Gene: SLIT3

6586
MEGF5|SLIL2|SLIT1|Slit-3|slit2
slit guidance ligand 3
protein-coding
5q34-q35.1
Ensembl:ENSG00000184347 MIM:603745 Vega:OTTHUMG00000130409 UniprotKB:O75094
NG_033081.1
PubMed
0   ANCO-SNPs
ND
3   
NA (AD)  NA (ND)   (Frontal_Cortex)
7.783e-1 (AD)  6.633e-3 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ARHGEF280.887
SLC7A140.874
PCDHGC50.866
LHFPL40.863
ERC20.863
GABRA30.862
EXOC60.862
SORBS20.86
ATP8A20.857
DGKI0.855

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
IMPA2-0.531
GRTP1-0.517
CDKN2C-0.517
NBPF10-0.513
STON2-0.512
MAPKAPK3-0.508
NXT2-0.504
YES1-0.504
DDIT4L-0.504
AKR1C3-0.503

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of SLIT3 mRNA"21346803
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SLIT3 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SLIT3 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SLIT3 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SLIT3 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SLIT3 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SLIT3 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SLIT3 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SLIT3 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SLIT3 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SLIT3 mRNA"27188386
D000079AcetaldehydeAcetaldehyde affects the expression of SLIT3 mRNA22634333
D016604Aflatoxin B1Aflatoxin B1 results in increased methylation of SLIT3 gene27153756
D000643Ammonium ChlorideAmmonium Chloride affects the expression of SLIT3 mRNA16483693
D018501Antirheumatic AgentsAntirheumatic Agents results in increased expression of SLIT3 mRNA24449571
D000068180AripiprazoleAripiprazole results in increased expression of SLIT3 mRNA17868501
D001151ArsenicArsenic affects the methylation of SLIT3 gene25304211
C015001arsenitearsenite results in increased methylation of SLIT3 promoter23974009
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of SLIT3 mRNA20064835
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of SLIT3 mRNA22228805
D004958EstradiolEstradiol results in increased expression of SLIT3 mRNA23019147
D004958EstradiolEstradiol results in increased expression of SLIT3 mRNA19484750
C006780bisphenol Abisphenol A results in increased expression of SLIT3 mRNA23019147
C006780bisphenol A[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of SLIT3 mRNA28628672
C006780bisphenol Abisphenol A results in decreased expression of SLIT3 mRNA28079927
C006780bisphenol Abisphenol A results in decreased expression of SLIT3 mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of SLIT3 gene28505145
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of SLIT3 mRNA18974090
D004390ChlorpyrifosChlorpyrifos affects the expression of SLIT3 mRNA26775027
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of SLIT3 gene20938992
D003300CopperCopper results in decreased expression of SLIT3 mRNA26293553
D003630DaunorubicinSLIT3 affects the susceptibility to Daunorubicin17545624
D003907DexamethasoneDexamethasone inhibits the reaction [RX3 gene mutant form affects the expression of SLIT3 mRNA]27941970
D003907DexamethasoneDexamethasone results in decreased expression of SLIT3 mRNA25047013
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of SLIT3 mRNA28628672
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in decreased expression of SLIT3 mRNA27392435
D002945CisplatinCisplatin results in decreased expression of SLIT3 mRNA27392435
D004041Dietary FatsDietary Fats results in decreased expression of SLIT3 mRNA18042831
D004221DisulfiramDisulfiram results in decreased expression of SLIT3 mRNA20530235
D004237DiuronDiuron results in decreased expression of SLIT3 mRNA21551480|2515243
D004317DoxorubicinDoxorubicin results in increased expression of SLIT3 mRNA16404146
C061365flusilazoleflusilazole affects the expression of SLIT3 mRNA22634333
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of SLIT3 gene20938992
D004397FonofosFonofos results in increased methylation of SLIT3 promoter22847954
D005557FormaldehydeFormaldehyde results in increased expression of SLIT3 mRNA28937961
C039281furanfuran results in increased expression of SLIT3 mRNA27387713
D019833GenisteinGenistein results in increased expression of SLIT3 mRNA23019147
D005839GentamicinsGentamicins results in decreased expression of SLIT3 mRNA22061828
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of SLIT3 mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of SLIT3 mRNA28628672
C544151jinfukang[Cisplatin co-treated with jinfukang] results in decreased expression of SLIT3 mRNA27392435
C042720mercuric bromidemercuric bromide results in increased expression of SLIT3 mRNA26272509
C042720mercuric bromide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SLIT3 mRNA"27188386
D008628MercuryMercury results in decreased expression of SLIT3 mRNA16823088
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of SLIT3 gene20938992
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of SLIT3 mRNA26011545
D015735MifepristoneMifepristone results in decreased expression of SLIT3 mRNA17584828
C016599mono-(2-ethylhexyl)phthalatemono-(2-ethylhexyl)phthalate results in decreased expression of SLIT3 mRNA22401849
D009532NickelNickel results in decreased expression of SLIT3 mRNA25583101
C041747nitazoxanideSLIT3 gene SNP affects the susceptibility to nitazoxanide25622337
C007350nitrofennitrofen results in increased expression of SLIT3 mRNA19944214
C009618O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate"PON1 gene polymorphism affects the susceptibility to [O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate affects the expression of SLIT3 mRNA]"21673326
C009618O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate"O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate results in decreased expression of SLIT3 mRNA"21673326
C009618O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate"PON1 protein affects the reaction [O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate results in decreased expression of SLIT3 mRNA]"21673326
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in increased expression of SLIT3 mRNA25729387
D000073878Palm OilPalm Oil results in decreased expression of SLIT3 mRNA18042831
C496932panobinostat"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SLIT3 mRNA"27188386
C496932panobinostatpanobinostat results in increased expression of SLIT3 mRNA26272509
D010278ParathionParathion results in increased methylation of SLIT3 promoter22847954
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SLIT3 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in increased expression of SLIT3 mRNA26272509
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of SLIT3 mRNA22714537
D011192Potassium DichromatePotassium Dichromate results in decreased expression of SLIT3 mRNA23608068
D011374ProgesteroneProgesterone results in increased expression of SLIT3 mRNA22238285
C005556propionaldehydepropionaldehyde results in increased expression of SLIT3 mRNA26079696
D015474IsotretinoinIsotretinoin results in increased expression of SLIT3 mRNA20436886
C017947sodium arsenitesodium arsenite affects the methylation of SLIT3 gene28589171
D012999SomanSoman results in increased expression of SLIT3 mRNA19281266
C012568terbufosterbufos results in increased methylation of SLIT3 promoter22847954
C009495titanium dioxidetitanium dioxide results in decreased expression of SLIT3 mRNA23557971
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in increased expression of SLIT3 mRNA25729387
D014212TretinoinTretinoin results in decreased expression of SLIT3 mRNA20530235
C012589trichostatin Atrichostatin A results in increased expression of SLIT3 mRNA24935251
C015559trimellitic anhydridetrimellitic anhydride results in decreased expression of SLIT3 mRNA19042947
C057693troglitazonetroglitazone results in increased expression of SLIT3 mRNA28973697
D014415TunicamycinTunicamycin results in decreased expression of SLIT3 mRNA22378314
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SLIT3 mRNA"27188386
D014635Valproic AcidValproic Acid results in increased expression of SLIT3 mRNA23179753|2438349
D014635Valproic AcidValproic Acid results in increased expression of SLIT3 mRNA24896083
D014638VanadatesVanadates results in increased expression of SLIT3 mRNA22714537
D001335Vehicle EmissionsVehicle Emissions affects the methylation of SLIT3 gene25560391
C025643vinclozolinvinclozolin affects the expression of SLIT3 mRNA19015723|2303416
D014800VitalliumVitallium analog results in decreased expression of SLIT3 mRNA23825117
C111237vorinostat"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SLIT3 mRNA"27188386
D015032ZincZinc deficiency results in decreased expression of SLIT3 mRNA20857495

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005509calcium ion binding-NAS9813312  
GO:0048495Roundabout binding-IPI15207848  
GO ID GO Term Qualifier Evidence PubMed
GO:0003180aortic valve morphogenesis-ISS-  
GO:0003181atrioventricular valve morphogenesis-ISS-  
GO:0007411axon guidance-IDA11748139  
GO:0008285negative regulation of cell proliferation-IEA-  
GO:0010629negative regulation of gene expression-IEA-  
GO:0021834chemorepulsion involved in embryonic olfactory bulb interneuron precursor migrationNOTIDA11748139  
GO:0030308negative regulation of cell growth-IMP18829537  
GO:0032870cellular response to hormone stimulus-IEP18566128  
GO:0035385Roundabout signaling pathway-IMP18829537  
GO:0048846axon extension involved in axon guidance-IDA16840550  
GO:0050919negative chemotaxis-IDA11748139  
GO:0051414response to cortisol-IEP18566128  
GO:0060412ventricular septum morphogenesis-ISS-  
GO:0061364apoptotic process involved in luteolysis-IEP18566128  
GO:0070100negative regulation of chemokine-mediated signaling pathway-IMP18829537  
GO ID GO Term Qualifier Evidence PubMed
GO:0005615extracellular space-IDA19741192  
GO:0005739mitochondrion-NAS11443047  
KEGG ID KEGG Term
hsa04360Axon guidance
Reactome ID Reactome Term Evidence
R-HSA-1266738Developmental BiologyTAS
R-HSA-1266738Developmental BiologyIEA
R-HSA-373752Netrin-1 signalingIEA
R-HSA-376176Signaling by ROBO receptorsTAS
R-HSA-376176Signaling by ROBO receptorsIEA
R-HSA-422475Axon guidanceTAS
R-HSA-422475Axon guidanceIEA
R-HSA-428542Regulation of commissural axon pathfinding by SLIT and ROBOIEA

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
15911247CpG island methylation and expression of tumour-associated genes in lung carcinoma. (2005 May)Dammann REur J Cancer
20838434MicroRNA-218 is deleted and downregulated in lung squamous cell carcinoma. (2010 Sep 3)Davidson MRPLoS One
20651036Expression of the repulsive SLIT/ROBO pathway in the human endometrium and Fallopian tube. (2010 Dec)Duncan WCMol Hum Reprod