Gene info: ID 6590

Gene: SLPI

GENE ID: 6590

Description: secretory leukocyte peptidase inhibitor

Gene type: protein-coding

Location: 20q13.12

dbXrefs: Ensembl:ENSG00000124107 MIM:107285 Vega:OTTHUMG00000033075 UniprotKB:P03973

RefSeq: NG_028137.1

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: ND

# Publications: 23

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 6.052e-1 (AD) 1.165e-1 (ND)

DNA Methylation

Probe	Locus(GRCh37)	Gene	Region	p-val	Trait	PubMed ID
cg08548498	chr20:43883546	SLPI	Promoter	6.067e-4	Alcohol use disorders	26763658

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
C7	0.786
MLPH	0.786
SLC16A12	0.776
SIX1	0.772
UBL4B	0.772
ASB9	0.764
TNFAIP8	0.76
GADL1	0.753
COL14A1	0.752
TFPI	0.752

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
ASPDH	-0.472
MYADML2	-0.454
HHATL	-0.447
ZNF835	-0.433
FUT9	-0.426
CYP46A1	-0.425
SORCS2	-0.422
CHRNA4	-0.421
TMEM143	-0.416
FAM43B	-0.414

There is no DrugBank record for this gene !

ID	Drug Name	Action	PubMed
C511295	2,2',4,4'-tetrabromodiphenyl ether	"2,2',4,4'-tetrabromodiphenyl ether affects the expression of SLPI mRNA"	23962555
C029141	2,2,5,7,8-pentamethyl-1-hydroxychroman	"2,2,5,7,8-pentamethyl-1-hydroxychroman results in decreased expression of SLPI mRNA"	21920950
C014211	2,3,7,8-tetrachlorodibenzofuran	"2,3,7,8-tetrachlorodibenzofuran affects the expression of SLPI mRNA"	18343893
C010914	2,4-diaminotoluene	"2,4-diaminotoluene results in increased expression of SLPI mRNA"	20713471
C049584	2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine	"2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased expression of SLPI mRNA"	15215175
C006551	2-amino-2-methyl-1-propanol	2-amino-2-methyl-1-propanol results in decreased expression of SLPI mRNA	25088246
C035207	4-amino-2,6-dinitrotoluene	"4-amino-2,6-dinitrotoluene affects the expression of SLPI mRNA"	21346803
D000082	Acetaminophen	Acetaminophen affects the expression of SLPI mRNA	17984051
D016604	Aflatoxin B1	Aflatoxin B1 results in increased expression of SLPI mRNA	19770486
D000643	Ammonium Chloride	Ammonium Chloride affects the expression of SLPI mRNA	16483693
D001151	Arsenic	Arsenic results in decreased expression of SLPI mRNA	19654921
D017638	Asbestos, Crocidolite	"Asbestos, Crocidolite results in decreased expression of SLPI mRNA"	24160326
D017638	Asbestos, Crocidolite	"Asbestos, Crocidolite results in increased expression of SLPI mRNA"	23917077
D001241	Aspirin	Aspirin results in decreased expression of SLPI mRNA	15928584
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of SLPI mRNA	20127859
D004958	Estradiol	[Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of SLPI mRNA	19619570
D004958	Estradiol	Estradiol results in decreased expression of SLPI mRNA	23019147
D004958	Estradiol	Estradiol results in increased expression of SLPI mRNA	19619570
D004958	Estradiol	Estradiol results in increased expression of SLPI mRNA	17010207
C006780	bisphenol A	bisphenol A results in increased methylation of SLPI promoter	27312807
C006780	bisphenol A	bisphenol A results in increased expression of SLPI mRNA	18180321
D001761	Bleomycin	Bleomycin results in increased expression of SLPI protein	26345256
D020122	tert-Butylhydroperoxide	SLPI protein results in decreased susceptibility to tert-Butylhydroperoxide	15003993
D020122	tert-Butylhydroperoxide	tert-Butylhydroperoxide results in increased expression of SLPI mRNA	14729362\|1500399
D002251	Carbon Tetrachloride	Carbon Tetrachloride results in increased expression of SLPI mRNA	27339419
D002330	Carmustine	SLPI mRNA affects the susceptibility to Carmustine	16365179
D002509	Cephaloridine	Cephaloridine results in increased expression of SLPI mRNA	18500788
C018021	cobaltous chloride	cobaltous chloride results in increased expression of SLPI mRNA	23052192
D003300	Copper	[NSC 689534 binds to Copper] which results in increased expression of SLPI mRNA	20971185
D003474	Curcumin	Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of SLPI mRNA]	18200517
C057862	cyanoginosin LR	cyanoginosin LR affects the expression of SLPI mRNA	20957730
D003520	Cyclophosphamide	Cyclophosphamide results in decreased expression of SLPI mRNA	15331540
D016572	Cyclosporine	Cyclosporine results in decreased expression of SLPI mRNA	20106945\|2798913
D003907	Dexamethasone	[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in decreased expression of SLPI mRNA	16054899
D002945	Cisplatin	Cisplatin results in decreased expression of SLPI mRNA	27392435
D002945	Cisplatin	SLPI protein affects the susceptibility to Cisplatin	16217747
D003633	Dichlorodiphenyl Dichloroethylene	Dichlorodiphenyl Dichloroethylene affects the expression of SLPI mRNA	27391359
D004041	Dietary Fats	Dietary Fats results in increased expression of SLPI mRNA	22609946
D004041	Dietary Fats	Dietary Fats results in decreased expression of SLPI mRNA	21852083
D004052	Diethylnitrosamine	[Diethylnitrosamine co-treated with Phenobarbital] results in increased expression of SLPI mRNA	24535843
D004052	Diethylnitrosamine	Diethylnitrosamine results in increased expression of SLPI mRNA	24535843
D004052	Diethylnitrosamine	[Diethylnitrosamine co-treated with Thioacetamide] results in increased expression of SLPI mRNA	28943392
D004054	Diethylstilbestrol	Diethylstilbestrol results in increased expression of SLPI mRNA	15171707
D004054	Diethylstilbestrol	Diethylstilbestrol results in increased expression of SLPI mRNA	17010207
D002117	Calcitriol	Calcitriol results in increased expression of SLPI mRNA	26485663
D004137	Dinitrochlorobenzene	Dinitrochlorobenzene affects the expression of SLPI mRNA	22302311
D004237	Diuron	Diuron metabolite results in increased expression of SLPI mRNA	24172598
D004997	Ethinyl Estradiol	[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of SLPI mRNA	17942748
D004997	Ethinyl Estradiol	Ethinyl Estradiol affects the expression of SLPI mRNA	23300682
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in increased expression of SLPI mRNA	15834898\|1755790
C000499	ferric oxide	[Magnetite Nanoparticles co-treated with ferric oxide] results in increased expression of SLPI mRNA	20540983
D005419	Flavonoids	Flavonoids results in increased expression of SLPI mRNA	18035473
D000068298	Fluticasone	[Fluticasone co-treated with Salmeterol Xinafoate] results in increased expression of SLPI mRNA	15862954
D000068298	Fluticasone	Fluticasone results in increased expression of SLPI mRNA	15860753
D000068298	Fluticasone	Salmeterol Xinafoate promotes the reaction [Fluticasone results in increased expression of SLPI mRNA]	15860753
C069837	fullerene C60	fullerene C60 results in increased expression of SLPI mRNA	20064541
C070081	fulvestrant	fulvestrant inhibits the reaction [Genistein results in increased expression of SLPI mRNA]	22553218
C039281	furan	furan results in increased expression of SLPI mRNA	27387713
D019833	Genistein	fulvestrant inhibits the reaction [Genistein results in increased expression of SLPI mRNA]	22553218
D019833	Genistein	Genistein results in increased expression of SLPI mRNA	21810550\|2255321
D005839	Gentamicins	Gentamicins results in increased expression of SLPI mRNA	22061828
D017313	Fenretinide	Fenretinide results in decreased expression of SLPI mRNA	28973697
D006861	Hydrogen Peroxide	Hydrogen Peroxide affects the expression of SLPI mRNA	20044591
D006861	Hydrogen Peroxide	Hydrogen Peroxide results in increased expression of SLPI mRNA	14729362\|1500399
C051890	irinotecan	irinotecan affects the expression of SLPI mRNA	20097248
D007501	Iron	Iron deficiency results in decreased expression of SLPI mRNA	20368581
D015056	1-Methyl-3-isobutylxanthine	[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in decreased expression of SLPI mRNA	16054899
C098607	JP8 aviation fuel	JP8 aviation fuel results in decreased expression of SLPI protein	17337753
C561695	(+)-JQ1 compound	(+)-JQ1 compound inhibits the reaction [Lipopolysaccharides results in increased expression of SLPI mRNA]	25890327
D008070	Lipopolysaccharides	Lipopolysaccharides results in increased expression of SLPI mRNA	22235868
D008070	Lipopolysaccharides	(+)-JQ1 compound inhibits the reaction [Lipopolysaccharides results in increased expression of SLPI mRNA]	25890327
D008070	Lipopolysaccharides	Lipopolysaccharides results in increased expression of SLPI mRNA	25890327\|2733941
D058185	Magnetite Nanoparticles	[Magnetite Nanoparticles co-treated with ferric oxide] results in increased expression of SLPI mRNA	20540983
D058185	Magnetite Nanoparticles	[Succimer binds to Magnetite Nanoparticles] which results in increased expression of SLPI mRNA	21641980
D008731	Methoxychlor	Methoxychlor affects the expression of SLPI mRNA	27391359
D037742	Nanotubes, Carbon	"Nanotubes, Carbon analog results in increased expression of SLPI mRNA"	25554681
D037742	Nanotubes, Carbon	"Nanotubes, Carbon results in increased expression of SLPI mRNA"	25554681
C031721	naphthalene	naphthalene results in increased expression of SLPI mRNA	18978301
C017557	nickel subsulfide	nickel subsulfide results in decreased expression of SLPI mRNA	21086188
C558013	NSC 689534	[NSC 689534 binds to Copper] which results in increased expression of SLPI mRNA	20971185
C558013	NSC 689534	NSC 689534 results in increased expression of SLPI mRNA	20971185
C474055	octylphenol	octylphenol results in increased expression of SLPI mRNA	17010207
C510784	ormosil	[ormosil binds to Polyethylene Glycols] which results in decreased expression of SLPI mRNA	24888373
C030110	oxaliplatin	[oxaliplatin co-treated with Topotecan] results in increased expression of SLPI mRNA	25729387
C030110	oxaliplatin	oxaliplatin results in increased expression of SLPI mRNA	25729387
D010098	Oxycodone	Oxycodone results in decreased expression of SLPI mRNA	23439660
D010269	Paraquat	Paraquat results in increased expression of SLPI protein	26345256
D052638	Particulate Matter	Particulate Matter results in increased expression of SLPI mRNA	28341207
C023036	perfluorooctanoic acid	perfluorooctanoic acid results in decreased expression of SLPI mRNA	16221955
D010634	Phenobarbital	[Diethylnitrosamine co-treated with Phenobarbital] results in increased expression of SLPI mRNA	24535843
D010634	Phenobarbital	NR1I3 protein affects the reaction [Phenobarbital results in increased expression of SLPI mRNA]	19482888
D010634	Phenobarbital	Phenobarbital results in increased expression of SLPI mRNA	19482888
C006253	pirinixic acid	[pirinixic acid co-treated with PPARA] results in increased expression of SLPI mRNA	20813756
C006253	pirinixic acid	pirinixic acid results in decreased expression of SLPI mRNA	17426115
C006253	pirinixic acid	pirinixic acid results in increased expression of SLPI mRNA	20813756
D011092	Polyethylene Glycols	[ormosil binds to Polyethylene Glycols] which results in decreased expression of SLPI mRNA	24888373
D011374	Progesterone	Progesterone affects the expression of SLPI mRNA	17251523
C005556	propionaldehyde	propionaldehyde results in decreased expression of SLPI mRNA	26079696
D011441	Propylthiouracil	Propylthiouracil results in decreased expression of SLPI mRNA	24780913
C089730	rosiglitazone	[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in decreased expression of SLPI mRNA	16054899
D000068299	Salmeterol Xinafoate	[Fluticasone co-treated with Salmeterol Xinafoate] results in increased expression of SLPI mRNA	15862954
D000068299	Salmeterol Xinafoate	Salmeterol Xinafoate promotes the reaction [Fluticasone results in increased expression of SLPI mRNA]	15860753
C541923	sandostatinLAR	sandostatinLAR results in increased expression of SLPI mRNA	17210224
D017632	Asbestos, Serpentine	"Asbestos, Serpentine results in decreased expression of SLPI mRNA"	24160326
D017632	Asbestos, Serpentine	"Asbestos, Serpentine results in increased expression of SLPI mRNA"	24160326
D012822	Silicon Dioxide	Silicon Dioxide analog results in decreased expression of SLPI mRNA	25895662
D012822	Silicon Dioxide	Silicon Dioxide analog results in increased expression of SLPI mRNA	23806026
D012822	Silicon Dioxide	Silicon Dioxide results in increased expression of SLPI mRNA	26345256
D012822	Silicon Dioxide	Silicon Dioxide results in increased expression of SLPI protein	26345256
D012906	Smoke	Smoke results in decreased expression of SLPI mRNA	21095227
D053260	Soot	Soot results in increased expression of SLPI mRNA	22461453\|2655175
D004113	Succimer	[Succimer binds to Magnetite Nanoparticles] which results in increased expression of SLPI mRNA	21641980
C047246	temozolomide	SLPI mRNA affects the susceptibility to temozolomide	16365179
C020806	tetrabromobisphenol A	tetrabromobisphenol A results in increased expression of SLPI mRNA	25172293
D013749	Tetrachlorodibenzodioxin	[Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of SLPI mRNA	19619570
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of SLPI mRNA	19619570
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of SLPI mRNA	18343893\|2157046
D013749	Tetrachlorodibenzodioxin	[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of SLPI mRNA	17942748
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of SLPI mRNA	21215274
D013853	Thioacetamide	[Diethylnitrosamine co-treated with Thioacetamide] results in increased expression of SLPI mRNA	28943392
C009495	titanium dioxide	titanium dioxide results in increased expression of SLPI mRNA	19464567\|2355797
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution results in decreased expression of SLPI mRNA	28065790
D014028	Tobacco Smoke Pollution	NFE2L2 protein affects the reaction [Tobacco Smoke Pollution affects the expression of SLPI mRNA]	20133372
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution affects the expression of SLPI mRNA	20133372
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution results in decreased expression of SLPI mRNA	18087596
C116664	tolvaptan	tolvaptan results in increased expression of SLPI mRNA	28115652
C116664	tolvaptan	tolvaptan results in increased expression of SLPI protein	28115652
D019772	Topotecan	[oxaliplatin co-treated with Topotecan] results in increased expression of SLPI mRNA	25729387
D019772	Topotecan	Topotecan results in increased expression of SLPI mRNA	25729387
D014118	Toxins, Biological	"Toxins, Biological affects the expression of SLPI mRNA"	19682533
D014241	Trichloroethylene	Trichloroethylene results in decreased expression of SLPI mRNA	17905399
C015559	trimellitic anhydride	trimellitic anhydride affects the expression of SLPI mRNA	22302311
D014302	Trinitrobenzenesulfonic Acid	Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of SLPI mRNA]	18200517
D014302	Trinitrobenzenesulfonic Acid	Trinitrobenzenesulfonic Acid results in increased expression of SLPI mRNA	18200517
C022884	undecane	undecane results in decreased expression of SLPI protein	17337753
D014635	Valproic Acid	Valproic Acid results in decreased methylation of SLPI gene	29154799
D001335	Vehicle Emissions	Vehicle Emissions results in decreased methylation of SLPI gene	25560391
C088658	zoledronic acid	zoledronic acid results in increased expression of SLPI mRNA	24714768
C088658	zoledronic acid	zoledronic acid results in increased expression of SLPI protein	28871336

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0003677	DNA binding	-	IDA	2467900
GO:0003729	mRNA binding	-	IDA	2467900
GO:0004866	endopeptidase inhibitor activity	-	TAS	3485543
GO:0004867	serine-type endopeptidase inhibitor activity	-	IDA	3462719
GO:0005515	protein binding	-	IPI	19333378 25416956
GO:0019899	enzyme binding	-	IPI	19333378

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0006955	immune response	-	ISS	-
GO:0010951	negative regulation of endopeptidase activity	-	IEA	-
GO:0019731	antibacterial humoral response	-	IDA	18714013
GO:0019731	antibacterial humoral response	-	ISS	-
GO:0032091	negative regulation of protein binding	-	IDA	19333378
GO:0032496	response to lipopolysaccharide	-	ISS	-
GO:0035821	modification of morphology or physiology of other organism	-	IDA	2467900
GO:0043312	neutrophil degranulation	-	TAS	-
GO:0045071	negative regulation of viral genome replication	-	IDA	19333378
GO:0045087	innate immune response	-	ISS	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005576	extracellular region	-	TAS	-
GO:0005615	extracellular space	-	IDA	3462719 18714013
GO:0035580	specific granule lumen	-	TAS	-
GO:0062023	collagen-containing extracellular matrix	colocalizes_with	HDA	20551380
GO:0070062	extracellular exosome	-	HDA	19199708

KEGG ID	KEGG Term

Reactome ID	Reactome Term	Evidence
R-HSA-168249	Innate Immune System	TAS
R-HSA-168256	Immune System	TAS
R-HSA-6798695	Neutrophil degranulation	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
12753532	Secretory leukocyte proteinase inhibitor, alpha-1-antitrypsin deficiency and emphysema: Preliminary study, speculation and an hypothesis. (2003 Jun)	Ayad MS	Respirology
9441132	The proteinase-antiproteinase theory of emphysema: a speculative analysis of recent advances into the pathogenesis of emphysema. (1997 Jun)	Knight KR	Respirology
23467841	Human papillomavirus infection in head and neck cancer: the role of the secretory leukocyte protease inhibitor. (2013 May)	Hoffmann M	Oncol Rep
28298400	Antimicrobial peptide levels are linked to airway inflammation, bacterial colonisation and exacerbations in chronic obstructive pulmonary disease. (2017 Mar)	Persson LJ	Eur Respir J
21426578	Smoking status and anti-inflammatory macrophages in bronchoalveolar lavage and induced sputum in COPD. (2011 Mar 22)	Kunz LI	Respir Res
21635782	Sputum and nasal lavage lung-specific biomarkers before and after smoking cessation. (2011 Jun 2)	Bouloukaki I	BMC Pulm Med
22574903	Inhibitory effect of Chinese green tea on cigarette smoke-induced up-regulation of airway neutrophil elastase and matrix metalloproteinase-12 via antioxidant activity. (2012 Sep)	Chan KH	Free Radic Res
18953959	[Effects of secretory leukocyte protease inhibitor on expression of inflammation mediators in normal human bronchial epithelial cells induced by cigarette smoke extract]. (2008 May)	Qu MY	Zhonghua Jie He He Hu Xi Za Zhi
24140751	Quantification of secretory leukocyte protease inhibitor (SLPI) in oral gargle specimens collected using mouthwash. (2013 Dec 31)	Pierce Campbell CM	J Immunol Methods
28811900	SLPI and AnxA2 expression in neoplasm-free palatine tonsils is associated with smoking habit of individuals. (2017 Sep)	Quabius ES	Mol Clin Oncol
25462861	The antileukoprotease secretory leukocyte protease inhibitor (SLPI) and its role in the prevention of HPV-infections in head and neck squamous cell carcinoma. (2015 Feb 1)	Quabius ES	Cancer Lett
23126266	Expression of oral secretory leukocyte protease inhibitor in HIV-infected subjects with long-term use of antiretroviral therapy. (2013 Mar)	Nittayananta W	J Oral Pathol Med
24285265	Regulation and activity of secretory leukoprotease inhibitor (SLPI) is altered in smokers. (2014 Feb)	Meyer M	Am J Physiol Lung Cell Mol Physiol
22333260	[Effects of secretary leukocyte protease inhibitor-transfected bone marrow mesenchymal stem cells on airway inflammation and mucus secretion in chronic obstructive pulmonary disease]. (2011 Dec 27)	Jiang DP	Zhonghua Yi Xue Za Zhi
21917606	Potential role of HE4 in multimodal screening for epithelial ovarian cancer. (2011 Nov 2)	Urban N	J Natl Cancer Inst
23996702	The role of the antileukoprotease SLPI in smoking-induced human papillomavirus-independent head and neck squamous cell carcinomas. (2014 Mar 15)	Quabius ES	Int J Cancer
29179866	miRNA-expression in tonsillar squamous cell carcinomas in relation to HPV infection and expression of the antileukoproteinase SLPI. (2017 Dec)	Quabius ES	Papillomavirus Res
10853853	Airways inflammation in chronic bronchitis: the effects of smoking and alpha1-antitrypsin deficiency. (2000 May)	Hill AT	Eur Respir J
18699806	Altered expression of antimicrobial molecules in cigarette smoke-exposed emphysematous mice lungs. (2008 Nov)	Shibata Y	Respirology
11120902	Relationship between airway inflammation and the frequency of exacerbations in patients with smoking related COPD. (2001 Jan)	Gompertz S	Thorax
27016010	Salivary secretory leukocyte protease inhibitor (SLPI) and head and neck cancer: The Cancer Prevention Study II Nutrition Cohort. (2016 Apr)	Pierce Campbell CM	Oral Oncol
15039315	Salivary secretory leukocyte protease inhibitor and oral candidiasis in human immunodeficiency virus type 1-infected persons. (2004 Apr)	Chattopadhyay A	Infect Immun
15167969	Human neutrophil defensins and secretory leukocyte proteinase inhibitor in squamous metaplastic epithelium of bronchial airways. (2004 Jun)	Aarbiou J	Inflamm Res