembrane transporter activity	-	EXP	9685390
GO:0015226	carnitine transmembrane transporter activity	-	IDA	9685390
GO:0015226	carnitine transmembrane transporter activity	-	IMP	9916797
GO:0015226	carnitine transmembrane transporter activity	-	TAS	-
GO:0015238	drug transmembrane transporter activity	-	IC	15238359
GO:0015293	symporter activity	-	IEA	-
GO:0015651	quaternary ammonium group transmembrane transporter activity	-	IDA	9618255
GO:0030165	PDZ domain binding	-	IPI	15523054

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0006814	sodium ion transport	-	IEA	-
GO:0006855	drug transmembrane transport	-	IEA	-
GO:0015697	quaternary ammonium group transport	-	IDA	9618255
GO:0015711	organic anion transport	-	IEA	-
GO:0015879	carnitine transport	-	IDA	9685390
GO:0015879	carnitine transport	-	IMP	9916797
GO:0015893	drug transport	-	IC	15238359
GO:0052106	quorum sensing involved in interaction with host	-	IMP	18005709
GO:0060731	positive regulation of intestinal epithelial structure maintenance	-	IMP	18005709
GO:0070715	sodium-dependent organic cation transport	-	IDA	9685390 15238359
GO:1902603	carnitine transmembrane transport	-	TAS	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005886	plasma membrane	-	IC	9618255
GO:0005886	plasma membrane	-	TAS	-
GO:0016324	apical plasma membrane	-	IDA	17274673 18641280
GO:0031526	brush border membrane	-	IDA	15238359
GO:0031526	brush border membrane	-	ISS	15523054
GO:0070062	extracellular exosome	-	HDA	19056867

KEGG ID	KEGG Term

Reactome ID	Reactome Term	Evidence
R-HSA-1430728	Metabolism	TAS
R-HSA-1643685	Disease	TAS
R-HSA-200425	Import of palmitoyl-CoA into the mitochondrial matrix	TAS
R-HSA-382551	Transport of small molecules	TAS
R-HSA-425366	Transport of bile salts and organic acids, metal ions and amine compounds	TAS
R-HSA-425407	SLC-mediated transmembrane transport	TAS
R-HSA-549127	Organic cation transport	TAS
R-HSA-549132	Organic cation/anion/zwitterion transport	TAS
R-HSA-556833	Metabolism of lipids	TAS
R-HSA-5619053	Defective SLC22A5 causes systemic primary carnitine deficiency (CDSP)	TAS
R-HSA-5619102	SLC transporter disorders	TAS
R-HSA-5619115	Disorders of transmembrane transporters	TAS
R-HSA-8978868	Fatty acid metabolism	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal