Gene: SLN

6588
-
sarcolipin
protein-coding
11q22.3
Ensembl:ENSG00000170290 MIM:602203 Vega:OTTHUMG00000166364 UniprotKB:O00631
NC_000011.10
PubMed
0   ANCO-SNPs
OD|ND
3   
NA (AD)  2.831e-1 (ND)   (Frontal_Cortex)
7.015e-1 (AD)  4.730e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
KRT310.605
DRD50.585
FIBCD10.575
GALNT140.565
CREB3L10.562
NXPH40.561
PCDH170.559
GRIK30.541
FILIP10.532
CYP26A10.532

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
GLI1-0.347
IMPA2-0.327
FXYD3-0.324
OLAH-0.32
ACSS3-0.313
CDKN2C-0.304
FOXJ1-0.303
CDA-0.299
ADAM33-0.294
ZIC5-0.293

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of SLN mRNA"19114083
C0065512-amino-2-methyl-1-propanol2-amino-2-methyl-1-propanol results in decreased expression of SLN mRNA25088246
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of SLN mRNA"28973690
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SLN mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SLN mRNA"27188386
D000082AcetaminophenAcetaminophen affects the expression of SLN mRNA17562736
D020106AcrylamideAcrylamide results in decreased expression of SLN mRNA28959563
D000249Adenosine MonophosphateAdenosine Monophosphate inhibits the reaction [Adenosine Triphosphate promotes the reaction [SLN protein affects the transport of Phosphates]]19917222
D000255Adenosine TriphosphateAdenosine Monophosphate inhibits the reaction [Adenosine Triphosphate promotes the reaction [SLN protein affects the transport of Phosphates]]19917222
D000255Adenosine TriphosphateAdenosine Triphosphate promotes the reaction [SLN protein affects the transport of Phosphates]19917222
D000255Adenosine Triphosphatephenylphosphonic acid inhibits the reaction [Adenosine Triphosphate promotes the reaction [SLN protein affects the transport of Phosphates]]19917222
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of SLN gene27153756
D000447AldehydesAldehydes results in increased expression of SLN mRNA25014914
C006703benzo(b)fluoranthenebenzo(b)fluoranthene results in decreased expression of SLN mRNA26377693
C022921benzo(k)fluoranthenebenzo(k)fluoranthene results in increased expression of SLN mRNA26377693
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of SLN mRNA22228805|2261060
C072553benzyloxycarbonylleucyl-leucyl-leucine aldehydebenzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased expression of SLN mRNA25566086
C006780bisphenol Abisphenol A results in increased expression of SLN mRNA24465770
C006780bisphenol Abisphenol A results in decreased expression of SLN mRNA25181051
C018475butyraldehydebutyraldehyde results in increased expression of SLN mRNA26079696
D002706ChlordanChlordan results in increased expression of SLN mRNA20403969
D002712ChloridesSLN protein affects the transport of Chlorides19917222
D003561CytarabineCytarabine results in decreased expression of SLN mRNA21198554
D002945CisplatinCisplatin results in decreased expression of SLN mRNA27392435
D004041Dietary FatsDietary Fats results in increased expression of SLN mRNA18042831
D0151279,10-Dimethyl-1,2-benzanthracene"9,10-Dimethyl-1,2-benzanthracene results in decreased expression of SLN mRNA"22485181
C069837fullerene C60fullerene C60 affects the expression of SLN mRNA19167457
C039281furanfuran results in decreased expression of SLN mRNA25539665
D006108GraphiteGraphite results in increased expression of SLN mRNA27440207
C029424hydrazinehydrazine results in decreased expression of SLN mRNA15282401
C041508indeno(1,2,3-cd)pyrene"indeno(1,2,3-cd)pyrene results in decreased expression of SLN mRNA"26377693
C016517indole-3-carbinolindole-3-carbinol affects the expression of SLN mRNA21396975
D007854LeadLead affects the expression of SLN mRNA28903495
D017258Medroxyprogesterone AcetateMedroxyprogesterone Acetate results in increased expression of SLN mRNA20843944
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of SLN mRNA23179753
C028577monobutyl phthalatemonobutyl phthalate affects the expression of SLN mRNA19162170
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of SLN mRNA"25620056
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of SLN mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of SLN mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of SLN mRNA"25620056
C572573N-nitroso-tris-chloroethylurea[N-nitroso-tris-chloroethylurea co-treated with pioglitazone] results in decreased expression of SLN mRNA27935865
C572573N-nitroso-tris-chloroethylurea[N-nitroso-tris-chloroethylurea co-treated with XL147] results in decreased expression of SLN mRNA27935865
D000073878Palm OilPalm Oil results in increased expression of SLN mRNA18042831
C046012pentanalpentanal results in increased expression of SLN mRNA26079696
D010634PhenobarbitalPhenobarbital affects the expression of SLN mRNA19136022
C023604phenylphosphonic acidphenylphosphonic acid inhibits the reaction [Adenosine Triphosphate promotes the reaction [SLN protein affects the transport of Phosphates]]19917222
D010710PhosphatesAdenosine Monophosphate inhibits the reaction [Adenosine Triphosphate promotes the reaction [SLN protein affects the transport of Phosphates]]19917222
D010710PhosphatesAdenosine Triphosphate promotes the reaction [SLN protein affects the transport of Phosphates]19917222
D010710Phosphatesphenylphosphonic acid inhibits the reaction [Adenosine Triphosphate promotes the reaction [SLN protein affects the transport of Phosphates]]19917222
D010710PhosphatesSLN protein affects the transport of Phosphates19917222
C060836pioglitazone[N-nitroso-tris-chloroethylurea co-treated with pioglitazone] results in decreased expression of SLN mRNA27935865
C006253pirinixic acidpirinixic acid affects the expression of SLN mRNA19136022
C005556propionaldehydepropionaldehyde results in increased expression of SLN mRNA26079696
D011441PropylthiouracilPropylthiouracil results in increased expression of SLN mRNA24780913
D020849Raloxifene Hydrochloride[Raloxifene Hydrochloride co-treated with ESR1 protein] results in decreased expression of SLN mRNA19059307
C089730rosiglitazonerosiglitazone results in increased expression of SLN mRNA21172411
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of SLN mRNA25895662
D053260SootSoot affects the expression of SLN mRNA26551751
D013629Tamoxifen[Tamoxifen co-treated with ESR1 protein] results in decreased expression of SLN mRNA19059307
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of SLN mRNA21215274
C009495titanium dioxidetitanium dioxide results in decreased expression of SLN mRNA23557971
C012589trichostatin Atrichostatin A results in increased expression of SLN mRNA24935251
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SLN mRNA"27188386
D014635Valproic AcidValproic Acid results in increased expression of SLN mRNA26272509|2800136
C581157XL147[N-nitroso-tris-chloroethylurea co-treated with XL147] results in decreased expression of SLN mRNA27935865
D015032ZincZinc deficiency results in decreased expression of SLN mRNA19111725

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004857enzyme inhibitor activity-ISS12032137  
GO:0005515protein binding-IPI25416956  
GO:0051117ATPase binding-ISS12032137  
GO ID GO Term Qualifier Evidence PubMed
GO:0006816calcium ion transport-NAS9367679  
GO:0043086negative regulation of catalytic activity-ISS12032137  
GO:0043242negative regulation of protein complex disassembly-ISS12032137  
GO:0051924regulation of calcium ion transport-ISS-  
GO:0070296sarcoplasmic reticulum calcium ion transport-ISS-  
GO:0090281negative regulation of calcium ion import-ISS12032137  
GO:1901020negative regulation of calcium ion transmembrane transporter activity-ISS12032137  
GO:1901077regulation of relaxation of muscle-ISS-  
GO:1901877negative regulation of calcium ion binding-ISS12032137  
GO:1901881positive regulation of protein depolymerization-ISS12032137  
GO:1901894regulation of calcium-transporting ATPase activity-IDA11781085  
GO ID GO Term Qualifier Evidence PubMed
GO:0016021integral component of membrane-NAS9367679  
GO:0016529sarcoplasmic reticulum-IDA9575189  
GO:0033017sarcoplasmic reticulum membrane-ISS-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-382551Transport of small moleculesTAS
R-HSA-397014Muscle contractionTAS
R-HSA-5576891Cardiac conductionTAS
R-HSA-5578775Ion homeostasisTAS
R-HSA-936837Ion transport by P-type ATPasesTAS
R-HSA-983712Ion channel transportTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
22776004Smoking among troops deployed in combat areas and its association with combat exposure among navy personnel in Sri Lanka. (2012 Jul 9)de Silva VASubst Abuse Treat Prev Policy
25254557Mental health status of Sri Lanka Navy personnel three years after end of combat operations: a follow up study. (2014)Hanwella RPLoS One
26987474Cannabis use among Navy personnel in Sri Lanka: a cross sectional study. (2016 Mar 17)de Silva VABMC Res Notes