Gene: SLPI

6590
ALK1|ALP|BLPI|HUSI|HUSI-I|MPI|WAP4|WFDC4
secretory leukocyte peptidase inhibitor
protein-coding
20q13.12
Ensembl:ENSG00000124107 MIM:107285 Vega:OTTHUMG00000033075 UniprotKB:P03973
NG_028137.1
PubMed
ND
23   
NA (AD)  NA (ND)   (Frontal_Cortex)
6.052e-1 (AD)  1.165e-1 (ND)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg08548498chr20:43883546SLPIPromoter6.067e-4Alcohol use disorders26763658

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
C70.786
MLPH0.786
SLC16A120.776
SIX10.772
UBL4B0.772
ASB90.764
TNFAIP80.76
GADL10.753
COL14A10.752
TFPI0.752

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ASPDH-0.472
MYADML2-0.454
HHATL-0.447
ZNF835-0.433
FUT9-0.426
CYP46A1-0.425
SORCS2-0.422
CHRNA4-0.421
TMEM143-0.416
FAM43B-0.414

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether affects the expression of SLPI mRNA"23962555
C0291412,2,5,7,8-pentamethyl-1-hydroxychroman"2,2,5,7,8-pentamethyl-1-hydroxychroman results in decreased expression of SLPI mRNA"21920950
C0142112,3,7,8-tetrachlorodibenzofuran"2,3,7,8-tetrachlorodibenzofuran affects the expression of SLPI mRNA"18343893
C0109142,4-diaminotoluene"2,4-diaminotoluene results in increased expression of SLPI mRNA"20713471
C0495842-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine"2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased expression of SLPI mRNA"15215175
C0065512-amino-2-methyl-1-propanol2-amino-2-methyl-1-propanol results in decreased expression of SLPI mRNA25088246
C0352074-amino-2,6-dinitrotoluene"4-amino-2,6-dinitrotoluene affects the expression of SLPI mRNA"21346803
D000082AcetaminophenAcetaminophen affects the expression of SLPI mRNA17984051
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of SLPI mRNA19770486
D000643Ammonium ChlorideAmmonium Chloride affects the expression of SLPI mRNA16483693
D001151ArsenicArsenic results in decreased expression of SLPI mRNA19654921
D017638Asbestos, Crocidolite"Asbestos, Crocidolite results in decreased expression of SLPI mRNA"24160326
D017638Asbestos, Crocidolite"Asbestos, Crocidolite results in increased expression of SLPI mRNA"23917077
D001241AspirinAspirin results in decreased expression of SLPI mRNA15928584
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of SLPI mRNA20127859
D004958Estradiol[Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of SLPI mRNA19619570
D004958EstradiolEstradiol results in decreased expression of SLPI mRNA23019147
D004958EstradiolEstradiol results in increased expression of SLPI mRNA19619570
D004958EstradiolEstradiol results in increased expression of SLPI mRNA17010207
C006780bisphenol Abisphenol A results in increased methylation of SLPI promoter27312807
C006780bisphenol Abisphenol A results in increased expression of SLPI mRNA18180321
D001761BleomycinBleomycin results in increased expression of SLPI protein26345256
D020122tert-ButylhydroperoxideSLPI protein results in decreased susceptibility to tert-Butylhydroperoxide15003993
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in increased expression of SLPI mRNA14729362|1500399
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of SLPI mRNA27339419
D002330CarmustineSLPI mRNA affects the susceptibility to Carmustine16365179
D002509CephaloridineCephaloridine results in increased expression of SLPI mRNA18500788
C018021cobaltous chloridecobaltous chloride results in increased expression of SLPI mRNA23052192
D003300Copper[NSC 689534 binds to Copper] which results in increased expression of SLPI mRNA20971185
D003474CurcuminCurcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of SLPI mRNA]18200517
C057862cyanoginosin LRcyanoginosin LR affects the expression of SLPI mRNA20957730
D003520CyclophosphamideCyclophosphamide results in decreased expression of SLPI mRNA15331540
D016572CyclosporineCyclosporine results in decreased expression of SLPI mRNA20106945|2798913
D003907Dexamethasone[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in decreased expression of SLPI mRNA16054899
D002945CisplatinCisplatin results in decreased expression of SLPI mRNA27392435
D002945CisplatinSLPI protein affects the susceptibility to Cisplatin16217747
D003633Dichlorodiphenyl DichloroethyleneDichlorodiphenyl Dichloroethylene affects the expression of SLPI mRNA27391359
D004041Dietary FatsDietary Fats results in increased expression of SLPI mRNA22609946
D004041Dietary FatsDietary Fats results in decreased expression of SLPI mRNA21852083
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with Phenobarbital] results in increased expression of SLPI mRNA24535843
D004052DiethylnitrosamineDiethylnitrosamine results in increased expression of SLPI mRNA24535843
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with Thioacetamide] results in increased expression of SLPI mRNA28943392
D004054DiethylstilbestrolDiethylstilbestrol results in increased expression of SLPI mRNA15171707
D004054DiethylstilbestrolDiethylstilbestrol results in increased expression of SLPI mRNA17010207
D002117CalcitriolCalcitriol results in increased expression of SLPI mRNA26485663
D004137DinitrochlorobenzeneDinitrochlorobenzene affects the expression of SLPI mRNA22302311
D004237DiuronDiuron metabolite results in increased expression of SLPI mRNA24172598
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of SLPI mRNA17942748
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of SLPI mRNA23300682
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of SLPI mRNA15834898|1755790
C000499ferric oxide[Magnetite Nanoparticles co-treated with ferric oxide] results in increased expression of SLPI mRNA20540983
D005419FlavonoidsFlavonoids results in increased expression of SLPI mRNA18035473
D000068298Fluticasone[Fluticasone co-treated with Salmeterol Xinafoate] results in increased expression of SLPI mRNA15862954
D000068298FluticasoneFluticasone results in increased expression of SLPI mRNA15860753
D000068298FluticasoneSalmeterol Xinafoate promotes the reaction [Fluticasone results in increased expression of SLPI mRNA]15860753
C069837fullerene C60fullerene C60 results in increased expression of SLPI mRNA20064541
C070081fulvestrantfulvestrant inhibits the reaction [Genistein results in increased expression of SLPI mRNA]22553218
C039281furanfuran results in increased expression of SLPI mRNA27387713
D019833Genisteinfulvestrant inhibits the reaction [Genistein results in increased expression of SLPI mRNA]22553218
D019833GenisteinGenistein results in increased expression of SLPI mRNA21810550|2255321
D005839GentamicinsGentamicins results in increased expression of SLPI mRNA22061828
D017313FenretinideFenretinide results in decreased expression of SLPI mRNA28973697
D006861Hydrogen PeroxideHydrogen Peroxide affects the expression of SLPI mRNA20044591
D006861Hydrogen PeroxideHydrogen Peroxide results in increased expression of SLPI mRNA14729362|1500399
C051890irinotecanirinotecan affects the expression of SLPI mRNA20097248
D007501IronIron deficiency results in decreased expression of SLPI mRNA20368581
D0150561-Methyl-3-isobutylxanthine[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in decreased expression of SLPI mRNA16054899
C098607JP8 aviation fuelJP8 aviation fuel results in decreased expression of SLPI protein17337753
C561695(+)-JQ1 compound(+)-JQ1 compound inhibits the reaction [Lipopolysaccharides results in increased expression of SLPI mRNA]25890327
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of SLPI mRNA22235868
D008070Lipopolysaccharides(+)-JQ1 compound inhibits the reaction [Lipopolysaccharides results in increased expression of SLPI mRNA]25890327
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of SLPI mRNA25890327|2733941
D058185Magnetite Nanoparticles[Magnetite Nanoparticles co-treated with ferric oxide] results in increased expression of SLPI mRNA20540983
D058185Magnetite Nanoparticles[Succimer binds to Magnetite Nanoparticles] which results in increased expression of SLPI mRNA21641980
D008731MethoxychlorMethoxychlor affects the expression of SLPI mRNA27391359
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of SLPI mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of SLPI mRNA"25554681
C031721naphthalenenaphthalene results in increased expression of SLPI mRNA18978301
C017557nickel subsulfidenickel subsulfide results in decreased expression of SLPI mRNA21086188
C558013NSC 689534[NSC 689534 binds to Copper] which results in increased expression of SLPI mRNA20971185
C558013NSC 689534NSC 689534 results in increased expression of SLPI mRNA20971185
C474055octylphenoloctylphenol results in increased expression of SLPI mRNA17010207
C510784ormosil[ormosil binds to Polyethylene Glycols] which results in decreased expression of SLPI mRNA24888373
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in increased expression of SLPI mRNA25729387
C030110oxaliplatinoxaliplatin results in increased expression of SLPI mRNA25729387
D010098OxycodoneOxycodone results in decreased expression of SLPI mRNA23439660
D010269ParaquatParaquat results in increased expression of SLPI protein26345256
D052638Particulate MatterParticulate Matter results in increased expression of SLPI mRNA28341207
C023036perfluorooctanoic acidperfluorooctanoic acid results in decreased expression of SLPI mRNA16221955
D010634Phenobarbital[Diethylnitrosamine co-treated with Phenobarbital] results in increased expression of SLPI mRNA24535843
D010634PhenobarbitalNR1I3 protein affects the reaction [Phenobarbital results in increased expression of SLPI mRNA]19482888
D010634PhenobarbitalPhenobarbital results in increased expression of SLPI mRNA19482888
C006253pirinixic acid[pirinixic acid co-treated with PPARA] results in increased expression of SLPI mRNA20813756
C006253pirinixic acidpirinixic acid results in decreased expression of SLPI mRNA17426115
C006253pirinixic acidpirinixic acid results in increased expression of SLPI mRNA20813756
D011092Polyethylene Glycols[ormosil binds to Polyethylene Glycols] which results in decreased expression of SLPI mRNA24888373
D011374ProgesteroneProgesterone affects the expression of SLPI mRNA17251523
C005556propionaldehydepropionaldehyde results in decreased expression of SLPI mRNA26079696
D011441PropylthiouracilPropylthiouracil results in decreased expression of SLPI mRNA24780913
C089730rosiglitazone[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in decreased expression of SLPI mRNA16054899
D000068299Salmeterol Xinafoate[Fluticasone co-treated with Salmeterol Xinafoate] results in increased expression of SLPI mRNA15862954
D000068299Salmeterol XinafoateSalmeterol Xinafoate promotes the reaction [Fluticasone results in increased expression of SLPI mRNA]15860753
C541923sandostatinLARsandostatinLAR results in increased expression of SLPI mRNA17210224
D017632Asbestos, Serpentine"Asbestos, Serpentine results in decreased expression of SLPI mRNA"24160326
D017632Asbestos, Serpentine"Asbestos, Serpentine results in increased expression of SLPI mRNA"24160326
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of SLPI mRNA25895662
D012822Silicon DioxideSilicon Dioxide analog results in increased expression of SLPI mRNA23806026
D012822Silicon DioxideSilicon Dioxide results in increased expression of SLPI mRNA26345256
D012822Silicon DioxideSilicon Dioxide results in increased expression of SLPI protein26345256
D012906SmokeSmoke results in decreased expression of SLPI mRNA21095227
D053260SootSoot results in increased expression of SLPI mRNA22461453|2655175
D004113Succimer[Succimer binds to Magnetite Nanoparticles] which results in increased expression of SLPI mRNA21641980
C047246temozolomideSLPI mRNA affects the susceptibility to temozolomide16365179
C020806tetrabromobisphenol Atetrabromobisphenol A results in increased expression of SLPI mRNA25172293
D013749Tetrachlorodibenzodioxin[Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of SLPI mRNA19619570
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of SLPI mRNA19619570
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of SLPI mRNA18343893|2157046
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of SLPI mRNA17942748
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of SLPI mRNA21215274
D013853Thioacetamide[Diethylnitrosamine co-treated with Thioacetamide] results in increased expression of SLPI mRNA28943392
C009495titanium dioxidetitanium dioxide results in increased expression of SLPI mRNA19464567|2355797
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of SLPI mRNA28065790
D014028Tobacco Smoke PollutionNFE2L2 protein affects the reaction [Tobacco Smoke Pollution affects the expression of SLPI mRNA]20133372
D014028Tobacco Smoke PollutionTobacco Smoke Pollution affects the expression of SLPI mRNA20133372
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of SLPI mRNA18087596
C116664tolvaptantolvaptan results in increased expression of SLPI mRNA28115652
C116664tolvaptantolvaptan results in increased expression of SLPI protein28115652
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in increased expression of SLPI mRNA25729387
D019772TopotecanTopotecan results in increased expression of SLPI mRNA25729387
D014118Toxins, Biological"Toxins, Biological affects the expression of SLPI mRNA"19682533
D014241TrichloroethyleneTrichloroethylene results in decreased expression of SLPI mRNA17905399
C015559trimellitic anhydridetrimellitic anhydride affects the expression of SLPI mRNA22302311
D014302Trinitrobenzenesulfonic AcidCurcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of SLPI mRNA]18200517
D014302Trinitrobenzenesulfonic AcidTrinitrobenzenesulfonic Acid results in increased expression of SLPI mRNA18200517
C022884undecaneundecane results in decreased expression of SLPI protein17337753
D014635Valproic AcidValproic Acid results in decreased methylation of SLPI gene29154799
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of SLPI gene25560391
C088658zoledronic acidzoledronic acid results in increased expression of SLPI mRNA24714768
C088658zoledronic acidzoledronic acid results in increased expression of SLPI protein28871336

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003677DNA binding-IDA2467900  
GO:0003729mRNA binding-IDA2467900  
GO:0004866endopeptidase inhibitor activity-TAS3485543  
GO:0004867serine-type endopeptidase inhibitor activity-IDA3462719  
GO:0005515protein binding-IPI19333378  25416956  
GO:0019899enzyme binding-IPI19333378  
GO ID GO Term Qualifier Evidence PubMed
GO:0006955immune response-ISS-  
GO:0010951negative regulation of endopeptidase activity-IEA-  
GO:0019731antibacterial humoral response-IDA18714013  
GO:0019731antibacterial humoral response-ISS-  
GO:0032091negative regulation of protein binding-IDA19333378  
GO:0032496response to lipopolysaccharide-ISS-  
GO:0035821modification of morphology or physiology of other organism-IDA2467900  
GO:0043312neutrophil degranulation-TAS-  
GO:0045071negative regulation of viral genome replication-IDA19333378  
GO:0045087innate immune response-ISS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005576extracellular region-TAS-  
GO:0005615extracellular space-IDA3462719  18714013  
GO:0035580specific granule lumen-TAS-  
GO:0062023collagen-containing extracellular matrixcolocalizes_withHDA20551380  
GO:0070062extracellular exosome-HDA19199708  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-168249Innate Immune SystemTAS
R-HSA-168256Immune SystemTAS
R-HSA-6798695Neutrophil degranulationTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
12753532Secretory leukocyte proteinase inhibitor, alpha-1-antitrypsin deficiency and emphysema: Preliminary study, speculation and an hypothesis. (2003 Jun)Ayad MSRespirology
9441132The proteinase-antiproteinase theory of emphysema: a speculative analysis of recent advances into the pathogenesis of emphysema. (1997 Jun)Knight KRRespirology
23467841Human papillomavirus infection in head and neck cancer: the role of the secretory leukocyte protease inhibitor. (2013 May)Hoffmann MOncol Rep
28298400Antimicrobial peptide levels are linked to airway inflammation, bacterial colonisation and exacerbations in chronic obstructive pulmonary disease. (2017 Mar)Persson LJEur Respir J
21426578Smoking status and anti-inflammatory macrophages in bronchoalveolar lavage and induced sputum in COPD. (2011 Mar 22)Kunz LIRespir Res
21635782Sputum and nasal lavage lung-specific biomarkers before and after smoking cessation. (2011 Jun 2)Bouloukaki IBMC Pulm Med
22574903Inhibitory effect of Chinese green tea on cigarette smoke-induced up-regulation of airway neutrophil elastase and matrix metalloproteinase-12 via antioxidant activity. (2012 Sep)Chan KHFree Radic Res
18953959[Effects of secretory leukocyte protease inhibitor on expression of inflammation mediators in normal human bronchial epithelial cells induced by cigarette smoke extract]. (2008 May)Qu MYZhonghua Jie He He Hu Xi Za Zhi
24140751Quantification of secretory leukocyte protease inhibitor (SLPI) in oral gargle specimens collected using mouthwash. (2013 Dec 31)Pierce Campbell CMJ Immunol Methods
28811900SLPI and AnxA2 expression in neoplasm-free palatine tonsils is associated with smoking habit of individuals. (2017 Sep)Quabius ESMol Clin Oncol
25462861The antileukoprotease secretory leukocyte protease inhibitor (SLPI) and its role in the prevention of HPV-infections in head and neck squamous cell carcinoma. (2015 Feb 1)Quabius ESCancer Lett
23126266Expression of oral secretory leukocyte protease inhibitor in HIV-infected subjects with long-term use of antiretroviral therapy. (2013 Mar)Nittayananta WJ Oral Pathol Med
24285265Regulation and activity of secretory leukoprotease inhibitor (SLPI) is altered in smokers. (2014 Feb)Meyer MAm J Physiol Lung Cell Mol Physiol
22333260[Effects of secretary leukocyte protease inhibitor-transfected bone marrow mesenchymal stem cells on airway inflammation and mucus secretion in chronic obstructive pulmonary disease]. (2011 Dec 27)Jiang DPZhonghua Yi Xue Za Zhi
21917606Potential role of HE4 in multimodal screening for epithelial ovarian cancer. (2011 Nov 2)Urban NJ Natl Cancer Inst
23996702The role of the antileukoprotease SLPI in smoking-induced human papillomavirus-independent head and neck squamous cell carcinomas. (2014 Mar 15)Quabius ESInt J Cancer
29179866miRNA-expression in tonsillar squamous cell carcinomas in relation to HPV infection and expression of the antileukoproteinase SLPI. (2017 Dec)Quabius ESPapillomavirus Res
10853853Airways inflammation in chronic bronchitis: the effects of smoking and alpha1-antitrypsin deficiency. (2000 May)Hill ATEur Respir J
18699806Altered expression of antimicrobial molecules in cigarette smoke-exposed emphysematous mice lungs. (2008 Nov)Shibata YRespirology
11120902Relationship between airway inflammation and the frequency of exacerbations in patients with smoking related COPD. (2001 Jan)Gompertz SThorax
27016010Salivary secretory leukocyte protease inhibitor (SLPI) and head and neck cancer: The Cancer Prevention Study II Nutrition Cohort. (2016 Apr)Pierce Campbell CMOral Oncol
15039315Salivary secretory leukocyte protease inhibitor and oral candidiasis in human immunodeficiency virus type 1-infected persons. (2004 Apr)Chattopadhyay AInfect Immun
15167969Human neutrophil defensins and secretory leukocyte proteinase inhibitor in squamous metaplastic epithelium of bronchial airways. (2004 Jun)Aarbiou JInflamm Res