Gene: BMPR2

659
BMPR-II|BMPR3|BMR2|BRK-3|POVD1|PPH1|T-ALK
bone morphogenetic protein receptor type 2
protein-coding
2q33.1-q33.2
Ensembl:ENSG00000204217 MIM:600799 Vega:OTTHUMG00000133617 UniprotKB:Q13873
NG_009363.1
PubMed
0   ANCO-SNPs
ND
5   
NA (AD)  NA (ND)   (Frontal_Cortex)
5.903e-1 (AD)  8.932e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
NCKAP10.96
KRAS0.959
SHOC20.959
SEC23A0.957
PPP2R5E0.954
CAND10.953
UBE2K0.953
SLC25A460.952
LMBR10.95
GMPS0.949

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.579
OR4F29-0.537
CSAG1-0.385
S100A1-0.333
MYL3-0.325
MTRNR2L10-0.317
HEY2-0.304
COPZ2-0.303
ANPEP-0.302
OLAH-0.3

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB11639Dibotermin alfaBiotechDrug246539-15-1Approved|InvestigationalTarget
ID Drug Name Action PubMed
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of BMPR2 mRNA"19114083
C0294972,3-bis(3'-hydroxybenzyl)butyrolactone"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in decreased expression of BMPR2 mRNA"19167446
C0127962-butenal2-butenal results in decreased expression of BMPR2 mRNA20471460
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in increased expression of BMPR2 mRNA"18648102
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of BMPR2 mRNA"27188386
C0357635,5'-bis(8-(phenylamino)-1-naphthalenesulfonate)"5,5'-bis(8-(phenylamino)-1-naphthalenesulfonate) binds to BMPR2 protein"17363346
C0357635,5'-bis(8-(phenylamino)-1-naphthalenesulfonate)"5,5'-bis(8-(phenylamino)-1-naphthalenesulfonate) promotes the reaction [BMP7 protein binds to BMPR2 protein]"17363346
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of BMPR2 mRNA"27188386
C0524109-chloro-2-(2-furyl)-(1,2,4)triazolo(1,5-c)quinazolin-5-imine"9-chloro-2-(2-furyl)-(1,2,4)triazolo(1,5-c)quinazolin-5-imine results in increased expression of BMPR2 mRNA"25633564
D000082AcetaminophenAcetaminophen results in increased expression of BMPR2 mRNA22230336
D000393Air PollutantsAir Pollutants analog results in decreased expression of BMPR2 mRNA21757418
D000643Ammonium ChlorideAmmonium Chloride affects the expression of BMPR2 mRNA16483693
D039741Antigens, Dermatophagoides"BMPR2 protein affects the susceptibility to [Methacholine Chloride co-treated with Antigens, Dermatophagoides]"22427841
D001151ArsenicArsenic affects the expression of BMPR2 protein24675094
D001151ArsenicArsenic results in decreased expression of BMPR2 mRNA19654921
D001151ArsenicArsenic results in increased expression of BMPR2 protein28903487
C006632arsenic trioxidearsenic trioxide results in increased expression of BMPR2 mRNA20458559
C030935benz(a)anthracene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of BMPR2 mRNA27858113
C006703benzo(b)fluoranthene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of BMPR2 mRNA27858113
C006703benzo(b)fluoranthenebenzo(b)fluoranthene results in decreased expression of BMPR2 mRNA26377693
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of BMPR2 mRNA20064835|2010694
D001564Benzo(a)pyrene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of BMPR2 mRNA27858113
D004958EstradiolBMPR2 protein modified form inhibits the reaction [KITLG protein inhibits the reaction [FSHB protein results in increased abundance of Estradiol]]22366471
D004958EstradiolBMPR2 protein modified form promotes the reaction [SU 5402 inhibits the reaction [KITLG protein inhibits the reaction [FSHB protein results in increased abundance of Estradiol]]]22366471
D004958EstradiolSU 5402 promotes the reaction [BMPR2 protein modified form inhibits the reaction [KITLG protein inhibits the reaction [FSHB protein results in increased abundance of Estradiol]]]22366471
D004958EstradiolEstradiol results in decreased expression of BMPR2 mRNA20068009
C044887beta-methylcholinebeta-methylcholine affects the expression of BMPR2 mRNA21179406
C006780bisphenol Abisphenol A results in increased expression of BMPR2 mRNA25181051|2909715
C018475butyraldehydebutyraldehyde results in decreased expression of BMPR2 mRNA26079696
D019256Cadmium ChlorideCadmium Chloride results in increased expression of BMPR2 mRNA20883709
D002737ChloropreneChloroprene results in increased expression of BMPR2 mRNA23125180
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of BMPR2 gene20938992
C031180chrysene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of BMPR2 mRNA27858113
C018021cobaltous chloridecobaltous chloride results in decreased expression of BMPR2 mRNA19320972
D003042CocaineCocaine results in increased expression of BMPR2 mRNA17898221
D003375Coumestrol"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in decreased expression of BMPR2 mRNA"19167446
D003375Coumestrol[Coumestrol co-treated with resveratrol] results in decreased expression of BMPR2 mRNA19167446
D016572CyclosporineCyclosporine results in decreased expression of BMPR2 mRNA25562108|2798913
D004041Dietary FatsDietary Fats results in decreased expression of BMPR2 mRNA18042831
D004237DiuronDiuron results in decreased expression of BMPR2 mRNA25152437
D004365Drugs, Chinese Herbal"Drugs, Chinese Herbal inhibits the reaction [Puromycin Aminonucleoside results in increased expression of BMPR2 mRNA]"17803470
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of BMPR2 mRNA29097150
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in increased expression of BMPR2 mRNA23649840
D005277FenfluramineBMPR2 gene mutant form results in increased susceptibility to Fenfluramine12358323
D005473FluoxetineFluoxetine inhibits the reaction [Monocrotaline results in decreased expression of BMPR2 mRNA]21619414
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of BMPR2 gene20938992
D017328FosinoprilFosinopril inhibits the reaction [Puromycin Aminonucleoside results in increased expression of BMPR2 mRNA]17803470
D012701SerotoninSerotonin binds to and results in increased activity of BMPR2 protein20204739
D016285IloprostIloprost inhibits the reaction [BMPR2 gene mutant form results in decreased expression of ID1 protein]20522807
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of BMPR2 mRNA25613284
C561695(+)-JQ1 compound(+)-JQ1 compound results in increased expression of BMPR2 mRNA21889194
C119620kenpaullonekenpaullone results in increased expression of BMPR2 mRNA25633564
D008627Mercuric ChlorideMercuric Chloride results in decreased expression of BMPR2 mRNA27188386
D008628MercuryMercury results in increased expression of BMPR2 mRNA19937285
D016210Methacholine Chloride"BMPR2 protein affects the susceptibility to [Methacholine Chloride co-treated with Antigens, Dermatophagoides]"22427841
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of BMPR2 gene20938992
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of BMPR2 mRNA28001369
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in decreased expression of BMPR2 mRNA"26251327
D016686MonocrotalineFluoxetine inhibits the reaction [Monocrotaline results in decreased expression of BMPR2 mRNA]21619414
D016686MonocrotalineMonocrotaline results in decreased expression of BMPR2 mRNA21619414|2546036
D016686MonocrotalineMonocrotaline results in decreased expression of BMPR2 protein20522807
C406082monomethylarsonous acidmonomethylarsonous acid results in decreased expression of BMPR2 mRNA22108045
D037742Nanotubes, Carbon"Nanotubes, Carbon affects the expression of BMPR2 mRNA"23845593
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of BMPR2 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of BMPR2 mRNA"25554681
C007350nitrofennitrofen results in decreased expression of BMPR2 mRNA23780850
C007350nitrofennitrofen results in decreased expression of BMPR2 protein23780850
D010047OvalbuminBMPR2 protein affects the reaction [Ovalbumin results in increased expression of RETNLA mRNA]23383100
D010047OvalbuminBMPR2 protein affects the susceptibility to Ovalbumin23383100
D000073878Palm OilPalm Oil results in decreased expression of BMPR2 mRNA18042831
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in decreased expression of BMPR2 mRNA27153767
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of BMPR2 mRNA"27188386
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of BMPR2 mRNA22714537
D011374ProgesteroneProgesterone results in increased expression of BMPR2 mRNA23012394
D011692Puromycin Aminonucleoside"Drugs, Chinese Herbal inhibits the reaction [Puromycin Aminonucleoside results in increased expression of BMPR2 mRNA]"17803470
D011692Puromycin AminonucleosideFosinopril inhibits the reaction [Puromycin Aminonucleoside results in increased expression of BMPR2 mRNA]17803470
D011692Puromycin AminonucleosidePuromycin Aminonucleoside results in increased expression of BMPR2 mRNA17803470
C059514resveratrol[Coumestrol co-treated with resveratrol] results in decreased expression of BMPR2 mRNA19167446
C028632rutecarpinerutecarpine results in decreased expression of BMPR2 mRNA25633564
D012834SilverSilver results in increased expression of BMPR2 mRNA26014281
D019821SimvastatinSimvastatin affects the expression of BMPR2 mRNA16297860
D019821SimvastatinSimvastatin results in increased expression of BMPR2 protein16297860
D019821SimvastatinSimvastatin results in increased stability of BMPR2 mRNA16297860
C017947sodium arsenitesodium arsenite results in increased expression of BMPR2 mRNA20883709
C105686SU 5402BMPR2 protein modified form promotes the reaction [SU 5402 inhibits the reaction [KITLG protein inhibits the reaction [FSHB protein results in increased abundance of Estradiol]]]22366471
C105686SU 5402SU 5402 promotes the reaction [BMPR2 protein modified form inhibits the reaction [KITLG protein inhibits the reaction [FSHB protein results in increased abundance of Estradiol]]]22366471
C433985SU 9516SU 9516 results in increased expression of BMPR2 mRNA25633564
D013654TaurineTaurine results in decreased expression of BMPR2 mRNA16579726
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of BMPR2 mRNA12377990
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of BMPR2 mRNA21570461
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of BMPR2 mRNA21354282
D013750TetrachloroethyleneTetrachloroethylene results in increased expression of BMPR2 mRNA28973375
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of BMPR2 mRNA25613284
C009495titanium dioxidetitanium dioxide results in decreased expression of BMPR2 mRNA23557971
D014118Toxins, Biological"Toxins, Biological affects the expression of BMPR2 mRNA"19682533
D014212TretinoinTretinoin results in increased expression of BMPR2 mRNA21934132
C057693troglitazonetroglitazone results in decreased expression of BMPR2 mRNA28973697
D014520UrethaneUrethane results in increased expression of BMPR2 mRNA28818685
D014635Valproic AcidValproic Acid results in increased expression of BMPR2 mRNA23179753|2718838
D014635Valproic AcidValproic Acid affects the expression of BMPR2 mRNA17292431
C025643vinclozolinvinclozolin affects the expression of BMPR2 mRNA19015723
C111237vorinostatvorinostat results in decreased expression of BMPR2 mRNA27188386
C111237vorinostatvorinostat results in increased expression of BMPR2 mRNA26272509
C088658zoledronic acidzoledronic acid results in increased expression of BMPR2 mRNA20977926

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005024transforming growth factor beta-activated receptor activity-IBA21873635  
GO:0005026transforming growth factor beta receptor activity, type II-IBA21873635  
GO:0005515protein binding-IPI12045205  15188402  15657086  19229295  19424179  21976273  
24407287  
GO:0005524ATP binding-IEA-  
GO:0016362activin receptor activity, type II-TAS-  
GO:0019838growth factor binding-IBA21873635  
GO:0019838growth factor binding-IEA-  
GO:0036122BMP binding-IPI21976273  
GO:0046332SMAD binding-IBA21873635  
GO:0046872metal ion binding-IEA-  
GO:0098821BMP receptor activity-IBA21873635  
GO:0098821BMP receptor activity-ISS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0001568blood vessel development-IBA21873635  
GO:0001707mesoderm formation-ISS-  
GO:0001893maternal placenta development-IEA-  
GO:0001935endothelial cell proliferation-IMP25187962  
GO:0001938positive regulation of endothelial cell proliferation-IMP17992660  
GO:0001944vasculature development-IBA21873635  
GO:0001946lymphangiogenesis-ISS-  
GO:0001974blood vessel remodeling-ISS-  
GO:0002063chondrocyte development-IMP9442116  
GO:0003085negative regulation of systemic arterial blood pressure-IMP18364108  
GO:0003148outflow tract septum morphogenesis-ISS-  
GO:0003148outflow tract septum morphogenesisNOTISS-  
GO:0003151outflow tract morphogenesis-ISS-  
GO:0003181atrioventricular valve morphogenesisNOTISS-  
GO:0003183mitral valve morphogenesis-ISS-  
GO:0003186tricuspid valve morphogenesis-ISS-  
GO:0003197endocardial cushion development-ISS-  
GO:0003252negative regulation of cell proliferation involved in heart valve morphogenesis-ISS-  
GO:0006366transcription by RNA polymerase II-IMP12045205  
GO:0006468protein phosphorylation-IEA-  
GO:0007178transmembrane receptor protein serine/threonine kinase signaling pathway-IDA12045205  
GO:0007179transforming growth factor beta receptor signaling pathway-IBA21873635  
GO:0007389pattern specification process-IBA21873635  
GO:0007420brain development-IEA-  
GO:0009267cellular response to starvation-IEP15657086  
GO:0009952anterior/posterior pattern specification-ISS-  
GO:0010595positive regulation of endothelial cell migration-IMP17992660  
GO:0010634positive regulation of epithelial cell migration-IDA12819188  
GO:0010862positive regulation of pathway-restricted SMAD protein phosphorylation-IMP17992660  19366699  
GO:0014916regulation of lung blood pressure-IMP18364108  
GO:0014916regulation of lung blood pressure-ISS-  
GO:0030166proteoglycan biosynthetic process-ISS-  
GO:0030308negative regulation of cell growth-IDA12819188  
GO:0030501positive regulation of bone mineralization-IMP18436533  
GO:0030509BMP signaling pathway-IDA18436533  
GO:0030509BMP signaling pathway-IMP9442116  12045205  19366699  
GO:0030509BMP signaling pathway-ISS-  
GO:0030509BMP signaling pathway-TAS-  
GO:0030513positive regulation of BMP signaling pathway-IMP17992660  
GO:0032924activin receptor signaling pathway-IEA-  
GO:0042127regulation of cell proliferation-IMP11502704  
GO:0045669positive regulation of osteoblast differentiation-IMP18436533  
GO:0045778positive regulation of ossification-ISS-  
GO:0045906negative regulation of vasoconstriction-ISS-  
GO:0045944positive regulation of transcription by RNA polymerase II-IMP18326817  
GO:0045944positive regulation of transcription by RNA polymerase II-ISS-  
GO:0048010vascular endothelial growth factor receptor signaling pathway-ISS-  
GO:0048286lung alveolus development-ISS-  
GO:0048738cardiac muscle tissue developmentNOTISS-  
GO:0048842positive regulation of axon extension involved in axon guidance-IEA-  
GO:0060173limb development-IEA-  
GO:0060350endochondral bone morphogenesis-ISS-  
GO:0060412ventricular septum morphogenesis-ISS-  
GO:0060413atrial septum morphogenesis-ISS-  
GO:0060836lymphatic endothelial cell differentiation-ISS-  
GO:0060840artery development-ISS-  
GO:0060841venous blood vessel development-ISS-  
GO:0061036positive regulation of cartilage development-ISS-  
GO:0061298retina vasculature development in camera-type eye-ISS-  
GO:0061626pharyngeal arch artery morphogenesis-ISS-  
GO:0061626pharyngeal arch artery morphogenesisNOTISS-  
GO:0071773cellular response to BMP stimulus-IMP18326817  
GO:0072577endothelial cell apoptotic process-IMP25187962  
GO:1902731negative regulation of chondrocyte proliferation-IMP9442116  
GO:1905314semi-lunar valve development-ISS-  
GO:2000279negative regulation of DNA biosynthetic process-IMP19366699  
GO ID GO Term Qualifier Evidence PubMed
GO:0005615extracellular space-HDA22664934  
GO:0005654nucleoplasm-IDA-  
GO:0005737cytoplasm-IEA-  
GO:0005886plasma membrane-IDA15657086  25187962  
GO:0005886plasma membrane-TAS-  
GO:0005887integral component of plasma membrane-IBA21873635  
GO:0005887integral component of plasma membrane-IDA12045205  
GO:0005901caveolacolocalizes_withIMP15657086  
GO:0005913cell-cell adherens junction-IDA25468996  
GO:0009925basal plasma membrane-IEA-  
GO:0009986cell surface-IEA-  
GO:0014069postsynaptic density-IEA-  
GO:0016324apical plasma membrane-IEA-  
GO:0030425dendrite-IEA-  
GO:0043025neuronal cell body-IEA-  
GO:0043235receptor complex-IBA21873635  
GO:0044214spanning component of plasma membrane-TAS9442116  
KEGG ID KEGG Term
hsa04060Cytokine-cytokine receptor interaction
hsa04350TGF-beta signaling pathway
Reactome ID Reactome Term Evidence
R-HSA-162582Signal TransductionTAS
R-HSA-201451Signaling by BMPTAS
R-HSA-9006936Signaling by TGF-beta family membersTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
19307479Stress Doppler echocardiography in relatives of patients with idiopathic and familial pulmonary arterial hypertension: results of a multicenter European analysis of pulmonary artery pressure response to exercise and hypoxia. (2009 Apr 7)Grunig ECirculation
24977008Remodeling of rat pulmonary artery induced by chronic smoking exposure. (2014 Jun)Zhao LJ Thorac Dis
27077124A Functional Variant rs6435156C > T in BMPR2 is Associated With Increased Risk of Chronic Obstructive Pulmonary Disease (COPD) in Southern Chinese Population. (2016 Mar)Wang JEBioMedicine
20970515Similar gene expression profiles in smokers and patients with moderate COPD. (2011 Feb)Llinas LPulm Pharmacol Ther
26072521A Candidate-Pathway Approach to Identify Gene-Environment Interactions: Analyses of Colon Cancer Risk and Survival. (2015 Sep)Sharafeldin NJ Natl Cancer Inst